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The role of natural fracture activation in hydraulic fracturing for deep unconventional geo-energy reservoir stimulation

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Petroleum Science 2023年第4期20卷 2141-2164页

作者： jun Wang He-Ping Xie Stephan KMatthai jian-jun hu Cun-Bao Li Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyShenzhen UniversityShenzhen518060GuangdongPR China Shenzhen Key Laboratory of Deep Engineering Sciences and Green Energy College of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060GuangdongPR China Department of Infrastructure Engineering University of MelbourneMelbourneVIC3010Australia MOE Laboratory of Deep Earth Science and Engineering Sichuan UniversityChengdu610065SichuanPR China

The presence of sealed or semi-sealed,multiscale natural fracture systems appears to be crucial for the successful stimulation of deep *** explore the reaction of such systems to reservoir stimulation,a new numerical simulation approach for hydraulic stimulation has been developed,trying to establish a realistic model of the physics *** new model successfully reproduces dynamic fracture activation,network generation,and overall reservoir permeability *** outputs indicate that natural fractures facilitate stimulation far beyond the near-wellbore area,and can significantly improve the hydraulic conductivity of unconventional geo-energy *** to our model,the fracture activation patterns are jointly determined by the occurrence of natural fractures and the in situ ***-density natural fractures,high-fluid pressure,and low effective stress environments promote the formation of complex fracture networks during *** or multicluster fracturing treatments with an appropriate spacing also increase the stimulated reservoir area(SRA).The simulation scheme demonstrated in this work offers the possibility to elucidate the complex multiphysical couplings seen in the field through detailed site-specific modeling.

关键词： Natural fractures DFM Unconventional geo-energy reservoir Fracture reactivation Hydraulic stimulation

Oligouridylates Formation with N-(O,O'-Diisopropyl)-Phosphoryl Alanine in the presence of Poly(β-(N^7-Adeninyl)Ethyl Methacrylate)

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Chinese Chemical Letters 2001年第4期12卷 313-316页

作者： Hong Qi XIANG jian jun hu Yang jianG Yu Fen ZHAO Bioorganic Phosphorus Laboratory Department of ChemistrySchool of Life Science and EngineeringTsinghua UniversityBeijing 100084

The oligouridylates formation with N-(O,O-diisopropyl)-phosphoryl alanine in the presence of poly((-(N7-adeninyl)ethyl methacrylate) was studied. An increased yield by the presence of the polymeric nucleic acid analo... 详细信息

关键词： N-phosphoryl amino acid nucleoside interaction polymeric nucleic acid analog.

Consolidation mechanism of gold concentrates containing sulfur and carbon during oxygen-enriched air roasting

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International Journal of Minerals,Metallurgy and Materials 2017年第4期24卷 386-392页

作者： Qian Li Fang-zhou Ji Bin Xu jian-jun hu Yong-bin Yang Tao jiang School of Minerals Processing and Bioengineering Central South University Changsha 410083 China

Consolidation in calcines is a common problem in the oxygen-enriched air roasting of refractory gold concentrates containing sulfur and carbon when the initial temperature is greater than 600°C. To determine the phases that caused consolidation, gold concentrates were roasted under different conditions and the calcines were mainly detected by X-ray diffraction (XRD). The possible underlying mechanism was then studied through comparisons of the XRD patterns of different calcines. The results indicated that the generation of calcium magnesium silicate, iron-doped calcium aluminosilicate, and calcium aluminate caused the consolidation. Furthermore, an enriched oxygen atmosphere accelerated the oxidation reaction and the emitted heat increased the local temperature in calcines. The local temperature was inferred to have increased to the generation temperature zone of the corresponding liquid phases. Oxidation of the pyrite and decomposition of the dolomite and muscovite mainly occurred at the initial stage of oxygen-enriched air roasting. Calcium was confirmed to be essential to the consolidation process. © 2017, University of Science and Technology Beijing and Springer-Verlag Berlin Heidelberg.

关键词： Calcination Calcium Consolidation Gold Mechanisms Mica Oxygen Silicates Sulfur X ray diffraction

Magnetically controlled self-sealing pressure-preserved coring technology

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Petroleum Science 2024年第5期21卷 3464-3481页

作者： Gui-Kang Liu He-Ping Xie Cong Li Zhen-Xi You Xiao-jun Shi jian-jun hu Ming-Zhong Gao State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065SichuanChina Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060GuangdongChina School of Mechanical Engineering Sichuan UniversityChengdu610065SichuanChina

Pressure-preserved coring is an effective means to develop deep resources. However, due to the complexity of existing pressure-preserved technology, the average success rate of pressure-preserved coring is low. In response, a novel in situ magnetically controlled self-sealing pressure-preserved coring technology for deep reserves has been proposed and validated. This innovative technology distinguishes itself from conventional methods by employing noncontact forces to replace traditional pretensioning mechanisms, thereby enhancing the mechanical design of pressure-preserved coring equipment and significantly boosting the fault tolerance of the technology. Here, we report on the design,theoretical calculations, experimental validation, and industrial testing of this technology. Through theoretical and simulation calculations, the self-sealing composite magnetic field of the pressure controller was optimized. The initial pre-tensioning force of the optimal magnetic field was 13.05 N. The reliability of the magnetically controlled self-sealing pressure-preserved coring technology was verified using a self-developed self-sealing pressure performance testing platform, confirming the accuracy of the composite magnetic field calculation theory. Subsequently, a magnetically controlled self-triggering pressure-preserved coring device was designed. Field pressure-preserved coring was then conducted,preliminarily verifying the technology's effective self-sealing performance in industrial ***, the technology was analyzed and verified to be adaptable to complex reservoir environments with pressures up to 30 MPa, temperatures up to 80℃, and p H values ranging from 1 to 14. These research results provide technical support for multidirectional pressure-preserved coring, thus paving a new technical route for deep energy exploration through coring.

关键词： In situ pressure-preserved coring Magnetically controlled Self-sealing Magnetic design Deep earth exploration

Computerized cognitive remediation therapy on cognitive impairment and social function in patients with chronic schizophrenia

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World Journal of Psychiatry 2024年第6期14卷 884-893页

作者： jian-jun hu Xi-Rong Sun Shuang-Ming Ni Yan Kong Department of Psychiatry Shanghai Pudong New Area Mental Health Center(Mental Health Center of Tongji UniversityShanghai Pudong New Area Psychological Counseling Center)Shanghai 200124China

BACKGROUND Patients with schizophrenia may have various disease manifestations,most of which gradually tend toward incurable chronic decline,leading to mental *** basic symptoms of the disease can impair social function,whereas long-term hospitalization produces hospitalization syndrome,causing serious damage to social *** To investigate the effects of Computerized Cognitive Remediation Therapy(CCRT)on cognitive and social functioning in patients with chronic *** A retrospective analysis of 120 patients with chronic schizophrenia in Shanghai Pudong New Area Mental Health Center was *** were divided into an intervention group(60 cases treated with CCRT combined with conventional medication)and a control group(60 cases treated with conventional medication).After treatment,effects on cognitive function and social roles were observed in both *** Positive and Negative Syndrome Scale(PANSS)was used to assess the patients'psychiatric *** Wisconsin Card Sorting Test(WCST)was used to assess the patients'cognitive functioning,and the Social Functioning Scale for Psychiatric Inpatients(SSPI)was used to assess the social functioning of the inpatient psychiatric *** No significant differences were observed in the PANSS,WCST,and SSPI intergroup scores before treatment(P>0.05).After 2,4,and 6 wk of therapy,general psychopathological factors,positive symptoms,negative symptoms,and total PANSS scores of PANSS in the intervention group were lower than in the control group(P<0.05).After 2,4,and 6 wk of treatment,the number of false responses,number of persistent bugs,and total responses in the WCST were significantly lower in the intervention group than in the control group(P<0.05),and the amount of completed classification was significantly higher than in the control group(P<0.05).After 2,4,and 6 wk of therapy,the SSPI scores were significantly greater than those of the controls(P<0.05).After 6 wk of treatm

关键词： Computerized cognitive correction therapy Schizophrenia Cognitive function Social function Psychopathological factors

Analysis of workload of tank crew under the conditions of informatization

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Defence Technology（防务技术） 2014年第1期10卷 17-21页

作者： Ming MAO Fang XIE jian-jun hu Bo SU China North Vehicle Research Institute

A consensus has been reached that the tanks need to be integrated into the informatization battlefield. With the development of technology,the tank crew has being gradually decreased, so the research on two-soldier crew tank has become a hotspot. The workload of tank crew under the conditions of informatization is analyzed based on the combat mission of tank and the typical combat scenarios, and the impact of new technologies on workload is evaluated. The crew members in tank can be reduced from three to two, but it is necessary to substantially improve the automation of target search and the reliability of each subsystem and component.

关键词：信息化战场工作量坦克乘员作战任务工作负载目标搜索自动化

A Novel Synthesis of Methyl 4, 6-O-Benzylidene-α-D-Glucopyranoside 2, 3-Cyclic Phosphite Ethyl Ester

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Chinese Chemical Letters 1999年第6期10卷 457-458页

作者： jian jun hu Yong JU Yu Fen ZHAO(Bioorganic Phosphorus Chemistry Laboratory, Department of Chemisrty.Tsinghua University. Beijing. 100084) Tsing hua Univ Bioorgan Phosphorus Chem Lab Dept Chem Beijing 100084 Peoples R China

A new compound. methyl 4. 6-O-benzylidene-a-D-glucopyranoside 2. 3-cyclicphosphite ethyl ester was synthesized via the reaction of methyl 4. 6-O-benzylidene-a-D-glucopyranoside and ethyl dichlorophosphite. Its structu... 详细信息

关键词： 2. 3-Cyclic glucopyranosyl phosphite ester synthesis structure determination

A Study of Immunological Indices for Diagnosis of Chronic Berylliosis

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Biomedical and Environmental Sciences 1989年第4期2卷 318-324页

作者： YAO jian-jun hu SU-YING hunan Research Institute for Labor Protection against Nonferrous Metal,Changsha,hunan,China human Research Institute for Labor Protection against Nonferrous Metal Changsha Hunan China.

The results of the Be-induced leukocyte migration inhibition test(Be-MIT),the lymphocyte transformation test(LI),the E-rosette formation test(E-RFC),the old tuberculin test(OT),and sero-immunoglobulin(IgG,IgA,IgM)measurements on 13 cases of berylliosis,44 members of the observation group,and 51 members of the contact group are rè*** the Be-MIT,2 of the berylliosis patients were new cases that had been diagnosed and treated for a long time,and both tested positive(18%).Fourteen patients from the observation group tested positive(32%), and 15 from the contact group tested positive(30%).The 8 cases in the control group tested negative;7 patients from the observation group and 3 of the berylliosis cases tested negative after being *** lymphocyte transformation rates of the observation group and the berylliosis group were significantly lower than that of the control group(P<0.01).Both Et-RFC and Ea- RFC contents in the group with berylliosis were much lower than those in the control group(P <0.01).OT tests were performed on 8 berylliosis patients and 10 healthy *** patients showed negative reactions and one showed a positive *** the healthy men showed positive *** IgG and IgA levels of the observation group were significantly higher than those of the control group(P<0.01).The Be-MIT could detect active beryllium disease at an early stage as well as Be-sensitive *** test could be used as a supplementary diagnostic index for the differential diagnosis of berylliosis and for the evaluation of a curative effect.1989 Academic Press,Inc.

关键词： In A Study of Immunological Indices for Diagnosis of Chronic Berylliosis

Casein kinase 2 interacting protein 1 positively regulates caudal-related homeobox 1 in intestinal-type gastric cancer

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Chinese Medical Journal 2020年第2期133卷 154-164页

作者： Liang Ma Ying Cao jian-jun hu Ming-Liang Chu Guizhou University School of Medicine GuiyangGuizhou 550025China Department of Pathology Guizhou Provincial People’s HospitalGuiyangGuizhou 550002China

Background:Gastric cancer(GC)is one of the most common malignancies,and intestinal-type GC is the main histopathologic type of GC in *** previously reported that casein kinase 2 interacting protein 1(CKIP-1)acts as a candidate tumor suppressor in intestinal-type ***-1 participates in the regulation of multiple signaling pathways,including the Wnt/b-catenin pathway,of which caudal-related homeobox 1(CDX1)may be a downstream target *** purpose of this study was to investigate the relationship between CKIP-1 and CDX1 in intestinal-type ***:Sixty-seven gastroscopy biopsy specimens and surgically resected gastric specimens were divided into four groups:gastric mucosa group,intestinal metaplasia(IM)group,dysplasia group,and intestinal-type GC *** expression levels of CKIP-1 and CDX1 were detected in these groups and GC cell lines,and the correlations between these expression levels were ***7901 and BGC823 cells were divided into CKIP-1 shRNA groups and CKIP-1 over-expression groups,and CDX1 expression was detected.b-Catenin expression was detected in intestinal-type GC tissue samples and CKIP-1 shRNA and CKIP-1 overexpression SGC7901 cells,and its correlation with CKIP-1 expression in intestinal-type GC tissue was *** Wnt/b-catenin pathway inhibitor DKK-1 and activator LiCl were incubated with SGC7901 cells,BGC823 cells,and CKIP-1 shRNA and CKIP-1 over-expression SGC7901 and BGC823 cells,following which CDX1 and Ki-67 expression were ***:The expression levels of CKIP-1 and CDX1 were lower in patients with intestinal-type GC than in patients with IM and dysplasia(both P<0.05).CKIP-1 and CDX1 expression levels were positively correlated in IM,dysplasia,and intestinal-type GC tissue and cell lines(r=0.771,P<0.01;r=0.597,P<0.01;r=0.654,P<0.01;r=0.811,P<0.01,respectively).CDX1 expression was decreased in the CKIP-1 shRNA groups and increased in the CKIP-1 over-expression groups of SGC7901 and BGC823 cells compared to th

关键词： Casein kinase 2 interacting protein 1 Caudal-related homeobox 1 Intestinal-type gastric cancer Intestinal metaplasia