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New mechanism to promote long-term T-cell immunity by telomere transfer from antigen-presenting cells

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Cellular & Molecular Immunology 2023年第2期20卷 117-118页

作者： Meiling Jin jian-dong huang Chinese Academy of Sciences(CAS)Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SARChina Department of Clinical Oncology Shenzhen Key Laboratory for Cancer Metastasis and Personalized TherapyThe University of Hong Kong-Shenzhen HospitalShenzhenChina Guangdong-Hong Kong Joint Laboratory for RNA Medicine Sun Yat-Sen University510120GuangzhouChina

Telomeres protect the ends of chromosomes and are important biomarkers of cellular *** mechanism of telomere elongation in T cells is not clear.A recent study revealed that memory CD4+T cells can acquire telomeric DNA transferred via vesicles from antigen-presenting cells,which inhibits T-cell senescence and promotes T-cell expansion and long-lived immunity.

关键词： immunity mechanism transferred

New fossil mayflies （Insecta： Ephemeroptera） from the Middle Jurassic of Daohugou, Inner Mongolia, China

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Insect Science 2008年第2期15卷 193-198页

作者： jian-dong huang dong Ren Nina D. Sinitshenkova Chung-Kun Shih College of Life Science Capital Normal University Beijing China Palaeontological Institute of the Russian Academy of Sciences MoscowRussia

Abstract Jurassonurus amoenus, a new genus and species of Siphlonuridae s. I. is described from the Middle Jurassic Jiulongshan Formation of the Daohugou Village, Shantou Township, Ningcheng County, Inner Mongolia, China. The new species is estab- lished by more than 20 imago and subimago specimens in relatively good condition. Detailed description and illustration of the specimens along with a review of fossil Siphlonuridae s. I. are given. Comparing with two known dominant nymph species Fuyous gregarious Zhang and Kluge, 2007 and Shantous lacustri Zhang and Kluge, 2007 from the same locality, we could not find any relationship among them. The new species is another dominant species in Daohugou beds.

关键词： new genus new species Ephemeroptera Siphlonuridae fossil Daohugou,Middle Jurassic China

Nanostructured self-assemblies of photosensitive dyes: green and efficient theranostic approaches

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Green Chemical Engineering 2023年第4期4卷 399-416页

作者： Hao Liu Xue-Yan Li Xingshu Li jian-dong huang College of Chemistry State Key Laboratory of Photocatalysis on Energy and EnvironmentFujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyFuzhou UniversityFuzhou350108China

Recently,nano theranostics,by integrating diagnostic and therapeutic functions into a nano system,have provided increasing opportunities for the design of personalized medicine in *** the construction method of various theranostic nano systems,the design of single component nanoparticles which are composed of organic photosensitive dyes has become a promising approach to constructing multifunctional nano-theranostic systems,thanks to its unique advantages such as defined structure,100%loading,and high ***,depending on the inherent photonic imaging and therapeutic properties of the photosensitive dyes,the multifunctional purpose which integrates theranostic effects and targeting abilities can be realized via reasonable molecular modification and supramolecular *** this review,recent advances in the development of nanostructured self-assemblies of porphyrins,phthalocyanines,and boron-dipyrromethanes for theranostics are *** on their design consideration and theranostic applications are ***,prospects for clinical practice and potential challenges of this rapidly growing field are also provided.

关键词： Theranostic Dye Photosensitizer Multifunctional nanoparticle Self-assembly

Synthetic biology： a new approach to stud bioloaical pattern formation

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Frontiers of Electrical and Electronic Engineering in China 2013年第4期8卷 246-252页

作者： Chenli Liu Xiongfei Fu jian-dong huang Department of Biochemistry The University of Hong Kong Hong Kong China Department of Physics The University of Hong Kong Hong Kong China Center for Synthetic Biology Engineering Research Guangzhou Institute of Advanced Technology Chinese Academy of Sciences Guangzhou 511458 China

The principles and molecular mechanisms underlying biological pattern formation are difficult to elucidate in most cases due to the overwhelming physiologic complexity associated with the natural context. The understanding of a particular mechanism, not to speak of underlying universal principles, is difficult due to the diversity and uncertainty of the biological systems. Although current genetic and biochemical approaches have greatly advanced our understanding of pattern formation, the progress mainly relies on experimental phenotypes obtained from time- consuming studies of gain or loss of function mutants. It is prevailingly considered that synthetic biology will come to the application age, but more importantly synthetic biology can be used to understand the life. Using periodic stripe pattern formation as a paradigm, we discuss how to apply synthetic biology in understanding biological pattern formation and hereafter foster the applications like tissue engineering.

关键词： Pattern Formation Synthetic Biology Periodic Pattern Genetic Circuit Synthetic Biologist

Accurate simulations of pure-viscoacoustic wave propagation in tilted transversely isotropic media

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Petroleum Science 2024年第2期21卷 866-884页

作者： Qiang Mao jian-Ping huang Xin-Ru Mu Ji-dong Yang Yu-jian Zhang Geosciences Department China University of Petroleum(East China)Qingdao266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266207ShandongChina

Forward modeling of seismic wave propagation is crucial for the realization of reverse time migration(RTM) and full waveform inversion(FWI) in attenuating transversely isotropic media. To describe the attenuation and anisotropy properties of subsurface media, the pure-viscoacoustic anisotropic wave equations are established for wavefield simulations, because they can provide clear and stable wavefields. However, due to the use of several approximations in deriving the wave equation and the introduction of a fractional Laplacian approximation in solving the derived equation, the wavefields simulated by the previous pure-viscoacoustic tilted transversely isotropic(TTI) wave equations has low accuracy. To accurately simulate wavefields in media with velocity anisotropy and attenuation anisotropy, we first derive a new pure-viscoacoustic TTI wave equation from the exact complex-valued dispersion formula in viscoelastic vertical transversely isotropic(VTI) media. Then, we present the hybrid finite-difference and low-rank decomposition(HFDLRD) method to accurately solve our proposed pure-viscoacoustic TTI wave equation. Theoretical analysis and numerical examples suggest that our pure-viscoacoustic TTI wave equation has higher accuracy than previous pure-viscoacoustic TTI wave equations in describing q P-wave kinematic and attenuation characteristics. Additionally, the numerical experiment in a simple two-layer model shows that the HFDLRD technique outperforms the hybrid finite-difference and pseudo-spectral(HFDPS) method in terms of accuracy of wavefield modeling.

关键词： Pure-viscoacoustic TTI wave equation Attenuation anisotropy Seismic modeling Low-rank decomposition method

Overview of computation strategies on the dispersion analysis for explicit finite difference solution of acoustic wave equation

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Petroleum Science 2024年第4期21卷 2311-2328页

作者： jian-Ping huang Wei-Ting Peng Ji-dong Yang Lu-Feng Lou School of Geosciences China University of Petroleum (East China) Pilot National Laboratory for Marine Science and Technology (Qingdao)

Finite-difference(FD) method is the most extensively employed numerical modeling technique. Nevertheless, when using the FD method to simulate the seismic wave propagation, the large spatial or temporal sampling interval can lead to dispersion errors and numerical instability. In the FD scheme, the key factor in determining both dispersion errors and stability is the selection of the FD weights. Thus,How to obtain appropriate FD weights to guarantee a stable numerical modeling process with minimum dispersion error is critical. The FD weights computation strategies can be classified into three types based on different computational ideologies, window function strategy, optimization strategy, and Taylor expansion strategy. In this paper, we provide a comprehensive overview of these three strategies by presenting their fundamental theories. We conduct a set of comparative analyses of their strengths and weaknesses through various analysis tests and numerical modelings. According to these comparisons, we provide two potential research directions of this field: Firstly, the development of a computational strategy for FD weights that enhances stability; Secondly, obtaining FD weights that exhibit a wide bandwidth while minimizing dispersion errors.

关键词： Finite-difference scheme FD coefficients Dispersion error Forward modeling Numerical simulation

Protein translation:biological processes and therapeutic strategies for human diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1048-1064页

作者： Xuechao Jia Xinyu He Chuntian huang jian Li Zigang dong Kangdong Liu Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450000China China-US(Henan)Hormel Cancer Institute ZhengzhouHenan 450000China Department of Pathology and Pathophysiology Henan University of Chinese MedicineZhengzhouHenan 450000China Tianjian Laboratory of Advanced Biomedical Sciences ZhengzhouHenan 450052China Research Center for Basic Medicine Sciences Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052 HenanChina Provincial Cooperative Innovation Center for Cancer Chemoprevention Zhengzhou UniversityZhengzhouHenan 450000China State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou UniversityZhengzhouHenan 450000China The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention ZhengzhouHenan 450000China

Protein translation is a tightly regulated cellular process that is essential for gene expression and protein *** deregulation of this process is increasingly recognized as a critical factor in the pathogenesis of various human *** this review,we discuss how deregulated translation can lead to aberrant protein synthesis,altered cellular functions,and disease *** explore the key mechanisms contributing to the deregulation of protein translation,including functional alterations in translation factors,tRNA,mRNA,and ribosome *** translation leads to abnormal protein expression,disrupted cellular signaling,and perturbed cellular functions-all of which contribute to disease *** development of ribosome profiling techniques along with mass spectrometry-based proteomics,mRNA sequencing and single-cell approaches have opened new avenues for detecting diseases related to translation ***,we highlight recent advances in therapies targeting translation-related disorders and their potential applications in neurodegenerative diseases,cancer,infectious diseases,and cardiovascular ***,the growing interest lies in targeted therapies aimed at restoring precise control over translation in diseased cells is *** conclusion,this comprehensive review underscores the critical role of protein translation in disease and its potential as a therapeutic *** in understanding the molecular mechanisms of protein translation deregulation,coupled with the development of targeted therapies,offer promising avenues for improving disease outcomes in various human ***,it will unlock doors to the possibility of precision medicine by offering personalized therapies and a deeper understanding of the molecular underpinnings of diseases in the future.

关键词： translation offering precise

A redescription of the ichnospecies Koreanaornis anhuiensis(Aves) from the Lower Cretaceous Qiuzhuang Formation at Mingguang city, Anhui Province, China

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Journal of Palaeogeography 2018年第1期7卷 58-65页

作者： Li-Da Xing Yuan-Chao Hu jian-dong huang Qing He Martin G.Lockley Michael E.Burns Jun Fang State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Beijing 100083China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina Anhui Geological Museum Hefei 230031Anhui ProvinceChina School of Resources and Environmental Engineering Anhui UniversityHefei 230039Anhui Province China Dinosaur Trackers Research Group University of Colorado DenverPO Box 173364DenverCO 80217USA Department of Biology Jacksonville State University700Pelham RdJacksonvilleFL 36265USA

The Cretaceous bird trackway originally labeled Aquatilavipes anhuiensis, in 1994, had previously been examined, photographed and replicated, but never described or illustrated in detail. However, it has been part of a widening discussion about the distribution of Aquatilavipes and Koreanaornis in China(and Korea). Here we illustrate and formally describe the holotype in detail and assign it to Koreanaornis(Koreanaornis anhuiensis) as informally proposed by previous authors. We also demonstrate that most authenticated reports of Koreanaornis, including the Anhui occurrence, are from the Lower Cretaceous, not from the Upper Cretaceous as previously reported.

关键词： Lower Cretaceous Ichnospecies Koreanaornis Aquatilavipes Qiuzhuang Formation Anhui Province

Molecularly imprinted sensor based on carboxylated carbon nanotubes/Keggin-type polyoxometalates nanocomposite for the detection of furazolidone

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Tungsten 2024年第2期6卷 394-409页

作者： Yu-Lan huang Bing Zhang Yu-Lian Li Li Wang Le dong jian Li College of Ocean Food and Biological Engineering Jimei UniversityXiamen 361021China College of Oceanology and Food Science Quanzhou Normal UniversityQuanzhou 362000China

Due to its properties of mutagenic,teratogenic,and carcinogenic,the detection of furazolidone(FZD)in aquaculture is of great importance for food safety and human *** this study,molecularly imprinted fi lms modifi ed with carboxylated multi-walled carbon nanotube-phosphomolybdic acid composite were used to fabricate an electrochemical sensor for the determination of *** nanocomposites were characterized using infrared spectroscopy,scanning electron microscopy,energy-dispersive X-ray spectroscopy,and X-ray diff *** electrochemical characteristics of the modifi ed electrodes were examined using electrochemical impedance spectroscopy,cyclic voltammetry,and diff erential pulse *** sensor exhibited exceptional catalytic *** calibration curves were acquired in the concentration range of 6 nmol·L^(−1)to 0.6μmol·L^(−1),with a limit of detection of 3.38 nmol·L^(−1).Additionally,the sensor proved successful in recognizing FZD in shrimp samples with satisfactory recoveries and *** method provides a strategy to construct a molecularly imprinted electrochemical sensing platform using nanomaterials,which has great promise in the field of food safety.

关键词： Phosphomolybdate Furazolidone Polyoxometalates Carboxylated multi-walled carbon nanotube Molecularly imprinted polymers Electrochemical sensor