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Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro

World Journal of Stem Cells 2024年第2期16卷 163-175页

作者： Yan ren Yan-Ni Cui Hong-wei Wang The Second Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology Key Laboratory of Molecular Diagnosis and Treatment of Blood Diseases in Shanxi ProvinceTaiyuan 030001Shanxi ProvinceChina

BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital ***(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cells(HSPCs,CD34^(+)CD38)and functional subtypes of HSCs-shortterm repopulating HSCs(ST-HSCs,CD34^(+)CD38CD45RACD49f^(+))and long-term repopulating HSCs(LT-HSCs,CD34^(+)CD38CD45RACD49f^(+)CD90^(+))is not yet *** a sirtuin 1(SIRT1)inhibitor,NAM participates in regulating cell adhesion,polarity,migration,proliferation,and ***,SIRT1 exhibits dual effects by promoting or inhibiting differentiation in different tissues or *** propose that the concentration of NAM may influence proliferation,differentiation,and SIRT1 signaling of *** To evaluate the effects and underlying mechanisms of action of different concentrations of NAM on HSC proliferation and *** CD34^(+)cells were purified from umbilical cord blood using MacsCD34 beads,and cultured for 10-12 d in a serum-free medium supplemented with cytokines,with different concentrations of NAM added according to experimental *** cytometry was used to detect phenotype,cell cycle distribution,and apoptosis of the cultured ***-time polymerase chain reaction was used to detect the transcription levels of target genes encoding stemness-related factors,che mokines,components of hypoxia pathways,and antioxidant ***-dihydro-fluorescein diacetate probes were used to evaluate intracellular production of reactive oxygen species(ROS).Determination of the effect of different culture conditions on the balance of cytokine by cytometric bead *** Compared with the control group,the proportion and expansion folds of HSPCs(CD34^(+)CD38)incubated with 5 mmol/L or 10 mmol/L NAM were significantly increased(all P<0.05).The ST-HSCs ratio and fold expansion of the 5 mmol/L NAM group were significantly

关键词： Hematopoietic stem cells Nicotinamide Concentration Proliferation Differentiation Sirtuin 1

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Link between mutations in ACVRL1 and PLA2G4A genes and chronic intestinal ulcers:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 932-943页

作者： Yong-Jing Tang jian Zhang Jie Wang ren-Dong Tian wei-wei Zhong Ben-Sheng Yao Bing-Yu Hou Ying-Hua Chen wei He Yi-Huai He Department of Infectious Diseases The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Dafang County People's HospitalBijie 551600Guizhou ProvinceChina Department of Internal Medicine Puchang BranchMedical CommunitySuiyang County People's HospitalZunyi 563300Guizhou ProvinceChina Department of Infectious Diseases Jingmen Central HospitalJingmen 448000Hubei ProvinceChina Department of Infectious Diseases Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

BACKGROUND Genetic factors of chronic intestinal ulcers are increasingly garnering *** present a case of chronic intestinal ulcers and bleeding associated with mu-tations of the activin A receptor type II-like 1(ACVRL1)and phospholipase A2 group IVA(PLA2G4A)genes and review the available relevant *** SUMMARY A 20-year-old man was admitted to our center with a 6-year history of recurrent abdominal pain,diarrhea,and dark *** the onset 6 years ago,the patient had received treatment at a local hospital for abdominal pain persisting for 7 d,under the diagnosis of diffuse peritonitis,acute gangrenous appendicitis with perforation,adhesive intestinal obstruction,and pelvic *** surgical treat-ment included exploratory laparotomy,appendectomy,intestinal adhesiolysis,and pelvic abscess *** patient’s condition improved and he was ***,the recurrent episodes of abdominal pain and passage of black stools started again one year after *** the basis of these features and results of subsequent colonoscopy,the clinical diagnosis was established as in-flammatory bowel disease(IBD).Accordingly,aminosalicylic acid,immunotherapy,and related symptomatic treatment were administered,but the symptoms of the patient did not improve *** investigations revealed mutations in the ACVRL1 and PLA2G4A ***1 and PLA2G4A are involved in angiogenesis and coagulation,*** suggests that the chronic intestinal ulcers and bleeding in this case may be linked to mutations in the ACVRL1 and PLA2G4A *** Kangfuxin liquid was administered to promote healing of the intestinal mucosa and effectively manage clinical *** Mutations in the ACVRL1 and PLA2G4A genes may be one of the causes of chronic intestinal ulcers and bleeding in *** administered Kangfuxin liquid may have therapeutic potential.

关键词： Intestinal ulcers Crohn’s disease Ulcerative colitis Activin A receptor type II-like 1 Phospholipase A2 group 4A Case report

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The Influence of Different Solar System Planetary Ephemerides on Pulsar Timing

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Research in Astronomy and Astrophysics 2024年第8期24卷 87-101页

作者： jian-Peng Dai wei Han Na Wang School of Physical Science and Technology Xinjiang University Xinjiang Astronomical Observatory Chinese Academy of Sciences University of Chinese Academy of Sciences Xinjiang Key Laboratory of Radio Astrophysics

Pulsar timing offers a comprehensive avenue for exploring diverse topics in physics and *** solar system planetary ephemeris is crucial for pulsar timing as it provides the positions and velocities of solar system planets including the ***,it is inevitable that inherent inconsistencies exist in these *** between various ephemerides can significantly impact pulsar timing and parameter ***,pulsar timing highly depends on the JPL DE ephemeris,for instance,the Pulsar Timing Array data analysis predominantly utilizes *** this study,we examine inconsistencies across various ephemeris series,including JPL DE,EPM,and ***,discrepancies emerge particularly between the current ephemeris DE436 and the earliest released ephemeris DE200,as well as the most recent ephemerides,e.g.,DE440,INPOP21A,and *** detailed analysis of the effects of ephemeris on geometric correction procedures for the conversion of measured topocentric times of arrival is presented in this *** researches reveal that variations in the Roemer delays across different ephemerides lead to distinct *** timing residuals and the fact that these discrepancies can be readily incorporated into the subsequent pulsar parameters,leading to inconsistent fitting estimates,suggest that the influence of errors in the ephemeris on the timing process might currently be underappreciated.

关键词： (stars:) pulsars: general ephemerides Planetary Systems time

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New insight into Ca^(2+)-permeable channel in plant immunity

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Journal of Integrative Plant Biology 2024年第3期66卷 623-631页

作者： wei Wang Hang-Yuan Cheng jian-Min Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

Calcium ions(Ca^(2+)) are crucial intracellular second messengers in eukaryotic cells. Upon pathogen perception, plants generate a transient and rapid increase in cytoplasmic Ca^(2+)levels, which is subsequently decoded by Ca^(2+)sensors and effectors to activate downstream immune responses. The elevation of cytosolic Ca^(2+)is commonly attributed to Ca^(2+)influx mediated by plasma membranelocalized Ca^(2+)–permeable channels. However, the contribution of Ca^(2+)release triggered by intracellular Ca^(2+)-permeable channels in shaping Ca^(2+)signaling associated with plant immunity remains poorly understood. This review discusses recent advances in understanding the mechanism underlying the shaping of Ca^(2+)signatures upon the activation of immune receptors, with particular emphasis on the identification of intracellular immune receptors as non-canonical Ca^(2+)-permeable channels. We also discuss the involvement of Ca^(2+)release from the endoplasmic reticulum in generating Ca^(2+)signaling during plant immunity.

关键词： Ca^(2+)-permeable channels endoplasmic reticulum phosphorylation plant immunity resistosome

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In situ embedded bismuth nanoparticles among highly porous carbon fibers for efficient carbon dioxide reduction

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Rare Metals 2024年第9期43卷 4312-4320页

作者： wei-jian Guo Ao Zhou Wen-Wen Cai Jin-Tao Zhang Key Laboratory for Colloid and Interface Chemistry (Ministry of Education) School of Chemistry and Chemical EngineeringShandong University

Electrocatalysis provides an optimal approach for the conversion of carbon dioxide(CO2) into high-value chemicals, thereby presenting a promising avenue toward achieve carbon neutrality. However, addressing the selectivity and stability challenges of metal catalysts in electrolytic reduction remains a daunting task. In this study, the electrospinning method is employed to fabricate porous carbon nanofibers loaded with bismuth nanoparticles with the help of in situ pyrolysis. The porous carbon nanofibers as conductive support would facilitate the dispersion of bismuth active sites while inhibiting their aggregation and promoting the mass transfer, thus enhancing their electrocatalytic activity and stability. Additionally, nitrogen doping induces electron delocalization in bismuth atoms through metal-support interactions, thus enabling efficient adsorption of intermediates for improving selectivity based on the theoretical calculation. Consequently, Bi@PCNF-500 exhibits the exceptional selectivity and stability across a wide range of potential windows. Notably, its faradaic efficiency(FE) of formate reaches 92.7% in H-cell and94.9% in flow cell, respectively, with good electrocatalytic stability. The in situ characterization and theoretical calculations elucidate the plausible reaction mechanism to obtain basic rules for designing efficient electrocatalyst.

关键词： Carbon dioxide reduction Electron delocalization N-doping Porous carbon nanofiber

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Hexagonal boron nitride based slippery liquid infused porous surface with anti-corrosion, anti-contaminant and anti-icing properties for protecting magnesium alloy

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Chinese Chemical Letters 2024年第4期35卷 532-538页

作者： Wenhao Yan Shuaiya Xue Xuerui Zhao wei Zhang jian Li Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China

In an era where the concept of green development is deeply rooted, magnesium(Mg) alloy as a light metal has a long-term development prospect in the process of energy saving, emission reduction and environmental improvement. However, anti-corrosion performance of Mg alloy is poor due to the high chemical activity and low equilibrium potential, which limits the development of Mg alloy ***, three-dimensional mesopore hollow polypyrrole spheres(MHPS) were prepared, and the MHPS was inserted into the middle of the stacked hexagon boron nitride(h-BN) lamellae, which allowed the hBN to be separated forming a further composite with abundant pore structure. Subsequently, the MHPS/hBN-OH composite was uniformly sprayed on the Mg alloy surface via simple spraying method to form the superhydrophobic surface(SHS). Finally, the slippery liquid infused porous surface(SLIPS) was successfully fabricated by applying drops of silicone lubricant on the superhydrophobic coating surface. After a series of characterization and testing, the results showed that the stacking of h-BN lamellae was significantly reduced after h-BN was successfully embedded by MHPS. In addition, the fabricated SLIPS have excellent self-cleaning, mechanical stability, anti-icing and anti-corrosion properties. Therefore, the method of embedding polymer microspheres not only offers a new strategy for h-BN exfoliation, but also the successful prepared SLIPS largely retards the corrosion of Mg alloy while providing new ideas for the development of SLIPS.

关键词： Anti-corrosion Mg alloy Hexagon boron nitride Polypyrrole SLIPS

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Digital signal acquisition system for complex nuclear reaction experiments

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Nuclear Science and Techniques 2024年第1期35卷 124-133页

作者： wei-Liang Pu Yan-Lin Ye jian-Ling Lou Jia-Hao Chen School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100094China

A digital data-acquisition system based on XIA LLC products was used in a complex nuclear reaction experiment using radioactive ion beams.A flexible trigger system based on a field-programmable gate array(FPGA)parametrization was developed to adapt to different experimental sizes.A user-friendly interface was implemented,which allows converting script language expressions into FPGA internal control *** proposed digital system can be combined with a conventional analog data acquisition system to provide more *** performance of the combined system was veri-fied using experimental data.

关键词： Digital signal acquisition system Trigger Programmable logic Timestamp

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Quality assessment of friction-stir-welded aluminum alloy welds via three-dimensional force signals

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Advances in Manufacturing 2024年第1期12卷 61-75页

作者： Ji-Hong Dong Yi-Ming Huang Jia-Lei Zhu wei Guan Xu-Kai ren Huan-wei Yu Lei Cui Beijing Institute of Petrochemical Technology Beijing102617People’s Republic of China Beijing Academy of Safety Engineering and Technology Beijing102617People’s Republic of China AVIC Manufacturing Technology Institute Beijing100024People’s Republic of China Tianjin Key Laboratory of Advanced Joining Technology School of Materials Science and EngineeringTianjin UniversityTianjin300350People’s Republic of China Shaoxing Special Equipment Testing Institute Shaoxing Key Laboratory of Special Equipment Intelligent Testing and EvaluationShaoxing312071ZhejiangPeople’s Republic of China

An online detection technology must be developed for realizing the real-time control of friction stir *** this study,the three-dimensional force exerted on a material during friction stir welding was collected synchronously and the relationship between the forces and welding quality was *** results indicated that the fluctuation period of the traverse force was equal to that of the lateral force during the stable welding *** phase difference between two horizontal forces wasπ/*** values of the horizontal forces increased with welding speed,whereas their amplitudes remained the *** proposed force model showed that the traverse and lateral forces conformed to an elliptical curve,and this result was consistent with the behavior of the measured *** variational mode decomposition was used to process the plunge *** intrinsic mode function that represented the real fluctuation in the plunge force varied at the same frequency as the spindle rotational *** tunnel defects occurred,the fluctuation period features were consistent with those obtained during normal welding,whereas the ratio parameter defined in this study increased significantly.

关键词： Friction stir welding(FSW) Three-dimensional force model Variational mode decomposition Tunnel defect

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Study on frictional behavior of SiC_(f)/SiC composite clad tube clamping condition under nuclear irradiation

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Friction 2024年第5期12卷 919-938页

作者： Chenglong XIAO Liangliang SHEN Tianqi ZHU jianbo TANG Ximing XIE Xinyu FAN jian XU Zhiying ren School of Mechanical Engineering Zhejiang University of TechnologyHangzhou310023China Engineering Laboratory of Advanced Energy Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China State Key Laboratory of Fine Chemicals Liaoning High-Performance Polymer Engineering Research CenterSchool of Chemical EngineeringDalian University of TechnologyDalian116024China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou350116China School of Computer Science and Technology Shandong UniversityQingdao266237China Aviation Industry Corporation of China Ltd.Beijing100028China

Silicon carbide fiber reinforced silicon carbide matrix(SiC_(f)/SiC)composite is the key cladding material of nuclear fuel,which determines the safety and reliability of nuclear fuel storage and *** replacement of its storage and transportation scenario needs to be completed by the manipulator,but the application of SiC_(f)/SiC wear,fracture,and nuclear leakage in the snatching process of brittle-flexible-rigid contact in the irradiation environment has been seriously restricted due to unclear understanding of the damage ***,the effects of irradiation dose and clamping load on the friction characteristics of the contact interface between SiC_(f)/SiC clad tube are studied in this paper,and the effects of irradiation parameters and clamping force on the static friction coefficient of the contact interface between the clad tube and flexible nitrile are *** on the Greenwood-Williamson tribological model,a numerical model of the shape and structure of the contact micro-convex at the micro-scale of the clamping interface is constructed by introducing the multi-surface integral,and finally verified by *** research results show that there is a unique“Irradiation suppression zone”under the clamping condition of SiC_(f)/SiC cladding tube under the nuclear irradiation environment,and the growth of static friction coefficient slows down until stagnates after irradiation reaches a certain extent(600 kGy),and there will be a decline when the irradiation dose continues to increase,among which the clamping force of 15.2 N within the irradiation interval of 1,000 kGy can meet the safety of nuclear environment *** results of this paper can provide an important theoretical basis and application guidance for the safe operation of SiC_(f)/SiC cladding tubes in the storage and transportation clamping process.

关键词： SiC_(f)/SiC Clad tube nuclear irradiation conditions Greenwood-Williamson tribological model multi-surface integral

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Can soil organic carbon sequestration and the carbon management index be improved by changing the film mulching methods in the semiarid region?

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Journal of Integrative Agriculture 2024年第5期23卷 1541-1556页

作者： Jialin Yang Liangqi ren Nanhai Zhang Enke Liu Shikun Sun Xiaolong ren Zhikuan Jia Ting wei Peng Zhang College of Agronomy Northwest A&F UniversityYangling 712100China Key Laboratory of Crop Physi-Ecology and Tillage Science in Northwestern Loess Plateau Ministry of Agriculture and Rural AfairsNorthwest A&FUniversityYangling 712100China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100China

Plastic film mulching has been widely used to increase maize yield in the semiarid area of ***, whether long-term plastic film mulching is conducive to agricultural sustainability in this region remains controversial.A field experiment was initiated in 2013 with five different film mulching methods:(i) control method, flat planting without mulching (CK),(ii) flat planting with half film mulching (P),(iii) film mulching on ridges and planting in narrow furrows(S),(iv) full film mulching on double ridges (D), and (v) film mulching on ridges and planting in wide furrows (R).The effects on soil organic carbon (SOC) content, storage, and fractions, and on the carbon management index (CMI)were evaluated after nine consecutive years of plastic film *** results showed that long-term plastic film mulching generally maintained the initial SOC *** with no mulching, plastic film mulching increased the average crop yield, biomass yield, and root biomass by 48.38, 35.06, and 37.32%, respectively, which led to the improvement of SOC ***, plastic film mulching significantly improved CMI, and increased the SOC content by 13.59%, SOC storage by 7.47%and easily oxidizable organic carbon (EOC) by 13.78%on average,but it reduced the other labile *** sequestration and CMI were improved by refining the plastic film mulching *** S treatment had the best effect among the four mulching methods, so it can be used as a reasonable film mulching method for sustainable agricultural development in the semiarid area.

关键词： plastic film mulching soil organic carbon labile organic carbon fractions semiarid area

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