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Diagnostic strategies and the incidence of prostate cancer： reasons for the low reported incidence of prostate cancer in China

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Asian Journal of Andrology 2009年第1期11卷 9-13页

作者： Ling Zhang Shan Wu Li-rong guo Xue-jian Zhao Department of Pathophysiology Prostate Diseases Prevention and Treatment Research Centre Department of Patho-logy Norman Bethune Medical School Jilin University Changchun 130021 China

We have analysed the reasons for the low reported incidence of prostate cancer in China and argue for early diagnosis and treatment of this disease. According to the 2002 database of the International Agency for Research on Cancer （IARC）, the age-standardized incidence of prostate cancer in China is 1.6/105 person years （PY）, with a mortality rate of 1.0/105 PY and mortality-to-incidence rate ratio （MR/IR） = 0.63. The MR/IR ratio of prostate cancer in China was found to be higher than the average in Asia （MR/IR = 0.57） and much higher than that in North America （MR/IR = 0.13）. These data indicate that in China most prostate cancers were in the advanced stages at the time of diagnosis, and that patients had a short survival time thereafter. In 2004, Stamey et al. reported a retrospective American study of prostate cancer for the years 1983-2003. It was shown that most cases of prostate cancer detected by prostate-specific antigen （PSA） screening were in the advanced stage at the start of this 20-year period. These early follow-up data are quite similar to the results obtained from mass PSA screening of elderly men in Changchun, China. However, after the American programmes for early diagnosis and treatment of prostate cancer were accepted, tumours were diagnosed at earlier stages. On the basis of these findings, mass screening should be performed in the whole of China using serum PSA to facilitate early diagnosis and treatment of prostate cancer.

关键词： diagnosis metastasis prostate cancer prostate carcinoma tumour antigen

Responses of Cloud-Radiative Forcing to Strong El Nino Events over the Western Pacific Warm Pool as Simulated by CAMS-CSM

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Journal of Meteorological Research 2020年第3期34卷 499-514页

作者： Baichao ZHANG Zhun guo Xiaolong CHEN Tianjun ZHOU Xinyao rong jian LI Nanjing University of Information Science&Technology Nanjing 210044 Climate Change Research Center Chinese Academy of SciencesBeijing 100029 State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences(CAS)Beijing 100101 University of Chinese Academy of Sciences Beijing 100049 Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081

Cloud-radiative forcing(CRF)at the top of the atmosphere(TOA)over the western Pacific warm pool(WP)shows unique characteristics in response to El Nino *** this region,the responses of CRF to El Nino events have been a useful metric for evaluating climate *** data are used to analyze the CRF anomalies to El Nino events simulated by the new and old versions of the Climate System Model of the Chinese Academy of Meteorological Sciences(CAMS-CSM),which has participated in the Atmospheric Model Intercomparison Project(AMIP).Here,simulations for super El Nino years,El Nino years,and normal years are compared with *** results show that the mean values of both longwave CRF(LWCRF)and shortwave CRF(SWCRF)in CAMS-CSM are weaker than the observations for each category of El Nino *** with the old version of CAMS-CSM,the decrease in LWCRF during El Nino events is well simulated by the new version of ***,both new and old models cannot reproduce the anomalous SWCRF in El Nino *** biases in the CRF response to El Nino events are attributed to the biases in the cloud vertical structure because of a weaker crash of the Walker circulation in *** to the modification of the conversion rate from cloud droplets to raindrops in the cumulus convection scheme,the new version of CAMS-CSM has better CRF skills in normal years,but biases in El Nino events still exist in the new *** the response of the Walker circulation to El Nino events is key to higher skills in simulating the cloud radiative responses.

关键词： cloud-radiative forcing(CRF) El Nino model evaluation warm pool(WP) western Pacific

酵母丙氨酸转移核糖核酸3’-端十九核苷酸(58～76)的合成

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化学学报 1983年第12期41卷 1164-1178页

作者：陈海宝徐静范鲍建绍庄建华郭荣汉施才能陈法贤张恭勤冯晓黎丁晓华江鹏中国科学院上海有机化学研究所中国科学院上海生物化学研究所

研究了两个低聚核糖核苷酸的3′-端磷酸化方法.以3′-端带磷酸单酯的低聚核苷酸为供体,用T4 RNA连接酶将AUUC,CGGA,CUCGUCCA和CCAp等按低的供受体摩尔配比（1∶1.1至1∶2）,以87～90％的连接率合成了相应于酵母丙氨酸转移核糖核酸3′-... 详细信息

研究了两个低聚核糖核苷酸的3′-端磷酸化方法.以3′-端带磷酸单酯的低聚核苷酸为供体,用T4 RNA连接酶将AUUC,CGGA,CUCGUCCA和CCAp等按低的供受体摩尔配比（1∶1.1至1∶2）,以87～90％的连接率合成了相应于酵母丙氨酸转移核糖核酸3′-端53～76核苷酸顺序的十九核苷酸AUUCCGGACUCGUCCACCAp.

关键词：酵母丙氨酸转移核糖核酸 RNA GGA UUO 反应溶液人工合成磷酸化反应核昔酸低聚层析分离 DEAE 连接酶合成酶核苷酸

Does mRNA structure contain genetic information for regulating co-translational protein folding？

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Zoological Research 2017年第1期38卷 36-43页

作者： jian-rong Yang Department of Biology Zhongshan School of Medicine Sun Yat-sen University Guangzhou 510080 China

Currently many facets of genetic information are illdefined. In particular, how protein folding is genetically regulated has been a long-standing issue for genetics and protein biology. And a generic mechanistic model with supports of genomic data is still lacking. Recent technological advances have enabled much needed genome-wide experiments. While putting the effect of codon optimality on debate, these studies have supplied mounting evidence suggesting a role of m RNA structure in the regulation of protein folding by modulating translational elongation rate. In conjunctions with previous theories, this mechanistic model of protein folding guided by m RNA structure shall expand our understandings of genetic information and offer new insights into various biomedical puzzles.

关键词： Translational folding mRNA secondary bias elongation rate Protein structure Codon usage

Epitaxial growth and thermostabiUty of cubic and hexagonal SrMnO3 films on SrTiO3（111）

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Frontiers of physics 2015年第3期10卷 83-88页

作者： Rui-Nan Song Min-Hui Hu Xiang-rong Chen jian-Dong guo Institute of Atomic and Molecular Physics College of Physical Science and Technology Sichuan University Chengdu 610065 China Institute of Physics Chinese Academy of Sciences Beijing 100190 China Key Laboratory of High Energy Density Physics and Technology of Ministry of Education Sichuan University Chengdu 610064 China Collaborative Innovation Center of Quantum Matter Beijing 100871 China

The growth of SrMnO3 films on SrTiO3（111） substrates by pulsed laser deposition was studied and found to produce cubic and hexagonal （4H） structures in the SrMnO3 films. By adjusting the substrate temperature and oxygen pressure, the stability of the two phases was fine-tuned, resulting in the growth of cubic-SrMnO3（lll） or 4H-SrMn03（0001） film, with the 4H phase being the more stable at room temperature and ambient pressure in the bulk form. The growth temperature of the cubic phase was also further lowered relative to the bulk thermodynamics by strain at the heterointerface, and once obtained, it was stable at temperatures of up to 800 ℃.

关键词： oxide film pulsed laser deposition heteroepitaxy SrMn03

An Assessment of ENSO Stability in CAMS Climate System Model Simulations

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Journal of Meteorological Research 2019年第1期33卷 80-88页

作者： Lijuan HUA Lin CHEN Xinyao rong jian LI guo ZHANG Lu WANG State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological Administration Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science &Technology State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences

We present an overview of the El Ni?o–Southern Oscillation(ENSO) stability simulation using the Chinese Academy of Meteorological Sciences climate system model(CAMS-CSM). The ENSO stability was quantified based on the Bjerknes(BJ) stability index. Generally speaking, CAMS-CSM has the capacity of reasonably representing the BJ index and ENSO-related air–sea feedback processes. The major simulation biases exist in the underestimated thermodynamic damping and thermocline feedbacks. Further diagnostic analysis reveals that the underestimated thermodynamic feedback is due to the underestimation of the shortwave radiation feedback, which arises from the cold bias in mean sea surface temperature(SST) over central–eastern equatorial Pacific(CEEP). The underestimated thermocline feedback is attributed to the weakened mean upwelling and weakened wind–SST feedback(μ_a) in the model simulation compared to observation. We found that the weakened μ_a is also due to the cold mean SST over the *** study highlights the essential role of reasonably representing the climatological mean state in ENSO simulations.

关键词： coupled general circulation model(CGCM) Bjerknes(BJ) stability index air–sea feedback

Generalization of 3D Mandelbrot and Julia sets

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 134-141页

作者： CHENG Jin TAN jian-rong State Key Laboratory of CAD ＆ CG Zhejiang University Hangzhou 310027 China

In order to further enrich the form of 3D Mandelbrot and Julia sets, this paper first presents two methods of generating 3D fractal sets by utilizing discrete modifications of the standard quaternion algebra and analyzes the limitations in them. To overcome these limitations, a novel method for generating 3D fractal sets based on a 3D number system named ternary algebra is proposed. Both theoretical analyses and experimental results demonstrate that the ternary-algebra-based method is superior to any one of the quad-algebra-based methods, including the first two methods presented in this paper, because it is more intuitive, less time consuming and can completely control the geometric structure of the resulting sets. A ray-casting algorithm based on period checking is developed with the goal of obtaining high-quality fractal images and is used to render all the fractal sets generated in our experiments. It is hoped that the investigations conducted in this paper would result in new perspectives for the generalization of 3D Mandelbrot and Julia sets and for the generation of other deterministic 3D fractals as well.

关键词： Mandelbrot set Julia set Fractal Ray-casting Quad algebra Ternary algebra

Special Issue on Innovative Design of Complex Products

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Chinese Journal of Mechanical Engineering 2018年第2期31卷 10-11页

作者： jian-rong Tan State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University

With the development of science and technology as well as the diversification and individualization of market demand,modern products update more and more rapidly.e rapid development of new products to satisfy the increasingly improved and personalized customer demands greatly depends on the progress in the innovative design theory and performance optimization

关键词： In Special Issue on Innovative Design of Complex Products

Fluorescence Quenching of Anthracene by N,N-Diethylaniline and Phenothiazine in Triton X-100/n-C_(10)H_(21) OH/H_2O Microemulsion

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Chemical Research in Chinese Universities 2003年第4期19卷 484-488页

作者： guo Xia XU Hui guo rong Department of Chemistry Yangzhou UniversityYangzhou 225002P.R.China

The photo-induced electron transfer reactions of anthracene with N,N -diethylaniline(DEA) and phenothiazine(PTZ) occur in the membrane phase of a Triton X-100/ n -C 10 H 21 OH(1-decanol)/H 2O microemulsion. DEA and PTZ exist in the membrane phase of the microemulsion. Anthracene exists in the oil continuous phase of the W/O microemulsion and in the oil core and membrane phase of the O/W microemulsion.

关键词： Electron transfer process Fluorescence quenching Anthracene,Phenothiazine N,N -dieth\|ylaniline Microemulsion