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Role of hsa_circ_0007482 in pterygium development: insights into proliferation, apoptosis, and clinical correlations

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1387-1395页

作者： Li-Yun Zhang Xin Liu Shuo Zheng Wen-Qun Xi Xue-ping Wu Dan-Yao Nie Hui-Ling Hu jian-Tao Wang Xin-Hua Liu Jing Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518000Guangdong ProvinceChina

AIM:To investigate the impact of hsa_circ_0007482 on the proliferation and apoptosis of human pterygium fibroblasts(HPFs)and its correlation with the severity grades of ***:Pterygium and normal conjunctival tissues were collected from the superior area of the same patient’s eye(n=33).The correlation between pterygium severity and hsa_circ_0007482 expression using quantitative reversetranscription polymerase chain reaction(RT-qPCR)were *** distinct siRNA sequences targeting hsa_circ_0007482,along with a negative control sequence,were transfected into *** proliferation was assessed using the cell counting *** levels of Ki67,proliferating cell nuclear antigen(PCNA),Cyclin D1,Bax,B-cell lymphoma-2(Bcl-2),and Caspase-3 were measured via *** staining was employed to detect Ki67 and vimentin *** was evaluated using flow ***:Hsa_circ_0007482 expression was significantly higher in pterygium tissues compared to normal conjunctival tissues(P<0.001).Positive correlations were observed between hsa_circ_0007482 expression and pterygium severity,thickness,and vascular *** of hsa_circ_0007482 inhibited cell proliferation,reducing the mRNA expression of Ki67,PCNA,and Cyclin D1 in ***_circ_0007482 knockdown induced apoptosis,increasing mRNA expression levels of Bax and Caspase-3,while decreasing Bcl-2 expression in ***,hsa_circ_0007482 knockdown attenuated vimentin expression in ***:The downregulation of hsa_circ_0007482 effectively hampers cell proliferation and triggers apoptosis in *** are discernible positive correlations detected between the expression of hsa_circ_0007482 and the severity of pterygium.

关键词： hsa_circ_0007482 circular RNA pterygium cell proliferation apoptosis

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Periampullary duodenal neuroendocrine tumor in a patient with neurofibromatosis-1:A case report

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World Journal of Clinical Oncology 2024年第9期15卷 1222-1231页

作者： Xiao-Yu Zhang jian-Fa Yu Yang Li ping Li The First Central Hospital Clinical School Tianjin Medical UniversityTianjin 300192China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Patients with neurofibromatosis type 1(NF1)are exposed to a higher risk of developing neuroendocrine tumors(NETs).Periampullary neuroendocrine neoplasms(NENs)in NF1 patients primarily affect the duodenum and periampullary *** SUMMARY A 50-year-old male patient was admitted to our hospital due to progressive skin and scleral yellowing for over 6 *** abdominal contrast-enhanced computed tomography scan revealed a tumor in the periampullary region,which measured 1.2 cm×1.4 cm in size and showed a progressive *** resonance cholangiopancreatography indicated the dilation of intrahepatic and extrahepatic bile *** patient was diagnosed with an ampullary tumor with the possibility of malignancy.A Whipple procedure was ***,the duodenum tumor was found to invade the mucosa,sphincter,and muscular layer of the duodenal *** hematoxylin and eosin staining confirmed the presence of duodenal G1 ***,a bibliometric analysis was performed to evaluate the state of NEN *** about periampullary NENs showed an annual increase,with most of them focusing on the treatment and diagnosis of *** This article reported a case of periampullary duodenal NET in a patient with NF1,and a bibliometric analysis was conducted.

关键词： Neuroendocrine tumor Neurofibromatosis-1 Endocrine carcinoma Bibliometric analysis Case report

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Hongjin Xiaojie Capsule, a Chinese patent medicine, for treating moderate to severe cyclical breast pain: A single-blind randomized controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 552-560页

作者： Qiong Zhang Ying-yi Fan Xue-qing Wu Yan-dan Huo Chun-hui Wang Shi-bing Liang Ting Wang Rong Zhong Xuan Wang Bao-yong Lai Xiao-hua Pei jian-ping Liu Graduate School Beijing University of Chinese Medicine Department of Breast Beijing University of Chinese Medicine Third Affiliated Hospital Department of Breast Shuguang HospitalShanghai University of Traditional Chinese Medicine Department of Breast Sichuan Second Hospital of Traditional Chinese Medicine Department of Breast Xiamen HospitalBeijing University of Chinese Medicine Center for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine

Background: Moderate to severe breast pain has major effects on the quality of life for patients. Patent Chinese medicines are widely used in the treatment of breast pain due to their stable dosage form and good ***: To evaluate the beneficial effects and safety of Hongjin Xiaojie Capsule(HJXJC), a Chinese patent medicine, for the treatment of cyclical breast ***, setting, participants and intervention: This is a multicenter, single-blind randomized controlled trial conducted in 3 medical centers in China from 2019 to 2021. Patients with moderate to severe cyclic breast pain were randomly divided into the intervention group(who took HJXJC, four capsules per dose,three times a day for 12 weeks) and the control group(waiting for the treatment) in a 1:1 *** outcome measures: The primary outcome was pain duration, and the patients recorded measurements at baseline and at the end of weeks 4, 8, 12 and 16 on a patient log ***: The full analysis set(FAS) population included 298 participants(intervention group, n = 150;control group, n = 148), while the per-protocol analysis set(PPS) included 274 participants. After12 weeks, the duration of breast pain was significantly shorter in the intervention group(FAS: mean difference, –6.69; 95% CI, –7.58 to –5.80; P < 0.01, vs control. PPS: mean difference, –7.09; 95% CI, –8.01 to –6.16; P < 0.01, vs control). The Short-form McGill Pain Questionnaire(SF-MPQ) scores were significantly lower in the intervention group(FAS: mean difference, –12.55; 95% CI, –13.90 to –11.21; P < 0.01, vs control. PPS: mean difference, –13.07; 95% CI, –14.48 to –11.66; P < 0.01, vs control). The above indicators continued to be significantly different through week 16. Moreover, in the intervention group, breast lumps shrank after 12 weeks and the size of breast lumps was statistically smaller than that in the control group(P < 0.05), whereas the sizes of breast nodules and uterine fibroid showed no statistically sign

关键词： Hongjin Xiaojie Capsule Cyclical breast pain Randomized controlled trial Traditional Chinese medicine

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Efficacy of percutaneous mechanical thrombus removal in acute lower extremity deep venous thrombosis

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World Journal of Clinical Cases 2024年第21期12卷 4590-4600页

作者： Jun-Qiang Xue ping Yin jian-ping He Hui Wei Cui-Jie Geng Yu-Xian Luo Department of Vascular Surgery Shijiazhuang People's HospitalShijiazhuang 050011Hebei ProvinceChina Department of Laboratory Medicine Shijiazhuang Hospital of Traditional Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Catheter Room Shijiazhuang People's HospitalShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary *** treatments like catheter-directed thrombolysis(CDT)often result in variable success rates and *** To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute *** A retrospective analysis was performed to examine 58 hospitalised patients with acute LEDVT between August 2019 and August *** patients were categorised into the percutaneous mechanical thrombectomy(PMT)group(n=24)and CDT group(n=32).The follow-up,safety and treatment outcomes were compared between the two *** main observational indexes were venous patency score,thrombus removal effect,complications,hospitalisation duration and *** The venous patency score was 9.04±1.40 in the PMT group and 8.81±1.60 in the CDT group,and the thrombus clearance rate was 100%in both *** complication rate was 8.33%in the PMT group and 34.84%in the CDT group,and the difference was statistically significant(P<0.05).The average hospitalisation duration was 6.54±2.48 days in the PMT group and 8.14±3.56 days in the CDT *** incidence of PTS was lower in the PMT group than in the CDT group;however,the difference was not statistically significant(P<0.05).CONCLUSION Compared with CDT,treatment of LEDVT via PMT was associated with a better thrombus clearance rate,clinical therapeutic effect and PTS prevention function,but the difference was not statistically ***,PMT was associated with a reduced urokinase dosage,shortened hospitalisation duration and reduced incidence of complications,such as infections and small *** results indicate that PMT has substantial beneficial effects in the treatment of LEDVT.

关键词： Post-thrombotic syndrome Catheter-directed thrombolysis Percutaneous mechanical thrombectomy Acute lower extremity deep venous thrombosis

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Projected near-surface wind speed and wind energy over Central Asia using dynamical downscaling with bias-corrected global climate models

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Advances in Climate Change Research 2024年第4期15卷 669-679页

作者： Jin-Lin ZHA Ting CHUAN Yuan QIU jian WU De-Ming ZHAO Wen-Xuan FAN Yan-Jun LYU Hui-ping jianG Kai-Qiang DENG Miguel ANDRES-MARTIN Cesar AZORIN-MOLINA Deliang CHEN Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunming 650091China Key Laboratory of Regional Climate and Environment for Temperate East Asia Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Center for Energy&Environmental Policy Research Beijing Institute of Technology Beijing 100081China Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Centro de Investigaciones Sobre Desertificacion Consejo Superior de Investigaciones Cientificas(CIDECSIC-UV-Generalitat Valenciana)ClimateAtmosphere and Ocean Laboratory(Climatoc-Lab)Moncada 46113Spain Regional Climate Group.Deparment of Earth Sciences University of GothenburgGothenburg 40530Sweden

Wind energy development in Central Asia can help alleviate drought and fragile ***,current studies mainly used the global climate models(GCMs)to project wind speed and *** simulated biases in GCMs remain prominent,which induce a large uncertainty in the projected *** reduce the uncertainties of projected near-surface wind speed(NSW)and better serve the wind energy development in Central Asia,the Weather Research and Forecasting(WRF)model with bias-corrected GCMs was *** with the outputs of GCMs,dynamical downscaling acquired using the WRF model can better capture the high-and low-value centres of NSWS,especially those of Central Asia's ***,the simulated NSWS bias was also *** future changes in wind speed and wind energy,under the Representative Concentration Pathway 4.5(RCP4.5)scenario,NSWS during 2031-2050 is projected to decrease compared with that in *** magnitude of NSwS reduction during 2031-2050 willreach 0.1 m s^(-1).and the maximum reduction is projected to occur over the central and western regions(>0.2 m s^(-1)).Furthermore,future wind power density(WPD)can reveal nonstationarity and strong volatility,although a downward trend is expected during *** addition,the higher frequency of wind speeds at the turbine hub height exceeding 3.0 m s^(-1)can render the plain regions more suitable for wind energy development than the mountains from 2031 to *** study can serve as a guide in gaining insights into future changes in wind energy across Central Asia and provide a scientific basis for decision makers in the formulation of policies for addressing climate change.

关键词： Near-surface wind speed Wind power density Dynamical downscaling Central Asia WRF

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Natural Products Improve Organ Microcirculation Dysfunction Following Ischemia/Reperfusion-and Lipopolysaccharide-Induced Disturbances:Mechanistic and Therapeutic Views

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Engineering 2024年第7期38卷 77-99页

作者： Jingyan Han Quan Li Kai Sun Chunshui Pan jian Liu ping Huang Juan Feng Yanchen Liu Gerald A.Meininger Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China Tasly Microcirculation Research Center Peking University Health Science CenterBeijing 100191China Key Laboratory of Stasis and Phlegm State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaBeijing 100191China Beijing Laboratory of Integrative Microangiopathy Peking University Health Science CenterBeijing 100191China Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology University of MissouriColumbiaMO 65211USA

Microcirculatory disturbances are complex processes caused by many factors,including abnormal vasomotor responses,decreased blood flow velocity,vascular endothelial cell injury,altered leukocyte and endothelial cell interactions,plasma albumin leakage,microvascular hemorrhage,and *** disturbances involve multiple mechanisms and interactions among mechanisms that can include energy metabolism,the mitochondrial respiratory chain,oxidative stress,inflammatory factors,adhesion molecules,the cytoskeleton,vascular endothelial cells,caveolae,cell junctions,the vascular basement membrane,neutrophils,monocytes,and *** clinical practice,aside from drugs that target abnormal vasomotor responses and platelet adhesion,there continues to be a lack of multi-target drugs that can regulate the complex mechanistic links and interactions underlying microcirculatory *** products have demonstrated obvious positive therapeutic effects in treating ischemia/reperfusion(I/R)-and lipopolysaccharide(LPS)-induced microcirculatory *** recent years,numerous research papers on the improvement of microcirculatory function by natural products have been published in international *** 2008 and 2017,the first listed author of this review was invited to publish reviews in the journal of Pharmacology&Therapeutics on the improvement of microcirculatory disturbances and organ injury induced by I/R using Salvia miltiorrhiza ingredients and other natural components of compounded Chinese medicine,*** review systematically summarizes the effects,targets of action,and mechanisms of natural products regarding improving I/R-and LPSinduced microcirculatory disturbances and tissue *** on this summary,scientific proposals are suggested for the discovery of new drugs to improve microcirculatory disturbances in disease.

关键词： Ischemia/reperfusion Lipopolysaccharide Natural products Leukocyte activation Hyperpermeability

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融合注意力机制的残差型双向LSTM汽车电机轴承诊断

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汽车安全与节能学报 2024年第4期15卷 511-519页

作者：姜健王平绵阳职业技术学院绵阳621000 兰州理工大学电气工程与信息工程学院兰州730050

为保障汽车的安全行驶,准确诊断和监测电机轴承故障,该文提出一种融合注意力机制的残差型双向长短期记忆网络(LSTM)汽车电机轴承故障诊断方法。利用特征提取模块结合正反向移动的LSTM组以充分感知汽车电机轴承故障特征;信号诊断模块采... 详细信息

为保障汽车的安全行驶,准确诊断和监测电机轴承故障,该文提出一种融合注意力机制的残差型双向长短期记忆网络(LSTM)汽车电机轴承故障诊断方法。利用特征提取模块结合正反向移动的LSTM组以充分感知汽车电机轴承故障特征;信号诊断模块采用残差型双向LSTM架构,并结合局部增强注意力机制优化权值,获得隐藏状态量;通过故障分类模块采用全局平均池化(GAP)方法与SoftMax模型,有效完成故障检测。结果表明:该方法汽车电机轴承故障检测准确率可达93.1%;在训练样本仅为30的条件下,准确率可达66.3%;当测试集的信噪比从10 dB降低至2 dB时,准确率仅下降8.5%。因此,该方法具有更高的准确性和更强的鲁棒性。

关键词：汽车安全电机轴承故障诊断注意力机制特征提取准确率信噪比

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Treatment of fat-poor renal angiomyolipoma with ectopic blood supply by fluorescent laparoscopy:A case report and review of literature

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World Journal of Clinical Oncology 2024年第11期15卷 1435-1443页

作者： jian-Er Tang Rong-jiang Wang Zhi-Hai Fang ping-Ya Zhu jian-Xiang Yao Hua Yang Department of Urology First Affiliated Hospital of Huzhou Normal CollegeHuzhou 313000Zhejiang ProvinceChina Department of Andrology Huzhou Women and Children's HospitalHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Renal angiomyolipoma and renal cell carcinoma are the most common benign and malignant tumors of the kidney respectively,and the preoperative differential diagnosis is crucial due to the wide difference in treatment ***-poor renal angiomyolipoma is a relatively rare type of in renal *** fat imaging features are not obvious,and it is easily misdiagnosed as renal cell *** SUMMARY We report the case of a 41-year-old man who complained of *** abdominal computed tomography scans revealed that a heterogeneous mass was seen in the lower pole of the right kidney,with the size of about 53 mm×47 *** showed two right renal arteries,with the mass supplied by an ectopic vessel from the abdominal *** laparoscopic blockade of the right renal heterotopic artery and partial nephrectomy was *** on histological and immunohistochemical findings,the tumor was diagnosed as fatpoor renal *** The use of fluorescent laparoscopy can effectively help intraoperative management,and the fluorescence pattern provided by intravenous indocyanine green can help suggest the final diagnosis,effectively guide the surgical decisionmaking,and avoid preoperative imaging diagnosis leading to nephrectomy for benign renal tumors,through fluorescent navigation of tumor supply vessel precise block,minimize the loss of renal function.

关键词： Renal angiomyolipoma Renal cell carcinoma Ectopic blood supply luorescent laparoscopic Partial nephrectom Case report

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Global trends in publications regarding macrophages-related diabetic foot ulcers in the last two decades

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World Journal of Diabetes 2024年第7期15卷 1627-1644页

作者： jian-ping Wen Shuan-Ji Ou Jia-Bao Liu Wei Zhang Yu-Dun Qu Jia-Xuan Li Chang-Liang Xia Yang Yang Yong Qi Chang-Peng Xu Department of Orthopaedics The Affiliated Guangdong Second Provincial General Hospital of Jinan UniversityGuangzhou 510000Guangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are one of the most severe and popular complications of *** persistent non-healing of DFUs is the leading cause of amputation,which causes significant mental and financial stress to patients and their *** are critical cells in wound healing and perform essential roles in all phases of wound ***,no studies have been carried out to systematically illustrate this area from a scientometric point of *** there have been some bibliometric studies on diabetes,reports focusing on the investigation of macrophages in DFUs are *** To perform a bibliometric analysis to systematically assess the current state of research on macrophage-related *** The publications of macrophage-related DFUs from January 1,2004,to December 31,2023,were retrieved from the Web of Science Core Collection on January 9,*** different analytical tools:VOSviewer(v1.6.19),CiteSpace(v6.2.R4),HistCite(v12.03.07),and Excel 2021 were used for the scientometric *** A total of 330 articles on macrophage-related DFUs were *** most published countries,institutions,journals,and authors in this field were China,Shanghai Jiao Tong University of China,Wound Repair and Regeneration,and Aristidis *** the analysis of keyword co-occurrence networks,historical direct citation networks,thematic maps,and trend topics maps,we synthesized the prevailing research hotspots and emerging trends in this *** Our bibliometric analysis provides a comprehensive overview of macrophage-related DFUs research and insights into promising upcoming research.

关键词： Diabetic foot ulcers Macrophage Macrophage polarization Bibliometrics Wound healing Inflammation

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基于多样真实任务生成的鲁棒小样本分类方法

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软件学报 2024年第4期35卷 1587-1600页

作者：刘鑫景丽萍于剑交通数据分析与挖掘北京市重点实验室(北京交通大学) 北京100044 北京交通大学计算机与信息技术学院北京100044

随着大数据、计算机与互联网等技术的不断进步,以机器学习和深度学习为代表的人工智能技术取得了巨大成功,尤其是最近不断涌现的各种大模型,极大地加速了人工智能技术在各个领域的应用.但这些技术的成功离不开海量训练数据和充足的计算... 详细信息

随着大数据、计算机与互联网等技术的不断进步,以机器学习和深度学习为代表的人工智能技术取得了巨大成功,尤其是最近不断涌现的各种大模型,极大地加速了人工智能技术在各个领域的应用.但这些技术的成功离不开海量训练数据和充足的计算资源,大大限制了这些方法在一些数据或计算资源匮乏领域的应用.因此,如何利用少量样本进行学习,也就是小样本学习成为以人工智能技术引领新一轮产业变革中一个十分重要的研究问题.小样本学习中最常用的方法是基于元学习的方法,这类方法通过在一系列相似的训练任务上学习解决这类任务的元知识,在新的测试任务上利用元知识可以进行快速学习.虽然这类方法在小样本分类任务上取得了不错的效果,但是这类方法的一个潜在假设是训练任务和测试任务来自同一分布.这意味着训练任务需要足够多才能使模型学到的元知识泛化到不断变化的测试任务中.但是在一些真正数据匮乏的应用场景,训练任务的数量也是难以保证的.为此,提出一种基于多样真实任务生成的鲁棒小样本分类方法(DATG).该方法通过对已有少量任务进行Mixup,可以生成更多的训练任务帮助模型进行学习.通过约束生成任务的多样性和真实性,该方法可以有效提高小样本分类方法的泛化性.具体来说,先对训练集中的基类进行聚类得到不同的簇,然后从不同的簇中选取任务进行Mixup以增加生成任务的多样性.此外,簇间任务Mixup策略可以减轻学习到与类别高度相关的伪判别特征.同时,为了避免生成的任务与真实分布太偏离,误导模型学习,通过最小化生成任务与真实任务之间的最大均值差异(MMD)来保证生成任务的真实性.最后,从理论上分析了为什么基于簇间任务Mixup的策略可以提高模型的泛化性能.多个数据集上的实验结果进一步证明了所提出的基于多样性和真实性任务扩充方法的有效性.

关键词：小样本学习元学习任务Mixup 多样性真实性

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