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Continuous intravenous infusion of recombinant human endostatin using infusion pump plus chemotherapy in non-small cell lung cancer

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World Journal of Clinical Cases 2022年第4期10卷 1164-1171页

作者： Zhi-Quan Qin Si-Fu Yang Yun Chen Chao-Jin Hong Tong-Wei Zhao guo-rong Yuan Liu Yang Liang Gao Xiao Wang Li-Qin Lu Department of Medical Oncology Zhejiang Provincial People’s Hospital(People’s Hospital of Hangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina

BACKGROUND Lung cancer is one of the deadliest cancers in the world with the highest incidence and mortality rate among all ***-small cell lung cancer(NSCLC)accounts for approximately 80%of primary lung ***,efficacy and safety of the current regimens for NSCLC is ***,there has been an increasing urgency for development of potential therapeutic therapies for *** To investigate the therapeutic outcomes and safety of continuous intravenous infusion of recombinant human endostatin(Rh-endostain)using an infusion pump in retreated advanced *** Patients with retreated advanced NSCLC who were admitted to Zhejiang Provincial People's Hospital from October 2017 to April 2019 were *** patients received continuous intravenous infusion of Rh-endostain using an infusion *** response rate(ORR),clinical benefit rate(CBR),median progression-free survival(mPFS),and incidences of adverse events(AEs)were analyzed after *** A total of 45 patients with retreated advanced NSCLC were included,and all of them were *** these patients,ORR was 22.2%,CBR was 84.4%,and mPFS was 5.3 *** following AEs were observed,decreased hemoglobin(34 cases,75.6%),nausea/vomiting(32 cases,71.1%),elevated transaminase(24 cases,53.3%),leukopenia(16 cases,35.6%),thrombocytopenia(14 cases,31.1%),and constipation(1 case,3.4%).None of the patients had leukopenia,nausea/vomiting,and constipation of grade III and *** The patients showed improved adherence to 5-d continuous intravenous infusion of Rh-endostain using an infusion *** efficacy and safety of this treatment regimen were achieved in retreated advanced NSCLC.

关键词： Non-small cell lung cancer Chemotherapy Recombinant human endostatin Continuous intravenous infusion

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How to Write Essentially Defect-free Code:A Preliminary Study

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计算机教育 2012年第10期 35-36,40页

作者： rong guo-ping ZHUANG Chen-yi SHAO Dong Software Institute Nanjing University China

This paper presents the findings of a study on the helpful approaches to write essentially defectfree code among senior students majored in software *** the first phase of the lab study,we prepared 9 coding projects for students which will help them to find their own best practices or principles to write essentially defect-free code before unit *** students were interviewed regarding the use of their own best practices,their principles,and problems arising from the coding *** present qualitative and quantitative findings as well as our plans for second study phase including an industry field study.

关键词： Defect-Free Quality of Code

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脑机接口中基于小波包最优基的特征抽取

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上海交通大学学报 2005年第11期39卷 1879-1882页

作者：杨帮华颜国正严荣国上海交通大学电子信息与电气工程学院上海200030

在脑机接口研究中,针对脑电特征抽取,提出一种基于小波包最优基分解的方法.依据距离准则,从小波包库中选择一个对分类最优的小波包基;在该小波包基包含的所有分解系数中,抽取部分具有最大可分性的系数作为有效特征;不同通道脑电信号有... 详细信息

在脑机接口研究中,针对脑电特征抽取,提出一种基于小波包最优基分解的方法.依据距离准则,从小波包库中选择一个对分类最优的小波包基;在该小波包基包含的所有分解系数中,抽取部分具有最大可分性的系数作为有效特征;不同通道脑电信号有效特征的结合,构成分类的特征矢量.通过对该特征矢量可分性和识别精度两个性能指标的评估,并与现有分类结果进行比较,表明了所提出方法的有效性.

关键词：脑机接口小波包分解脑电特征抽取最优基

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航天器内部充电效应及典型事例分析

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物理学报 2010年第4期59卷 2907-2913页

作者：黄建国韩建伟中国科学院空间科学与应用研究中心北京100190

航天器内部充电效应是由空间高能电子诱发的,通常发生在航天器内部以及表面绝缘材料深层,所产生的放电击穿及静电放电脉冲干扰较表面充电更为严重.对内部充放电的一般规律进行了总结,并就一次典型的航天器异常事件,从异常的时空表现特... 详细信息

航天器内部充电效应是由空间高能电子诱发的,通常发生在航天器内部以及表面绝缘材料深层,所产生的放电击穿及静电放电脉冲干扰较表面充电更为严重.对内部充放电的一般规律进行了总结,并就一次典型的航天器异常事件,从异常的时空表现特征及其与高能电子环境扰动的相关性角度进行了深入分析和定量计算,得出了高能电子产生的内部充电引起的卫星异常的结论,为卫星异常诊断提供了范例.

关键词：高能电子内部充电静电放电空间环境

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Role of transition-metal electrocatalysts for oxygen evolution with Si-based photoanodes

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Chinese Journal of Catalysis 2021年第8期42卷 1387-1394页

作者： Rajender Boddula Guancai Xie Beidou guo jian Ru Gong Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience CAS Key Laboratory of Nanosystem and Hierarchy FabricationNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

A comprehensive understanding of the role of the electrocatalyst in photoelectrochemical(PEC)water splitting is central to improving its ***,taking the Si-based photoanodes(n^(+)p-Si/SiO_(x)/Fe/FeOx/MOOH,M=Fe,Co,Ni)as a model system,we investigate the effect of the transition-metal electrocatalysts on the oxygen evolution reaction(OER).Among the photoanodes with the three different electrocatalysts,the best OER activity,with a low-onset potential of∼1.01 VRHE,a high photocurrent density of 24.10 mA cm^(-2)at 1.23 VRHE,and a remarkable saturation photocurrent density of 38.82 mA cm^(-2),was obtained with the NiOOH overlayer under AM 1.5G simulated sunlight(100 mW cm^(-2))in 1 M KOH *** optimal interfacial engineering for electrocatalysts plays a key role for achieving high performance because it promotes interfacial charge transport,provides a larger number of surface active sites,and results in higher OER activity,compared to other *** study provides insights into how electrocatalysts function in water-splitting devices to guide future studies of solar energy conversion.

关键词： Solar water splitting Artificial photosynthesis Oxygen evolution reaction Photoanode Interfacial engineering Transition-metal electrocatalyst

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A Nonnegative Garrote-based Method for Multivariate Fault Isolation 36

A Nonnegative Garrote-based Method for Multivariate Fault Is...

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第36届中国控制会议

作者： Yi-Min guo jian-guo Wang Bang-Hua Yang Shi-Wei Ma Min-Rui Fei Li-Lan Liu Hui Xu Yuan Yao Yi-Ping Wu School of Mechatronical Engineering and Automation Shanghai UniversityShanghai Key Lab of Power Station Automation Technology Department of Chemical Engineering National Tsing-Hua University Shanghai Baosight Software Co Ltd

ISBN: (纸本)9781538629185

Fault isolation is an essential step in multivariate statistical process monitoring,which discovers the cause of the detected *** common adopted techniques for fault isolation,such as contribution plots,reconstruction analysis,branch and bound,etc.,often suffer from the problems of the smearing effect,insufficient historical fault data,and heavy computational *** this paper,the nonnegative garrote（NNG） estimator is utilized for multivariate statistical fault isolation,which solves the problems of the existing *** proposed method is based on the finding that there is equivalence between fault isolation and variable selection in discriminant *** from the existing methods,the NNG-based fault isolation method does not suggest a single set of faulty ***,it provides a sequence of process variables according to their responsibilities for the detected *** results are informative for diagnosing the root cause of the fault.

关键词： Fault isolation Variable selection Nonnegative garrote Process monitoring

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基于浮动车数据的行程速度估计算法及优化

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北京工业大学学报 2007年第5期33卷 459-464页

作者：翁剑成荣建于泉任福田北京工业大学交通工程北京市重点实验室北京100022

依托重点实验室构建的浮动车采集处理实验系统,从行程速度的交通工程学定义出发,利用实时上传的浮动车数据,构建了以浮动车的驻留时间和路段长度为基础的行程速度估计算法．通过对比现场跟车实验测得的行程速度与算法计算结果,验证了该... 详细信息

依托重点实验室构建的浮动车采集处理实验系统,从行程速度的交通工程学定义出发,利用实时上传的浮动车数据,构建了以浮动车的驻留时间和路段长度为基础的行程速度估计算法．通过对比现场跟车实验测得的行程速度与算法计算结果,验证了该算法的行程速度结果精度达到90％以上,从而为交通信息服务系统提供了简单、准确的区间速度计算方法．最后,对算法进行了优化,有效地提高了算法效率,为满足大规模应用奠定了基础．

关键词：智能交通系统浮动车数据行程速度交通数据处理

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A novel mutation in PRPF31,causative of autosomal dominant retinitis pigmentosa,using the BGISEQ-500 sequencer

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 31-35页

作者： Yu Zheng Hai-Lin Wang jian-Kang Li Li Xu Laurent Tellier Xiao-Lin Li Xiao-Yan Huang Wei Li Tong-Tong Niu Huan-Ming Yang jian-guo Zhang Dong-Ning Liu BGI Education Center University of Chinese Academy of SciencesShenzhen 518083China BGI-Shenzhen Shenzhen 518083China China National GeneBank BGI-ShenzhenShenzhen 518120China The Fourth People's Hospital of Shenyang Shenyang 110031Liaoning ProvinceChina James D.Watson Institute of Genome Sciences Hangzhou 310058China

AIM： To study the genes responsible for retinitis ***： A total of 15 Chinese families with retinitis pigmentosa, containing 94 sporadically afflicted cases, were recruited. The targeted sequences were captured using the Target_Eye_365_V3 chip and sequenced using the BGISEQ-500 sequencer, according to the manufacturer＇s instructions. Data were aligned to UCSC Genome Browser build hg19, using the Burroughs Wheeler Aligner MEM algorithm. Local realignment was performed with the Genome Analysis Toolkit（GATK v.3.3.0） Indel Realigner, and variants were called with the Genome Analysis Toolkit Haplotypecaller, without any use of imputation. Variants were filtered against a panel derived from 1000 Genomes Project, 1000 G_ASN, ESP6500, Ex AC and db SNP138. In all members of Family ONE and Family TWO with available DNA samples, the genetic variant was validated using Sanger ***： A novel, pathogenic variant of retinitis pigmentosa, c.357_358 del AA（***119 Serfs X5） was identified in PRPF31 in 2 of 15 autosomal-dominant retinitis pigmentosa（ADRP） families, as well as in one, sporadic case. Sanger sequencing was performed uponprobands, as well as upon other family members. This novel, pathogenic genotype co-segregated with retinitis pigmentosa phenotype in these two families. CONCLUSION： ADRP is a subtype of retinitis pigmentosa, defined by its genotype, which accounts for 20%-40% of the retinitis pigmentosa patients. Our study thus expands the spectrum of PRPF31 mutations known to occur in ADRP, and provides further demonstration of the applicability of the BGISEQ500 sequencer for genomics research.

关键词： retinitis pigmentosa PRPF31 BGISEQ-500

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新时代粤港澳大湾区的开放使命

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中山大学学报（社会科学版） 2019年第2期59卷 159-167页

作者：荣健欣中山大学粤港澳发展研究院

中国特色社会主义进入新时代,全面对外开放成为新时代的重要发展方略。当前,我国对外开放面临参与全球价值链层次偏低、服务业开放不足、衔接国际贸易投资新规则有差距、对外投资竞争力不强等问题。新时代全面扩大开放将围绕提升创新能... 详细信息

中国特色社会主义进入新时代,全面对外开放成为新时代的重要发展方略。当前,我国对外开放面临参与全球价值链层次偏低、服务业开放不足、衔接国际贸易投资新规则有差距、对外投资竞争力不强等问题。新时代全面扩大开放将围绕提升创新能力开放合作、扩大敏感服务业开放、全面对接国际贸易投资新规则、强化"一带一路"下双向投资合作等领域开展。改革开放40年来,粤港澳合作在国家对外开放进程中发挥了重要作用。新时代粤港澳大湾区仍具备独特优势,可以通过助力内地敏感服务业开放、实现湾区三地营商规则对接、携手参与"一带一路"建设、强化创新能力开放合作等路径手段,继续在国家全面对外开放的各个领域中发挥重要作用。为此,在CEPA框架下广东继续"先行先试"、推动湾区要素便捷流动、发挥粤港澳合作发展平台制度创新优势、创新粤港澳合作机制等对于打造粤港澳大湾区改革开放新高地具有重要意义。

关键词：全面对外开放粤港澳大湾区开放新优势路径

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Extension Multi-factorial Evaluation Method on Water Quality Early-warning

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Asian Agricultural Research 2013年第6期5卷 95-97页

作者： rong guo Yong ZHANG Fangjian XIE Sheng ZHONG Environmental Monitoring Center of jiangsu Province Scientific Institute of Environmental Sciences

Extension multi-factorial evaluation method was used in water quality early-earning in Yincungang River based on MATLAB. The results showed that water quality in summer was safe,while that in other three seasons were ... 详细信息

关键词： Extension multi-factorial evaluation Water quality

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