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Junshanyinzhen tea extract prevents obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats

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Food Science and Human Wellness 2024年第4期13卷 2036-2047页

作者： jian Ouyang Xiuping Li Changwei liu Danmin Lu Jie Ouyang Fang Zhou qi liu jianan Huang Zhonghua liu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals Hunan Agricultural UniversityChangsha 410128China Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients Hunan Agricultural UniversityChangsha 410128China Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops Ministry of Agriculture and Rural AffairsHunan Agricultural UniversityChangsha 410128China

Obesity is associated with gut dysbiosis and metabolic *** tea extract(JSTE)reduced fat accumulation and body weight in obese ***,the effects and mechanism of JSTE in preventing obesity were ***,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of ***,our results showed that JSTE could significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(P<0.05).In addition,JSTE increased the expression of intestinal tight junction proteins(P<0.05),relieved metabolic endotoxemia(P<0.05)and chronic low-grade inflammation in HFD *** of fecal samples showed that JSTE could effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed *** and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were ***,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.

关键词： Junshanyinzhen tea Obesity Gut microbiota Gut barrier function Metabolic endotoxemia

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Asymmetric reversible structural switching of a diene coordination polymer promoted by UV-visible light

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Science China Chemistry 2024年第2期67卷 536-541页

作者： Yong Wang qiaoqiao Zhang Yong-Yong Cao qi liu Brendan F.Abrahams jian-Ping Lang College of Chemistry Chemical Engineering and MaterialsSoochow UniversitySuzhou215123China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing314001China School of Chemistry University of MelbourneVictoria3010Australia

In natural and artificial systems,reversible reactions are commonly asymmetric with respect to the time scale and nature of the stimuli which drive the forward and backward *** applications for which switching behavior is required,it is desirable that the reversible reaction goes as close to symmetric as possible;however,such systems are ***,we report an example of ultraviolet(UV)-visible light-regulated asymmetric reversible structural switching involving a diene-based coordination polymer,CP1 and its monocyclobutane product,*** is possible to cycle at least ten times through a forward [2+2] photocycloaddition reaction and the reverse,photocleavage reaction.A single cycle can be completed within a few *** transformation is accompanied by fast and distinct fluorescence changes,arising from optimisation of the reaction *** functional theory calculations allow rationalisation of the asymmetric reversible transformation between CP1 and CP1a rather than between CP1 and its dicyclobutane product *** work provides a clear illustration of reversible structural switching which approaches symmetric behaviour with respect to reaction rate and *** insights gained from this work also assist in the design of fast,reversible switching materials.

关键词： asymmetrical reversible structural switching coordination polymer photocycloaddition UV-visible light-controlled fluorescence switching

Postoperative accurate pain assessment of children and artificial intelligence: A medical hypothesis and planned study

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World Journal of Clinical Cases 2024年第4期12卷 681-687页

作者： jian-Ming Yue qi Wang Bin liu Leng Zhou Department of Anesthesiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Although the pediatric perioperative pain management has been improved in recent years,the valid and reliable pain assessment tool in perioperative period of children remains a challenging *** perioperative pain management is intractable not only because children cannot express their emotions accurately and objectively due to their inability to describe physiological characteristics of feeling which are different from those of adults,but also because there is a lack of effective and specific assessment tool for *** addition,exposure to repeated painful stimuli early in life is known to have short and long-term adverse *** short-term sequelae can induce a series of neurological,endocrine,cardiovascular system stress related to psychological trauma,while long-term sequelae may alter brain maturation process,which can lead to impair neurodevelopmental,behavioral,and cognitive ***’s facial expressions largely reflect the degree of pain,which has led to the developing of a number of pain scoring tools that will help improve the quality of pain mana-gement in children if they are continually studied in *** artificial inte-lligence(AI)technology represented by machine learning has reached an unprecedented level in image processing of deep facial models through deep convolutional neural networks,which can effectively identify and systematically analyze various subtle features of children’s facial *** on the construction of a large database of images of facial expressions in children with perioperative pain,this study proposes to develop and apply automatic facial pain expression recognition software using AI *** study aims to improve the postoperative pain management for pediatric population and the short-term and long-term quality of life for pediatric patients after operational event.

关键词： Pediatric Perioperative pain Assessment tool Facial expression Machine learning Artificial intelligence

Devolatilization of high viscous fluids with high gravity technology

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Chinese Journal of Chemical Engineering 2024年第7期71卷 249-257页

作者： Jibing qi Youzhi liu Yandong liu Taiyuan University Taiyuan 030032China Shanxi Province Key Laboratory of Higee-Oriented Chemical Engineering North University of ChinaTaiyuan 030051China

Volatile organic compounds(VOCs)are generally toxic and harmful substances that can cause health and environmental *** removal of VOCs from polymers has become a key *** effective devolatilization to remove VOCs from high viscous fluids such as polymer is necessary and is of great *** this study,the devolatilization effect of a rotating packed bed(RPB)was studied by using polydimethylsiloxane as the viscous fluid and acetone as the *** devolatilization rate and liquid phase volume(KLa)have been *** results indicated that the optimum conditions were the high-gravity factor of 60,liquid flow rate of 10 L·h^(-1),and vacuum degree of 0.077 *** dimensionless correlation of KLa was established,and the deviations between predicted and experimental values were less than±28%.The high-gravity technology will result in lower mass transfer resistance in the devolatilization process,enhance the mass transfer process of acetone,and improve the removal effect of *** work provides a promising path for the removal of volatiles from polymers in combination with high-gravity *** can provide the basis for the application of RPB in viscous fluids.

关键词： High-gravity technology Devolatilization rate High viscous fluid Volatile organic compounds(VOCs)

A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： Hao-qi Yu Tao Yu jian-Hua Ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)

A 128×128 SPAD LiDAR sensor with column-parallel 25 ps resolution TA-ADCs

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Journal of Semiconductors 2024年第8期45卷 34-40页

作者： Na Tian Zhe Wang Kai Ma Xu Yang Nan qi jian liu Nanjian Wu Runjiang Dou Liyuan liu State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

This paper presents a design of single photon avalanche diode(SPAD)light detection and ranging(LiDAR)sensor with 128×128 pixels and 128 column-parallel time-to-analog-merged-analog-to-digital converts(TA-ADCs).Unlike the conventional TAC-based SPAD LiDAR sensor,in which the TAC and ADC are separately implemented,we propose to merge the TAC and ADC by sharing their capacitors,thus avoiding the analog readout noise of TAC’s output buffer,improving the conversion rate,and reducing chip *** reverse start-stop logic is employed to reduce the power of the *** in a 180 nm CMOS process,our prototype sensor exhibits a timing resolution of 25 ps,a DNL of+0.30/−0.77 LSB,an INL of+1.41/−2.20 LSB,and a total power consumption of 190 mW.A flash LiDAR system based on this sensor demonstrates the function of 2D/3D imaging with 128×128 resolution,25 kHz inter-frame rate,and sub-centimeter ranging precision.

关键词： 3D imaging CMOS imagers direct time-of-flight(dTOF) time-to-analog converter(TAC)

Reducing the vacancies associated with ferroelectric polarization to promote photocatalytic overall water splitting

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Science China Chemistry 2024年第10期67卷 3258-3264页

作者： Haozhi qi Yuyang Kang jian-An liu Lichang Yin Wenyu Zhang Shangyi Ma jianhang qiu Lingli Li Weijin Hu Lianzhou Wang Gang liu Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Nanomaterials Centre School of Chemical Engineering and Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandSt LuciaBrisbane QLD 4072Australia

Ferroelectric materials hold great promise in photocatalytic water splitting because their built-in electric field induced by the depolarization field can fulfill the separation of photogenerated ***,a number of intrinsic charged vacancy defects are simultaneously generated to screen the depolarized field for stabilizing the crystal structure,always resulting in severe recombination of photogenerated carriers and thus poor overall water splitting ***,we proposed a strategy to promote the separation and transport of photogenerated carriers of ferroelectric photocatalysts by adjusting the ferroelectric polarization and altering the coordination environment of elements to reduce the defect ***,we prepared a series of Ta-doped PbTiO_(3)with low Pb(V_(Pb))and O(V_(O))vacancy concentrations by reducing the polarization intensity and strengthening the Pb–O *** Ta-doped PbTiO_(3)shows efficient charge separation and greatly enhanced photocatalytic overall water splitting activity with the assistance of *** work highlights the importance of regulating ferroelectric polarization and vacancy defect concentration by the doping strategy in charge separation for photocatalytic water splitting.

关键词： PbTiO_(3) ferroelectric polarization vacancy defect element doping photocatalytic overall water splitting

Chaotic Map-Based Authentication and Key Agreement Protocol with Low-Latency for Metasystem

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Computers, Materials & Continua 2024年第3期78卷 4471-4488页

作者： Guojun Wang qi liu School of Electronics&Information Engineering Nanjing University of Information Science&TechnologyNanjing210044China Yancheng Polytechnic College Yancheng224000China jiangsu Province Engineering Research Center of Advanced Computing and Intelligent Services School of SoftwareNanjing University of Information Science and TechnologyNanjingChina

With the rapid advancement in exploring perceptual interactions and digital twins,metaverse technology has emerged to transcend the constraints of space-time and reality,facilitating remote AI-based *** this dynamic metasystem environment,frequent information exchanges necessitate robust security measures,with Authentication and Key Agreement(AKA)serving as the primary line of defense to ensure communication ***,traditional AKA protocols fall short in meeting the low-latency requirements essential for synchronous interactions within the *** address this challenge and enable nearly latency-free interactions,a novel low-latency AKA protocol based on chaotic maps is *** protocol not only ensures mutual authentication of entities within the metasystem but also generates secure session *** security of these session keys is rigorously validated through formal proofs,formal verification,and informal *** confronted with the Dolev-Yao(DY)threat model,the session keys are formally demonstrated to be secure under the Real-or-Random(ROR)*** proposed protocol is further validated through simulations conducted using VMware workstation compiled in HLPSL language and C *** simulation results affirm the protocol’s effectiveness in resisting well-known attacks while achieving the desired low latency for optimal metaverse interactions.

关键词： Metasystem authentication and key agreement chaotic map secure communication

Improved Double Deep Q Network-Based Task Scheduling Algorithm in Edge Computing for Makespan Optimization

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Tsinghua Science and Technology 2024年第3期29卷 806-817页

作者： Lei Zeng qi liu Shigen Shen Xiaodong liu School of Computer Science Nanjing University of Information Science and TechnologyNanjing 210044China School of Software Nanjing University of Information Science and TechnologyNanjing 210044China School of Information Engineering Huzhou UniversityHuzhou 313000China School of Computing Edinburgh Napier UniversityEdinburghEH105DTUK

Edge computing nodes undertake an increasing number of tasks with the rise of business ***,how to efficiently allocate large-scale and dynamic workloads to edge computing resources has become a critical *** study proposes an edge task scheduling approach based on an improved Double Deep Q Network(DQN),which is adopted to separate the calculations of target Q values and the selection of the action in two networks.A new reward function is designed,and a control unit is added to the experience replay unit of the *** management of experience data are also modified to fully utilize its value and improve learning *** learning agents usually learn from an ignorant state,which is *** such,this study proposes a novel particle swarm optimization algorithm with an improved fitness function,which can generate optimal solutions for task *** optimized solutions are provided for the agent to pre-train network parameters to obtain a better cognition *** proposed algorithm is compared with six other methods in simulation *** show that the proposed algorithm outperforms other benchmark methods regarding makespan.

关键词： edge computing task scheduling reinforcement learning makespan Double Deep Q Network(DQN)