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Hemorrhagic transformation in patients with large-artery atherosclerotic stroke is associated with the gut microbiota and lipopolysaccharide

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Neural Regeneration Research 2024年第7期19卷 1532-1540页

作者： Qin Huang Minping Wei Xianjing feng Yunfang Luo Yunhai Liu jian Xia Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Neurology Peking University People’s HospitalBeijingChina Clinical Research Center for Cerebrovascular Disease of Hunan Province Central South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Hemorrhagic transformation is a major complication of large-artery atheroscle rotic stroke(a major ischemic stro ke subtype)that wo rsens outcomes and increases *** of the gut microbiota is an important feature of stroke,and some specific bacteria and bacterial metabolites may contribute to hemorrhagic transformation *** aimed to investigate the relationship between the gut microbiota and hemorrhagic transformation in largearte ry atheroscle rotic stro *** observational retrospective study was *** May 2020 to September 2021,blood and fecal samples were obtained upon admission from 32 patients with first-ever acute ischemic stroke and not undergoing intravenous thrombolysis or endovascular thrombectomy,as well as 16 healthy *** with stro ke who developed hemorrhagic transfo rmation(n=15)were compared to those who did not develop hemorrhagic transformation(n=17)and with healthy *** gut microbiota was assessed through 16S ribosomal ribonucleic acid *** also examined key components of the lipopolysaccharide pathway:lipopolysaccharide,lipopolysaccharide-binding protein,and soluble *** observed that bacterial diversity was decreased in both the hemorrhagic transformation and non-hemorrhagic transfo rmation group compared with the healthy *** patients with ischemic stro ke who developed hemorrhagic transfo rmation exhibited altered gut micro biota composition,in particular an increase in the relative abundance and dive rsity of members belonging to the Enterobacteriaceae *** lipopolysaccharide and lipopolysaccharide-binding protein levels were higher in the hemorrhagic transformation group compared with the non-hemorrhagic transfo rmation ***,lipopolysaccharide-binding protein,and soluble CD14 concentrations were associated with increased abundance of Enterobacte ***,the role of the gut microbiota in hemorrhagic transformation was evaluated using

关键词： gut microbiota hemorrhagic transformation inflammation lipopolysaccharide stroke

A Transparent Photoresist Made of Titanium Dioxide Nanoparticle-Embedded Acrylic Resin with a Tunable Refractive Index for UV-Imprint Lithography

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Engineering 2024年第6期37卷 96-104页

作者： Yinglu Liu Dan Wang Changlin Liu Qianqian Hao jian Li Jie-Xin Wang Xiuyun Chen Peng Zhong Xibin Shao jian-feng Chen State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China BOE Technology Group Co. Ltd.Beijing 100176China

Transparent photoresists with a high refractive index(RI)and high transmittance in visible wavelengths have promising functionalities in optical *** work reports a kind of tunable optical material composed of titanium dioxide nanoparticles embedded in acrylic resin with a high RI for ultraviolet(UV)-imprint *** hybrid film exhibits a tunable RI of up to 1.67(589 nm)after being cured by UV light,while maintaining both a high transparency of over 98%in the visible light range and a low haze of less than 0.05%.The precision machining of optical microstructures can be imprinted easily and efficiently using the hybrid resin,which acts as a light guide plate(LGP)to guide the light from the side to the top in order to conserve the energy of the display *** preliminary studies based on both laboratory and commercial experiments pave the way for exploiting the unparalleled optical properties of nanocomposite resins and promoting their industrial application.

关键词： Photoresist Tunable refractive index Hanson solubility Ultraviolet imprint Organic-inorganic composites

Mineralogical properties and co-sintering characteristics of fluxed iron ore with magnetite concentrates

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Journal of Iron and Steel Research International 2024年第2期31卷 318-328页

作者： Le-le Niu Zheng-jian Liu jian-liang Zhang Yao-zu Wang Zhen-xing Yang Si-da Li Chang-dong Shan Ben feng School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of Artificial Intelligence University of Science and Technology BeijingBeijing100083China Xinxing Casting Pipe Xinjiang Co. Bayingol841300XinjiangChina

To investigate the feasibility of co-sintering of fluxed iron ore with magnetite concentrates, the mineralogical properties of a novel fluxed iron ore were studied using particle size analysis, microscopic morphology characterization, and X-ray diffraction Rietveld analysis. Following that, the experiments for granulation performance and basic sintering characteristics were designed under seven different fluxed iron ore ratios, and the integrated ranking of different fluxed iron ore ratios was determined using gray relation analysis. Finally, the results of the industrial trails were combined with the feasibility analysis. Test and experimental results show that the fraction of the fluxed iron ore particles larger than 0.5 mm can account for more than 48%, and the particles have two morphologies: spherical-rough and flaky-smooth. Ca elements are found in the form of calcite (CaCO3) and dolomite (CaMg(CO3)2). The average particle size of granules and powder removal rate can be improved from 2.50 to 3.16 mm and 39.60% to 24.20%, respectively, with the increase in the fluxed iron ore ratio. Furthermore, the fluxed iron ore can improve assimilability and liquid fluidity of magnetite concentrates. In terms of overall granulation performance and sintering characteristics, the fluxed iron ore ratios are graded from best to worst as follows: 12%, 15%, 9%, 18%, 21%, 6% and 3%. The industrial trails show that when the fluxed iron ore ratio is increased, the beneficial effect of the superior sintering characteristics of the fluxed iron ore itself is ideally balanced with the negative effect of the lower amount of additional CaO at 12% ratio, and thus, it is feasible to bring the fluxed iron ore into production at a level of roughly 12%.

关键词： Fluxed iron ore Magnetite concentrate Granulation performance Sintering characteristics Gray relation analysis

Understanding the Thermal Impedance of Silicone Rubber/Hexagonal Boron Nitride Composites as Thermal Interface Materials

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Chinese Journal of Polymer Science 2024年第3期42卷 352-363,I0008页

作者： Yuan Ji Shi-Da Han Hong Wu Shao-Yun Guo feng-Shun Zhang jian-Hui Qiu The State Key Laboratory of Polymer Materials Engineering Sichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyPolymer Research InstituteSichuan UniversityChengdu 610065China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Department of Mechanical Engineering Faculty of Systems Science and TechnologyAkita Prefectural UniversityAkita 015-0055Japan

Silicone rubber(SR) composites are most widely used as thermal interface materials(TIMs) for electronics heat dissipation. Thermal impedance as the main bottleneck limiting the performance of TIMs is usually neglected. Herein, the thermal impedance of SR composites loaded with different levels of hexagonal boron nitride(h-BN) as TIMs was elaborated for the first time by the ASTM D 5470 standard test and finite element analysis. It was found that elastic modulus and surface roughness of SR composites increased with the increase of h-BN content, indicating that the conformity was reduced. When the assembly pressure was 0.69 MPa, there existed an optimal h-BN content at which the contact resistance was minimum(0.39 K·cm^(2)·W^(-1)). Although the decreased bond line thickness(BLT) by increasing the assembly pressure was beneficial to reduce the thermal impedance, the proper assembly pressure should be selected to prevent the warpage of the contact surfaces and the increase in contact resistance, according to the compression properties of the SR composites. This study provides valuable insights into fabrication of high-performance TIMs for modern electronic device applications.

关键词： Thermal interface materials Hexagonal boron nitride Thermal impedance Surfaces

Formation mechanism of fault accommodation zones under combined stress in graben basin:Implications from geomechanical modeling

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Petroleum Science 2024年第1期21卷 54-76页

作者： Qi-Qiang Ren Jin-Liang Gao Rong-Tao jiang Jin Wang Meng-Ping Li jian-Wei feng Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China jianghan Oilfield Oil and Gas Production Capacity Construction Management Center Chongqing408000China Sinopec Chongqing Fuling Shale Gas Exploration and Development Company Chongqing408000China College of Energy Chengdu University of TechnologyChengdu 610059SichuanChina School of Geoscience China University of Petroleum(East China)Qingdao 266580ShandongChina

A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults *** numbers of fault accommodation zones are being identified in graben basins,indicating the potential exploration target and petroleum accumulation *** study aims to analyze the formation mechanism and development of fault accommodation zones under combined stress by a numerical simulation method considering geomechanical *** three-dimensional(3-D)seismic interpretation and fractal dimension method,exampled with the Dongxin fault zone,the fault activity and fault combination pattern were conducted to quantitatively characterize the activity difference in fault accommodation *** with mechanical experiment test,a geomehcanical model was established for fault accommodation zones in a graben *** the paleostress numerical simulations and structural physical simulation experiment,the developmental characteristics and genetic mechanism of fault accommodation zones were *** by multi movements and combined stresses,three significant tectonic evolution stages of the Dongxing Fault Zone(DXFZ)were distinguished:during the E_(s)^(3)sedimentary period,the large difference in the stress,strain,and rupture distribution in various faults were significant,and this stage was the key generation period for the prototype of the DXFZ,including the FAZ between large-scale *** the E_(s)^(2)sedimentary period,the EW-trending symmetric with opposite dipping normal faults and the NE-SW trending faults with large scale were furtherly *** junction area of two secondary normal faults were prone to be ruptured,performing significant period for inheriting and developing characteristics of fault accommodation *** the Es1 sedimentary period,the high-order faults in the DXFZ exhibited the obvious fault depressions and strike-slip activity,and the fault accommodation zones were

关键词： Fault accommodation zone Graben basin Fault activity Tectonic physical simulation experiment Finite element numerical simulation Dongxin fault zone

Patterns and drivers of avian taxonomic and phylogenetic beta diversity in China vary across geographical backgrounds and dispersal abilities

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Zoological Research 2024年第1期45卷 125-135页

作者： jian-Chao Liang Zhi-feng Ding Chun-Lin Li Yi-Ming Hu Zhi-Xin Zhou Gan-Wen Lie Xiao-Nan Niu Wen-Bin Huang Hui-jian Hu Xing-feng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Resources and Environmental Engineering Anhui UniversityHefeiAnhui 230601China Guangdong Eco-Engineering Polytechnic GuangzhouGuangdong 510520China Huizhou Institute of Forestry(Huizhou Botanical Garden Management Service Center) HuizhouGuangdong 516001China Administration of National Nature Reserve for Marine Ecology of Guangdong Nanpeng Islands ShantouGuangdong 515900China Zhejiang Zhoushan Archipelago Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Geographical background and dispersal ability may strongly influence assemblage dissimilarity;however,these aspects have generally been overlooked in previous large-scale beta diversity ***,we examined whether the patterns and drivers of taxonomic beta diversity(TBD)and phylogenetic beta diversity(PBD)of breeding birds in China vary across(1)regions on both sides of the Hu Line,which demarcates China’s topographical,climatic,economic,and social patterns,and(2)species with different dispersal *** and PBD were calculated and partitioned into turnover and nestedness components using a moving window *** representing climate,habitat heterogeneity,and habitat quality were employed to evaluate the effects of environmental *** distance was considered to assess the impact of dispersal *** partitioning analysis was applied to assess the relative roles of these *** general,the values of TBD and PBD were high in mountainous areas and were largely determined by environmental ***,different dominant environmental filters on either side of the Hu Line led to divergent beta diversity ***,climate-driven species turnover and habitat heterogeneity-related species nestedness dominated the regions east and west of the line,***,bird species with stronger dispersal ability were more susceptible to environmental filtering,resulting in more homogeneous *** results indicated that regions with distinctive geographical backgrounds may present different ecological factors that lead to divergent assemblage dissimilarity patterns,and dispersal ability determines the response of assemblages to these ecological *** a single universal explanation for the observed pattern without considering these aspects may lead to simplistic or incomplete ***,a comprehensive understanding of large-scale beta diversity patterns and effective pla

关键词： Beta diversity Environmental filtering Dispersal limitation Hu Line Species dispersal ability Breeding birds

Molecular Chain Flexibility and Dielectric Loss at High-Frequency:Impact of Ester Bond Arrangement in Poly(ester imide)s

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Chinese Journal of Polymer Science 2024年第8期42卷 1122-1133页

作者： Ya-Dong Li Hong Li Lu-Kun feng feng Bao Ming-Liang Wang Cai-Zhen Zhu Zhao-Hui Zheng Xiao-Bin Ding jian Xu Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100081China Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China

The evolution of high-frequency communication has accentuated the significance of controlling dielectric properties in polymer ***,it has been theorized that rigid molecular chains lead to lower dielectric ***,the validity of this proposition at high frequencies remains *** scrutinize the correlation between chain flexibility and dielectric properties,we synthesized six poly(ester imide)s(PEIs)with systematically varied molecular chain flexibilities by modifying the ester's substitution on the aromatic *** introduction of ester bonds bestowed all PEI films with a low dielectric dissipation factor(D_(f)),ranging from 0.0021 to 0.0038 at 10 GHz in dry *** dry D_(f)displayed a pattern consistent with volume polarizability(P/V).Unexpectedly,PI-mmm-T,featu ring the most flexible molecular chain,exhibited the lowest dielectric loss under both dry(0.0021@10 GHz)and hygroscopic(0.0029@10 GHz)***,the observed increase in D_(f)after humidity absorption suggests that the high dielectric loss of PEI in applications may be attributed to its hygroscopic *** simulations and characterization of the aggregation structure revealed that the smaller cavities within flexible molecular chains,after close stacking,impede the entry of water *** sacrificing high-temperature resistance,the precursor exhibited enhanced solubility properties and could be processed into high-quality *** research unveils new insights into the relationship between flexibility and highfrequency dielectric loss,offering innovative perspectives on synthesizing aromatic polymers with exceptional dielectric properties.

关键词： 5G communications Poly(ester imide)s Molecular chain flexibility Dielectric properties Humidity absorption

Multi-Branch Fault Line Location Method Based on Time Difference Matrix Fitting

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Energy Engineering 2024年第1期121卷 77-94页

作者： Hua Leng Silin He jian Qiu feng Liu Xinfei Huang Jiran Zhu School of Electrical and Information Engineering Hunan UniversityChangsha410082China Distribution Network Technical Center State Grid Hunan Electric Power Research InstituteChangsha410007China Technical Center China Energy Construction Group Hunan Thermal Power ConstructionZhuzhou412011China School of Electrical and Information Engineering Changsha University of Science and TechnologyChangsha410076China

The distribution network exhibits complex structural characteristics,which makes fault localization a challenging *** when a branch of the multi-branch distribution network fails,the traditional multi-branch fault location algorithm makes it difficult to meet the demands of high-precision fault localization in the multi-branch distribution network *** this paper,the multi-branch mainline is decomposed into single branch lines,transforming the complex multi-branch fault location problem into a double-ended fault location *** on the different transmission characteristics of the fault-traveling wave in fault lines and non-fault lines,the endpoint reference time difference matrix S and the fault time difference matrix G were *** time variation rule of the fault-traveling wave arriving at each endpoint before and after a fault was comprehensively *** realize the fault segment location,the least square method was *** was used to find the first-order fitting relation that satisfies the matching relationship between the corresponding row vector and the first-order function in the two matrices,to realize the fault segment ***,the time difference matrix is used to determine the traveling wave velocity,which,combined with the double-ended traveling wave location,enables accurate fault location.

关键词： Multi-branch lines distribution network fault location double-ended traveling wave positioning least square method

Incidence,Risk Factors,and Prognosis of Patients with Hepatocellular Carcinoma and Brain Metastases

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Current Medical Science 2024年第1期44卷 180-186页

作者： Jin-cheng feng Ying HE Georgios Polychronidis jian XIN Shen YOU Jun XIONG Department of Liver Transplantation Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Key Laboratory of Transplant Engineering and Immunology Laboratory of Liver TransplantationFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Department of General Visceral and Transplant SurgeryUniversity of HeidelbergIm Neuenheimer Feld 110Heidelberg 69120Germany Department of Hepatobiliary and Pancreatic Surgery Fujian Provincial HospitalFuzhou 350001China

Objective Brain metastases significantly impact the clinical course of patients with hepatocellular carcinoma(HCC).This study aimed to examine the age-related incidence,demographics,and survival of patients with HCC and brain *** Data of HCC patients from 2010 to 2015 in the Surveillance,Epidemiology,and End Results(SEER)Registry were screened for the presence of brain *** were stratified by age and *** logistic and Cox regression analyses were used to identify factors associated with brain metastases and those with overall survival(OS)and liver cancer-specific survival(CSS),*** A total of 141 HCC patients presenting with brain metastases were identified,accounting for 0.35% of all HCC patients and 2.37% of patients with metastatic *** all HCC patients,the incidence rate was the highest among patients aged 30-49 years old(0.47%).Ethnicity was not associated with the presence of brain metastases at the time of HCC ***,African-American patients presented with a significantly lower disease-specific survival[median time:1 month;interquartile range(IQR):0-3.0 months].Initial lung or bone metastasis was independently associated with an increased risk of the presence of brain metastases[odds ratio(OR):12.62,95% confidence interval(CI):8.40-18.97]but was not associated with a worse OS or CSS among those with brain *** This study identified the age-related incidence and risk factors of brain metastases in HCC *** results may contribute to the consideration of brain screening among patients with initial metastatic HCC with lung or bone metastases,and influence the counseling of this patient population regarding their prognosis.

关键词： brain metastases hepatocellular carcinoma age-related incidence cancer-specific survival overall survival