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应用DCPR评估老年冠心病患者感染SARS-Cov-2.的心身相关障碍

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中华全科医学 2024年第4期22卷 544-547,650页

作者：何欢孙中华翁阳阳贾坚曲晨南京医科大学第二附属医院老年医学科江苏南京210000 江苏省人民医院全科医学科江苏南京210000

目的为改善老年冠心病患者的生活质量提供个性化的干预措施,采用心身研究的诊断标准(DCPR)评估老年冠心病患者在感染严重急性呼吸综合征冠状病毒2.SARS-CoV-2.后产生的心身相关障碍程度。方法采用简单随机抽样的方法,选取南京医科大学... 详细信息

目的为改善老年冠心病患者的生活质量提供个性化的干预措施,采用心身研究的诊断标准(DCPR)评估老年冠心病患者在感染严重急性呼吸综合征冠状病毒2.SARS-CoV-2.后产生的心身相关障碍程度。方法采用简单随机抽样的方法,选取南京医科大学第二附属医院2.2.年9月—2.2.年6月收治的101例老年冠心病患者作为研究对象,根据是否感染SARS-CoV-2.组,分为感染组(69例)和未感染组(32.)。采用DCPR量表评估患者目前的心身状态,并使用成组t检验、Wilcoxon秩和检验、χ^(2.检验和logistic回归分析等统计学方法进行分析。结果感染组更容易产生抑郁情绪[轻度抑郁:2.(39.10%)vs.5(15.60%);中重度抑郁:9(13.10%)vs.1(3.10%)]和心身症状[37(53.60%)vs.2.(78.10%),χ^(2.=5.537,P2.幸福感总分、睡眠困扰总分、心理困扰总分、异常疾病行为总分比较差异均有统计学意义(P2.老年冠心病患者产生心身相关障碍的影响因素之一,利用DCPR可以更全面地评估并有助于及时提出合理、具有针对性的干预措施。

关键词：老年人冠心病严重急性呼吸综合征冠状病毒2 心身相关障碍量表评估

Ensemble learning HMM for motion recognition and retrieval by Isomap dimension reduction

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第12期7卷 2063-2072页

作者： XIANG jian, weng jian-guang, ZHUANG Yue-ting, WU Fei (School of Computer Science, Zhejiang University, Hangzhou 31002., China) School of Computer Science Zhejiang University Hangzhou China

Along with the development of motion capture technique, more and more 3D motion databases become available. In this paper, a novel approach is presented for motion recognition and retrieval based on ensemble HMM (hidden Markov model) learning. Due to the high dimensionality of motion’s features, Isomap nonlinear dimension reduction is used for training data of ensemble HMM learning. For handling new motion data, Isomap is generalized based on the estimation of underlying eigen- functions. Then each action class is learned with one HMM. Since ensemble learning can effectively enhance supervised learning, ensembles of weak HMM learners are built. Experiment results showed that the approaches are effective for motion data recog- nition and retrieval.

关键词： Feature Isomap HMM (hidden Markov model) Ensemble learning Motion recognition and retrieval

Cryptanalysis of a signcryption scheme with fast online signing and short signcryptext

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Science China(Information Sciences) 2014年第7期57卷 149-153页

作者： ZHOU DeHua weng jian GUAN ChaoWen DENG Robert CHEN MinRong CHEN KeFei Department of Computer Science Jinan University Department of Computer Science Shanghai Jiao Tong University School of Information Systems Singapore Management University College of Information Engineering Shenzhen University School of Computer South China Normal University

Signcryption is functional combination of encryption and signature,efficiency higher than the separate signing and ***,Youn et *** a new signcryption scheme,which has fast online signing and short signcryptext,and is efficient enough for mobile *** scheme is claimed to be both existentially unforgeable and semantically ***,in this paper we shall show that it is not existentially unforgeable.

关键词： signcryption existential unforgeability semantical security insider attack bilinear pairing

Multi-loop node line states in ternary MgSrSi-type crystals

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npj Computational Materials 2019年第1期5卷 1056-1062页

作者： Jinling Lian Lixian Yu Qi-Feng Liang jian Zhou Rui Yu Hongming weng Department of Physics Shaoxing University312000 ShaoxingChina National Laboratory of Solid State Microstructures and Department of Materials Science and Engineering Nanjing University210093 NanjingChina School of Physics and Technology Wuhan University430072 WuhanChina Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of Sciences100190 BeijingChina Songshan Lake Materials Laboratory Guangdong 523808China

Node line band-touchings protected by mirror symmetry(named as m-NLs),the product of inversion and time reversal symmetry S=PT(named as s-NLs),or nonsymmorphic symmetry are nontrivial topological objects of topological semimetals in the Brillouin *** this work,we screened a family of MgSrSi-type crystals using first principles calculations,and discovered that more than 70 members are node-line semimetals.A new type of multi-loop structure was found in AsRhTi that a s-NL touches robustly with a m-NL at some“nexus point”,and in the meanwhile a second m-NL crosses with the s-NL to form a *** the previously proposed Hopf-link formed by two s-NLs or two m-NLs,a Hopf-link formed by a s-NL and a m-NL requires a minimal three-band model to characterize its essential electronic *** associated topological surface states on different surfaces of AsRhTi crystal were also *** more complicated and exotic multi-loop structure of NLs were predicted in AsFeNb and *** work may shed light on search for exotic multi-loop node-line semimetals in real materials.

关键词： structure materials topological

Carbon spheres with rational designed surface and secondary particle-piled structures for fast and stable sodium storage

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Journal of Energy Chemistry 2021年第3期30卷 368-376页

作者： Wenlong Shao Fangyuan Hu Siyang Liu Tianpeng Zhang Ce Song Zhihuan weng Jinyan Wang Xigao jian State Key Laboratory of Fine Chemicals Department of Polymer Materials&EngineeringLiaoning Province Engineering Research Centre of High Performance ResinsDalian University of TechnologyDalian 116024LiaoningChina School of Materials Science and Engineering Key Laboratory of Energy Materials and Devices(Liaoning Province)State Key Laboratory of Fine ChemicalsLiaoning Province Engineering Centre of High Performance ResinsDalian University of TechnologyDalian 116024LiaoningChina School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

The electrochemical performance of hard carbon in sodium storage is still limited by its poor cycling stability and rate capability because of the sluggish kinetics *** this study,we use a simple and effective method to accelerate the kinetics process by engineering the structure of the electrode to promote its surface and near-surface *** goal is realized by the use of slightly aggregated ultra-small carbon *** large specific surface area formed by the small spheres can provide abundant active sites for electrochemical *** abundant mesopores and macropores derived from the secondary particle piled structure of the carbon spheres could facilitate the transport of electrolytes,shorten the diffusion distance of Na^(+)and accommodate the volume expansion during *** from these unique structure features,PG700-3(carbon spheres with the diameters of 40-60 nm carbonized at 700℃)exhibits high performance for sodium storage.A high reversible capacity of 163 mAh g^(-1) could be delivered at a current density of 1.0 A g^(-1) after 100 ***,at a current density of 10.0 A g^(-1),the specific capacity of PG700-3 gradually increases to 140 mAh g^(-1) after 10000 cycles,corresponding to a capacity retention of 112..Given the enhanced kinetics of SIBs reactions,PG700-3 exhibits an excellent rate capability,i.e.,2.0 and 138 mAh g^(-1) at 0.1 and 5.0 A g^(-1),*** study provides a facile method to attain high performance anode materials for *** design strategy and improvement mechanism could be extended to other materials for high rate applications.

关键词： Sodium ion batteries Anode Carbon spheres High rate capability Surface reactions

Chemical constituents from Schisandra sphenanthera

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Chinese Chemical Letters 2008年第6期19卷 696-698页

作者： Rong Tao Li Zhi Ying weng jian Xin Pu Han Dong Sun State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China The College of Life Sciences and Technology Kunming University of Science and Technology 253 Xuehu Road Kunming 650093 China

The chemical constituents of the stems of Schisandra sphenanthera are described for the first time. This investigation has resulted in the isolation of a new phenolic glycoside （1）, along with seven known compounds.... 详细信息

关键词： Schisandra sphenanthera Phenolic glycoside 4,6-Dihydroxyphenyl-l-butanone-2.β-D-O-glucopyranoside

Triptolide Inhibits Expression of Inflammatory Cytokines and Proliferation of Fibroblast-like Synoviocytes Induced by IL-6/sIL-6R-Mediated JAK2.STAT3 Signaling Pathway

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Current Medical Science 2021年第1期41卷 133-139页

作者： jian-jing LIN Ke TAO Nan GAO Hui ZENG De-li WANG Jun YANG jian {2. National&Local Joint Engineering Research Center of Orthopaedic Biomaterials Department of Bone and Joint SurgeryPeking University Shenzhen HospitalShenzhen518000China Arthritis Clinical and Research Center Peking University People’s HospitalBeijing100044China Department of Rheumatism and Immunology Peking University Shenzhen HospitalShenzhen518000China Department of Radiology Peking University Shenzhen HospitalShenzhen518000China

Triptolide,a component of the Chinese herb Tripterygium wilfordii Hook F,has been proved to be effective in the treatment of rheumatoid arthritis(RA).However,its underlying mechanisms on RA have not yet been well *** observed the inhibitory effect of triptolide on the expression of inflammatory cytokines and proliferation of fibroblast-like synoviocytes(FLS)induced by the complex of interleukin-6(IL-6)and the soluble form of the IL-6 receptor(sIL-6R).Furthermore,to clarify the underlying mechanisms,we treated FLS with the Janus-activated kinase 2.JAK2.inhibitor/signal transducer and activator of transcription 3(STAT3)activation blocker *** this study,immunohistochemical staining was used to identify vimentin(+)and CD68(−)in *** FLS proliferation was measured by cell proliferation assay,and the cell cycles were analyzed by flow ***,ELISA was used to detect the expression of the inflammatory factors in culture *** expression levels of p-JAK2.JAK2.p-STAT3 and STAT3 were investigated through Western blotting *** results showed that IL-6/sIL-6R significantly increased the cell proliferation and expression of inflammatory cytokines,including IL-6,interleukin-1β(IL-1β)and vascular endothelial growth factor(VEGF).Triptolide or AZD1480 inhibited the cell proliferation and inflammatory cytokine expression in IL-6/sIL-6R-stimulated FLS by suppressing JAK2.*** study suggested that the physiological effects of triptolide on RA were due to its contribution to the inhibition of the inflammatory cytokine expression and FLS proliferation by suppressing the JAK2.STAT3 signaling *** may provide an innovative insight into the effect of triptolide in preventing RA pathogenesis.

关键词： triptolide inflammatory cytokines proliferation fibroblast-like synoviocytes JAK2.STAT3

SRF易位富于细胞性血管周肌样肿瘤2.临床病理学分析

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中华病理学杂志 2024年第1期53卷 64-70页

作者：印唐臣邵梦圆孙蒙赵露刘绮颖姚茜岚柏乾明喻林周晓燕王坚复旦大学附属肿瘤医院病理科复旦大学上海医学院肿瘤学系复旦大学病理研究所上海200032

目的:探讨SRF易位富于细胞性血管周肌样肿瘤的临床病理学特征、免疫表型、诊断及鉴别诊断。方法:收集复旦大学附属肿瘤医院病理科2.2.年10月至2.2.年3月诊断的2.SRF易位富于细胞性血管周肌样肿瘤病例,分析其临床病理学资料,行免疫组织... 详细信息

目的:探讨SRF易位富于细胞性血管周肌样肿瘤的临床病理学特征、免疫表型、诊断及鉴别诊断。方法:收集复旦大学附属肿瘤医院病理科2.2.年10月至2.2.年3月诊断的2.SRF易位富于细胞性血管周肌样肿瘤病例,分析其临床病理学资料,行免疫组织化学染色、荧光原位杂交(FISH)和二代测序,并复习相关文献。结果:例1,患儿男,3个月,头皮皮下无痛性肿块,直径约2.cm。例2.患儿女,3岁,膝关节处无痛性肿物,直径约1.5 cm。镜下观察,肿瘤边界清楚,呈多结节状生长;主要由长条束状或交叉束状排列梭形细胞组成,间质中可见裂隙状或分支状扩张的薄壁血管,局部形成血管外皮瘤样结构。瘤细胞丰富,但无明显异型性,可见核分裂象(3~4个/10 HPF)。2.均表达h-caldesmon和平滑肌肌动蛋白;例1结蛋白弥漫强阳性,局灶表达广谱细胞角蛋白;Ki-67阳性指数分别为2.%和30%。FISH检测显示例1存在NCOA2.因易位,例2.在RELA基因易位。二代测序检测显示例1存在SRF-NCOA2.因融合,例2.在SRF-RELA基因融合。2.均行局部肿块切除,随访5~14个月,例1无局部复发,例2.后1年发生局部复发。结论:SRF易位富于细胞性血管周肌样肿瘤是血管周细胞肿瘤的一种新变异型,好发于儿童和青少年,其形成从血管周细胞肿瘤至肌样肿瘤及混杂性血管周-肌样肿瘤的广泛形态学谱系。因瘤细胞丰富,可见活跃的核分裂象,且呈平滑肌样免疫表型,容易误诊为肌源性肉瘤。该肿瘤大多为良性,少数可复发。

关键词：软组织肿瘤基因血管周细胞肿瘤

A high-performance Mg-4.9Gd-3.2.-1.1Zn-0.5Zr alloy via multidirectional forging after analyzing its compression behavior

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Journal of Materials Science & Technology 2021年第11期70卷 156-167页

作者： Xiaojie Zhou Yuan Yao jian Zhang Xiaomin Chen Weiying Huang Jing Pan Haoran Wang Maopeng weng Hunan Provincial Key Laboratory of Intelligent Manufacturing Technology for High-performance Mechanical Equipment Changsha University of Science and TechnologyChangsha410114China

A high-performance Mg-4.9Gd-3.2.-1.1Zn-0.5Zr alloy has been fabricated by multidirectional forging(MDF)after analyzing its compression *** as-homogenized alloy exhibits a high activation energy Q of deformation(~2.5 kJ/mol).The size of DRXed grains after compression tends to decrease as the Z-H parameter(Z)increases,showing a grain size exponent m of~*** LPSO phases,kinking deformation,and bimodal microstructure are detected at the relatively low compression temperature of 350 and 400℃,while sufficient DRX can be achieved at 500℃,accompanied by the dissolution of lamellar *** to the processing maps,MDF was successfully conducted under an appropriate *** peak-aged at 2.0℃for 78 h,the MDFed billet exhibits a tensile yield strength(TYS)of 331 and 305 MPa at room temperature and 2.0℃,*** high strength mainly results from the combination of fine grains,low Schmid factor for basal slip,sufficientβ’ageing precipitates,and directionally arranged interdendritic LPSO phases,*** paper provides a feasible way for the fabrication of high-performance,low-RE-content,and large-scale Mg components for industrial production.

关键词： Mg-Gd-Y-Zn-Zr Deformation behavior Activation energy Forge Dynamic recrystallization Mechanical properties