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Chitin nanocrystal-assisted 3D bioprinting of gelatin methacrylate scaffolds

Regenerative Biomaterials 2023年第1期10卷 1192-1201页

作者： Zhengyun ling jian zhao Shiyu Song Shuwei Xiao Pengchao Wang Ziyan An Zhouyang Fu Jinpeng Shao Zhuang Zhang Weijun Fu Shenghan Song School of Medicine Nankai UniversityTianjin 300071China Department of Urology The Third Medical CenterPLA General HospitalBeijing 100039China Medical School of PLA Beijing 100853China Department of Urology 960th Hospital of PLAJinan 250031China Undergraduate Student Majoring in Clinical Pharmacy Chongqing Medical UniversityChongqing 400016China Department of Urology Air Force Medical CenterBeijing 100142China Beijing Institute of Basic Medical Sciences Beijing 100850China Department of Vascular Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

In recent years,there has been an increasing focus on the application of hydrogels in tissue *** integration of 3D bioprinting technology has expanded the potential applications of ***,few commercially available hydrogels used for 3D biological printing exhibit both excellent biocompatibility and mechanical *** methacrylate(GelMA)has good biocompatibility and is widely used in 3D ***,its low mechanical properties limit its use as a standalone bioink for 3D *** this work,we designed a biomaterial ink composed of GelMA and chitin nanocrystal(ChiNC).We explored fundamental printing properties of composite bioinks,including rheological properties,porosity,equilibrium swelling rate,mechanical properties,biocompatibility,effects on the secretion of angiogenic factors and fidelity of 3D *** results showed that adding 1%(w/v)ChiNC to 10%(w/v)GelMA improved the mechanical properties and printability of the GelMA hydrogels,promoted cell adhesion,proliferation and vascularization and enabled the printing of complex 3D *** strategy of incorporating ChiNC to enhance the performance of GelMA biomaterials could potentially be applied to other biomaterials,thereby expanding the range of materials available for ***,in combination with 3D bioprinting technology,this approach could be leveraged to bioprint scaffolds with complex structures,further broadening the potential applications in tissue engineering.

关键词： 3D bioprinting gelatin methacrylate chitin nanocrystal hydrogels scaffolds

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Large circuit models: opportunities and challenges

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Science China(Information Sciences) 2024年第10期67卷 25-66页

作者： Lei CHEN Yiqi CHEN Zhufei CHU Wenji FANG Tsung-Yi HO Ru HUANG Yu HUANG Sadaf KHAN Min LI Xingquan LI Yu LI Yun LIANG Jinwei LIU Yi LIU Yibo LIN Guojie LUO Hongyang PAN Zhengyuan SHI Guangyu SUN Dimitrios TSARAS Runsheng WANG Ziyi WANG Xinming WEI Zhiyao XIE Qiang XU Chenhao XUE Junchi YAN Jun YANG Bei YU Mingxuan YUAN Evangeline F.Y.YOUNG Xuan ZENG Haoyi ZHANG Zuodong ZHANG Yuxiang zhao Hui-ling ZHEN Ziyang ZHENG Binwu ZHU Keren ZHU Sunan ZOU Huawei Noah’s Ark Lab School of Integrated Circuits Peking University Faculty of Electrical Engineering and Computer Science Ningbo University Department of Electronic and Computer Engineering Hong Kong University of Science and Technology Department of Computer Science and Engineering The Chinese University of Hong Kong School of Integrated Circuits Southeast University Huawei HiSilicon Peng Cheng Laboratory School of Computer Science Peking University School of Microelectronics State Key Laboratory of Integrated Chips and System Fudan University School of Artificial Intelligence Shanghai Jiao Tong University

Within the electronic design automation(EDA) domain, artificial intelligence(AI)-driven solutions have emerged as formidable tools, yet they typically augment rather than redefine existing methodologies. These solutions often repurpose deep learning models from other domains, such as vision, text, and graph analytics, applying them to circuit design without tailoring to the unique complexities of electronic circuits. Such an “AI4EDA” approach falls short of achieving a holistic design synthesis and understanding,overlooking the intricate interplay of electrical, logical, and physical facets of circuit data. This study argues for a paradigm shift from AI4EDA towards AI-rooted EDA from the ground up, integrating AI at the core of the design process. Pivotal to this vision is the development of a multimodal circuit representation learning technique, poised to provide a comprehensive understanding by harmonizing and extracting insights from varied data sources, such as functional specifications, register-transfer level(RTL) designs, circuit netlists,and physical layouts. We champion the creation of large circuit models(LCMs) that are inherently multimodal, crafted to decode and express the rich semantics and structures of circuit data, thus fostering more resilient, efficient, and inventive design methodologies. Embracing this AI-rooted philosophy, we foresee a trajectory that transcends the current innovation plateau in EDA, igniting a profound “shift-left” in electronic design methodology. The envisioned advancements herald not just an evolution of existing EDA tools but a revolution, giving rise to novel instruments of design-tools that promise to radically enhance design productivity and inaugurate a new epoch where the optimization of circuit performance, power, and area(PPA) is achieved not incrementally, but through leaps that redefine the benchmarks of electronic systems' capabilities.

关键词： AI-rooted EDA large circuit models (LCMs) multimodal circuit representation learning circuit optimization

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Communication efficiency optimization of federated learning for computing and network convergence of 6G networks

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 713-727页

作者： Yizhuo CAI Bo LEI Qianying zhao Jing PENG Min WEI Yushun ZHANG Xing ZHANG Wireless Signal Processing and Network Laboratory Beijing University of Posts and TelecommunicationsBeijing 100876China Research Institute of China Telecom Co. Ltd.Beijing 102209China Beijing Telecom Beijing 100011China

Federated learning effectively addresses issues such as data privacy by collaborating across participating devices to train global ***,factors such as network topology and computing power of devices can affect its training or communication process in complex network *** and network convergence(CNC)of sixth-generation(6G)networks,a new network architecture and paradigm with computing-measurable,perceptible,distributable,dispatchable,and manageable capabilities,can effectively support federated learning training and improve its communication *** guiding the participating devices'training in federated learning based on business requirements,resource load,network conditions,and computing power of devices,CNC can reach this *** this paper,to improve the communication eficiency of federated learning in complex networks,we study the communication eficiency optimization methods of federated learning for CNC of 6G networks that give decisions on the training process for different network conditions and computing power of participating *** simulations address two architectures that exist for devices in federated learning and arrange devices to participate in training based on arithmetic power while achieving optimization of communication efficiency in the process of transferring model *** results show that the methods we proposed can cope well with complex network situations,effectively balance the delay distribution of participating devices for local training,improve the communication eficiency during the transfer of model parameters,and improve the resource utilization in the network.

关键词： Computing and network convergence Communication efficiency Federated learning Two architectures

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坎地沙坦联合氨氯地平对原发性高血压疗效分析

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世界临床药物 2024年第7期45卷 726-730页

作者：高兴赵玲胡玲雍雪飞周琳成都市第六人民医院药物临床试验Ⅰ期病房四川成都610051 成都市第六人民医院肾内科四川成都610051 成都市第六人民医院心内科四川成都610051

目的探究坎地沙坦联合氨氯地平对原发性高血压(essential hypertension,EH)的临床疗效。方法选取2022年2月至2023年1月我院收治的EH患者120例,按随机数字表法分为观察组(氨氯地平+坎地沙坦)与对照组(氨氯地平),每组60例,所有患者疗程... 详细信息

目的探究坎地沙坦联合氨氯地平对原发性高血压(essential hypertension,EH)的临床疗效。方法选取2022年2月至2023年1月我院收治的EH患者120例,按随机数字表法分为观察组(氨氯地平+坎地沙坦)与对照组(氨氯地平),每组60例,所有患者疗程均为8周。比较两组疗效、动态血压[日间收缩压变异系数(coefficient of variation in daytime systolic blood pressure,SCV)、夜间收缩压变异系数(coefficient of variation in nocturnal systolic blood pressure,nSCV)、24 h收缩压变异系数(coefficient of variation of 24-hour systolic blood pressure,24hSCV)、日间舒张压变异系数(coefficient of variation in diastolic blood pressure,DCV)、夜间舒张压变异系数(coefficient of variation in nocturnal diastolic blood pressure,nDCV)、24 h舒张压变异系数(coefficient of variation of 24-hour diastolic blood pressure,24hDCV)]、颈动脉内膜中层厚度(intimal medial thickness,IMT)、血清基质交感分子(stromal interaction molecule,STIM)1水平及不良反应发生情况等。结果治疗后,观察组临床总有效率高于对照组(98.33% vs 80.00%),差异有统计学意义(P0.05)。结论坎地沙坦联合氨氯地平能有效降低EH患者血压变异性、IMT及STIM1水平,改善预后,提高临床疗效。

关键词：坎地沙坦氨氯地平原发性高血压血压变异性

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Features of Tropical Volcanic Rock and Soil of Jakarta-Bandung HSR and Engineering Countermeasures

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Chinese Railways 2024年第1期 30-37页

作者： zhao Dou WANG Shujie ZHENG Mingda(Translated) China Railway Design Corporation Track Station and Yard Design and Research InstituteChina Railway Design Corporation 不详

The geological features of three types of tropical volcanic rock and soil distributed along Jakarta-Bandung high-speed railway(HSR),including pozzolanic clayey soil,mud shale and deep soft soil,are studied through field and laboratory *** paper analyzes the mechanism and causes of engineering geological problems caused by tropical volcanic rock and soil and puts forward measures to control subgrade slope instability by rationally determining project type,making side slope stability control and strengthening waterproofing and ***“zero front slope”tunneling technology at the portal,the simplified excavation method of double-side wall heading and the cross brace construction method of arch protection within the semi-open cut row pile frame in the“mountainside”eccentrically loaded soft soil stratum are adopted to control the instability of tunnel side and front slopes,foundation pits and working faces;CFG or pipe piles shall be used to reinforce soft and expansive foundation or replacement measures shall be taken,and the scheme of blind ditch+double-layer water sealing in ballastless track section shall be put forward to prevent arching deformation of foundation;the treatment measures of CFG pile,pipe pile and vacuum combined piled preloading are adopted to improve the bearing capacity of foundation in deep soft soil section and solve the problems of settlement control and uneven *** engineering countermeasures have been applied during the construction of Jakarta-Bandung HSR and achieved good results.

关键词： Jakarta-Bandung HSR tropical volcanic rock and soil engineering geological features engineering geological problems engineering countermeasures

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精细景观制图揭示城市环境的同质性

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Science Bulletin 2024年第12期69卷 1802-1805页

作者：徐知宇赵淑清 College of Urban and Environmental Sciences Peking UniversityBeijing 100871China School of Ecology Hainan UniversityHaikou 570228China

Urbanization,characterized by multifaceted interactions encompassing social,economic,institutional,and environmental dimensions[1,2],generate intricate and heterogeneous urban landscape with interwoven blue,green,and gray elements[3].Unlocking the delicate urban landscape structure requires finegrained urban blue-green-gray landscape mapping for an accurate measurement of irregularities,fragmentation,and shape complexity within the urban fabric[4,5].

关键词： landscape 景观制图 dimensions

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应急物资采购及代储服务交易的逆向组合拍卖机制设计

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控制与决策 2024年第5期39卷 1527-1536页

作者：张萌孔昭君北京理工大学管理与经济学院北京100081

建立市场化的政企联合储备模式已经成为应急物资储备体系建设的重要方式.基于此,着眼于应急物资采购及代储服务的交易问题,设计一个逆向组合拍卖机制.在此拍卖机制中,政府是拍卖的买方兼委托人,企业是拍卖的卖方兼竞拍者,应急物资采购... 详细信息

建立市场化的政企联合储备模式已经成为应急物资储备体系建设的重要方式.基于此,着眼于应急物资采购及代储服务的交易问题,设计一个逆向组合拍卖机制.在此拍卖机制中,政府是拍卖的买方兼委托人,企业是拍卖的卖方兼竞拍者,应急物资采购及代储服务是拍卖商品.首先,通过一个报童模型建立政府决策行为与拍卖活动之间的关系,并提出企业的投标策略;其次,建立最小化供需偏差和最大化供给数量的竞胜标决定模型;最后,提出一个符合实际背景的数值算例对拍卖机制进行模拟和验证.研究表明,所提出的逆向组合拍卖机制不仅具有经济效率,还能够促进政府一次性达成与多家企业在多个周期的合作.由此可见,运用拍卖机制解决应急物资政企联合储备的交易问题具备理论的优越性和现实的适用性.

关键词：应急物资采购政企联合储备模式逆向组合拍卖机制报童模型供需匹配竞胜标决定原则

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A new photon kinetic-measurement based on the kinetics of electron-hole pairs in photodegradation of textile wastewater using the UV-H_2O_(2FS)-TiO_2 process

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Journal of Environmental Sciences 2007年第3期19卷 367-373页

作者： SHIGWEDHA Nditange HUA zhao-zhe CHEN jian Laboratory of Environmental Biotechnology School of Biotechnology Southern Yangtze University Wuxi 214036 China Key Laboratory of Industrial Biotechnology Ministry of Education Southern Yangtze University Wuxi 214036 China

Actual textile wastewater and synthesized wastewater containing various textile dyes were photocatalytic degraded by the UVH2O2Fs-TiO2 process in an aimular-flow photocatalytic reactor. In this process, a photon kinetic-measure was adopted to obtain constant rates of dyes decomposition. It was theorized that, by illumination at different UV frequencies, the electrons within the semiconductor were excited from the valence band to the conduction band, yielding the formation of electron-hole pairs which are the pre-requisites for photocatalysis. CPT （critical photonic time） exposure required to cause 90% of vibrations between the double and single bonds along the molecular chain of the dyes to be oxidized, was taken to measure the photocatalytic activities. The CPTs varied with the frequencies of the UV spectral areas. The derivatization of CPT from the first-order kinetic law was presented.

关键词： critical photonic time (CPT) photon efficiency UV frequencies regression line textile wastewater

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网络空间多粒度时空数据模型构建及其适配双变量不确定性表达符号研究

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地球信息科学学报 2024年第7期26卷 1577-1593页

作者：赵帅张政华一新赵文双赵鑫科陈敏颉吉晓宇战略支援部队信息工程大学地理空间信息学院郑州450000 武警特种警察学院北京102211 西藏农牧学院资源与环境学院林芝860000 郑州师范学院信息科学与技术学院郑州450000

不确定性可视化是网络空间地图可视化领域的重点和难点,合理的不确定性符号设计对网络空间地图信息的快速读取挖掘与精准分析决策至关重要。本文提出了一种基于多粒度时空对象数据模型的网络空间双变量不确定性符号表达方法,解决网络空... 详细信息

不确定性可视化是网络空间地图可视化领域的重点和难点,合理的不确定性符号设计对网络空间地图信息的快速读取挖掘与精准分析决策至关重要。本文提出了一种基于多粒度时空对象数据模型的网络空间双变量不确定性符号表达方法,解决网络空间节点链接图中变量符号无法及时高效地体现节点、连边不确定性表达不一致的情况。以地理社交网络为案例,首先采用多粒度时空数据模型建模的方法,分析网络空间对象建模的内容和流程,设计网络空间实体对象类并创建相应时空对象;在此基础上结合传统符号在网络空间节点链接图表达方面存在的问题,分析网络空间不确定性表达原理和模型,制作相应的视觉熵符号;最后开展对照实验,并采用统计方法对符号实验结果进行检验。结果表明基于对象化建模的方法有助于网络空间多粒度、全类型、多维动态的表达,通过可视化和交互技术能生动直观、全面多维地表现网络空间的发展变化;新设计的视觉熵符号在网络空间双变量不确定性差异表达方面的效果较好,有助于及时高效准确地获取网络空间的不确定性信息。研究可以为网络空间地图可视化领域的发展提供一定借鉴和参考。

关键词：网络空间多粒度时空数据模型视觉熵符号双变量不确定性网络空间地图可视化

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Efficient and stable hybrid perovskite-organic light-emitting diodes with external quantum efficiency exceeding 40 per cent

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Light(Science & Applications) 2024年第7期13卷 1364-1371页

作者： lingmei Kong Yun Luo Qianqian Wu Xiangtian Xiao Yuanzhi Wang Guo Chen jianhua Zhang Kai Wang Wallace CHChoy Yong-Biao zhao Hongbo Li Takayuki Chiba Junji Kido Xuyong Yang Key Laboratory of Advanced Display and System Applications of Ministry of Education Shanghai UniversityShanghai 200072China. Institute of Nanoscience and Applications Department of Electrical and Electronic EngineeringSouthern University of Science and TechnologyShenzhen 518055China. Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina. Department of Physics and Lakeside AR/VR Laboratory International Joint Research Center for Optoelectronic and Engineering ResearchYunnan UniversityKunming 650091China. Experimental Center of Advanced Materials School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China. Graduate School of Organic Materials Science Frontier Center for Organic MaterialsYamagata University4-3-16 JonanYonezawa 992–8510Japan

Light-emitting diodes(LEDs)based on perovskite semiconductor materials with tunable emission wavelength in visible light range as well as narrow linewidth are potential competitors among current light-emitting display technologies,but still suffer from severe instability driven by electric ***,we develop a stable,efficient and highcolor purity hybrid LED with a tandem structure by combining the perovskite LED and the commercial organic LED technologies to accelerate the practical application of *** LED and organic LED with close photoluminescence peak are selected to maximize photon emission without photon reabsorption and to achieve the narrowed emission *** designing an efficient interconnecting layer with p-type interface doping that provides good opto-electric coupling and reduces Joule heating,the resulting green emitting hybrid LED shows a narrow linewidth of around 30 nm,a peak luminance of over 176,000 cd m^(−2),a maximum external quantum efficiency of over 40%,and an operational half-lifetime of over 42,000 h.

关键词： diodes narrow quantum

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