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Jetting of a near-wall cavitation bubble induced by another tandem bubble

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Journal of Hydrodynamics 2024年第3期36卷 444-456页

作者： Hui Han Jing-zhu Wang jian-lin huang Peng-bo Bai Yong-gang Chen Yi-wei Wang Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China School of Engineering Science University of Chinese Academy of SciencesBeijing100049China Guangdong Aerospace Research Academy Guangzhou511458China School of Future Technology University of Chinese Academy of SciencesBeijing100049China jianghuai Advance Technology Center Hefei230088China

Double bubbles near a rigid wall surface collapse to produce a significant jet impact,with potential applications in surface cleaning and ultrasonic ***,the dynamic behaviors of near-wall bubbles remain *** this study,we investigate the jetting of a near-wall bubble induced by another tandem *** define two dimensionless standoff distances,γ_(1),γ_(2),to represent the distances from the center of the near-wall bubble to the rigid wall and the center of controlling bubble to the center of the near-wall bubble,*** observations reveal three distinct jetting regimes for the near-wall bubble:transferred jetting,double jetting,and directed *** further investigate the jetting mechanism,numerical simulations are conducted using the compressibleInterFoam solver in the open-source framework of OpenFOAM.A detailed analysis shows that the transferred jet flow is caused by the pinch-off resulting from the axial contraction velocity at the lower end of the near-wall bubble being greater than the vertical contraction velocity,leading to a maximum jet velocity of 682.58 m/*** the case of double jetting,intense stretching between the controlling bubble and the wall leads to a pinch-off and a double jetting with a maximum velocity of 1096.29 m/*** directed jet flow is caused by the downward movement of the high-pressure region generated by the premature collapse of the controlling bubble,with the maximum jet velocity reaching 444.62 m/s.

关键词： Jetting of near-wall bubble controlling bubble impact velocity

Assembling Stabilization of the R-T Instability by the Effects of Finite Larmor Radius and Sheared Axial Flow

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Southwestern Institute of Physics Annual Report

Southwestern Institute of Physics Annual Report 2005年第1期 131-133页

作者： jian Guangde huang lin QIU Xiaoming

In the present paper, based on the incomepressible finite Larmor radius （FLR） magnetohydrodynamic （ MHD ） equations, we consider the stabilizing effect of the finite Larmor radius on the Rayleigh-Taylor （ RT ） instability in implosions of annular Z-pinch plasma. Here, the FLR is considered as a type of viscositytll, independent of any collisions （i.e., collisionless viscosity, or gyrouiscosity ）. Since we are introducing a sheared velocity,

关键词： Z-pinch Implosion Rayleigh-Taylor instability

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自然陶养自我化育——论生态美育

福建师范大学学报（哲学社会科学版） 2007年第4期 79-82页

作者：林建煌福建师范大学文学院福建福州350108

生态危机说到底是人性的危机,改善生态环境,化解生态危机,关键是解决人的问题。生态美育以培养生态审美的人为根本任务,以自然陶养为基本途径,唤醒人们的生态意识,树立正确的生态审美观、生态价值观和生态伦理观,使人性向善、向美提升,... 详细信息

生态危机说到底是人性的危机,改善生态环境,化解生态危机,关键是解决人的问题。生态美育以培养生态审美的人为根本任务,以自然陶养为基本途径,唤醒人们的生态意识,树立正确的生态审美观、生态价值观和生态伦理观,使人性向善、向美提升,以生态文明促进物质文明和精神文明,构建和谐社会。

关键词：生态美育自然陶养生态规律美的规律生态价值观生态伦理观

Inhibition of smoothened decreases proliferation of Synoviocytes in rheumatoid arthritis

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Cellular & Molecular Immunology 2017年第2期14卷 214-222页

作者： Shang-ling Zhu jian-lin huang Wei-xiang Peng Dan-chun Wu Min-qi Luo Qiu-xia Li Zhao-xia Li Xiao-xue Feng Fang Liu Ming-xia Wang Wei-qian Chen Nancy Olsen Song Guo Zheng Division of Rheumatology Department of Internal Medicine the Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong Province People's Republic of China Center for Clinic Immunology the Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong Province People's Republic of China Division of Rheumatology Penn State University Hershey College of Medicine Hershey PA USA Both Shang-ling Zhu and jian-lin huang equally contributed to this work

Fibroblast-like synoviocytes （FLSs） contribute to synovial hyperplasia in rheumatoid arthritis （RA）. Smoothened （Smo） is a key component of sonic hedgehog （Shh） signaling and contributes to tumor cell proliferation. The objective of this study was to investigate the role of Smo in RA synoviocyte proliferation. FLSs were isolated from RA synovium. Shh signaling was studied using a Smo antagonist （GDC-0449） and small interfering RNA （siRNA） targeting the Smo gene in FLSs. Cell proliferation was quantified by using kit-8 assay and cell cycle distribution and apoptosis were evaluated by flow cytometry. Cell cycle-related genes and proteins were detected by real-time PCR and western blot. FLSs treated with GDC-0449 or Smo-siRNA showed significantly decreased proliferation compared to controls （P〈0.05）. Incubation with GDC-0449 or transfection with Smo-siRNA resulted in a significant increase of G1 phase cells compared to controls （P 〈 0.05）. Cell cycle arrest was validated by the significant increase in cyclin D1 and E1 mRNA expression, decrease in cyclin-dependent kinase p21 mRNA expression in Smo-siRNA transfected cells （P 〈 0.05）. Protein expression of cyclin D1 was also downregulated after Smo gene knockdown （P 〈0.05）.The results suggest that Shh signaling plays an important role in RA-FLSs proliferation in a Smo-dependent manner and may contribute to synovial hyperplasia. Targeting Shh signaling may help control joint damage in patients with RA.

关键词： cell proliferation rheumatoid arthritis smoothened protein sonic hedgehog signaling synoviocyte

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数据仓库的视图动态物化调整策略

铁道学报 2001年第4期23卷 59-62页

作者：励晓健林友芳黄厚宽北方交通大学计算机科学技术系北京100044

数据仓库中视图的物化策略是数据仓库研究领域的一个重要课题 ,物化策略的选择直接影响数据仓库的查询效率。对于这一问题许多研究人员都提出了各自的算法 ,其中较有影响力的是文献 [1,3],但是文献 [1,3,4]提出的物化策略不能动态反映... 详细信息

数据仓库中视图的物化策略是数据仓库研究领域的一个重要课题 ,物化策略的选择直接影响数据仓库的查询效率。对于这一问题许多研究人员都提出了各自的算法 ,其中较有影响力的是文献 [1,3],但是文献 [1,3,4]提出的物化策略不能动态反映查询趋势 ,针对于此。

关键词：数据仓库数据立方体物化策略聚集函数视图调整策略

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胸部结节病CT影像表现

中国医学计算机成像杂志 2011年第2期17卷 118-121页

作者：林建煌于红李惠民福建省漳州市中医院(福建中医药大学附属漳州中医院)放射科第二军医大学附属长征医院影像科上海交通大学医学院附属新华医院放射科

目的：分析胸部结节病CT影像,探讨其典型性及不典型性,以进一步提高认识,帮助诊断。方法：回顾性分析38例确诊的胸部结节病CT图像,男12例,女26例,年龄17~56岁,平均45.2岁。CT扫描层厚7mm或5mm,同时均有1mm或1.25mm薄层图像,32例完成增... 详细信息

目的：分析胸部结节病CT影像,探讨其典型性及不典型性,以进一步提高认识,帮助诊断。方法：回顾性分析38例确诊的胸部结节病CT图像,男12例,女26例,年龄17~56岁,平均45.2岁。CT扫描层厚7mm或5mm,同时均有1mm或1.25mm薄层图像,32例完成增强扫描。结果：全部有肺门或纵隔淋巴结肿大,典型双侧肺门对称性淋巴结肿大及纵隔右气管旁和主肺动脉窗淋巴结肿大33例（86.8%）。出现肺部病变21例（55.3%）,典型网织结节改变12例（57.1%）,5例出现奇特的双下肺斑片和不规则结节伴有网格线影。不典型淋巴结表现的5例结节病中3例有奇特肺内改变。结论：胸部结节病多数有双侧肺门对称性淋巴结肿大及纵隔右气管旁和主肺动脉窗淋巴结肿大的典型表现,有高特异性。奇特的双下肺斑片和不规则结节伴有网格线影可能有助于不典型胸部结节病的诊断。

关键词：结节病胸部 X线计算机,体层摄影术

Construction and analysis of SSH cDNA library of different pathogenicity strains of Bursaphelenchus xylophilus

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Construction and analysis of SSH cDNA library of different p...

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

第三届全国生物入侵大会

作者： Xu-ling Xu,Xiao-qin Wu~*,jian-ren Ye,lin huang Nanjing Forestry University,The key Laboratory of the pest prevention and control of jiangsu Province, Nanjing 210037,China

Bursaphelenchus xylophilus as the pathogen of pine wilt disease,has caused destructive damage to pine plantations and resulted in the annual loss of millions of pine trees in *** of B. xylophilus is an important factor in the *** has been reported that the pathogenicity of B. xylophilus isolated from different geographical origins has significant *** present,the molecular mechanism of pathogenicity differentiation is still *** order to screen the

关键词： Bursaphelenchus xylophilus Cdna Pathogenicity SSH

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu huang Qiuyu Pang Lexin Zheng Jiaxi lin Hanxi Li lingbo Wan Tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin