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Pulmonary vein isolation implemented by second-generation cryoballoon for treating hypertrophic cardiomyopathy patients with symptomatic atrial fibrillation:a case-control study

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Journal of Geriatric Cardiology 2020年第8期17卷 476-485页

作者： Zhong-Jing CAO Xiao-Gang GUO Qi SUN jian-du yang Hui-Qiang WEI Shu ZHANG jian MA Arrhythmia Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical ScienceGuangzhouChina

Background Atrial fibrillation(AF)is a generally acknowledged turning-point of the natural history of hypertrophic cardiomyopathy(HCM);however,data from the cryoballoon ablation(CBA)for AF in HCM patients are relatively *** study aimed to evaluate the efficacy and safety of CBA in HCM patients with *** We retrospectively analyzed HCM patients among 1253 patients with symptomatic AF who underwent CBA for pulmonary vein isolation in a single *** study analyzed the AF recurrence and assessed the CBA indexes,including nadir temperature,time-to-isolation,CBA failure,pulmonary vein potentials(PVPs),and redo *** A total of 108 patients were included(mean age:59.0±6.9 years),27 patients(25%)had HCM,with the median follow-up duration of 25.5 *** one-year AF-free rates were 79.0%vs.63.0%(non-HCM ***),while the two-year AF-free rates were 77.8%vs.55.1%[hazard ratio(HR)=2.758,log-rank P=0.024].Patients with persistent AF had poor AF-free rates compared to those with paroxysmal AF(P<0.001).The CBA failure was the most common in the right inferior pulmonary veins,which had the lowest *** Cox regression analysis indicated that HCM and persistent AF were risk factors for AF recurrence(HR=2.74,95%CI:1.29–5.79,P=0.008;and HR=3.97,95%CI:1.85–8.54,P<0.001,respectively).Conclusions The CBA can be effectively and safely used to treat HCM patients with symptomatic *** freedom from AF for HCM patients after CBA is relatively low compared to that for non-HCM patients.

关键词： Atrial fibrillation Cryoballoon ablation Hypertrophic cardiomyopathy Pulmonary vein isolation

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Cryoballoon ablation of persistent atrial fibrillation for de novo pulmonary vein isolation:a single-center follow-up study

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Journal of Geriatric Cardiology 2022年第10期19卷 725-733页

作者： Zhong-Jing CAO Xiao-Gang GUO Qi SUN Yan-Qiao CHEN Hai-yang XIE jian-du yang Hui-Qiang WEI Jia-Hui LI jian MA Department of Cardiology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of Medicine UESTCChengduChina State Key Laboratory of Cardiovascular Disease Arrhythmia CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People’s HospitalGuangdong Academy of Medical ScienceGuangzhouChina

BACKGROUND Pulmonary vein isolation(PVI)alone for persistent atrial fibrillation(PersAF)remains *** characteristics of cryoballoon ablation(CBA)to treat PersAF and the blanking period recurrence are *** This study retrospectively analyzed patients with PersAF undergoing second-generation CBA for de novo *** post-procedural efficacy and survival analysis were compared between patients with different PersAF *** multivariate Cox regression analysis was used to detect the risk factors for *** and long-term recurrence were analyzed relative to each *** A total of 329 patients were enrolled,with a median PersAF duration of 4.0 months(interquartile range:2.0–12.0 months);257 patients(78.1%)were ***-Meier analysis of freedom from atrial fibrillation recurrence at 12,24,and 30 months showed 71.0%,58.5%,and 54.9%,*** PersAF had a relatively favorable survival rate and a narrow P-wave duration of restoring sinus rhythm compared with that of PersAF lasting more than three months(Pduration and left atrial anteroposterior diameter≥42 mm were the risk factors for atrial fibrillation recurrence after CBA[hazard ratio(HR)=1.89,95%CI:1.01–1.4,P=0.042;HR=3.6,95%CI:2.4–5.4,Pduration and left atrial size were risk factors for atrial fibrillation recurrence after *** period recurrence was associated with long-term recurrence.

关键词： balloon fibrillation atrial

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Assessment of the right and left ventricular function in patients with cor pulmonale using high-definition CT

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Chinese Medical Journal 2013年第19期126卷 3639-3644页

作者： GAO Yan QIN jian du Xiang-ying yang Jing LI Kun-cheng Department of Radiology Xuanwu Hospital of Capital MedicalUniversity Beijing 100053 China

Background Cor pulmonale is often associated with changes of structure and function of the right ventricle （RV） and thus further affects functional changes of the left *** study aimed to assess the left ventricular （LV） and RV function in patients with cor pulmonale using high-definition CT （HDCT）.Methods We prospectively studied 18 cor pulmonale patients determined by the pulmonary function test,clinical examination,chest radiograph,electrocardiogram,and *** subject group was compared to a control group consisting of 18 *** RV and LV functions and RV myocardial mass （MM） were obtained by HDCT in the two *** results were compared between the two groups using the independent sample t *** examination for cardiac function analysis was performed on the same *** The RV end-diastolic volume （EDV）,RV end-systolic volume （ESV） and RV myocardial mass were significantly larger in the 18 cor pulmonale patients than in the control group （P〈0.05）.The right ventricular ejection fraction （RVEF） was significantly lower in the 18 cor pulmonale patients than in controls （P〈0.01）.The left ventricular EDV （LVEDV） and LVEF were significantly lower in cor pulmonale patients than in controls （P〈0.01）.There were strong correlations between MDCT and echocardiography,rRVEF=0.839 and rLVEF=0.916,*** HDCT can accurately quantify RV and LV *** right ventricular function is impaired in patients with cor pulmonale,while at the same time the left ventricular function is also impaired.

关键词： cor pulmonale ventricular function high-definition CT myocardial mass

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大企业税务风险控制的二维视角

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特区经济 2009年第11期 108-111页

作者：杜剑杨杨贵州财经学院会计学院贵州贵阳550004

随着财务风险管理受到越来越多企业的重视,大企业财务风险中的税收风险也日益受到企业的关注,本文从税务机关及大企业两个不同的角度分析了税收风险控制问题。

关键词：税务风险财务风险税务机关大企业

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制浆造纸废水处理的经济评价

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中华纸业 2009年第2期30卷 14-16页

作者：杜建阳云南云景林纸股份有限公司云南景谷666400

通过对硫酸盐法制浆废水处理成本与排污费用缴纳的分析与对比,对废水深度处理作出经济分析与评价。

关键词：废水排放深度处理排缴费运行费用经济评价制浆造纸

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Continuous infusion of midazolam and fentanyl during cryoballoon ablation compared with during radiofrequency catheter ablation of atrial fibrillation:Results from a retrospective study

Continuous infusion of midazolam and fentanyl during cryobal...

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2015年中国药学大会暨第十五届中国药师周

作者： Xu Liu Xiao-gang Guo Gong-bu Zhou jian-du yang Qi Sun Keping Chen jian Ma Shu Zhang Arrhythmias Center State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College

Aims Cryoballoon ablation（CBA） or radiofrequency catheter ablation（RFCA） of atrial fibrillation（AF） can be performed under sedation/analgesic. We sought to investigate the feasibility, safety with continuous infusion of midazolam and fentanyl for CBA and *** and Results One hundred and sixty paroxysmal atrial fibrillation patients were enrolled into two groups by ablation technique used（CBA or RFCA, 80 patients for each group）. We recorded patient characteristics and perioperative data including peripheral oxygen saturation, heart rate, and noninvasive blood pressure. Dosage of midazolam was not significantly different between the two groups（13.7 ± 1.6 mg in CBA vs. 13.7 ± 1.8 mg in RFCA, P=0.11）. However, dosage of fentanyl was significantly less in CBA group（199.0 ± 26.5 μg vs. 278.5 ± 31.8 μg, P＜0.001）. Frequency of applied oropharyngeal airway due to upper airway obstruction or desaturation（SpO2＜90%） was significantly lower in CBA group（30 vs. 44, P=0.03）, while the incidence of restlessness was similar between the two groups. There were 3 patients in RFCA group who left atrial geometry required remapping because restlessness influenced the reference patch. The Ramsay sedation score（RSS） was similar between groups, while operator satisfaction score was significantly higher in CBA group（3.1 ± 0.5 vs. 2.8 ± 0.7, P=0.01）. Conclusion Continuous infusion of midazolam and fentanyl by cardiologists wasfeasible and safe for CBA and mostly RFCA of atrial fibrillation. A higher operator satisfaction level was obtained for CBA of atrial fibrillation.

关键词： Sedation Midazolam Fentanyl Cryoballoon ablation Radiofrequency catheter ablation Atrial fibrillation

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge duo Xu Xiao Feng Xing yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong du Zhe Sun Weilin Xu jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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改进GA机制融合的二进制蜂群算法研究

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数学的实践与认识 2017年第2期47卷 166-175页

作者：霍凤财任伟建杜颖刘洋东北石油大学电气信息工程学院黑龙江大庆163318

为了克服人工蜂群算法蜜源更新过程中的随机性并保留蜜源中个体序列合理的组合形式,通过分析基本蜂群算法更新公式的机理,提出一种改进GA(Genetic A1gorithm)机制融合的二进制蜂群算法.算法以二进制编码,首先依概率对任意两蜜源进行"去... 详细信息

为了克服人工蜂群算法蜜源更新过程中的随机性并保留蜜源中个体序列合理的组合形式,通过分析基本蜂群算法更新公式的机理,提出一种改进GA(Genetic A1gorithm)机制融合的二进制蜂群算法.算法以二进制编码,首先依概率对任意两蜜源进行"去同存异"操作后随机排列,将排列结果放入到其中某个体中形成新个体.然后依概率进行二进制个体的"翻转"操作,上述两种操作从其本质上相当于GA的类交叉和类变异操作;其次利用GA机制收敛性的证明方式在理论上证明算法是收敛的.最后通过应用不同特性的多维基准函数和算法之间的比较验证改进蜂群算法具有良好的收敛能力和鲁棒性.

关键词： GA机制二进制去同存异蜂群算法

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Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng yang jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing Dong Bixian Chen Lujie Jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge Yin Tingting Fu Jing Liu Yuji du Jiahui Kong Rongrong Chang jian Ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

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