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Cancer Communications 2024年第5期44卷 589-592页

作者： jian-Rong Li Chao Cheng Institute for Clinical and Translational Research Baylor College of MedicineHoustonTexasUSA Section of Epidemiology and Population Sciences Department of MedicineBaylor College of MedicineHoustonTexasUSA Dan L Duncan Comprehensive Cancer Center Baylor College of MedicineHoustonTexasUSA

Infiltrating immune cells in the tumor microenvironment(TME)play critical roles in the initiation,progression,and metastasis of cancer[1].Previous studies have reported that the infiltration levels of various immune cell types are significantly associated with patient prognosis in different cancers[2,3].Specifically,in non-small cell lung cancer(NSCLC)the prognostic associations of major immune cell types have been investigated[4–6],however,some of the reported associations are inconsistent and remain debated[7].Limited by technical issues,most studies focused on a few immune cell lineages or relied on inferred immune cell levels from computational *** investigate the prognostic effects of all major immune cell types unbiasedly,more systematic high-quality immune cell profiling data with matched patient survival information are needed.

关键词： prognosis cancer lung

Exploring changes of precipitation extremes under climate change through global variable-resolution modeling

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Science Bulletin 2024年第2期69卷 237-247页

作者： Wei Sun jian Li Rucong Yu Nina Li Yi Zhang State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Institute of Tibetan Plateau Meteorology China Meteorological AdministrationChengdu 610072China Department of Atmospheric Science Yunnan UniversityKunming 650091China National Meteorological Center China Meteorological AdministrationBeijing 100081China 2035 Future Laboratory PIESAT Information Technology Co.Ltd.Beijing 100105China

Understanding the responses of precipitation extremes to global climate change remains limited owing to their poor representations in models and complicated interactions with multi-scale *** we take the record-breaking precipitation over China in 2021 as an example,and study its changes under three different climate scenarios through a developed pseudo-global-warming(PGW)experimental framework with 60-3 km variable-resolution global ensemble *** to the present climate,the precipitation extreme under a warmer(cooler)climate increased(decreased)in intensity,coverage,and total amount at a range of 24.3%-37.8%(18.7%-56.1%).With the help of the proposed PGW experimental framework,we further reveal the impacts of the multi-scale system interactions in climate change on the precipitation *** the warmer climate,large-scale water vapor transport converged from double typhoons and the subtropical high marched into central China,enhancing the convective energy and instability on the leading edge of the transport *** a result,the mesoscale convective system(Mcs)that directly contributed to the precipitation extreme became stronger than that in the present *** the contrary,the cooler climate displayed opposite changing characteristics relative to the warmer climate,ranging from the large-scale systems to local environments and to the *** summary,our study provides a promising approach to scientifically assess the response of precipitation extremes to climate change,making it feasible to perform ensemble simulations while investigating the multi-scale system interactions over the globe.

关键词： Precipitation extreme Climate change Pseudo-global-warming experiment Variable-resolution modeling Multi-scale system interaction

Processing of a low-costγ-γ'NiPtAl coating with improved oxidation resistance

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Rare Metals 2024年第6期43卷 2832-2841页

作者： Yan jiang Liang-Liang Wei jian He Hong-Bo Guo School of Materials Science and Engineering Beihang UniversityBeijing 100191China Key Laboratory of High-Temperature Structural Materials and Protective Coatings Ministry of Industry and Information TechnologyBeihang UniversityBeijing 100191China

A novelγ-γ'(Ni solid solution—Ni_(3)Al)NiPtAl coating was produced on advanced single-crystal(SC)superalloy N5 by electroplating of a thin Pt coating with~3μm in thickness followed by heat treatment at 1000℃in *** comparison,a traditionalγ-γ'NiPtAl coating was also produced by electroplating of a thick Pt coating with~6μm in thickness followed by heat treatment at 1100℃in *** novel coating has a mass gain of~0.5 mg·cm^(-2)after 100 h 1-h cyclic oxidation at 1150℃,showing better oxidation resistance than the traditional *** oxide scale mostly consisting ofα-Al_(2)O_(3)grew on the novel coating because the element Cr from the SC alloy substrate contributes to the formation ofα-Al_(2)O_(3).Pt content in the novel coating has significant effect on the oxidation *** optimized Pt content in the coating is about 16 at%,which is helpful to reduce the diffusion of harmful elements from the substrate into the coating but also to reduce the cost of the coating.

关键词： γ-γ'NiPtAl coating Platinum Oxidation Al_(2)O_(3) Superalloy

MXene Key Composites:A New Arena for Gas Sensors

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Nano-Micro Letters 2024年第10期16卷 350-391页

作者： Yitong Wang Yuhua Wang Min jian Qinting jiang Xifei Li Hubei Province Key Laboratory of Systems Science in Metallurgical Process Wuhan University of Science and TechnologyWuhan 430081People's Republic of China Key Materials and Components of Electrical Vehicles for Overseas Expertise Introduction Center for Discipline Innovation Institute of Advanced Electrochemical Energy and School of Materials Science and EngineeringXi'an University of TechnologyXi'an 710048People's Republic of China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108FujianPeople's Republic of China

With the development of science and technology,the scale of industrial production continues to grow,and the types and quantities of gas raw materials used in industrial production and produced during the production process are also constantly *** gases include flammable and explosive gases,and even contain toxic ***,it is very important and necessary for gas sensors to detect and monitor these gases quickly and *** recent years,a new two-dimensional material called MXene has attracted widespread attention in various *** abundant surface functional groups and sites,excellent current conductivity,tunable surface chemistry,and outstanding stability make them promising for gas sensor *** the birth of MXene materials,researchers have utilized the efficient and convenient solution etching preparation,high flexibility,and easily functionalize MXene with other materials to pre-pare composites for gas *** has opened a new chapter in high-performance gas sensing materials and provided a new approach for advanced sensor ***,previous reviews on MXene-based composite materials in gas sensing only focused on the performance of gas sensing,without systematically explaining the gas sensing mechanisms generated by different gases,as well as summarizing and predicting the advantages and disadvantages of MXene-based composite *** article reviews the latest progress in the application of MXene-based composite materials in gas ***,a brief summary was given of the commonly used methods for preparing gas sens-ing device structures,followed by an introduction to the key attributes of MXene related to gas sensing *** article focuses on the performance of MXene-based composite materials used for gas sensing,such as MXene/graphene,MXene/Metal oxide,MXene/Transition metal sulfides(TMDs),MXene/Metal-organic framework(MOF),MXene/*** summarizes the advantages and disad

关键词： MXene Compound material Gas sensor Gas sensitive preparation Gas sensitivity performance

Current status of liver transplantation for human immunodeficiency virus-infected patients in China's Mainland

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World Journal of Gastroenterology 2024年第14期30卷 1958-1962页

作者： jian-Xin Tang Dong Zhao Department of Liver Surgery and Organ Transplantation Center Shenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518000Guangdong ProvinceChina

According to the report from the Chinese Center for Disease Control and Prevention,the prevalence of human immunodeficiency virus(HIV)infection exceeded 1.2 million individuals by the year 2022,with an annual increase of about 80000 *** overall prevalence of hepatitis B surface antigen among individuals co-infected with HIV reached 13.7%,almost twice the rate of the general population in *** addition to the well-documented susceptibility to opportunistic infections and new malignancies,HIV infected patients frequently experience liver-related organ damage,with the liver and kidneys being the most commonly *** often leads to the development of end-stage liver and kidney ***,organ transplantation has emerged as an important part of active treatment for HIV infected ***,the curative effect is not *** infection has been considered a contraindication for organ *** the emergence of highly active anti-retroviral therapy in 1996,the once intractable replication of retrovirus was effectively *** prolonged survival,the failure of important organs has become the main cause of death among HIV ***,transplant centers worldwide have resu-med exploration of organ transplantation for HIV-infected individuals and reached a positive *** study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation(LT)in main-land *** date,our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV,and all but one,who died two months postoperatively due to sepsis and progressive multi-organ failure,have *** analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions,cytomegalovirus infection,bacteremia,pulmonary infections,acute kidney injury,new-onset cancers,or vascular and biliary co

关键词： Liver transplantation Human immunodeficiency virus Infection Hepatitis B virus End-stage liver disease China'Mainland

Nanostructured lubricant additives for titanium alloy:Lubrication by the solid-liquid interface with Coulomb repulsion

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Friction 2024年第7期12卷 1564-1579页

作者： Linlin DUAN Dan JIA jian LI jianfang LIU Haitao DUAN State Key Laboratory of Special Surface Protection Materials and Application Technology Wuhan Research Institute of Materials ProtectionWuhan 430030China Hubei Longzhong Laboratory Xiangyang 441000China College of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430030China

In this work,the advantage of Coulomb repulsion in the intermolecular forces experienced by molecules on the solid–liquid nanosized contact interface is taken,and the superior friction-reducing property of Cu_(3)(PO_(4))2·3H_(2)O(CuP)oil-based additives has been confirmed for titanium ***-dimensional(3D)CuP nanoflowers(CuP-Fs)with a strong capillary absorption effect are prepared to achieve the homogeneous mixing of solid CuP and lubricating *** by CuP-Fs additives for titanium alloy,friction coefficient(COF)can be reduced by 73.68%,and wear rate(WR)reduced by 99.69%.It is demonstrated that the extraordinary friction-reducing property is due to the repulsive solid–liquid interface with low viscous shear force originating from Coulomb repulsion between polar water molecules in CuP and non-polar oil ***,any steric hindrance or connection between this repulsive solid–liquid interface will trigger the adhesion and increase the viscous shear force,for example,dispersant,hydrogen bondings,and shaky adsorbed water ***,the lamellar thickness of CuP and the molecular size of lubricant both have a great influence on tribological *** the lubrication mechanism based on interface Coulomb repulsion is proposed that may help broaden the scope of the exploration in low-friction nanomaterial design and new lubricant systems.

关键词： lubrication nanomaterial additive solid-liquid interface wear

Frequency and size change of ice–snow avalanches in the central Himalaya:A case from the Annapurna Ⅱ glacier

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Advances in Climate Change Research 2024年第3期15卷 464-475页

作者： Yao LI Yi-Fei CUI jian-Sheng HAO Zheng-Tao ZHANG Hao WANG jian GUO Shuo-Fan WANG State Key Laboratory of Hydroscience and Engineering Department of Hydraulic EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Hydrosphere Sciences of the Ministry of Water Resources Beijing 100084China Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of National Safety and Emergency Management Beijing Normal UniversityBeijing 100875China Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China

Glaciers have retreated and shrunk in High Mountain Asia since the mid-20th century because of global warming,leading to glacier instability and hazardous iceesnow ***,the complex relationship between iceesnow avalanches and factors such as climate and potential triggers are difficult to understand because of the lack of observational ***,we addressed iceesnow avalanches on the Annapurna Ⅱ glacier in Nepal,Central *** constructed an iceesnow avalanche history using long-term multi-source remote sensing images(1988-2021)and mapped the velocity fields of glaciers using cross-correlation analysis on SAR and optical ***,we investigated the impact of climate change and earthquakes on the frequency and size of iceesnow *** results demonstrate that the frequency of iceesnow avalanches has increased from 10 in 1988 to 27 in 2020,but the average area of iceesnow avalanche deposits has decreased by approximately 70%,from 3.4×10^(5) m^(2) in 1988 to 1.2×10^(5) m^(2) in *** evolutionary characteristic of ice avalanches is linked to the impact of glacier retreat(reduction in ice material supply)and increased activity under climate *** glacier movement velocity controls the size of iceesnow avalanches and can be set as an indicator for iceesnow avalanche *** the Annapurna Ⅱ glacier,an iceesnow avalanche occurred when the glacier velocities were greater than 1.5 m d^(-1).These results offer insights into iceesnow avalanche risk assessment and prediction in high-mountain areas,particularly in regions characterised by dense glacier distribution.

关键词： Iceesnow avalanche Glacier instability Climate change Central Himalaya Remote sensing

Three-dimensional cell-based strategies for liver regeneration

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BIOCELL 2024年第7期48卷 1023-1036页

作者： DAN GUO XI XIA jian YANG Liver Transplant Center Transplant CenterWest China HospitalSichuan UniversityChengdu610041China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu610212China

Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern *** recent years,the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical *** review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver ***,we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver ***,we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical *** collective insights presented herein highlight the signiﬁcance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.

关键词： Three-Dimensional Liver regeneration Organoids Stem cells Cell therapy

Application of immune checkpoint inhibitors and microsatellite instability in gastric cancer

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World Journal of Gastroenterology 2024年第21期30卷 2734-2739页

作者： Shi-Yan Yan jian-Gao Fan Department of Gastroenterology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China

In this editorial we comment on the article by Li published in the recent issue of the World Journal of *** focus specifically on the application of immune checkpoint inhibitors(ICIs)and microsatellite instability(MSI)in gastric cancer(GC).The four pillars of GC management have long been considered,including surgery,chemotherapy,radiotherapy and targeted ***,immunotherapy has recently emerged as a“fifth pillar”,and its use is rapidly *** are four principal strategies for tumor immunotherapy:ICIs,tumor vaccines,adoptive immunotherapy and nonspecific *** them,ICIs are the most advanced and widespread type of cancer immunotherapy for *** breakthrough results for ICIs have paved the way to a new era of cancer *** particular,inhibition of the PD-1/PD-L1 axis with ICIs,including nivolumab and pembrolizumab,has emerged as a novel treatment strategy for advanced ***,these therapies are sometimes associated with often subtle,potentially fatal immune-related adverse events(irAEs),including dermatitis,diarrhea,colitis,endocrinopathy,hepatotoxicity,neuropathy and *** must be aware of these irAEs and improve the detection of these processes to prevent inappropriate discharges,emergency department revisits,and downstream *** studies have revealed that MSI-high or mismatch-repair-deficient tumors,regardless of their primary site,have a promising response to ***,it is important to detect MSI before applying ICIs for treatment of GC.

关键词： Gastric cancer Immune checkpoint inhibitors Microsatellite instability Immunotherapy Immune-related adverse events

Research on the MPPT of Photovoltaic Power Generation Based on Improved WOA and P&O under Partial Shading Conditions

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Energy Engineering 2024年第4期121卷 951-971页

作者： jian Zhong Lei Zhang Ling Qin School of Electrical Engineering Nantong UniversityNantong226019China

Partial shading conditions(PSCs)caused by uneven illumination become one of the most common problems in photovoltaic(PV)systems,which can make the PV power-voltage(P-V)characteristics curve show *** maximum power point tracking(MPPT)methods have shortcomings in tracking to the global maximum power point(GMPP),resulting in a dramatic decrease in output *** order to solve the above problems,intelligent algorithms are used in ***,the existing intelligent algorithms have some disadvantages,such as slow convergence speed and large search ***,an improved whale algorithm(IWOA)combined with the P&O(IWOA-P&O)is proposed for the MPPT of PV power generation in this ***,IWOA is used to track the range interval of the GMPP,and then P&O is used to accurately find the MPP in that *** with other algorithms,simulation results show that this method has an average tracking efficiency of 99.79%and an average tracking time of 0.16 s when tracking ***,experimental verification is conducted,and the results show that the proposed algorithm has better MPPT performance compared to popular particle swarm optimization(PSO)and PSO-P&O algorithms.

关键词： Photovoltaic power generation maximum power point tracking whale algorithm perturbation and observation