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Correction to: Hantavirus Infection during Pregnancy

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Virologica Sinica 2021年第4期36卷 829-829页

作者： Deng-Hui Lu Hong jiang jian-qi lian The Center of Diagnosis and Treatment of Infectious Diseases The Second Affiliated HospitalAir Force Medical UniversityXi'an710038China

Correction to:Virologica Sinica https://***/10.1007/s12250-020-00300-8 The original version of this article,published online on October 19,2020,contained redundant color in the legend of *** corrected Fig.1 is given *... 详细信息

关键词： redundant corrected Infection

Relations of Budd-Chiari syndrome to prothrombin gene mutation

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 214-218页

作者： Guo-Ling Lin, Pei-qin Xu, Hua qi, jian-Hua lian, Hong Zheng and Xiao-Wei Dang Zhengzhou, ChinaDepartment of General Surgery, First Affiliated Hospi- tal of Zhengzhou University the Faculty of Cytobiology and Medical Genetics, Medical School, Zhengzhou Univer- sity , Zhengzhou 450052, China Department of General Surgery First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China.

BACKGROUND: Budd-Chiari syndrome (BCS) is a type of disease characterized by portal hypertension and/or hy- pertension of the inferior vena cava (IVC) due to the ob- struction of the hepatic veins (HV) and/or intrahepatic IVC outlet. Being etiologically complicated and obscure, BCS can be acquired or idiopathic and several gene muta- tions may be contributable. This study was to explore whether prothrombin gene mutation (F G20210A) takes part in the pathogenesis of BCS and to investigate their cor- relativity. METHODS: In 38 proven BCS patients and 70 controls, polymerase chain reaction-restriction fragment length poly- morphism (PCR-RFLP) was used to find F G20210A mutation. To detect whether there are any mutations, four steps were taken: purification of genome DNA from whole blood, amplification of special fragment by polymerase chain reaction, digestion of the fragment via restriction en- donuclease, and analysis of results by polyacrylamide gel electrophoresis. RESULTS: F G20210A mutation was not detected in all patients and controls. CONCLUSIONS: No F G20210A mutation exists in Chi- nese patients with BCS, nor correlativity between the oc- currence of BCS and F G20210A mutation. The etiology of BCS in the Chinese needs further investigation.

关键词： hepatic vein thrombosis etiology F G20210A gene mutation

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大通县政策性森林保险的发展及建议

青海农林科技 2019年第2期 72-74页

作者：祁建莲青海省大通县林业工作站

森林保险是应对森林灾害、维护林农利益、巩固林权改革的有效手段。大通县政策性森林保险开展起步较晚,但发展速度较快。本文结合大通县自然地理条件及森林资源状况,从政策性森林保险的发展现状谈起,总结了大通县森林保险理赔情况及存... 详细信息

森林保险是应对森林灾害、维护林农利益、巩固林权改革的有效手段。大通县政策性森林保险开展起步较晚,但发展速度较快。本文结合大通县自然地理条件及森林资源状况,从政策性森林保险的发展现状谈起,总结了大通县森林保险理赔情况及存在的问题,对大通县今后开展政策性森林保险提出了对策建议。

关键词：大通县政策性森林保险建议

A small yeast RNA inhibits HCV IRES mediated translation and inhibits replication of poliovirus in vivo

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World Journal of Gastroenterology 2003年第5期9卷 1008-1013页

作者： Xue-Song liang jian-qi lian Yong-Xing Zhou qing-He Nie Chun-qiu Hao The center of diagnosis and treatment for infectious diseases of Tangdu Hospital of Military Medical University of PLA,Xi’an 710038,Shaanxi Province,China The center of diagnosis and treatment for infectious diseases of Tangdu Hospital of Military Medical University of PLA Xi''an. 710038 Shaanxi Province China

AIM: To investigate the anti-virus infection activity of internal ribosome entry site (IRES) specific inhibitor RNA (IRNA).METHODS: IRNA eukaryotic vector pcRz-IRNA or mIRNA eukaryotic vector pcRz-mIRNA was tansfected into human hepatocarcinoma cells (HHCC), then selected with neomycin G418 for 4 to 8 weeks, and then infected with polio virus vaccinas line. The cytopethogenesis effect was investigated and the cell extract was collected. At last the polio virus titer of different cells was determined by plaque ***: Constitutive expression of IRNA was not detrimental to cell growth. HCV IRES-mediated capindependent translation was markedly inhibited in cells constitutively expressing IRNA compared to control hepatoma cells. However, cap-dependent translation was not significantly affected in these cell line. Additionally, HHCC cells constitutively expressing IRNA became refractory to infection of polio ***: IRES specific IRNA can inhibit HCV IRES mediated translation and poliovirus replication.

关键词：脊髓灰质炎病毒病毒复制丙型肝炎病毒体内实验肝癌逆转录聚合酶链反应

基于NURBS插补方法的五轴数控双样条曲线后处理研究

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机电产品开发与创新 2012年第3期25卷 163-164页

作者：简启廉广州市沥滘污水处理厂广东广州510290

为得到NURBS插补方法的五轴数控NC代码,在完成相应的刀具路径源文件(CLSF)生成后,分析研究其后处理方法,并通过利用UG/GRIP二次开发语言在UG软件中生成相应的NC代码,生成后的NC代码在仿真软件中能很好的显示出其加工轨迹。

关键词： NURBS插补方法 NC代码 UG/GRIP

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

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Signal Transduction and Targeted Therapy 2021年第1期6卷 95-104页

作者： Ke Wang Wei Chen Zheng Zhang Yongqiang Deng jian-qi lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan jian-Li jiang Ling Li Jiao Wu Peng Lin Wan Huang liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu qing-Yi Wang Huijie Bian Ping ZhuZhi-Nan Chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Biotechnology Beijing 100071China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Tangdu Hospital Fourth Military Medical UniversityXi’an 710038China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter Xi’an Jiaotong UniversityXi’an 710049China Sino Biological Inc. Beijing 100176China Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi’an 710032China School of Basic Medicine Fourth Military Medical UniversityXi’an 710032China

In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until ***-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike *** ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the *** the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its ***,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike *** loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 *** of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular *** loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type ***,virions are observed in lymphocytes of lung tissue from a COVID-19 *** T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by ***,CD147 mediates virus entering host cells by ***,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19.

关键词： ACE2 CD147 intestine

基于NURBS插补方法的五轴数控CLSF文件生成

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机械设计与制造 2009年第6期 66-67页

作者：简启廉张平黄堪丰广东工业大学机电学院广州510006

为解决NURBS插补方法在五轴数控应用中所面临的问题,在对五轴数控编程和NURBS插补方法的深入分析后,提出五轴数控编程中CLSF文件的NURBS插补方法和格式,并利用UG/GRIP二次开发语言予以生成,生成后的CLSF能大大地减小加工数据量。

关键词： CLSF文件 NURBS插补方法 UG/GRIP

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-lian Wang Yun-Feng Wang Fan Yang jian-qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

肝硬化患者外周血单核细胞表面TLR4和TLR2表达的临床意义

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世界华人消化杂志 2006年第34期14卷 3278-3283页

作者：苟艳子连建奇聂青和庄严刘清泉邵彬第四军医大学唐都医院传染病科全军感染病诊疗中心陕西省西安市710038

目的:探讨肝硬化患者外周血中单个核细胞(PBMC)表面Toll样受体4(Toll-likereceptor4,TLR4)、TLR2表达与肝硬化患者细菌感染的关系,观察抗生素治疗对TLR4与TLR2表达的影响.方法:采用三色荧光染色法,荧光素标记的抗TLR2/抗TLR4/抗CD14mAb... 详细信息

目的:探讨肝硬化患者外周血中单个核细胞(PBMC)表面Toll样受体4(Toll-likereceptor4,TLR4)、TLR2表达与肝硬化患者细菌感染的关系,观察抗生素治疗对TLR4与TLR2表达的影响.方法:采用三色荧光染色法,荧光素标记的抗TLR2/抗TLR4/抗CD14mAb对42例肝硬化患者及正常人的血液单核细胞表面TLR2、TLR4及CD14分子进行免疫荧光染色,应用流式细胞仪检测.结果:肝硬化腹水组TLR2和TLR4表达(n=30,TLR2,47.65±0.75;TLR4,22.28±0.80)与正常对照组(n=15,TLR2,24.40±2.77;TLR4,14.45±3.23)比较有显著性差异(P0.05).结论:肝硬化腹水患者TLR4与TLR2的表达显著上调,抗生素治疗后显著下调.

关键词： Tou样受体肝硬化抗生素流式细胞术单克隆抗体