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Erythropoietin reduces apoptosis of brain tissue cells in rats after cerebral ischemia/reperfusion injury:a characteristic analysis using magnetic resonance imaging

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Neural Regeneration Research 2016年第9期11卷 1450-1455页

作者： Chun-juan jiang Zhong-juan Wang Yan-jun Zhao Zhui-yang Zhang Jing-jing Tao jian-yong ma Department of Radiology Wuxi Second People's Hospital Affiliated to Nanjing Medical University

Some in vitro experiments have shown that erythropoietin （EPO） increases resistance to apoptosis and facilitates neuronal survival follow- ing cerebral ischemia. However, results from in vivo studies are rarely reported. Perfusion-weighted imaging （PWI） and diffusion-weighted imaging （DWI） have been applied successfully to distinguish acute cerebral ischemic necrosis and penumbra in living animals; therefore, we hypothesized that PWI and DWI could be used to provide imaging evidence in vivo for the conclusion that EPO could reduce apoptosis in brain areas injured by cerebral ischemia/reperfusion. To validate this hypothesis, we established a rat model of focal cerebral ischemia/ reperfusion injury, and treated with intra-cerebroventricular injection of EPO （5,000 U/kg） 20 minutes before injury. Brain tissue in the ischemic injury zone was sampled using MRI-guided localization. The relative area of abnormal tissue, changes in PWI and DWI in the ischemic injury zone, and the number of apoptotic cells based on TdT-mediated dUTP-biotin nick end-labeling （TUNEL） were assessed. Our findings demonstrate that EPO reduces the relative area of abnormally high signal in PWI and DWI, increases cerebral blood volume, and decreases the number of apoptotic cells positive for TUNEL in the area injured by cerebral ischemia/reperfusion. The experiment pro- vides imaging evidence in vivo for EPO treating cerebral ischemia/reperfusion injury.

关键词： nerve regeneration nerve protection cerebral ischemia/reperfusion erythropoietin magnetic resonance imaging diffusion-weightedimaging apparent diffusion coefficient perfusion-weighted imaging cerebral blood volume mean transit time apoptosis neural regeneration

Clinical characteristics of 4355 patients with anterior cruciate ligament injury

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Chinese Medical Journal 2013年第23期126卷 4487-4492页

作者： MEI Yu AO Ying-fang WANG jian-quan ma yong ZHANG Xin WANG Jia-ning ZHU Jing-xian Institute of Sports Medicine Peking University Third HospitalBeijing 100191 China

Background Clinical features of anterior cruciate ligament （ACL） injury are important for its prevention,diagnosis and ***,few studies have reported such data,especially in *** purpose of this study was to describe the clinical characteristics of ACL injury on a large *** Between 1993 and 2007,a total of 4355 ACL deficient inpatients （612 athletes and 3743 non-athletes） were *** were collected using a special database *** the distributions of characteristics in different groups were compared and analyzed *** All subjects were confirmed with ACL tear during *** analysis revealed that the percentage of females in Athlete Group was significantly higher than that in Non-athlete Group （56.05％ vs.24.95％,P＜0.001）.This study also found that sports trauma was the main cause of ACL ***,basketball,judo,wrestling and track and field were the five most responsible activities for *** average injury time for athletes was significantly shorter than that for non-athletes （413.3 days vs.717.5 days,P＜0.001）.Three thousand nine hundred and eight cases were ordered ACL reconstruction （76.04％ single-bundle,18.30％ double-bundle）.Three hundred and forty-five patients （7.92％）were combined with other ligaments injuries,2667 （61.24％） were found with various grades of cartilage lesions,and 3377 （77.54％） were found with meniscal *** Sports trauma was the main cause of ACL tears in China,and reconstruction had become the principal surgical *** order to restore knee joint stability and reduce the incidence of cartilage and meniscal injury,patienttailored ACL reconstruction should be suggested at the right moment.

关键词： anterior cruciate ligament clinical characteristics incidence secondary injuries

Second-look arthroscopic evaluation of the articular cartilage after primary single-bundle and double-bundle anterior cruciate ligament reconstructions

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Chinese Medical Journal 2011年第21期124卷 3551-3555页

作者： WANG Hai-jun AO Ying-fang CHEN Lian-xu GONG Xi WANG yong-jian ma yong LEUNG Kevin Kar Ming YU Jia-kuo Institute of Sports Medicine Peking University Third Hospital Beijing 100191 China

Background Several reports have shown the progression of articular cartilage degeneration after anterior cruciate ligament （ACL） reconstruction. No report has been published about the cartilage comparing changes after single-bundle （SB） and double-bundle （DI3） ACL reconstructions. The purpose of this study was to evaluate the articular cartilage changes after SB and DB ACL reconstructions by second-look arthroscopy. Methods Ninety-nine patients who received arthroscopic ACL reconstruction were retrospectively reviewed at an average of 14 months after reconstruction, 58 patients underwent SB ACL reconstruction and 41 patients underwent DB ACL reconstruction. Hamstring tendon autografts were used in all patients. Second-look arthroscopy was done in conjunction with the tibial staple fixation removal at least one year after the initial ACL reconstruction. Arthroscopic evaluation and grading of the articular cartilage degeneration for all patients were performed at the initial ACL reconstruction, and at the second-look arthroscopy. Results The average cartilage degeneration at the patellofemoral joint （PFJ） was found significantly worsened after both SB and DB ACL reconstructions. This worsening were not seen at medial tibiofemoral joint （TFJ） and lateral TFJ. Grade II cartilage damage was the most common. At second-look arthroscopy, the average patellar cartilage degeneration was 1.14±0.14 （at first look 0.52±0.11） for the SB group, and 1.22±0.15 （at first look 0.56±0.12） for the DB group. The average trochlear cartilage degeneration was 1.05±0.16 （at fist look 0.10±0.06） and 0.66±0.17 （at fist look 0.17±0.09）, respectively. The average patellar cartilage degeneration showed no significant difference in both groups. However, the average trochlea cartilage degeneration in DB group was significantly less than in SB group. Conclusions Patellofemoral cartilage degeneration continued to aggravate after ACL reconstruction. DB ACL reconstruction could significantly decrease t

关键词： anterior cruciate ligament single bundle double bundle patellofemoral joint cartilage second-look arthroscopy

Structural designs and mechanism insights into electrocatalytic oxidation of 5-hydroxymethylfurfural

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Journal of Energy Chemistry 2025年第1期100卷 792-814页

作者： Jing Lei Huijie Zhang jian Yang Jia Ran Jiqiang Ning Haiyan Wang yong Hu Key Laboratory of the Ministry of Education for Advanced Catalysis materials Department of Chemistry Zhejiang Normal University Jinhua Advanced Research Institute Department of Optical Science and Engineering Fudan University College of Chemistry and materials Engineering Zhejiang A&F University

Biomass conversion offers an efficient approach to alleviate the energy and environmental *** oxidation of 5-hydroxymethylfurfural(HMF) has attracted tremendous attention in the latest few years for the mild synthesis conditions and high conversion efficiency to obtain 2,5-furan dicarboxylic acid(FDCA), but there still remain problems such as limited yield, short cycle life,and ambiguous reaction mechanism. Despite many reviews highlighting a variety of electrocatalysts for electrochemical oxidation of HMF, a detailed discussion of the structural modulation of catalyst and the underlying catalytic mechanism is still lacking. We herein provide a comprehensive summary of the recent development of electrochemical oxidation of HMF to FDCA, particularly focusing on the mechanism studies as well as the advanced strategies developed to regulate the structure and optimize the performance of the electrocatalysts, including heterointerface construction, defect engineering,single-atom engineering, and in situ reconstruction. Experimental characterization techniques and theoretical calculation methods for mechanism and active site studies are elaborated, and challenges and future directions of electrochemical oxidation of HMF are also prospected. This review will provide guidance for designing advanced catalysts and deepening the understanding of the reaction mechanism beneath electrochemical oxidation of HMF to FDCA.

关键词： Structural design

Positive effect of Mo on mechanical properties of a Ni-42W-10Co-x Mo medium heavy alloy

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China Foundry 2025年

作者： Guo-xin Cao jian-xin Dong yong-sheng He He jiang Fang Hao Zhi-hua Nie Teng-fei ma Bao-quan Fu School of materials Science and Engineering University of Science and Technology Beijing Xi'an Superalloy Technology Co. Ltd. School of materials Science and Engineering Beijing Institute of Technology Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou University

In this study,a novel Ni-W-Co-Mo medium heavy alloy (MHA) was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-xM o alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypoeutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-xM o alloys is Mo-induced solid solution strengthening and precipitation strengthening.

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Distribution of the subtypes of GABAergic neurons in neocortical layer 1

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Distribution of the subtypes of GABAergic neurons in neocort...

雷替曲塞联合伊立替康治疗转移性胃癌对血清ESM-1、IGFBP3表达的影响

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： jian ma,yong-Chun YU~* Laboratory of Development of Neural Synaptic Microcircuit,Institute of Neurobiology,Fudan University,Shanghai 200032,China

Objective Layer 1(L1) is located superficial of the neocortex,which is composed of GABAergic interneurons and Cajal-Retzius(C-R) *** recently known the majority of layer 1 interneurons migrated from CGE,yet little is known about the distribution of different types of intemeurons in the layer 1 with the neocortical development,especially in the three distinct cortical areas,motor cortex,somatosensory cortex and visual cortex. The present study is to explore the distribution of the subtypes of GABAergic neurons and C-R cells in developing neocortical layer *** We have taken an important first step towards understanding this process by double and triple immunostaining mouse cortical slices with a panel of antibodies at the different early postnatal stages(P1-P14), which has been used extensively for classifying developing ***(1) There is no significant difference of the distribution of the specific intemeurons among the three cortical areas.(2) From P1 to P6,layer 1 was occupied by C-R cells,but which decrease rapidly with the neocortical development from *** P8 to P14,the population of marked interneuron increased from 20%to 80%,70%of the intemeurons express reelin,48%express GAB ARδ,the population of NPY,VIP and calretinin positive intemeurons were rather small,about 5%.(3) Triple immunostaining showed VIP and reelin identify two nonoverlapping distinct *** data also showed reelin and NPY expressed in the neurogliaform cells liked intemeurons.(4) The percentage of the population of distinct intemeurons in layer la and layer lb is *** The different types of neurons distributed differently in developing neocortical layer 1 which indicated that the different function of layer 1 contributes the neocortical circuit networks.

关键词： neocortex layer 1 development intemeuron distribution

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世界华人消化杂志 2019年第3期27卷 203-208页

作者：彭江华马建永绍兴市人民医院全科医疗科浙江省绍兴市312000

目的探讨雷替曲塞联合伊立替康治疗转移性胃癌(gastric cancer,GC)对血清内皮细胞特异性分子-1(endothelial cellspecificmolecule-1,ESM-1)及胰岛素样生长因子结合蛋白3(insulin-like growth factor binding protein 3,IGFBP3)表达的影响.方法选取2015-12/2017-12入住绍兴市人民医院肿瘤内科并接受治疗的转移性GC患者55例进行研究.所有患者均采用雷替曲塞与伊立替康联合疗法:第一天,伊立替康:剂量180 mg/m^2,静脉滴注1.5h;第二天,雷替曲塞:剂量3 mg/m^2,静脉滴注1.5 h.以3 wk为一个周期,依据患者病情,最多进行6个周期.随访至2018-06-31.考察治疗后近远期疗效、治疗前后患者ESM-1和IGFBP3表达水平变化,统计治疗过程中患者发生不良反应种类及等级.结果完全缓解3例(5.45%),部分缓解10例(18.18%),稳定28例(50.91%),进展14例(25.45%),客观有效率为23.64%(13/55),疾病抑制率为74.55%(41/55).中位肿瘤进展时间为6.1 mo(95%CI:5.2-6.9 mo);中位生存时间为9.4 mo(95%CI:8.7-11.2 mo);治疗后ESM-1表达水平(0.72μg/L±0.54μg/L)显著低于治疗前(1.03μg/L±0.67μg/L)(P<0.05);治疗后IGFBP3表达水平(3.27μg/L±0.45μg/mL)显著高于治疗前(2.93μg/L±0.43μg/mL)(P <0.05);患者最常见的不良反应主要有中性粒细胞减少(19/55, 34.55%)、肝功能异常(15/55, 27.27%)、贫血(18/55, 32.73%)及恶心呕吐(14/55, 25.45%).结论雷替曲塞联合伊立替康治疗转移性GC,可降低患者血清ESM-1的表达,抑制肿瘤血管的生成,并提高IGFBP3表达水平,减少癌细胞的扩散,从而有效控制病情的发展,提高患者存活期,且不良反应较少,安全性高,可为临床转移性GC患者的治疗提供前期治疗方案参考.

关键词：雷替曲塞转移性胃癌血清内皮细胞特异性分子-1 胰岛素样生长因子结合蛋白3

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun ma Bao Du yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

Merging polymers of intrinsic microporosity and porous carbon-based zinc oxide composites in novel mixed matrix membranes for efficient gas separation

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Green Energy & Environment 2025年第1期10卷 203-213页

作者： Muning Chen Jiemei Zhou Jing ma Weigang Zheng Guanying Dong Xin Li Zhihong Tian Yatao Zhang Jing Wang yong Wang School of Chemical Engineering Zhengzhou UniversityZhengzhou450001HenanChina State Key Laboratory of materials-Oriented Chemical Engineering and College of Chemical Engineering Nanjing Tech UniversityNanjing211816JiangsuChina Singapore Membrane Technology Centre Nanyang Environment and Water Research InstituteNanyang Technological UniversitySingapore637141Singapore Engineering Research Center for Nanomaterials Henan UniversityKaifeng475004HenanChina State Key Laboratory of Coking Coal Resources Green Exploitation Zhengzhou UniversityZhengzhou 450001China School of Energy and Environment Southeast UniversityNanjing210096JiangsuChina

Mixed matrix membranes(MMMs)have demonstrated significant promise in energy-intensive gas separations by amalgamating the unique properties of fillers with the facile processability of ***,achieving a simultaneous enhancement of permeability and selectivity remains a formidable challenge,due to the difficulty of achieving an optimal match between polymers and *** this study,we incorporate a porous carbon-based zinc oxide composite(C@ZnO)into high-permeability polymers of intrinsic microporosity(PIMs)to fabricate *** dipole–dipole interaction between C@ZnO and PIMs ensures their exceptional compatibility,mitigating the formation of non-selective voids in the resulting ***,C@ZnO with abundant interconnected pores can provide additional low-resistance pathways for gas transport in *** a result,the CO_(2) permeability of the optimized C@ZnO/PIM-1 MMMs is elevated to 13,215 barrer,while the CO_(2)/N_(2) and CO_(2)/CH4 selectivity reached 21.5 and 14.4,respectively,substantially surpassing the 2008 Robeson upper ***,molecular simulation results further corroborate that the augmented membrane gas selectivity is attributed to the superior CO_(2) affinity of C@*** summary,we believe that this work not only expands the application of MMMs for gas separation but also heralds a paradigm shift in the application of porous carbon materials.

关键词： Mixed matrix membranes Polymers of intrinsic microporosity CO_(2)separation Porous carbon materials