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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui huang Ajing Xu Yan Liu jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Negative PO3-implanted bionic ion transport channels for promoting Li-S battery

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Science China Chemistry 2025年

作者： Wenhuan huang Shun Wang Xuehan Hou Yanan Zhang Xingxing Zhang Yaoxiao Zhao Xilang Jin Huabin Zhang Fei Wang jian Zhang Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and Technology School of Materials and Chemical Engineering Xi'an Technological University Chemistry Program Physical Science and Engineering Division King Abdullah University of Science and Technology State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Lithium-sulfur （Li-S） battery,as a promising next-generation high-energy-density battery,suffers from lithium polysulfides（LPSs） shuttle and Li dendrites *** crystalline framework-based membranes as separator can effectively absorb and restrain LPSs but without precise structural design principal exploration and mechanism ***,bio-inspired 1D oriented lithium-ion transport channels with molecular negatively charged PO3（-1） have been developed in hybrid tetrazole frameworks for promoting the transmission of Li+*** theoretical calculations and in situ spectroscopy demonstrated the higher binding energy and inhibited diffusion of LPSs in *** assembled PP@PO3Janus separator in Li-S coin cell delivered a high initial capacity of 1410.9 mAh g-1at 0.1 C and a low attenuation rate of 0.038%per cycle over 500 cycles at 5 ***,the high capacities of 862,542 and 409 mAh g-1based on high-sulfur-loading cathodes of 2.6,3.8 and 5.0 mg cm-2at0.5 C were achieved,***,the punch battery of PO3@PP separator with S-cathode of 1.2 mg cm-2has been developed for demonstrating its potentials commercial application,which displays impressive capacity of 873.4 mAh g-1with the retention of～78.9%over 50 cycles.

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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基于聚类算法的路径频散曲线拾取方法

中国海洋大学学报（自然科学版） 2025年第1期55卷 149-157页

作者：何建张建中黄忠来中国海洋大学海洋地球科学学院山东青岛266100 中国海洋大学海底科学与探测技术教育部重点实验室山东青岛266100

多道地震资料面波分析方法是目前确定近地表横波速度的有效工具,但由于反演的一维横波速度模型仅反映了检波器排列中点垂直方向上的横波速度变化,因此其横向分辨率较差。与面波分析方法相比,面波层析反演方法具有更大的潜力来提高近地... 详细信息

多道地震资料面波分析方法是目前确定近地表横波速度的有效工具,但由于反演的一维横波速度模型仅反映了检波器排列中点垂直方向上的横波速度变化,因此其横向分辨率较差。与面波分析方法相比,面波层析反演方法具有更大的潜力来提高近地表特征的横向分辨率。但是面波层析反演方法需要从大量检波器对之间(路径)的平均频散能量谱中拾取频散曲线,人工拾取将耗费大量的时间成本。针对这个问题,本文进行了聚类算法自动从路径平均频散能量谱中拾取相速度频散曲线的研究。理论模型正演数据以及实际资料面波数据的实验结果都验证了本文方法的正确性。

关键词：聚类算法频散曲线面波层析反演横波速度

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Neural-Network-Based Nonlinear Model Predictive Tracking Control of a Pneumatic Muscle Actuator-Driven Exoskeleton

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IEEE/CAA Journal of Automatica Sinica 2020年第6期7卷 1478-1488页

作者： Yu Cao jian.huang IEEE Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhan 430074China

Pneumatic muscle actuators(PMAs)are compliant and suitable for robotic devices that have been shown to be effective in assisting patients with neurologic injuries,such as strokes,spinal cord injuries,etc.,to accomplish rehabilitation ***,because PMAs have nonlinearities,hysteresis,and uncertainties,etc.,complex mechanisms are rarely involved in the study of PMA-driven robotic *** this paper,we use nonlinear model predictive control(NMPC)and an extension of the echo state network called an echo state Gaussian process(ESGP)to design a tracking controller for a PMA-driven lower limb *** dynamics of the system include the PMA actuation and mechanism of the leg orthoses;thus,the system is represented by two nonlinear uncertain *** facilitate the design of the controller,joint angles of leg orthoses are forecasted based on the universal approximation ability of the ESGP.A gradient descent algorithm is employed to solve the optimization problem and generate the control *** stability of the closed-loop system is guaranteed when the ESGP is capable of approximating system *** and experiments are conducted to verify the approximation ability of the ESGP and achieve gait pattern training with four healthy subjects.

关键词： Echo state Gaussian process model predictive control neural network pneumatic muscle actuators-driven exoskeleton

Effect of different doping elements on performance of Ce-Mn/TiO_(2)catalyst for low temperature denitration

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Journal of Rare Earths 2023年第5期41卷 689-697,I0002页

作者： Lihua huang jian Hua Insititute of Environment and Resources Southwest University of Science and TechnologyMianyang 621010China National Engineering Research Center for Flue Gas Desulfurization Chengdu 610065China

Sm and Ho were doped in Ce-Mn/TiO_(2)catalyst respectively to enhance its denitration performance at low temperature.X-ray diffraction(XRD),N2adsorption-desorption,X-ray photoelectron spectroscopy(XPS),NH3-temperature programmed desorption(NH3-TPD),H2-temperature programmed reduction(H2-TPR)and in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)techniques were used to analyze the structure and performance of *** results demonstrate that Ho doping increases the amount of acid sites and improves low temperature redox property of Ce-Mn/TiO_(2),which lead to excellent DeNOxperformance of Ho-Ce-Mn/TiO_(2)in the whole reaction temperature *** doping results in decline of redox property,but it is beneficial to increasing the acid sites of Ce-Mn/TiO_(2).The increased surface acid sites and moderate oxidative ability impart Sm-Ce-Mn/TiO_(2)higher denitration activity and N2selectivity at temperature above 150℃.Lewis acid sites and redox property are the main factors affecting the activity of *** of Ho and Sm both improves sulfur resistance performance of Ce-Mn/TiO_(2)by inhibiting the adsorption of SO_(2)and formation of ***-Mn/TiO_(2)modified by Ho shows better sulfur resistance than that doped with Sm because of its more surface acid sites.

关键词： Ce-Mn/TiO_(2)catalyst Doping Sm Ho Denitration performance Rareearths

Thermal comfort in winter incorporating solar radiation effects at high altitudes and performance of improved passive solar design-Case of Lhasa

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Building Simulation 2021年第6期14卷 1633-1650页

作者： Lingjiang huang jian Kang Department of Architecture Wuhan UniversityWuhan 430072China UCL Institute for Environmental Design and Engineering The BartlettUniversity College London(UCL)London WC1H 0NNUK

The solar incidence on an indoor environment and its occupants has significant impacts on indoor thermal *** can bring favorable passive solar heating and can result in undesired overheating(even in winter).This problem becomes more critical for high altitudes with high intensity of solar irradiance,while received limited *** this study,we explored the specific overheating and rising thermal discomfort in winter in Lhasa as a typical location of a cold climate at high ***,we evaluated the thermal comfort incorporating solar radiation effect in winter by field ***,we investigated local occupant adaptive responses(considering the impact of direct solar irradiance).This was followed by a simulation study of assessment of annual based thermal comfort and the effect on energy-saving potential by current solar ***,we discussed winter shading design for high altitudes for both solar shading and passive solar use at high altitudes,and evaluated thermal mass shading with solar louvers in terms of indoor environment *** results reveal that considerable indoor overheating occurs during the whole winter season instead of summer in Lhasa,with over two-thirds of daytime beyond the comfort ***,various adaptive behaviors are adopted by occupants in response to overheating due to the solar ***,it is found that the energy-saving potential might be overestimated by 1.9 times with current window to wall ratio requirements in local design standards and building codes due to the thermal adaption by drawing *** developed thermal mass shading is efficient in achieving an improved indoor thermal environment by reducing overheating time to an average of 62.2% during the winter and a corresponding increase of comfort time.

关键词： thermal comfort overheating passive solar design high altitude Tibet solar shading

Composites of sodium manganese oxides with enhanced electrochemical performance for sodium-ion batteries: Tailoring properties via controlling microstructure

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Science China(Technological Sciences) 2016年第7期59卷 1042-1047页

作者： huang JiaJia LUO jian Department of Nano Engineering Program of Materials Science and Engineering University of California

Composites of Na_(0.44)Mn O_2, Na_(0.7)Mn O_(2.05), and Na_(0.91) Mn O_2 were synthesized by facile solid-state reaction, ball milling, and annealing methods. Two different composites of identical overall composition but drastically different morphologies and microstructures were synthesized. A composite of a hierarchical porous microstructure with primary and secondary particles(i.e., a "meatball-like" microstructure) achieved an excellent stable capacity of 126 m A h g^(-1) after 100 cycles. The rate capability of the composite could be dramatically enhanced by another round of high-energy ball milling and reannealing; subsequently, a composite that was made up of irregular rods was obtained, for which the capacity was improved by more than 230% to achieve ~53 m A h g^(-1) at a particularly high discharge rate of 50 C. This study demonstrated the feasibility of tailoring the electrochemical performance of electrode materials by simply changing their microstructures via facile ball milling and heat treatments, which can be particularly useful for optimizing composite electrodes for sodium-ion batteries.

关键词： sodium-ion battery cathode material composite electrode microstructure morphology