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Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10

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Neural Regeneration Research 2011年第26期6卷 2005-2012页

作者： rong guo Kui Huang Tongzi jiang jian Li Yu Li Xiaona Xing Yunpeng Cao Department of Neurology First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China Department of Neurolo-gy Shenyang Red Cross Hospital Shenyang 110013 Liaoning Province China Department of Neurology First Affiliated Hospital of Liaoning Medical College Jinzhou 121001 Liaoning Province China

Immunotherapy for Alzheimer＇s disease （AD） is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 [beta-amyloid （Aβ） 1-42] vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a nove） vaccine to avoid the T cell mediated immune response caused by the Aβ1-42. Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 x Aβ3-10 repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 × Aβ3-10 vaccine immunization, high titers of anti-Aβ42 IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 × Aβ3-10 immunized mice showed significantly improved memories compared to control mice. The 10 × Aβ3-10 vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 × Aβ3-10 vaccine might be more efficient if administered before Aβ aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 × Aβ-10 is a promising vaccine for AD.

关键词： Alzheimer's disease immunotherapy gene vaccine amyloid plaque T cell immunity response neural regeneration

Internal structural optimization of hollow fan blade based on sequential quadratic programming algorithm

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航空动力学报 2011年第4期26卷 787-793页

作者： YANG jian-qiu WANG Yan-rong School of Jet Propulsion Beijing University of Aeronautics and Astronautics Beijing 100191 China

Several structural design parameters for the description of the geometric features of a hollow fan blade were determined.A structural design optimization model of a hollow fan blade which based on the strength constraint and minimum mass was established based on the finite element method through these ***,the sequential quadratic programming algorithm was employed to search the optimal *** groups of value for initial design variables were chosen,for the purpose of not only finding much more local optimal results but also analyzing which discipline that the variables according to could be benefit for the convergence and *** surface method and Monte Carlo simulations were used to analyze whether the objective function and constraint function are sensitive to the variation of variables or *** the robust results could be found among a group of different local optimal solutions.

关键词： hollow fan blade structural optimization sequential quadratic algorithm finite element method Monte Carlo simulations

Caveolin-1,E-cadherin and β-catenin in Gastric Carcinoma,Precancerous Tissues and Chronic Non-atrophic Gastritis

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Chinese Journal of Cancer Research 2012年第1期24卷 23-28页

作者： guo-yang Sun Jun-xia Wu jian-sheng Wu Yu-ting Pan rong Jin Department of Gastroenterology the First Affiliated HospitalWenzhou Medical CollegeWenzhou 325000China Department of Gastroenterology Shaoxing Municipal People's HospitalShooxing 312000China Department of Epidemiology the First Affiliated HospitalWenzhou Medical CollegeWenzhou 325000China

Objective： To investigate the expressions of caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous gastric and chronic non-atrophic gastritis tissues, and evaluate the correlation of these expressions with the development of gastric cancer. Methods： The expressions of caveolin-1, E-cadherin and β-catenin were detected by biotin-streptavidinperoxidase （SP） immunohistochemistry on 58 gastric cancer tissues, 40 precancerous gastric tissues and 42 chronic non-atrophic gastritis tissues. The correlation between the expressions of caveolin-1, E-cadherin and β-catenin, and the clinicopathologic parameters of gastric cancer was analyzed retrospectively. Results： The positive rates of caveolin-1 and E-cadherin expressions in gastric carcinoma were significantly lower than precancerous gastric and chronic non-atrophic gastritis tissues （P〈0.01）. An abnormal rate of β-catenin expression in gastric carcinoma was higher than precancerous gastric and chronic non-atrophic gastritis tissues （P〈0.01）. Moreover, low expressions of caveolin-1, E-cadherin and β-catenin correlated with tumor size, depth of invasion, lymph node metastasis and TNM stage （P〈0.05）. The positive rates of caveolin-1 and E-cadherin expressions decreased （P〈0.01）, while an abnormal rate of β-catenin expression increased inversely, with the degree of atypical hyperplasia （P〈0.01）. Caveolin-1 expression correlated positively with E-cadherin （r=0.41, P〈0.05）. Caveolin-1 （r=-0.36, P〈0.05） and E-cadherin （r=-0.45, P〈0.05） expressions negatively correlated with abnormal β-catenin expression. Conclusion： These results suggested that dysregulated expressions of caveolin-1, E-cadherin and β-catenin correlated with the development of gastric cancer and its biological behavior.

关键词： Gastric carcinoma Caveolin-1 E-cadherin β-catenin Immunohistochemistry

A New Proof of the Lattice Structure of Many-to-Many Pairwise-Stable Matchings

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Journal of the Operations Research Society of China 2014年第3期2卷 369-377页

作者： jian-rong Li School of Mathematics South China Normal UniversityGuangzhou 510631China

This paper studies,under substitutable and cardinal monotone preferences,the lattice structure of the set SePT of many-to-many pairwise-stable *** proves that the selection matchings are increasing functions on *** fact,along with a few auxiliary results,is then used to prove that SePT is a distributive *** contribution of this paper is not new,but the alternative proof is interesting as it avoids the use of abstract lattice theory.

关键词： Pairwise-stable matching Lattice Cardinal monotonicity

The photometric monitoring of γ-ray-loud narrow-line Seyfert 1 galaxy 1H0323+342 from 2006 to 2010

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Research in Astronomy and Astrophysics 2017年第7期17卷 47-56页

作者： Fang Wang Ding-rong Xiong Jin-Ming Bai Shao-Kun Li jian-guo Wang Yunnan Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Center for Astronomical Mega-Science Chinese Academy of Sciences

1H 0323＋342 is a γ-ray-loud narrow-line Seyfert 1 galaxy（NLS1）. The variability mechanism of γ-ray-loud NLS1 s remains unclear. We have observed 1H 0323＋342 photometrically from 2006 to2010 with a total of 41 nights of observations in order to constrain the variability mechanism. Intraday variabilities（IDVs） are detected on four nights. When considering the nights with time spans 〉 2 hours,the duty cycle is 28.3%. The average variability amplitude is 10.8% for IDVs and possibly variable nights. In the color-magnitude diagram, there are bluer-when-brighter chromatic trends for intraday and long-term timescales, which could be explained by the shock-in-jet model, and also could possibly be due to two distinct components or an accretion disk model.

关键词： galaxies active - galaxies individual (1H 0323+342)- galaxies jets

Effect of Inoculation with Arbuscular Mycorrhizal Fungus on Nitrogen and Phosphorus Utilization in Upland Rice-Mungbean Intercropping System

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Agricultural Sciences in China 2010年第4期9卷 528-535页

作者： XIAO Tong-jian YANG Qing-song RAN Wei XU guo-hua SHEN Qi-rong Department of Plant Nutrition College of Resoures and Environmental Sciences Nanjing Agricultural University Nanjing 210095 P.R.China

The effect of arbuscular mycorrhiza fungi （AMF） on plant growth and nutrition utilization in upland rice and mungbean intercropping system was studied. A pot experiment was conducted in the greenhouse and AMF colonization rates of rice and mungbean roots, plant nutrient contents, the ability of nitrogen fixation, and nutrient contents changed in the soil were analyzed. The results were obtained as follows： the rates of AMF colonization of rice and mungbean roots were reached to 14.47 and 92.2% in intercopping system, and increased by 4.11 and 11.95% compared with that of in monocropping; the nirtrogen contents of mungbean and rice were increased by 83.72 and 64.83% in shoots, and 53.76 and 41.29% in roots, respectively, while the contents of iron in shoot and root of mungbean were increased by 223.08 and 60.19%, respectively. In the intercropping system with inoculation of AMF, the biomass of mungbean increased by 288.8%. However, the biomass of rice was not significantly changed among all treatments with or without inoculation of AMF recorded. The number and dry weight of nodules were significantly increased either when mungbean was intercropped with rice or inoculated with AMF. When compared with that of monocropping without AMF inoculation, the contents of nitrogen, phosphorus and iron in nodules of intercropping mungbean with inoculation increased by 80.14, 69.54 and 39.62%, respectively. Additionally, intercropping with AMF inoculation significantly increased soil nitrogen content, but reduced soil phosphorus content. We concluded that upland rice-mungbean intercropping system and inoculation with AMF improved the nutrient uptake, the ability of nitrogen fixation and the growth of mungbean.

关键词： mungbean rice arbuscular mycorrhizal fungi (AMF) intercropping nitrogen phosphorus iron root nodule

Water consumption in summer maize and winter wheat cropping system based on SEBAL model in Huang-Huai-Hai Plain, China

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Journal of Integrative Agriculture 2015年第10期14卷 2065-2076页

作者： YANG jian-ying MEI Xu-rong HUO Zhi-guo YAN Chang-rong JU Hui ZHAO Feng-hua LIU Qin Chinese Academy of Meteorological Sciences Key Laboratory of Dryland Agriculture Ministry of Agriculture/Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences Key Laboratory of Agricultural Environment Ministry of Agriculture/Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

Crop consumptive water use is recognized as a key element to understand regional water management performance. This study documents an attempt to apply a regional evapotranspiration model（SEBAL） and crop information for assessment of regional crop（summer maize and winter wheat） actual evapotranspiration（ET a） in Huang-Huai-Hai（3H） Plain, China. The average seasonal ET a of summer maize and winter wheat were 354.8 and 521.5 mm respectively in 3H Plain. A high-ET a belt of summer maize occurs in piedmont plain, while a low ET a area was found in the hill-irrigable land and dry land area. For winter wheat, a high-ET a area was located in the middle part of 3H Plain, including low plain-hydropenia irrigable land and dry land, hill-irrigable land and dry land, and basin-irrigable land and dry land. Spatial analysis demonstrated a linear relationship between crop ET a, normalized difference vegetation index（NDVI）, and the land surface temperature（LST）. A stronger relationship between ET a and NDVI was found in the metaphase and last phase than other crop growing phase, as indicated by higher correlation coefficient values. Additionally, higher correlation coefficients were detected between ET a and LST than that between ET a and NDVI, and this significant relationship ran through the entire crop growing season. ET a in the summer maize growing season showed a significant relationship with longitude, while ET a in the winter wheat growing season showed a significant relationship with latitude. The results of this study will serve as baseline information for water resources management of 3H Plain.

关键词： ETa winter wheat summer maize SEBAL crop information Huang-Huai-Hai Plain

Painlevé Property and Complexiton Solutions of a Special Coupled KdV Equation

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Communications in Theoretical Physics 2008年第10期50卷 809-813页

作者： YANG jian-rong MAO Jie-jian Department of Physics Jiangxi Shangrao Normal College Shangrao 334001 China Department of Physics Ningbo University Ningbo 315211 China

A special coupled KdV equation is proved to be the Painleve property by the Kruskal＇s simplification of WTC method. In order to search new exact solutions of the coupled KdV equation, Hirota＇s bilinear direct method and the conjugate complex number method of exponential functions are applied to this system. As a result, new analytical eomplexiton and soliton solutions are obtained synchronously in a physical field. Then their structures, time evolution and interaction properties are further discussed graphically.

关键词： special coupled KdV equation Painleve integrability bilinear method complexiton solution

Soliton Solutions of Coupled KdV System from Hirota's Bilinear Direct Method

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Communications in Theoretical Physics 2008年第1期49卷 22-26页

作者： YANG jian-rong MAO Jie-jian Department of Physics Shangrao Normal College Shangrao 334001 China Department of Physics Ningbo University Ningbo 315211 China

With Hirota＇s bilinear direct method, we study the special coupled KdV system to obtain its new soliton solutions. Then we further discuss soliton evolution, corresponding structures, and interesting interactive phenomena in detail with plot. As a result, we find that after the interaction, the solitons make elastic collision and there are no exchanges of their physical quantities including energy, velocity and shape except the phase shift.

关键词： coupled KdV system Hirota's bilinear method soliton solutions interactive property