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对初患的2型糖尿病患者使用胰岛素进行短期强化治疗的效果探析

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当代医药论丛 2016年第19期14卷 6-8页

作者：邹丽张美春陈剑锋胡俊灵湖北民族学院附属医院内分泌科湖北恩施445000 武警湖北省总队医院湖北武汉430061

目的：探讨对初患的2型糖尿病患者使用胰岛素进行短期强化治疗的临床效果。方法：对2012年3月-2014年6月期间在我科住院治疗的68例初次被诊断患有2型糖尿病患者的临床资料进行回顾性研究。按照治疗方法的区别将这68例患者分为口服降... 详细信息

目的：探讨对初患的2型糖尿病患者使用胰岛素进行短期强化治疗的临床效果。方法：对2012年3月-2014年6月期间在我科住院治疗的68例初次被诊断患有2型糖尿病患者的临床资料进行回顾性研究。按照治疗方法的区别将这68例患者分为口服降糖药组和胰岛素强化治疗组,其中口服降糖药组有36例患者,胰岛素强化治疗组有32例患者。为口服降糖药组患者使用口服降糖药进行治疗,为胰岛素强化治疗组患者使用胰岛素进行短期强化治疗。然后,比较两组患者FBG（空腹血糖）的水平、2h PG（餐后2小时血糖）的水平、FINS（空腹胰岛素）的水平、FCP（空腹血清C肽）的水平、Hb A1c（糖化血红蛋白）的水平及其低血糖的发生率。结果：经治疗,两组患者的血糖水平均得到了较好的控制。与进行治疗前相比,两组患者的血糖水平均明显下降,差异具有统计学意义（P〈0.05）。胰岛素强化治疗组患者FBG的水平和2h PG的水平均明显优于口服降糖药组患者,差异具有统计学意义（P〈0.05）。胰岛素强化治疗组患者FINS的水平和FCP的水平均明显高于口服降糖药组患者,差异具有统计学意义（P〈0.05）。两组患者Hb A1c的水平和低血糖的发生率相比差异无统计学意义（P〉0.05）。结论：对初患的2型糖尿病患者使用胰岛素进行短期强化治疗的效果显著,可迅速降低其血糖水平,改善其胰岛β细胞的功能,降低其胰岛素抵抗的发生率。

关键词：初患的2型糖尿病患者胰岛素短期强化治疗口服降糖药效果

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住院癌痛患者服药依从性现状及影响因素分析

护理管理杂志 2017年第7期17卷 463-465页

作者：宋健胡君娥胡欢欢杨栋梁长江大学医学院护理系荆州市434020 荆州市中心医院肿瘤科 434020 沧州医学高等专科学校沧州市061001

目的了解住院癌痛患者口服止痛药物依从性现状,探讨癌痛患者服药依从性影响因素。方法采用一般资料问卷、服药依从性问卷、患者服药现状问卷对236例患者进行调查。结果癌痛患者服药依从性差,依从率仅41.53%;Logistic回归分析结果显示,... 详细信息

目的了解住院癌痛患者口服止痛药物依从性现状,探讨癌痛患者服药依从性影响因素。方法采用一般资料问卷、服药依从性问卷、患者服药现状问卷对236例患者进行调查。结果癌痛患者服药依从性差,依从率仅41.53%;Logistic回归分析结果显示,居住情况、医疗费用支付方式、知识、信念、行为是癌痛患者服药依从性的影响因素。结论癌痛患者的服药依从性不容乐观,应针对独居患者及医疗费用支付方式、患者知识、信念、行为给予干预,以提高其服药依从性,保证止痛治疗效果,提高其生活质量。

关键词：癌痛服药依从性

Magnetic entropy change of Ce6Ni2Si3-type and large refrigerant capacity GdCoSiGe compound＊

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Chinese Physics B 2011年第2期20卷 482-486页

作者： Shen jun Zhang hu Wu jian-Feng Key Laboratory of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China state Key Laboratory for Magnetism Institute of Physics Chinese Academy of Sciences Beijing 100190 China

Magnetic entropy change （△SM） and refrigerant capacity （RC） of Ce6Ni2Si3-type Gd6Co1.67Si2.5Geo.5 compounds have been investigated. The Gd6Col.67Si2.5Geo.5 undergoes a reversible second-order phase transition at the Curie temperature Tc = 296 K. The high saturation magnetization leads to a large ASM and the maximal value of △SM is found to be 5.9 J/kg. K around TC for a field change of 0-5 T. A broad distribution of the △SM peak is observed and the full width at half maximum of the △SM peak is about 101 K under a magnetic field of 5 T. The large RC is found around TC and its value is 424 J/kg.

关键词： Gd6Col.67Si2.sGe0.5 compound magnetocaloric effect refrigerant capacity

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-hui Wei Shu-hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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新常态下常州高新园区经济转型升级的对策研究

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江苏理工学院学报 2017年第1期23卷 46-51页

作者：张建军胡登峰李向东安徽财经大学工商管理学院安徽蚌埠233030 江苏理工学院商学院江苏常州213001

叠加的战略机遇和经济下行压力背景下,常州高新园区发展呈现出一区多园发展势头强劲、产城融合逐步推进、科技孵化器创新能力不断提升的特点以及产业结构不优、产业集群规模偏小、要素制约突出的问题。新常态下常州高新园区应通过强化... 详细信息

叠加的战略机遇和经济下行压力背景下,常州高新园区发展呈现出一区多园发展势头强劲、产城融合逐步推进、科技孵化器创新能力不断提升的特点以及产业结构不优、产业集群规模偏小、要素制约突出的问题。新常态下常州高新园区应通过强化产业集聚推动产业发展高端化,强化科技创新推动产业集群创新化,强化产城融合推动高新园区城市化等措施,转型升级成为真正意义上的高端要素集聚区、体制机制创新区、现代化发展新城区。

关键词：常州高新园区经济转型升级新理念新思维新举措新常态

Vibration absorption of parallel-coupled nonlinear energy sink under shock and harmonic excitations

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Applied Mathematics and Mechanics(English Edition) 2021年第8期42卷 1135-1154页

作者： jian’en CHEN Wei ZHANG jun LIU Wenhua hu Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical EngineeringTianjin University of TechnologyTianjin 300384China National Demonstration Center for Experimental Mechanical and Electrical Engineering Education Tianjin University of TechnologyTianjin 300384China Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures College of Mechanical EngineeringBeijing University of TechnologyBeijing 100124China

Nonlinear energy sink(NES)can passively absorb broadband energy from primary *** multiple NESs connected in parallel exhibit superior performance to single-degree-of-freedom(SDOF)*** this work,a linear coupling spring is installed between two parallel NESs so as to expand the application scope of such vibration *** vibration absorption of the parallel and parallel-coupled NESs and the system response induced by the coupling spring are *** results show that the responses of the system exhibit a significant difference when the heavier cubic oscillators in the NESs have lower stiffness and the lighter cubic oscillators have higher ***,the efficiency of the parallel-coupled NES is higher for medium shocks but lower for small and large shocks than that of the parallel *** parallel-coupled NES also shows superior performance for medium harmonic excitations until higher response branches are *** performance of the parallel-coupled NES and the SDOF NES is *** is found that,regardless of the chosen SDOF NES parameters,the performance of the parallel-coupled NES is similar or superior to that of the SDOF NES in the entire force range.

关键词： coupling influence nonlinear energy sink(NES) vibration absorption

Is it possible to foot reflexology for infants with sensorineural hearing loss?

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World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang Zhang jun-Bang Feng Chuan-Ming Li Wen-Jing Wang Meng-Die hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

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基于KNN-SVM的混合气体检测方法研究

光谱学与光谱分析 2025年第1期45卷 117-124页

作者：孙超胡润泽吴中旭刘年松丁建军江汉大学智能制造学院湖北武汉430056 精细爆破国家重点实验室湖北武汉430056

当今混合气体检测的研究中,针对多组分气体数据进行分类预测的数学算法百花齐放,如何快速且准确的检测出气体的成分和浓度逐渐成为当今研究的热门。然而在一些研究中,气体数据特征难以捕捉和判断,泛化能力不足,对气体数据进行分类预测... 详细信息

当今混合气体检测的研究中,针对多组分气体数据进行分类预测的数学算法百花齐放,如何快速且准确的检测出气体的成分和浓度逐渐成为当今研究的热门。然而在一些研究中,气体数据特征难以捕捉和判断,泛化能力不足,对气体数据进行分类预测的精度和效率表现较差。为此,针对一些数据偏差和泛化误差无界的问题,提出了一种K最近邻-支持向量机(KNN-SVM)算法,对一些难以作出分类的模糊气体数据进行二次分类,采用KNN和SVM两种算法共同抉择,更加全面的捕捉数据特征,根据实验确定各自算法的权重比从而提高判别气体类别的准确率,两种算法的集成也能提高算法的效率,对于不同种类的气体也能有良好的适应性的稳定性。该实验气体组分由12 mg·L^(-1)的C_(2)H_(2)、NO_(2)、SF_(6),10 mg·L^(-1)的NO_(2)、SF_(6)和5 mg·L^(-1)的C_(2)H_(2)(背景气体皆为N_(2))以及两瓶纯N_(2)的气瓶组成;通过互相混合和与N_(2)配比制备出实验设定的气体浓度。实验过程通过单一气体的检测可分别对三种气体获得60组训练集,并通过这60组数据可进行线性拟合得到每种气体的拟合线,得到气体浓度与气体吸收峰值的关系,通过实验检测得到的三种气体拟合线,其中C_(2)H_(2)拟合线的调整后R^(2)为0.991,NO_(2)拟合线的调整后R^(2)为0.981,SF_(6)拟合线的调整后R^(2)为0.987,可得气体检测的准确性。再通过互相混合进行检测可分别获得40组训练集,采用KNN-SVM算法对混合气体进行分类和预测,后通过拟合线即可反演出混合气体中每种气体的浓度。将该算法与传统SVM算法进行各种分类指标对比均可显示出该算法的有效性和优越性。实验结果表明,KNN-SVM算法在气体分类预测方面表现出卓越的性能,准确率高达99.167%,AUC(area under curve)值达99.375%。这一算法不仅提高了气体检测的准确性,还增强了泛化能力可适应多样化的气体组分,为实时气体检测系统提供了有力支持。

关键词：光声光谱气体检测 KNN-SVM 分类预测

Experimental Investigation on Starting Process of Supersonic Single-stage Air Ejector

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Journal of Thermal Science 2012年第4期21卷 348-353页

作者： Zou jian-jun Zhou Jin Lu hui-qiang hu Yong College of Aerospace and Material Engineering National University of Defense Technology Changsha 410073 China

This paper deals with experimental study of flow field of starting process in two-dimensional, single-stage supersonic ejector on different air total pressure. Schlieren pictures of flow field were taken, static pressure distribu-tions on side wall were measured. The obtained results show that, on critical pressure, the starting main shock waves in ejector oscillated back and forth between the second throat and the middle section of the mixing chamber, it causes the pressure in the second half of the mixing chamber acutely fluctuated .When the working pressure of the active flow is higher than the critical starting pressure, ejector starts normally and the inner flow-field of the mixing chamber keeps stable and the shock waves in the second throat have a certain degree of oscillation . After ejector starts, the operating pressure of the active flow may be lower than the starting pressure .

关键词： supersonic ejector start process flow-field shock waves