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Tissue-engineered rhesus monkey nerve grafts for the repair of long ulnar nerve defects:similar outcomes to autologous nerve grafts

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Neural Regeneration Research 2016年第11期11卷 1845-1850页

作者： Chang-qing jiang Jun Hu jian-ping xiang Jia-kai Zhu Xiao-lin Liu Peng Luo Department of Sports Medicine and Rehabilitation Peking Universtiy Shenzhen Hospital Shenzhen Guangdong Province China Department of Microscopy First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong Province China The Sixth People's Hospital of Shenzhen City Shenzhen Guangdong Province China

Acellular nerve allografts can help preserve normal nerve structure and extracellular matrix composition. These allografts have low immunogenicity and are more readily available than autologous nerves for the repair of long-segment peripheral nerve defects. In this study, we repaired a 40-mm ulnar nerve defect in rhesus monkeys with tissue-engineered peripheral nerve, and compared the outcome with that of autograft. The graft was prepared using a chemical extract from adult rhesus monkeys and seeded with allogeneic Schwann cells. Pathomo- rphology, electromyogram and immunohistochemistry findings revealed the absence of palmar erosion or ulcers, and that the morphology and elasticity of the hypothenar eminence were normal 5 months postoperatively. There were no significant differences in the mean peak compound muscle action potential, the mean nerve conduction velocity, or the number of neurofilaments between the experimental and control groups. However, outcome was significantly better in the experimental group than in the blank group. These findings suggest that chemically extracted allogeneic nerve seeded with autologous Schwann cells can repair 40-mm ulnar nerve defects in the rhesus monkey. The outcomes are similar to those obtained with autologous nerve graft.

关键词： nerve regeneration peripheral nerve injury tissue engineering rhesus monkey ulnar nerve chemical extraction allogenic nerve autologous nerve transplantation Schwann cells neural regeneration

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Ab Initio Studies on Eight Electronic States of the BH_2 Radical

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Chemical Research in Chinese Universities 1993年第1期9卷 59-64页

作者： GU jian-ping WANG Zhi-xiang and HUANG Ming-bao (Department of Modern Chemistry, University of Science and Technology of China, Hefei, 230026)

The present paper covers ab initio UHF calculations with a d, p-polarized basis set performed for eight electronic states of BH2 and the equilibrium geometries, electronic term values Tc and vibrational frequencies of the five stable states X2A1, 2B1, 2B2, 22A1 and 2A2. On the basis of the UHF results, the states 22B2. 2B1 and 32A1 are predicted to be unstable. The MP2/6-31G * * calculations were performed for the X2A1 and 2B1, states, and the calculated equilibrium geometries, Tc value and vibrational frequencies are similar to the UHF results. The MP2/6-31G * * studies on the reaction BH2→BH + H for the X2A1 and 2B1 states were carried out and the HB-H bond energies of these two states were calculated.

关键词： Ab initio calculation Electronic excited state Borane( Ⅱ )

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Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms

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Current Medical Science 2024年第2期44卷 391-398页

作者： Kai-kai GUO Chang-ya LIU Gao-hui LI jian-ping xiang Xiao-chang LENG Yi-ke CAI Xue-bin HU Department of Neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Artery Flow Technology Co. Ltd.Hangzhou 310051China

Objective:The objective of this research was to explore the difference and correlation of the morphological and hemodynamic features between sidewall and bifurcation aneurysms in anterior circulation arteries,utilizing computational fluid dynamics as a tool for ***:In line with the designated inclusion criteria,this study covered 160 aneurysms identified in 131 patients who received treatment at Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,China,from January 2021 to September *** follow-up digital subtraction angiography(DSA)data,these cases were classified into two distinct groups:the sidewall aneurysm group and the bifurcation aneurysm *** and hemodynamic parameters in the immediate preoperative period were meticulously calculated and examined in both groups using a three-dimensional DSA reconstruction ***:No significant differences were found in the morphological or hemodynamic parameters of bifurcation aneurysms at varied locations within the anterior ***,pronounced differences were identified between sidewall and bifurcation aneurysms in terms of morphological parameters such as the diameter of the parent vessel(Dvessel),inflow angle(θF),and size ratio(SR),as well as the hemodynamic parameter of inflow concentration index(ICI)(P0.5,P<0.001).Conclusions:The significant differences in certain morphological and hemodynamic parameters between sidewall and bifurcation aneurysms emphasize the importance to contemplate variances in threshold values for these parameters when evaluating the risk of rupture in anterior circulation *** it is a bifurcation or sidewall aneurysm,these disparities should be *** morphological parameter SR has the potential to be a val

关键词： sidewall bifurcation unruptured aneurysms computational fluid dynamics

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A PARALLEL NUMERICAL MODEL OF SOLVING N-S EQUATIONS BY USING SEQUENTIAL REGULARIZATION METHOD

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Journal of Hydrodynamics 2003年第1期15卷 72-77页

作者： Project supported by the National Natural Science Foundation of China. (Grant No:69773021)Zhang She sheng, Zou Zao jian, xiang ping bo School of Science, Wuhan University of Technology, Wuhan 430063, China School of Science Wuhan University of Technology Wuhan 430063 China

A parallel numerical model was established for solving the Navier-Stokesequations by using Sequential Regu-larization Method (SRM). The computational domain is decomposedinto P sub-domains in which the difference formulae were obtained from the governing equations. Thedata were exchannged at the virtual boundary of sub-domains in parallel computation. Theclose-channel cavity flow was solved by the implicit method. The driven square cavity flow wassolved by the explicit method. The results were compared well those given by Ghia.

关键词： parallel computer sequential regularization method (SRM)

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The design of monitoring communication system Based on Power line carrier

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Journal of Measurement Science and Instrumentation 2010年第S1期1卷 23-26页

作者： Wei-tao MU,jian-jun HAO,ping-xiang jianG,Guo-wei LI (College of Information and Electrical Engineering,Shandong University of Science and Technology,qingdao266510,China) College of Information and Electrical Engineering Shandong University of Science and Technology

The design of the power line carrier communication system was introduced in this paper,DSP was adopted as the hardware platform to complete the core *** sending terminal delivered the collecting data to the DSP receiving terminal through the power line carrier, and the DSP receiving terminal send the data to PC through a serial *** design improved the power line carrier communication system and the data transmission became faster and more *** experiment results showed that the PER of the receiving data is less than 0.4%, which satisfied the power line carrier communication requirement Our design is feasible and effective.

关键词： DSP Power line carrier D/A A/D

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矿井提升机制动系统运行优化控制研究

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计算机仿真 2018年第5期35卷 225-228,321页

作者：李锋谭建平石理想中南大学机电工程学院湖南长沙410083

针对传统矿井提升机制动系统运行状态监测只关心运行参数的实时值,并未对变化趋势进行持续关注、运行控制困难且被动进行运行控制的问题,提出了矿井提升机制动系统运行优化控制方法。分析了制动系统运行控制原理,对液压数学模型优化并... 详细信息

针对传统矿井提升机制动系统运行状态监测只关心运行参数的实时值,并未对变化趋势进行持续关注、运行控制困难且被动进行运行控制的问题,提出了矿井提升机制动系统运行优化控制方法。分析了制动系统运行控制原理,对液压数学模型优化并优化控制模型,运用AMESim软件建立制动系统运行控制系统仿真模型,对制动系统运行状态特性进行仿真和控制,得到各参数的变化规律,最后利用现场运行数据进行了测试验证。仿真结果表明,现场实际大型复杂的制动系统可以利用图形化开发环境下的AMESim软件较为简单的实现,优化了制动系统的运行控制。

关键词：提升机制动系统运行优化控制仿真现场实验

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He jian-ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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抗坏血酸的催化动力学光度法测定

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分析测试学报 2001年第4期20卷 26-29页

作者：李建平曹香玉桂林工学院应用化学系广西桂林541004

建立了一种测定抗坏血酸的方便、快捷、高灵敏度的催化动力学光度法。对氨基苯磺酸与亚硝酸根进行重氮化反应生成重氮盐 ,抗坏血酸对重氮盐的分解有催化作用。利用加入8_羟基喹啉与该重氮盐反应生成偶氮染料来终止反应。在波长495nm处 ,... 详细信息

建立了一种测定抗坏血酸的方便、快捷、高灵敏度的催化动力学光度法。对氨基苯磺酸与亚硝酸根进行重氮化反应生成重氮盐 ,抗坏血酸对重氮盐的分解有催化作用。利用加入8_羟基喹啉与该重氮盐反应生成偶氮染料来终止反应。在波长495nm处 ,用1cm比色皿以水作参比测定其吸光度 ,最佳测定酸度为pH9.0。吸光度与空白体系的差值ΔA与抗坏血酸的质量浓度呈线性关系。该法测定抗坏血酸的线性范围为0.16～6.3mg/L,检出限为0.005mg/L。利用该法测定了维生素C片剂及荔枝晶中的抗坏血酸含量 ,并与碘量法进行对照。

关键词：催化动力学光度法抗坏血酸重氮盐测定分析催化痕量分析

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Stable copper boron–imidazolate cage as Cu-riched enzyme for highly efficient electrocatalytic CO2 reduction to ethylene

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Science China Chemistry 2025年

作者： Jun-Qiang Chen Qiao-Hong Li Qin-Long Hong ping Shao Hai-Xia Zhang jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Single-atom catalyst has garnered widespread attention to mimic mature enzymes due to its well-defined atomic structure and coordination environments. However, since the carbon–carbon（C–C） coupling reactions require synergistic catalysis of multiple sites, single-atom catalysts suffer from insufficient active sites and unclear reaction mechanisms. Controlling the reaction intermediates in a precisely targeted pocket through careful metal–organic cage design is therefore crucial. Here, we prepare a tetrahedral [Cu6L4]-type boron–imidazolate cage integrating highly active Cu sites and optimized cavity, which exhibits enzyme like specific catalytic performance in electrochemical CO2reduction reaction（CO2RR） to enhance the selectivity of *** analyses and computational calculations suggest that the single Cu site together with neighboring boron–imidazolate ligands provides suitably synergistic effects that enable the energetically favorable formation of an *COCHO intermediate, a key step determining selectivity. As a result, the [Cu6L4]-type cage of BIC-145 achieves a Faradaic efficiency of 28% for C2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour electrolysis period. This work represents the first example for studying single-metal site catalysts with ultra-low coordination numbers through the rational design of metal–organic cages.

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一种结合主动和被动方式的网络延迟测量方法

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武汉大学学报（理学版） 2004年第5期50卷 605-608页

作者：蔡志平殷建平刘湘辉吕绍和国防科技大学计算机学院湖南长沙410073

在利用被动测量设备检测到的用户包数量基础上,考虑相邻探测包的延迟变化关系,实现了一种结合主动和被动方式的网络延迟有效测量方法.这种测量方法不但具有与协议无关、对网络流量影响小、使用简单等特点,在网络拥塞甚至存在丢包的情况... 详细信息

在利用被动测量设备检测到的用户包数量基础上,考虑相邻探测包的延迟变化关系,实现了一种结合主动和被动方式的网络延迟有效测量方法.这种测量方法不但具有与协议无关、对网络流量影响小、使用简单等特点,在网络拥塞甚至存在丢包的情况下,能减小误差,更准确地反映网络的实际状况.

关键词：网络延迟网络性能监测延迟测量主动测量被动测量

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