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Silencing profilin-1 inhibits gastric cancer progression via integrin β1/focal adhesion kinase pathway modulation

World Journal of Gastroenterology 2015年第8期21卷 2323-2335页

作者： Ya-Jun Cheng Zhen-Xin Zhu jian-sheng zhou Zun-Qi Hu jian-Peng Zhang Qing-Ping Cai Liang-Hua Wang Gastrointestinal Surgery Department Shanghai Changzheng Hospital Second Military Medical University Biochemistry and Molecular Biology Department Second Military Medical University

AIM:To investigate the role of profilin-1(PFN1)in gastric cancer and the underlying ***:Immunohistochemical analysis,quan-titative real-time polymerase chain reaction(q RTPCR)and Western blot were performed to detect PFN1expression in clinical gastric carcinoma and adjacent tissues,and the association of PFN1 expression with patient clinicopathological characteristics was ***1 was knocked down to investigate the role of this protein in cell proliferation and metastasis in the SGC-7901 cell *** explore the underlying mechanisms,the expression of integrinβ1 and the activity of focal adhesion kinase(FAK)and the downstream proteins extracellular-regulated kinase(ERK)1/2,P38 mitogen-activated protein kinase(MAPK),phosphatidylinositol 3-kinase(PI3K),AKT and mammalian target of rapamycin(m TOR)were measured through Western blot or q RT-PCR ***(FN),a ligand of integrinβ1,was used to verify the correlation between alterations in the integrinβ1/FAK pathway and changes in tumor cell aggressiveness upon PFN1 ***:Immunohistochemical,Western blot and q RT-PCR analyses revealed that PFN1 expression was higher at both the protein and m RNA levels in gastric carcinoma tissues compared with the adjacent *** addition,high PFN1 expression(53/75,70.4%)was correlated with tumor infiltration,lymph node metastasis and TNM stage in gastric cancer,but not with gender,age,location,tumor size,or histological *** vitro experiments showed that PFN1knockdown inhibited the proliferation of SGC-7901cells through the induction G0/G1 *** PFN1 inhibited cell migration and invasion and downregulated the expression of matrix metalloproteinase(MMP)-2 and ***,silencing PFN1 reduced the expression of integrinβ1 at the protein level and inhibited the activity of FAK,and the downstream effectors ERK1/2,P38MAPK,PI3K,AKT and m ***-promoted cell proliferation and metastasis via the integrinβ1/FAK pathwa

关键词： Gastric cancer Profilin-1 Integrin β1 Focaladhesio

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A Study on Estimation of SOC of Emus Batteries

A Study on Estimation of SOC of Emus Batteries

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第三十九届中国控制会议

作者： Wen long Ma Li wei Li jian sheng zhou Fei Yu CRRC QINGDAO SIFANG CO. LTD College of Electrical Engineering Qingdao University China Railway Guangzhou Group CO. LTDGuangzhou EMU depot

The on-board batteries of the Emus have extremely high accuracy requirements for real-time estimation of state of charge SOC. The ordinary Ah integration method and the open-circuit voltage method cannot meet the actual requirements of the Emus. This paper estimates the battery SOC based on the extended Kalman filter（EKF） algorithm. By building a firstorder Thevenin equivalent circuit model to combining the car battery with the EKF algorithm, ultimately improve SOC estimation accuracy. In order to improve the estimation accuracy of the model, the variation law of the polarization voltage and polarization capacitance of the battery pack under different SOC values were obtained, and the functional relationship was fitted by the least square method. Finally, the simulation was performed in MATLAB/Simulink environment. The experimental results show that the EKF algorithm overcomes the shortcoming that the AH integration method cannot eliminate the accumulated error, and can implement the estimated battery SOC value, in addition the estimated error is controlled within 4%.

关键词： Emus Extended Kalman Filter SOC Simulink Thevenin equivalent model

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球面收敛二元矢量喷管气动及红外特性研究:模拟高空状态

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航空动力学报 2017年第2期32卷 390-397页

作者：征建生张靖周单勇季靖远南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室南京210016 先进航空发动机协同创新中心北京100191

针对高空状态下球面收敛二元矢量喷管排气系统,通过数值模拟研究了喷管俯仰偏转角对排气系统气动和红外辐射特性的影响,并与地面状态进行了对比分析.在该研究参数范围内,研究结果表明:在俯仰偏转角为20°范围内,俯仰偏转对排气系统推力... 详细信息

针对高空状态下球面收敛二元矢量喷管排气系统,通过数值模拟研究了喷管俯仰偏转角对排气系统气动和红外辐射特性的影响,并与地面状态进行了对比分析.在该研究参数范围内,研究结果表明:在俯仰偏转角为20°范围内,俯仰偏转对排气系统推力系数和总压恢复系数的影响微弱,气动推力矢量角与俯仰偏转角几乎相等,高空状态下,喷管的推力系数和总压恢复系数下降0.5%与1.1%;热喷流峰值红外辐射强度仅为地面状态的12%~24%,排气系统的总体红外辐射强度峰值与地面状态下的比值峰值在0.35~0.45之间;随着下俯仰偏转角的增加,排气系统红外辐射峰值呈现下降的趋势.

关键词：高空状态球面收敛二元矢量喷管俯仰偏转气动特性红外辐射特性

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Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： jian‑En zhou Yilin Li Xiaoming Lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

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Introduction to Ant Colony Algorithm and Its Application in CIMS

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厦门大学学报（自然科学版） 2002年第S1期41卷 182-页

作者： WANG jian, WANG Yue-sheng, zhou Ya-jun (Department of Automation, Hangzhou Institute of Electronic and Engin eering, Hangzhou 310037, China)

Ant colony algorithm is a novel simulated ecosystem e volutionary algorithm, which is proposed firstly by Italian scholars ***, A . Colormi and V. Maniezzo. Enlightened by the process of ants searching for food , scholars bring forward this new evolutionary algorithm. This algorithm has sev eral characteristics such as positive feedback, distributed computing and stro nger robustness. Positive feedback and distributed computing make it easier to find better solutions. Based on these characteristics, this algorithm provides a possible way for complicated combinatorial optimization problems, especially i n the field of discrete system. After a brief review on the essential principle, the research state of ant colony algorithm, this paper especially discusses the application of ant colony algorithm in CIMS.

关键词： ant colony algorithm CIMS combinatorial optimiz ation

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平行或垂直双钢板治疗中青年C型肱骨远端骨折的病例对照研究

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中国骨伤 2017年第6期30卷 532-537页

作者：俞叶锋戴加平盛建明周晓嘉兴市第二医院骨科浙江嘉兴314000

目的 :比较使用垂直双钢板或平行双钢板内固定治疗C型肱骨远端骨折的临床疗效。方法 :自2009年3月至2013年3月采用双钢板内固定治疗40例C型肱骨远端骨折患者,按固定方式不同分为两组:垂直双钢板固定组(A组)和平行双钢板固定组(B组)。A... 详细信息

目的 :比较使用垂直双钢板或平行双钢板内固定治疗C型肱骨远端骨折的临床疗效。方法 :自2009年3月至2013年3月采用双钢板内固定治疗40例C型肱骨远端骨折患者,按固定方式不同分为两组:垂直双钢板固定组(A组)和平行双钢板固定组(B组)。A组22例,男13例,女9例,年龄18~56岁,平均(37.56±9.24)岁;B组18例,男11例,女7例,年龄20~53岁,平均(41.35±9.03)岁;两组均为新鲜闭合性骨折,无血管及神经损伤。观察并比较两组患者的手术切口长度、手术时间、手术出血量、住院时间、影像学变化、肘关节活动范围、Mayo肘关节评分、肘关节屈伸肌肌肉力量以及并发症等情况。结果:全部病例术后切口愈合良好,两组术后各出现1例骨化性肌炎;A组2例、B组1例出现肘关节僵硬,术后骨折均获骨性愈合。A组随访20~36个月,平均(25.2±7.1)个月,B组随访18~35个月,平均(24.3±6.0)个月。两组手术出血量、手术时间比较差异有统计学意义;但手术切口、住院天数、肌肉力量、骨折愈合时间、肘关节活动范围等方面两组比较差异无统计学意义。A组Mayo肘关节评分为82.27±10.43,优6例,良12例,可3例,差1例;B组为81.94±12.02,优5例,良9例,可3例,差1例;两组比较差异无统计学意义。结论:垂直双钢板与平行双钢板对中青年C型肱骨远端骨折的临床疗效无明显差异,但具体术式的选择仍需要根据骨折的具体情况以及术者对术式的熟练程度。

关键词：肱骨远端骨折骨折固定术,内双钢板

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前牙美观区单牙即刻种植修复

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上海口腔医学 2003年第3期12卷 174-177页

作者：黄建生周磊宋光保广东省口腔医院广东广州510280

目的观察前牙单牙延期种植后即刻修复的临床效果。方法对6例8颗上前牙种植病例,在植入Frialit-2同时接入Pro-Tect基台行复合树脂暂时冠临时修复,根据骨质情况,4～6个月后,接入永久修复体。结果追踪7～14个月,无种植体丢失。前6个月平均... 详细信息

目的观察前牙单牙延期种植后即刻修复的临床效果。方法对6例8颗上前牙种植病例,在植入Frialit-2同时接入Pro-Tect基台行复合树脂暂时冠临时修复,根据骨质情况,4～6个月后,接入永久修复体。结果追踪7～14个月,无种植体丢失。前6个月平均边缘骨丧失为0.89mm。追踪期内,累积平均骨丧失为-1.28mm。结论严格掌握适应证后,种植后即刻修复,近期效果良好,长期效果有待追踪。

关键词：种植体美观区单牙即刻修复

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示踪法测定井中渗透流速的广义稀释模型研究

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长江科学院院报 2016年第10期33卷 126-130,139页

作者：张茜陈建生董海洲滕兆明淮阴工学院建筑工程学院江苏淮安223003 河海大学地球科学与工程学院南京210098 昆山市水利局江苏昆山215300

基于传统稀释公式和广义稀释公式存在的问题,对已有广义稀释公式在原模型基础上进行数学推导方法改进,给出理论上的严格解析解,解决了原有公式的舍入误差,简化了公式形式。以固定高度水柱为研究对象,重新建立模型,给出新的水平渗透流速... 详细信息

基于传统稀释公式和广义稀释公式存在的问题,对已有广义稀释公式在原模型基础上进行数学推导方法改进,给出理论上的严格解析解,解决了原有公式的舍入误差,简化了公式形式。以固定高度水柱为研究对象,重新建立模型,给出新的水平渗透流速计算方法。结合北江大堤文献资料给出具体应用结果,并与前人各公式进行对比分析,与考虑质量守恒和溶质弥散作用的公式结果相比误差较小,很好地反映了工程实际情况,且在数据处理和公式应用上具备简洁明了的优势,具有很好的工程应用价值。

关键词：示踪法渗透流速垂向流广义稀释原理渗漏探测

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong zhou Zhe-Yi Han Jun Xiao jian-Feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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3D打印技术在桡骨远端不稳定性骨折微创治疗中的应用

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蚌埠医学院学报 2019年第4期44卷 437-441页

作者：张衡刘扬官建中周建生蚌埠医学院第一附属医院骨科组织移植安徽省重点实验室安徽蚌埠233004

目的:探讨3D打印技术辅助下微创手术在桡骨远端不稳定性骨折治疗中的临床应用。方法:选取桡骨远端不稳定性骨折病人25例,分为3D打印技术辅助下微创(闭合或有限切开)复位克氏针内固定外固定支架外固定组(MIS组)12例和切开复位锁定板内固... 详细信息

目的:探讨3D打印技术辅助下微创手术在桡骨远端不稳定性骨折治疗中的临床应用。方法:选取桡骨远端不稳定性骨折病人25例,分为3D打印技术辅助下微创(闭合或有限切开)复位克氏针内固定外固定支架外固定组(MIS组)12例和切开复位锁定板内固定组(ORIF组)13例。比较2组病人手术时间和切口长度,术后随访病人腕关节掌屈、背伸、尺偏、桡偏、旋前、旋后六个方向的活动度,复查腕关节正侧位片,观察对掌倾角、尺偏角、桡骨长度及关节面恢复情况,应用Gartland-Werley腕关节功能评分表对2组病人腕关节功能进行评分并比较。结果:2组病人均顺利完成手术,MIS组手术时间明显短于ORIF组(P0.05)。结论:应用3D打印技术辅助下微创(闭合或有限切开)复位克氏针内固定外固定支架外固定治疗桡骨远端不稳定性骨折,切口小,手术时间短,腕关节功能恢复良好,且可避免二次手术。

关键词：桡骨骨折 3D打印微创外固定支架内固定

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