检索结果-南通市图书馆

Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China

引用

World Journal of Psychiatry 2024年第4期14卷 523-532页

作者： Jing-Wen Xu Xiao-Bo Guan Xue-Ying Wang Yang Feng Qi Zhang Jun-Juan Zhu jian-hua chen Department of Medicine Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China The Fourth Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Psychotic DisordersShanghai 200030China The First Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China

BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is *** To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS *** This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric *** plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid *** patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were *** Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female *** and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 *** male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total *** Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.

关键词： Antipsychotics Risperidone 9-hydroxyrisperidone Plasma drug concentration monitoring Chronic schizophrenia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

白铅矿(PbCO_(3))和菱锌矿(ZnCO_(3))硫化机理的DFT研究

引用

Transactions of Nonferrous Metals Society of China 2024年第7期34卷 2328-2341页

作者：陈晔唐箫琴陈建华刘萌广西大学资源环境与材料学院广西高校矿物工程重点实验室省部共建特色金属与组合结构全寿命安全国家重点实验室南宁530004 云南省战略金属矿产资源绿色分离与富集重点实验室昆明650093 广西大学化学化工学院南宁530004 四川大学化工学院低碳技术与化学反应工程研究室成都610065

采用密度泛函理论(DFT)比较研究白铅矿(PbCO_(3))和菱锌矿(ZnCO_(3))硫化机理的差异。通过在PbCO_(3)/ZnCO_(3)表面构建Pb-S/Zn-S层来模拟硫化结构。层距和Mulliken电荷的结果表明,PbCO_(3)上形成稳定的Pb-S层,而ZnCO_(3)上形成的Zn-S层不稳定。由于Pb-S层具有高的共价性,而Zn-S层具有高的离子性,因此,硫化-黄药法对PbCO_(3)浮选有效,对ZnCO_(3)浮选无效。为了回收ZnCO_(3),需要强离子性捕收剂,因此,硫化-胺法在ZnCO_(3)浮选中应用较广。PbCO_(3)和ZnCO_(3)表面硫化层结构和浮选行为差异主要是由于金属离子(Pb^(2+)和Zn^(2+))和配体(O配体和S配体)极化率的不同以及Zn^(2+)3d^(10)轨道的惰性造成的。

关键词：密度泛函理论白铅矿菱锌矿硫化-黄药法硫化-胺法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electronic structure and properties of FeS_2 with the space groups of Pa3 and P1

引用

International Journal of Minerals,Metallurgy and Materials 2013年第7期20卷 671-677页

作者： Cui-hua Zhao Bo-zeng Wu jian-hua chen Yu-qiong Li Ye chen School of Chemistry and Chemical Engineering Guangxi University China Tin Group Co. Ltd. College of Material Science and Engineering Guangxi University College of Resources and Metallurgy Guangxi University

The electronic structure and properties of FeS2 with the space groups of Pa3 and P1 were studied by the density functional theory. The generalized-gradient approximation exchange-correlation functional was used in conjunction with a plane wave-ultrasoft pseudopotential representation. Calculation results show that differences are observed in electronic structures and properties between Pa3 and P1 crystals. The band gap and energy loss of P1 are smaller than those of Pa3 crystal, while the dielectric constant, conductivity, refractive index, extinction coefficient, and intensity of optical absorption of P1 are larger than those of Pa3. These behaviors are attributed to the differences in symmetry, atomic arrangement, and Mulliken bond population of each unit for Pa3 and P1 crystals.

关键词： pyrites electronic structure optical properties crystal structure density functional theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

First-principles theory on electronic structure and floatability of spodumene

引用

Rare Metals 2014年第6期33卷 742-748页

作者： Gui-Chun He hua-Mei Xiang Wei jiang Qian Kang jian-hua chen Faculty of Resource and Environmental Engineering Jiangxi University of Science and Technology College of Resources and Metallurgy Guangxi University

The band structure, density of states, Mulliken populations, and frontier orbital of spodumene crystal were calculated using the first-principles method based on the density functional theory（DFT） and further analyzed in detail. The calculation results reveal that the O in spodumene is the most active and easily links with H＋in the water, but the active Li is very low, so it is better to add activator to increase the concentrate grade and recovery rate of spodumene in the flotation process. Si–O bonds in spodumene crystal are mainly covalent, since the covalency of Al–O bonds is stronger than that of Li–O bonds,and minerals dissociate along the weakest Li–O bonds. In addition, the study of the frontier orbital indicates that both O and Si atoms have large contribution to the frontier orbital in the spodumene crystal. Oleate and dodecylamine are used as the collectors of spodumene. The results contribute to the understanding of crystal structures of spodumene, and can be used in guiding related practical applications.

关键词： Spodumene Electronic structure Floatability First-principles method Frontier orbital

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermodynamics and density functional theory study of potassium dichromate interaction with galena

引用

International Journal of Minerals,Metallurgy and Materials 2014年第10期21卷 947-954页

作者： jian-hua chen Xian-Hao Long Li-Hong Lan Qian He College of Chemistry and Chemical Engineering Guangxi University College of Resources and Metallurgy Guangxi University Key Laboratory of Chemical and Biological Transformation Process of Guangxi Higher Education Institutes School of Chemistry and Chemical Engineering Guangxi University for Nationalities

The adsorption heat and reaction rate constant of potassium dichromate on the surface of galena were studied. The results indicate that potassium dichromate tends to adsorption on the galena surface. The reaction order is only 0.08385, suggesting that the concentration of potassium dichromate has little influence on its adsorption on the galena surface. In addition, the simulation of CrO2 4- adsorption on the PbS （100） surface in the absence and presence of O2 was carried out by density functional theory （DFT）. The calculated results show that CrO2 4- species adsorb energetically at the Pb-S bond site, and the presence of O2 can enhance this adsorption.

关键词： flotation potassium dichromate galena adsorption thermodynamics density functional theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancement of CTLs induced by DCs loaded with ubiquitinated hepatitis B virus core antigen

引用

World Journal of Gastroenterology 2012年第12期18卷 1319-1327页

作者： jian-hua chen Yong-Sheng Yu Xiao-hua chen Hong-Hong Liu Guo-Qing Zang Zheng-Hao Tang Department of Infec-tious Diseases Sixth People's Hospital Affiliated to ShanghaiJiaotong UniversityShanghai 200233China

AIM： To investigate whether hepatitis B virus （HBV） could induce a hepatitis B virus core antigen （HBcAg）specific cytotoxic T lymphocyte （CTL） response in vitro by dendritic cells （DCs） transduced with lentiviral vector-encoding ubiquitinated hepatitis B virus core antigen （LV-Ub-HBcAg）.METHODS： Recombinant LV-Ub-HBcAg were transfected into highly susceptible 293 T cells to obtain high virus titres, Bone marrow-derived DCs isolated from BALB/c mice were cultured with recombinant granulocyte-macrophage colony-stimulating factor and recombinant interleukin （IL）-4. LV-Ub-HBcAg, lentiviral vector-encoding hepatitis B virus core antigen （LV-HBcAg）, lentiviral vector （LV） or lipopolysaccharide were added to induce DC maturation, and the DC phenotypes were analyzed by flow cytometry. The level of IL-12 in the supernatant was detected by enzyme-linked immunosorbent assay （ELISA）. T lymphocytes were proliferated using Cell Counting Kit-8. DCs were cultured and induced to mature using different LVs, and co-cultured with allogeneic T cells to detect the secretion levels of IL-2, IL-4, IL-10and interferon-γ in the supernatants of T cells by ELISA. Intracellular cytokines of proliferative T cells were analyzed by flow cytometry, and specific CTL activity was measured by a lactate dehydrogenase release assay.RESULTS： LV-Ub-HBcAg-induced DCs secreted more IL-12 and upregulated the expression of CD80, CD86 and major histocompatibility class ]I, DCs sensitised by different LVs effectively promoted cytokine secretion; the levels of IL-2 and interferon-y induced by LV-Ub- HBcAg were higher than those induced by LV-HBcAg, Compared with LV-HBcAg-transduced DCs, LV-Ub- HBcAg-transduced DCs more efficiently stimulated the proliferation of T lymphocytes and generated HBcAgspecific cytotoxic T lymphocytes.CONCLUSION： LV-Ub-HBcAg effectively induced DC maturation. The mature DCs efficiently induced T cell polarisation to Thl and generated HBcAg-specific CTLs.

关键词： Ubiquitin Hepatitis B virus core antigen Lentiviruses Dendritic cells Cytotoxic T lymphocytes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 616-622页

作者： Zhou-wen chen Li-ying chen Hong-lei DAI jian-hua chen Li-zheng FANG Department of General Practice Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Objective： To investigate the relationship between alanine aminotransferase （ALT） levels and metabolic syndrome （MS） in nonalcoholic fatty liver disease （NAFLD）. Methods： A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study. The diagnosis of fatty liver was based on ultrasound imaging. MS was defined according to the criteria of the Adult Treatment Panel III. ALT, triglyceride （TG）, high density lipoprotein cholesterol （HDL-c）, fasting plasma glucose （FPG）, height, weight, waist circumference （WC）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were measured in each subject to analyze the relationship between MS and ALT activity Results：（1） The prevalence of NAFLD in men （30.94%） was significantly higher than that in women （15.65%）; （2） The incidence of MS in NAFLD （33.83%） was significantly greater than that in non-NAFLD （10.62%）; （3） Of the 6470 subjects with NAFLD, in the age-adjusted partial correlation analysis, there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex （P〈0.01）, except that ALT levels multiple stepwise regression analysis, SBP lost its significance, and had no correlation with HDL-c in women. Moreover, in the WC, body mass index （BMI）, age, DBP, TG and FPG were independently associated with ALT levels in both sexes （P〈0.05）. HDL-c remained significant and was independently related to ALT levels in men; （4） ALT levels were significantly higher in subjects with MS compared to those without MS （P〈0.001）. Mean ALT levels increased with the number of MS components in each sex （P〈0.05 for trend）. Conclusion： We found a strong relationship between ALT levels and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations.

关键词： Nonalcoholic fatty liver disease (NAFLD) Alanine aminotransferase (ALT) Metabolic syndrome (MS)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The emerging treatment landscape of targeted therapy in non-small-cell lung cancer

引用

Signal Transduction and Targeted Therapy 2019年第1期4卷 49-62页

作者： Min Yuan Li-Li huang jian-hua chen Jie Wu Qing Xu Department of Oncology Dermatology HospitalTongji University School of MedicineShanghai200443China Department of Oncology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai200072China Peggy and Charles Stephenson Cancer Center University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Department of Pathology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA

Lung cancer is one of the most common cancer in the *** 2018,there were over 2 million new cases of lung cancer and over 1.7 million deaths were attributed to lung *** therapy has emerged as an important mean of the disease management for patients with non-small-cell lung cancer(NSCLC).Herein,we review and analyze recent literature,discuss the targeting pathways and ongoing clinical trials in lung *** is no longer the best available treatment for all *** decisions should be guided by an understanding of the molecular features of patient’s tumor *** future gains will likely emerge from finding optimal ways of combining targeted therapy,immunotherapy,and chemotherapy.

关键词： lung targeted chemotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of amide type modified rapeseed oil as lubricating additive on friction and wear behavior of steel-steel and steel-aluminum alloy systems

引用

中国有色金属学会会刊：英文版 2004年第Z1期14卷 435-438页

作者： FANG jian-hua chen Bo-shui LIU Wei-min DONG Lin WANG Jiu Department of Petrochmistry Logistical Engineering University Chongqing 400016 China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China Department of Petrochmistry Logistical Engineering University Chongqing 400016 China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China Department of Petrochmistry Logistical Engineering University Chongqing 400016 China Department of Petrochmistry Logistical Engineering University Chongqing 400016 China

A new type of environmentally friendly lube additive-amide type modified rapeseed oil was synthesized and characterized by infrared spectrum. Its effect on the friction and wear behavior of steel-steel and steel-aluminum alloy systems were investigated with a four-ball machine and an Optimol SRV friction and wear tester *** morphographies of the worn surfaces were analyzed by means of scanning electron microscopy(SEM). The worn surfaces of the 2024Al alloy block were analyzed by means of X-ray photoelectron spectroscopy(XPS). The results show that the modified rapeseed oil as additives can obviously decrease the wear rate and friction coefficient of steel pair and steel-aluminum frictional pair. Its lubrication mechanism is inferred that a high strength complex protection films form on the worn surface of the Al alloy due to the adsorption or tribochemistry reaction of a long chain additive molecule and high reaction activity of N element.

关键词： environmentally friendly lube additive amide type rapeseed oil steel-steel pair steel-aluminum alloy pair tribochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improved FRACS parameterizations for cross sections of isotopes near the proton drip line in projectile fragmentation reactions

引用

Nuclear Science and Techniques 2018年第7期29卷 133-137页

作者： Yi-Dan Song Hui-Ling Wei Chun-Wang Ma jian-hua chen Institute of Particle and Nuclear Physics Henan Normal University Shanghai Institute of Applied Physics Chinese Academy of Sciences College of Information and Electronic Engineering Shangqiu Institute of Technology

The FRACS parameterizations,labeled as FRACS-C,have been improved in order to predict the presence of isotopes near the proton drip line produced in projectile fragmentation *** investigating the cross sections for proton-rich isotopes in a series of reactions with energies ranging from intermediate to relativistic,it is shown that the FRACS-C parameterizations can predict isotopes near the proton drip line considerably *** FRACS-C parameterizations are suggested to serve as an effective tool for predicting the presence of proton-rich isotopes with large asymmetry in a projectile fragmentation *** reactions have been investigated to check these results.

关键词：同位素质子反应破碎射弹滴线不对称现象有效工具

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：