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Different effects of valproate on methamphetamine-and cocaine-induced behavioral sensitization in mice

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中国药理通讯 2004年第2期21卷 44-45页

作者： jun-XuLi jian-huiLiang DepartmentofNeuropharmacology NationalInstituteonDrugDependencePekingUniversityBeijing100083

Multiple intermittent administration of psychostimulants induces a behavioral sensitization, which is characterized by the augmentation of locomotor activity and stereotyped behavior, even after their long-term withdrawal. This kind of behavioral effects is thought to serve as a useful animal model that mimics the behavioral responses in drug craving.

关键词： 2-丙基戊酸钠脱氧麻黄碱可卡因动作感受器大鼠

Rational design of heterostructured core-shell Co-Zn bimetallic selenides for improved sodium-ion storage

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Rare Metals 2022年第10期41卷 3381-3390页

作者： hua-jian Liang Xiao-Tong Li Wen-Zhi Zheng Zhi-Ting Liu Wei Yang Zi-Li Liu Yu-Fei Zhang Hao-Sen Fan Sheng-jun Lu College of Materials Science and Metallurgy Engineering Guizhou UniversityGuiyang550025China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou510006China

Bimetallic selenide with core-shell structure(CoSe_(2)/ZnSe/NC@ZnSe/NC)has been successfully prepared through facile carbonization and selenization processes of its core-shell metal-organic framework precursors,in which the precursor is synthesized by epitaxial growth of zinc-based zeolite imidazolate framework(ZIF-8)on the surface of cobalt-based and zinc-based zeolite imidazolate framework(ZIF-67@ZIF-8).The coreshell structure has the advantage of alleviating the volume expansion during repeated insertion and extraction of sodium ions which can effectively avoid structural ***,bimetallic selenides and heterostructure are effective strategies to greatly improve the rate capability of the ***,the core-shell structural CoSe2/ZnSe/NC@ZnSe/NC material can maintain the original dodecahedron structure and delivers a specific capacity of 308.6 mAh·g^(-1)at 1.0 A·g^(-1)after 300 cycles with the desirable capacity retention of 90%.With the synergistic effects of heterostructure and core-shell structure,CoSe_(2)/ZnSe/NC@ZnSe/NC exhibits better electrochemical performance than CoSe_(2)/ZnSe/NC and CoSe_(2)/*** prove that both core-shell structure and heterostructure have positive effects on improving the electrochemical properties of materials.

关键词： Co-Zn metal selenides Heterostructures Core-shell structure Sodium-ion battery(SIB)

Variable stars in the field of open cluster NGC 2126

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Research in Astronomy and Astrophysics 2009年第7期9卷 791-802页

作者： Shun-Fang Liu Zhen-Yu Wu Xiao-Bin Zhang jiang-hua Wu jun Ma Zhao-Ji jiang jian-Sheng Chen Xu Zhou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

We report the results of a time-series CCD photometric survey of variable stars in the field of open cluster NGC 2126. In about a one square degree field covering the cluster, a total of 21 variable candidates are detected during this survey, of which 16 are newly found. The periods, classifications and spectral types of 14 newly discovered variables are discussed, which consist of six eclipsing binary systems, three pulsating variable stars, three long period variables, one RS CVn star, and one W UMa or δ Scuff star. In addition, there are two variable candidates, the properties of which cannot be determined. By a method based on fitting observed spectral energy distributions of stars with theoretical ones, the membership probabilities and the fundamental parameters of this cluster are determined. As a result, five variables are probably members of NGC 2126. The fundamental parameters of this cluster are determined as： metallicity to be 0.008 Z, age log（t） = 8.95, distance modulus （m - M）0 = 10.34 and reddening value E（B - V） = 0.55 mag.

关键词： open clusters: individual (NGC 2126) - stars: variables (general) - bina- ties: general

Ni-22Cr-20Co-18W合金在1100℃时氧化膜的演变

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稀有金属材料与工程 2012年第3期41卷 486-489页

作者：马健胡锐常辉柏广海刘珺周廉西北工业大学凝固技术国家重点实验室陕西西安710072

采用扫描电子显微镜和X射线衍射分析仪研究了1100℃下Ni-22Cr-20Co-18W合金氧化膜的演变规律。结果显示,在氧化初始阶段,表面形成了Cr2O3,NiO和(Co,Ni,Mn,Cr)3O4混合氧化膜,后者为M3O4型氧化物。长时间氧化后,氧化膜由单层转变为双层,... 详细信息

采用扫描电子显微镜和X射线衍射分析仪研究了1100℃下Ni-22Cr-20Co-18W合金氧化膜的演变规律。结果显示,在氧化初始阶段,表面形成了Cr2O3,NiO和(Co,Ni,Mn,Cr)3O4混合氧化膜,后者为M3O4型氧化物。长时间氧化后,氧化膜由单层转变为双层,在内层形成连续的Cr2O3膜,在外层形成可以抑制内层Cr2O3挥发的致密NiO氧化膜;同时氧化空位在氧化膜与合金基体界面处形成,并且Al元素的内氧化也在该处发生。

关键词： Ni-22Cr-20Co-18W高温合金恒温氧化氧化膜空位

Reliability study of custom designed ADC for the jiangmen underground neutrino observatory

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Radiation Detection Technology and Methods 2020年第2期4卷 203-207页

作者： Ru-yi Jin jun hu Jia-yi Ren Zhe Ning Xiao-shan jiang State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Objective The jiangmen underground neutrino observatory(junO)is the largest and most precise liquid scintillator detector under construction in the south of *** front-end readout electronics system will be installed very close to the photomultiplier tubes under ***,the system’s absolute reliability is *** an important piece,the failure rate of the custom designed analog-to-digital convertor(ADC)must be *** The Arrhenius High Temperature Operating Life(HTOL)model is usually used to calculate the standard reliability value failure rate(λ).A temperature acceleration test of the ADC is performed with a 115℃ambient temperature based on a custom aging *** performance of ADC is compared before and after aging,and the most significant bit(MSB)of the digital output is monitored during the *** The result of a 2400-hour-long test shows that there were no *** upper limit of the failure rate is calculated as 5.8FIT,which can be added to the failure rate of other components to meet the overall failure rate requirements(84FIT).Conclusion With the test system,we established a method based on the HTOL model to obtain the upper limit of the ADC reliability for overall failure rate calculation in *** method can be applied to the reliability measurement for any other custom designed *** experiment can be repeated with a new set of parameters to get a satisfactory failure rate according to other overall system requirements.

关键词： ADC Reliability HTOL Failure rate

Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase(CYP51)

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Chinese Chemical Letters 2009年第8期20卷 935-938页

作者： Zhi Gang Dan jun Zhang Shi Chong Yu Hong Gang hu Xiao Yun Chai Qing Yan Sun Qiu Ye Wu Department of Organic Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

A series of 1-（1H-1,2,4-triazole-1-yl）-2-（2,4-difluoropheny1）-3-（N-isoproy1-N-substituted-amino）-2-propanols have been designed and synthesized on the basis of the active site of lanosterol 14a-demethylase （CYP51）. Their structures were confirmed by MS and ^1H NMR. In vitro antifungal activities of these synthesized compounds were evaluated against eight human pathogenic fungi. The results showed that all title compounds exhibited activity against fungi tested to some extent. Compounds 3c, 3d, 7a, 7b and 7e exhibited more potent antifungal activities against nearly all fungi tested except AspergiUus fumigatus than fluconazole. ？2009 Qiu Ye Wu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

关键词： Triazole Synthesis Antifungal activity

粉煤气化炉喷嘴受热分析和渣层模型的数值模拟

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中国电机工程学报 2007年第26期27卷 23-29页

作者：周俊虎匡建平周志军刘建忠岑可法能源清洁利用国家重点实验室(浙江大学) 浙江省杭州市310027

气化喷嘴高效、稳定运行是气化反应顺利进行的关键,根据热态数值模拟得到的温度场分布,建立喷嘴受热的模型,结果证明增加冷却水旋流和加大内管壁粗糙度可以起到降低喷嘴头部温度的作用。同时,根据气化炉渣层生成机理,对渣层物理建模进... 详细信息

气化喷嘴高效、稳定运行是气化反应顺利进行的关键,根据热态数值模拟得到的温度场分布,建立喷嘴受热的模型,结果证明增加冷却水旋流和加大内管壁粗糙度可以起到降低喷嘴头部温度的作用。同时,根据气化炉渣层生成机理,对渣层物理建模进行有限差分运算,得到不同控制区域内固态渣层厚度和液态渣层厚度,以及变工况条件下渣层厚度变化趋势,结果显示在气化反应的燃烧区域内固态渣层厚度明显低于其他区域的渣层厚度。氧碳比增加、汽煤比减少和负荷增大都会导致渣层厚度减薄。这些结果为今后粉煤气化炉运行、设计提供了理论指导。

关键词：气化冷热态运行喷嘴渣层

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压气机三维非定常动态失速过程试验研究

航空学报 2010年第11期31卷 2124-2129页

作者：屠宝锋胡骏南京航空航天大学能源与动力学院江苏南京210016

以一台双级低速轴流压气机为研究对象,采用在压气机周向、径向和轴向不同位置处布置多个动态压力传感器的方法,获取了动态失速过程中不同位置动态压力信号的变化情况,对各截面的动态总压信号分别进行了时域、频域和时频分析。研究结果表... 详细信息

以一台双级低速轴流压气机为研究对象,采用在压气机周向、径向和轴向不同位置处布置多个动态压力传感器的方法,获取了动态失速过程中不同位置动态压力信号的变化情况,对各截面的动态总压信号分别进行了时域、频域和时频分析。研究结果表明:压气机的失速类型是单团全叶高旋转失速;失速团形成前只出现了模态波扰动;模态波式动态失速过程具有三维非定常的特征,模态波扰动和失速团首先在压气机的局部位置形成,然后沿着轴向和径向扩散至其他位置,最终占据各叶排所有叶高位置。

关键词：压气机动态失速模态波三维非定常

Distinct Contributions of Replication and Transcription to Mutation Rate Variation of human Genomes

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Genomics, Proteomics & Bioinformatics 2012年第1期10卷 4-10页

作者： Peng Cui Feng Ding Qiang Lin Lingfang Zhang Ang Li Zhang Zhang Songnian hu jun Yu CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100029China Computational Bioscience Research Centre King Abchdlah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia.

Here, we evaluate the contribution of two major biological processes--DNA replication and transcription--to mutation rate variation in human genomes. Based on analysis of the public human tissue transcriptomics data, high-resolution replicating map of Hela cells and dbSNP data, we present significant correlations between expres- sion breadth, replication time in local regions and SNP density. SNP density of tissue-specific （TS） genes is sig- nificantly higher than that of housekeeping （HK） genes. TS genes tend to locate in late-replicating genomic re- gions and genes in such regions have a higher SNP density compared to those in early-replication regions. In addi- tion, SNP density is found to be positively correlated with expression level among HK genes. We conclude that the process of DNA replication generates stronger mutational pressure than transcription-associated biological processes do, resulting in an increase of mutation rate in TS genes while having weaker effects on HK genes. In contrast, transcription-associated processes are mainly responsible for the accumulation of mutations in highly-expressed HK genes.

关键词： replication transcription mutational pressure genetic variation