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Efficacy and safety of Yiqi Peiyuan granules for improving the short-term prognosis of patients with acute kidney injury:A multicenter,double-blind,placebo-controlled,randomized trial

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Journal of Integrative Medicine 2024年第3期22卷 279-285页

作者： Jia-jia Wu Tian-yi Zhang Ying-hui Qi Min-yan Zhu Yan Fang Chao-jun Qi Li-ou Cao Ji-fang Lu Bo-han Lu Lu-min Tang jian-xiao shen Shan Mou Department of Nephrology Molecular Cell Lab for Kidney DiseaseShanghai Peritoneal Dialysis Research CenterUremia Diagnosis and Treatment CenterRenji Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200127China Department of Nephrology Shanghai Pudong New Area Punan HospitalShanghai 200125China Department of Nephrology Ningbo Hangzhou Bay HospitalNingbo 315336Zhejiang ProvinceChina

Background:Yiqi Peiyuan(YQPY)prescription,a composite prescription of traditional Chinese medicine,has been used to prevent or delay the continued deterioration of renal function after acute kidney injury(AKI)in some institutions and has shown considerable ***:This is the first randomized controlled trial to assess efficacy and safety of YQPY for improving short-term prognosis in adult patients with ***,setting,participants and interventions:This is a prospective,double-blind,multicenter,randomized,and placebo-controlled clinical trial.A total of 144 enrolled participants were randomly allocated to two groups according to a randomization ***,caregivers and investigators assessing the outcomes were blinded to group *** in the YQPY group received 36 g YQPY granules twice a day for 28 *** in the placebo group received a placebo in the same dose as the YQPY *** outcome measures:The primary outcome was the change in the estimated glomerular filtration rate(eGFR)between baseline and after 4 and 24 weeks of *** secondary outcomes were the change of serum creatinine(Scr)level between baseline and after treatment,and the incidence of endpoint events,defined as eGFR increasing by more than 25%above baseline,eGFR>75 mL/min per1.73 m2or the composite endpoint,which was defined as the sum of patients meeting either of the above ***:Data from a total of 114 patients(59 in the YQPY group and 55 in the control group)were *** mean changes in eGFR and Scr in weeks 4 and 24 had no difference between the two *** further subgroup analysis(22 in the YQPY group and 31 in the control group),the mean change in eGFR after treatment for 4 weeks was 27.39 mL/min per 1.73 m2in the YQPY group and 5.78 mL/min per1.73 m2in the placebo group,and the mean difference between groups was 21.61 mL/min per 1.73 m2(P<0.001).Thirteen(59.1%)patients in the YQPY group and 5(16.1%)in the placebo g

关键词： Chinese herbal medicine Randomized controlled trial Acute kidney injury Renal function

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Physical neural networks with self-learning capabilities

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 23-42页

作者： Weichao Yu Hangwen Guo jiang xiao jian shen State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China Department of Physics Fudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

Physical neural networks are artificial neural networks that mimic synapses and neurons using physical systems or *** networks harness the distinctive characteristics of physical systems to carry out computations effectively,potentially surpassing the constraints of conventional digital neural networks.A recent advancement known as“physical self-learning”aims to achieve learning through intrinsic physical processes rather than relying on external *** article offers a comprehensive review of the progress made in implementing physical self-learning across various physical *** learning strategies that contribute to the realization of physical self-learning are *** challenges in understanding the fundamental mechanism of learning,this work highlights the progress towards constructing intelligent hardware from the ground up,incorporating embedded self-organizing and self-adaptive dynamics in physical systems.

关键词： self-learning physical neural networks neuromorphic computing physical learning

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Study on frictional behavior of SiC_(f)/SiC composite clad tube clamping condition under nuclear irradiation

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Friction 2024年第5期12卷 919-938页

作者： Chenglong xiao Liangliang shen Tianqi ZHU jianbo TANG Ximing XIE Xinyu FAN jian XU Zhiying REN School of Mechanical Engineering Zhejiang University of TechnologyHangzhou310023China Engineering Laboratory of Advanced Energy Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China State Key Laboratory of Fine Chemicals Liaoning High-Performance Polymer Engineering Research CenterSchool of Chemical EngineeringDalian University of TechnologyDalian116024China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou350116China School of Computer Science and Technology Shandong UniversityQingdao266237China Aviation Industry Corporation of China Ltd.Beijing100028China

Silicon carbide fiber reinforced silicon carbide matrix(SiC_(f)/SiC)composite is the key cladding material of nuclear fuel,which determines the safety and reliability of nuclear fuel storage and *** replacement of its storage and transportation scenario needs to be completed by the manipulator,but the application of SiC_(f)/SiC wear,fracture,and nuclear leakage in the snatching process of brittle-flexible-rigid contact in the irradiation environment has been seriously restricted due to unclear understanding of the damage ***,the effects of irradiation dose and clamping load on the friction characteristics of the contact interface between SiC_(f)/SiC clad tube are studied in this paper,and the effects of irradiation parameters and clamping force on the static friction coefficient of the contact interface between the clad tube and flexible nitrile are *** on the Greenwood-Williamson tribological model,a numerical model of the shape and structure of the contact micro-convex at the micro-scale of the clamping interface is constructed by introducing the multi-surface integral,and finally verified by *** research results show that there is a unique“Irradiation suppression zone”under the clamping condition of SiC_(f)/SiC cladding tube under the nuclear irradiation environment,and the growth of static friction coefficient slows down until stagnates after irradiation reaches a certain extent(600 kGy),and there will be a decline when the irradiation dose continues to increase,among which the clamping force of 15.2 N within the irradiation interval of 1,000 kGy can meet the safety of nuclear environment *** results of this paper can provide an important theoretical basis and application guidance for the safe operation of SiC_(f)/SiC cladding tubes in the storage and transportation clamping process.

关键词： SiC_(f)/SiC Clad tube nuclear irradiation conditions Greenwood-Williamson tribological model multi-surface integral

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Study of primordial deuterium abundance in Big Bang nucleosynthesis

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Nuclear Science and Techniques 2024年第3期35卷 208-215页

作者： Zhi-Lin shen jian-Jun He Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China

Big Bang nucleosynthesis(BBN)theory predicts the primordial abundances of the light elements^(2) H(referred to as deuterium,or D for short),^(3)He,^(4)He,and^(7) Li produced in the early *** these,deuterium,the first nuclide produced by BBN,is a key primordial material for subsequent *** date,the uncertainty in predicted deuterium abundance(D/H)remains larger than the observational *** this study,the Monte Carlo simulation code PRIMAT was used to investigate the sensitivity of 11 important BBN reactions to deuterium *** found that the reaction rate uncertainties of the four reactions d(d,n)^(3)He,d(d,p)t,d(p,γ)^(3)He,and p(n,γ)d had the largest influence on the calculated D/H ***,the calculated D/H uncertainty cannot reach observational precision even with the recent LUNA precise d(p,γ)^(3) He *** the nuclear physics aspect,there is still room to largely reduce the reaction-rate uncertainties;hence,further measurements of the important reactions involved in BBN are still necessary.A photodisintegration experiment will be conducted at the Shanghai Laser Electron Gamma Source Facility to precisely study the deuterium production reaction of p(n,γ)d.

关键词： Big Bang nucleosynthesis Abundance of deuterium Reaction cross section Reaction rate Monte Carlo method

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Recent advancements in hydrometallurgical recycling technologies of spent lithium-ion battery cathode materials

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Rare Metals 2024年第3期43卷 879-899页

作者： Juan Wu Li xiao Li shen jian-Jun Ran Hui Zhong Yi-Rong Zhu Han Chen College of Materials and Advanced Manufacturing Hunan University of TechnologyZhuzhou412007China School of Resources Processing and Bioengineering Central South UniversityChangsha410083China Guangdong jiana Energy Technology Company Qingyuan513000China

The rapidly increasing production of lithium-ion batteries(LIBs)and their limited service time increases the number of spent LIBs,eventually causing serious environmental issues and resource *** the perspectives of clean production and the development of the LIB industry,the effective recovery and recycling of spent LIBs require urgent *** study provides an overview of the current hydrometallurgical processes employed in the recycling of spent cathode materials,focusing on the leaching of valuable metals and their *** particular,this research reviews the various leaching systems(inorganic acid,organic acid,and ammonia)and the separation of valuable metals,and then,recommendations for subsequent study are offered in an attempt to contribute to the development of highly efficient methods for recycling spent cathode *** addition,a range of existing technologies,such as solvent extraction,chemical precipitation,electrochemical deposition,and regeneration,for the postprocessing of leaching solutions are ***,the promising technologies,existing challenges and suggestions with respect to the development of effective and environmentally friendly recycling methods for handling spent cathode materials are identified.

关键词： Spent lithium-ion batteries(LIBs) Cathode material Hydrometallurgy Leaching Recycling

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Synthesis of Organofluorine Compounds with Acylsilanes

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Chinese Journal of Chemistry 2024年第8期42卷 887-902页

作者： Youyuan Guo Gang Zhou xiao shen The Institute for Advanced Studies Engineering Research Center of Organosilicon Compounds&MaterialsMinistry of EducationWuhan University299 Bayi RoadWuhanHubei430072 China

Comprehensive Summary,Organofluorine compounds are central in synthetic chemistry,medicinal chemistry and material *** this review,we summarize the investigations on the synthesis of organofluorine compounds with *** the non-fluorinated acylsilanes,the in situ generation of difluoroenoxysilanes from the reactions of the acylsilanes with trifluoromethylation reagents is the major pathway,leading to the facile preparation of variousα,α-*** the fluoroalkylacylsilanes,apart from the in situ generation of difluoroenoxysilanes through anion Brook rearrangement,radical Brook rearrangement of the photoexcited acylsilanes and the selective control of reactivities of the biradicals pave the way for the synthesis of a variety of organofluorine *** general,most of these reactions gave racemic products,and the asymmetric synthesis of organofluorine compounds with acylsilanes is still rare,which would be a future.

关键词： Acylsilanes Organofluorine compounds Brook rearrangement Radical rearrangement β-Fluoride elimination Asymmetric catalysis Photocatalysis Defluoroalkylation

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A CELL-CENTERED GODUNOV METHOD BASED ON STAGGERED DATA DISTRIBUTION,PART Ⅰ:ONE-DIMENSIONAL CASE

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Journal of Computational Mathematics 2024年第4期42卷 1172-1196页

作者： Jiayin Zhai xiao Li Zhijun shen Institute of Applied Physics and Computational Mathematics LCPP.O.Box 8009-26Beijing 100088China College of Big Data and Internet Shenzhen Technology UniversityShenzhen 518118China Center for Applied Physics and Technology HEDPSPeking UniversityChina

This paper presents a cell-centered Godunov method based on staggered data distribu-tion in Eulerian *** motivation is to reduce the intrinsic entropy dissipation of classical Godunov methods in the calculation of an isentropic or rarefaction *** the same time,the property of accurate shock capturing is also *** analyzing the factors that cause nonphysical entropy in the conventional Godunov methods,we introduce two velocities rather than a single velocity in a cell to reduce kinetic energy dissipation.A series of redistribution strategies are adopted to update subcell quantities in order to improve *** examples validate that the present method can dramatically reduce nonphysical entropy *** subject classification:35Q35,76N15,76M12.

关键词： Godunov method Riemann solver Rarefaction wave Nonphysical entropy increase.

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Impact of Annealing on the Melt Recrystallization of a-PDLA/α-PLLA Double-layered Films

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Chinese Journal of Polymer Science 2024年第2期42卷 230-238,I0009页

作者： Yun-Peng Li Hao-Ran shen Shao-Juan Wang Hao Zhang jian Hu Rui Xin xiao-Li Sun Shou-Ke Yan Key Laboratory of Rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plasticsQingdao University of Science&TechnologyQingdao266042China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China

Poly(lactic acid)(PLA) as a bio-based polymer with biodegradability and biocompatibility has attracted much attention. To manipulate its properties for different applications, regulation of crystal structure and crystalline morphology becomes an attractive research topic. In this work, the structure evolution of layered samples containing an amorphous poly(D-lactide)(PDLA) layer and a crystalline poly(L-lactide)(PLLA)layer with highly oriented edge-on α lamellar crystals after annealing at 150 ℃ or/and after melt-recrystallization has been studied by AFM, FTIR,and TEM combined with electron diffraction. The results demonstrate that melt recrystallization of the as-prepared sample leads to the formation of abundant randomly oriented PLA stereo-complex(PLA SC) crystals. Annealing at 150 ℃ results in the formation of a small amount of oriented PLA SC crystals at the interface. These PLA SC crystals show great impact on the recrystallization behavior of sample after melting at 190 ℃ and then crystallizing at 90 ℃. First, they impede the mutual diffusion of the overlying PDLA and underlying PLLA, and thus reduce their stereocomplexation ability as manifested by the decreased amount of PLA SC crystals. Second, they act as substrate to initiate the epitaxial crystallization of the overlying PDLA and underlying PLLA, which ensures the production of a highly oriented structure of PDLA and PLLA after melt recrystallization again.

关键词： Poly(L-lactide) Poly(D-lactide) Double layer Stereocomplex

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Microstructure and magnetocaloric properties of melt-extracted SmGdDyCoAl high-entropy amorphous microwires

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Rare Metals 2024年第3期43卷 1234-1242页

作者： Shi-Jie Wei Hong-Xian shen Lun-Yong Zhang Lin Luo Xin-Xing Tang jian-Fei Sun xiao-Qing Li School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China Applied Materials Physics Department of Materials Science and EngineeringKTH-Royal Institute of Technology10044StockholmSweden

This paper presents a systematic investigation of the microstructure and magnetocaloric properties of melt-extracted Sm_(20)Gd_(20)Dy_(20)Co_(20)Al_(20)high-entropy *** fabricated wires exhibited an amorphous structure,and the temperature interval of the undercooled liquid AT was 45 *** microwires underwent a second-order magnetic transition from a ferromagnetic to a paramagnetic state near the Curie temperature(T_(C)=52 K),The maximum magnetic entropy change(-ΔS_M^(max)),the relative cooling power and the refrigeration capacity reached 6.34 J·kg^(-1)·K^(-1).422.09 J·kg^(-1)and 332.94 J·kg^(-1),respectively,under a magnetic field change of 5 *** addition,the temperature-averaged entropy changes with two temperature lifts(3 and 10 K)were 6.32 and 6.27 J·kg^(-1)·K^(-1),*** good magnetocalorie performance highlights the significant potential for the Sm_(20)Gd_(20)Dy_(20)Co_(20)Al_(20)microwires to be used as magnetic refrigerant materials in low-temperature region *** work will serve as a valuable reference for future investigations on low-temperature high-entropy magnetocaloric materials.

关键词： Melt-extraction High-entropy amorphous microwires Magnetocaloric effect Magnetic refrigeration

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MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1453-1464页

作者： Mei-Zhu shen Yong Zhang Fang Wu Mei-Zhen shen Jun-Lin Liang xiao-Long Zhang xiao-jian Liu Xin-Shu Li Ren-sheng Wang Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiotherapy People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Medicine Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Radiotherapy stands as a promising therapeutic modality for colorectal cancer(CRC);yet,the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC *** To elucidate the role played by microRNA-298(miR-298)in CRC *** To establish a radio-resistant CRC cell line,HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery *** quantification of miR-298 levels within CRC cells was conducted through quantitative RT-PCR,and protein expression determination was realized through Western *** viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and proliferation by clonogenic ***-induced apoptosis was discerned through flow cytometry *** We observed a marked upregulation of miR-298 in radio-resistant CRC ***-298 emerged as a key determinant of cell survival following radiation exposure,as its overexpression led to a notable reduction in radiation-induced ***,miR-298 expression exhibited a strong correlation with CRC cell *** investigation unveiled human dual-specificity tyrosine(Y)-regulated kinase 1A(DYRK1A)as miR-298’s direct *** Taken together,our findings underline the role played by miR-298 in bolstering radio-resistance in CRC cells by means of DYRK1A downregulation,thereby positioning miR-298 as a promising candidate for mitigating radioresistance in CRC.

关键词： MicroRNA-298 Human dual-specificity tyrosine(Y)-regulated kinase 1A Colorectal cancer Radio-resistance p53 binding protein 1

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