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Fractional Brownian Motion and Sheet as White Noise Functionals

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Acta Mathematica Sinica,English Series 2006年第4期22卷 1183-1188页

作者： Zhi Yuan HUANG Chu Jin LI jian ping wan Ying WU Department of Mathematics Huazhong University of Science and Technology Wuhan 430074 P. R. China

In this short note, we show that it is more natural to look the fractional Brownian motion as functionals of the standard white noises, and the fractional white noise calculus developed by Hu and Фksendal follows directly from the classical white noise functional calculus. As examples we prove that the fractional Girsanov formula, the Ito type integrals and the fractional Black-Scholes formula are easy consequences of their classical counterparts. An extension to the fractional Brownian sheet is also briefly discussed.

关键词： Fractional Brownian motion Fractional white noise functionals Fractional Girsanov formula Wick product

Benzo （a） pyrene induced tumorigenesity of human immortalized oral epithelial cells： transcription profiling

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Chinese Medical Journal 2008年第19期121卷 1882-1890页

作者： LI Jin-zhong PAN Hong-ya ZHENG Jia-wei ZHOU Xiao-jian ZHANG ping CHEN wan-tao ZHANG Zhi-yuan Department of Oral and Maxillofacial Surgery College of Stomatology Shanghai Ninth People's Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200011 China

Background The present study was designed to examine and analyze the global gene expression changes during the tumorigenesis of a human immortalized oral epithelial cell line, and search for the possible genes that may play a role in the carcinogenesis of oral cancer associated with benzo （a） pyrene. Methods The human immortalized oral epithelial cells, which have been established through transfection of E6/EZgenes of human papillomavirus type 16 and proved to be non-tumorigenic in nude mice, were treated with benzo （a） pyrene. Tumorigenesity of the treated cells were examined through nude mice subcutaneous injection. The global gene expression profiles of immortalized cells and the tumorigenic cells were acquired through hybridization of a microarray of Affymetrix U133 plus 2.0. The data were analyzed using Spring 7.0 software and treated statistically using one-way analysis of variance （ANOVA）. The differentially expressed genes were classified using a Venn diagram and annotated with gene ontology. Several highlighted genes were validated in cells using a real-time polymerase chain reaction. Results There were 883 differentially expressed genes during the tumorigenesis and most of them changed expression in the early stage of tumorigenesis. These genes mainly involved in macromolecule metabolism and signal transduction, possessed the molecular function of transition metal ion binding, nucleotide binding and kinase activity; their protein products were mainly integral to membranes or localized in the nucleus and cytoskeleton. The expression patterns of IGFBP3, S100A8, MAP2K, KRT6B, GDF15, METwere validated in cells using a real-time polymerase chain reaction; the expression of IGFBP3 was further validated in clinical oral cancer specimens. Conclusions This study provides the global transcription profiling associated with the tumorigenesis of oral epithelial cells exposed to benzo （a） pyrene; IGFBP3 may play a potential role in the initiation of oral cancer related

关键词： benzo (a) pyrene gene expression profiling tumorigenesity oral cavity neoplasms

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li jian-Hong Shi Tan Li wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Stable copper boron–imidazolate cage as Cu-riched enzyme for highly efficient electrocatalytic CO2 reduction to ethylene

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Science China Chemistry 2025年

作者： Jun-Qiang Chen Qiao-Hong Li Qin-Long Hong ping Shao Hai-Xia Zhang jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Single-atom catalyst has garnered widespread attention to mimic mature enzymes due to its well-defined atomic structure and coordination environments. However, since the carbon–carbon（C–C） coupling reactions require synergistic catalysis of multiple sites, single-atom catalysts suffer from insufficient active sites and unclear reaction mechanisms. Controlling the reaction intermediates in a precisely targeted pocket through careful metal–organic cage design is therefore crucial. Here, we prepare a tetrahedral [Cu6L4]-type boron–imidazolate cage integrating highly active Cu sites and optimized cavity, which exhibits enzyme like specific catalytic performance in electrochemical CO2reduction reaction（CO2RR） to enhance the selectivity of *** analyses and computational calculations suggest that the single Cu site together with neighboring boron–imidazolate ligands provides suitably synergistic effects that enable the energetically favorable formation of an *COCHO intermediate, a key step determining selectivity. As a result, the [Cu6L4]-type cage of BIC-145 achieves a Faradaic efficiency of 28% for C2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour electrolysis period. This work represents the first example for studying single-metal site catalysts with ultra-low coordination numbers through the rational design of metal–organic cages.

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

技术调节理论视野下的“师-技”关系及其实践指向

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黑龙江高教研究 2025年第1期43卷 118-123页

作者：周建平绍兴文理学院浙江绍兴312000

从技术调节理论看,“师-技”关系本质上是一种“共塑”关系。在教师使用技术情境中,教师与技术相互形塑,不仅技术调节着教师的经验和行动,而且教师也在“处置”、重构乃至重塑技术。“共塑”论不仅拒斥“替代论”、消除“恐惧论”,而且... 详细信息

从技术调节理论看,“师-技”关系本质上是一种“共塑”关系。在教师使用技术情境中,教师与技术相互形塑,不仅技术调节着教师的经验和行动,而且教师也在“处置”、重构乃至重塑技术。“共塑”论不仅拒斥“替代论”、消除“恐惧论”,而且超越“代具论”和“互补论”,其实践意蕴在于让我们重新认识技术使用中教师的地位,明晰教师的技术使用责任,突破对技术的功能性认识,倡导技术“使用的技艺”,在技术设计中融入教师的教育价值诉求,真正让教师使用好技术。

关键词：技术调节 “师一技”关系 “共塑”

RH-ENDOSTATIN PLUS GEMCITABINE/NAVELBINE AND CISPLATIN AS FIRST-LINE TREATMENT PROTOCOL FOR NON-SMALL CELL LUNG CANCER PATIENTS:A SINGLE CENTRE STUDY

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Medical Bulletin of Shanghai Jiaotong University 2011年第1期23卷 32-37页

作者：周剑平项轶万欢英高蓓莉 Department of Respiratory Medicine Ruijin HospitalShanghai Jiaotong University School of Medicine

Objective To assess the efficacy of Rh-endostatin plus the combination of gemcitabine/navelbine and cisplatin in patients with non-small cell lung cancer (NSCLC).Methods NSCLC patients,not receiving chemotherapy,were divided into two *** they were given the combination of gemcitabine/navelbine and cisplatin with or without Rh-endostatin at 2-week intervals for 4 treatment *** Forty patients were enrolled and all of them were assessable for response and *** had complete response but 4 patients had partial *** overall response rate was 10%.The survival rate was 65% at 1 year,with a median survival time of 16.2 *** complications were the most common toxic reactions,with grade≥3 reactions occurring at rates of 7%,7%,4% and 2%,*** Rh-endostatin may have anti-tumor activity with high clinical benefit rate and is well tolerated in lung cancer with stage Ⅲb/Ⅳ.Compared with single combination of gemcitabine/navelbine and cisplatin,no more significant unexpected adverse events were observed.

关键词： non-small cell lung cancer Rh-endostatin efficacy toxicity

On the Initial Layer and the Limit Behavior for Chemotaxis System with the Effect of Fluid in Fourier Space

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Acta Mathematicae Applicatae Sinica 2024年第4期40卷 1015-1024页

作者： jian-xiang wan Hai-ping ZHONG Department of Mathematics Jiangxi University of Finance and EconomicsNanchang 330032China School of Mathematics and Computer Yuzhang Normal UniversityNanchang 330103China

The paper deals with a Cauchy problem for the chemotaxis system with the effect of fluid■where d≥*** is known that for each∈>0 and all sufficiently small initial data(u_(0),n_(0),c_(0))belongs to certain Fourier space,the problem possesses a unique global solution(u^(∈),n^(∈),c^(∈))in Fourier *** present work asserts that these solutions stabilize to(u^(∞),n^(∞),c^(∞))as∈^(-1)→***,we show that c^(∈)(t)has the initial layer as∈^(-1)→*** one expects its limit behavior maybe give a new viewlook to understand the system.

关键词： chemotaxis system initial layer limit behavior Fourier space

无入路平台单切口腹腔镜与多孔腹腔镜治疗输卵管妊娠的效果比较

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中国妇幼保健 2017年第20期32卷 4950-4952页

作者：简萍高万里关宏俊李斌北京市大兴区人民医院北京102600 首都医科大学附属安贞医院北京102600

目的探讨不使用入路平台经脐单切口腹腔镜手术治疗输卵管妊娠的可行性。方法 2016年3月-2017年3月60例异位妊娠接受腹腔镜输卵管切除术患者,其中30例接受经脐单切口腹腔镜输卵管切除术,不使用单孔入路平台为SISL组,30例接受传统腹腔镜... 详细信息

目的探讨不使用入路平台经脐单切口腹腔镜手术治疗输卵管妊娠的可行性。方法 2016年3月-2017年3月60例异位妊娠接受腹腔镜输卵管切除术患者,其中30例接受经脐单切口腹腔镜输卵管切除术,不使用单孔入路平台为SISL组,30例接受传统腹腔镜输卵管切除术为MPLS组,比较两组患者手术时间、术中出血量、术中术后并发症、住院时间等。结果两组患者手术均顺利完成,无须中转开腹。SISL组与MPLS组手术时间分别为(53.5±8.8)、(49.3±10.4)min,差异无统计学意义(P>0.05);两组术中出血量分别为(10.6±10.5)、(16.4±8.2)ml,差异无统计学意义(P>0.05);两组术后血红蛋白降低分别为(13±4)、(12±3)g/L,差异无统计学意义(P>0.05);两组术后住院时间分别为(4.0±0.9)、(3.9±0.8)d,差异无统计学意义(P>0.05);两组术后发热分别为2例和3例,差异无统计学意义(P>0.05)。所有患者术后随访1个月,均恢复良好,无术后并发症发生。结论经脐单切口腹腔镜输卵管切除术可行。

关键词：单切口腹腔镜传统腹腔镜输卵管妊娠