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Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng jiang Zheng-De Xie Yi jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang jian-She Wang Lu-Zhao Feng Wei Liu Yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao jian-bo shao Daniel Kwok-keung Ng Gary Wing-kin Wong Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

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Vestibular function of pediatric patients with sudden sensorineural hearing loss:based on vertigo symptom and vestibular function testing

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World Journal of Pediatrics 2021年第6期17卷 637-642页

作者： Yan-Hong Li Bing Liu Yang Yang Min Chen Wei Liu jian-bo shao Xiao Zhang Jie Zhang Xin Ni Department of Otorhinolaryngology Head and Neck Surgery Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery Beijing Pediatric Research InstituteBeijingChina

Background This study aimed to evaluate the relationship between vestibular and auditory functions in pediatric patients with sudden sensorineural hearing loss(SSHL).Methods A total of 30 pediatric patients experiencing unilateral SSHL between 5.9 and 13.0 years of age were enrolled in this *** tone audiometry was evaluated prior to treatment initiation and again after one month of *** to treatment initiation,vertigo symptoms were noted;then several vestibular function tests were conducted including caloric testing,ocular vestibular evoked myogenic potentials(o-VEMPs)and cervical vestibular evoked myogenic potentials(c-VEMPs).Associations between pre and post-treatment vestibular function and hearing threshold levels were *** Initial hearing thresholds of children with vertigo were higher than thresholds of children without vertigo(92 dB vs 79 dB,F=0.033),while initial hearing thresholds of children with abnormal caloric test findings were higher than thresholds of children with normal caloric test findings(93 dB vs 67 dB.P=0.014).Cutoff values of hearing thresholds for those with vertigo symptoms and abnormal vestibular test results were 86.000-and 89.583-dB *** prognosis,children with vertigo exhibited lower recovery rates than children without vertigo(33%vs 75%,P=0.025);recovery rates of children with abnormal caloric test results were lower than the overall recovery rate(25%vs 73%,respectively,P=0.039).Conclusion Assessments of vertigo symptoms and vestibular function are useful tools in predicting pediatric SwSHL patient disease severity and prognosis.

关键词： Prognosis sudden sensorineural hearing loss Vertigo Vestibular function tests

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The influence of yttrium and manganese additions on the degradation and biocompatibility of magnesium-zinc-based alloys:In vitro and in vivo studies

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Journal of Magnesium and Alloys 2024年第2期12卷 608-624页

作者： Lei Shi Yang Yan Chun-sheng shao Kun Yu bo Zhang Liang-jian Chen Third Xiangya Hospital Central South UniversityChangsha 410013China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China Department of Mechanical Engineering City University of Hong KongHong KongChina

The repair and regeneration of bone defects are highly challenging orthopedic ***,Mg-based implants have gained popularity due to their unique biodegradation and elastic modulus similar to that of human *** aim of our study is to develop a magnesium alloy with a controllable degradation that can closely match bone tissue to help injuries heal in vivo and avoid cytotoxicity caused by a sudden increase in ion *** this study,we prepared and modified Mg-3Zn,Mg-3Zn-1Y,and Mg-2Zn-1Mn by hot extrusion,and used Mg-2.5Y-2.5Nd was as a *** then investigated the effect of additions of Y and Mn on alloys'*** results show that Mn and Y can improve not only compression strength but also corrosion *** alloy Mg-2Zn-1Mn demonstrated good cytocompatibility in vitro,and for this reason we selected it for implantation in *** degraded Mg-2Zn-1Mn implanted a bone defect area did not cause obvious rejection and inflammatory reaction,and the degradation products left no signs of damage to the heart,liver,kidney,or ***,we find that Mg-2Zn-1Mn can promote an osteoinductive response in vivo and the formation of bone regeneration.

关键词： Magnesium alloy Biodegradation Biocompatibility bone regeneration bone defect repair

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Effects of SARS-CoV-2 infection on neuroimaging and neurobehavior in neonates

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World Journal of Pediatrics 2021年第2期17卷 171-179页

作者： Kai Yan Fei-Fan Xiao Yu-Wei jiang Tian-Tian Xiao Da-jiang Zhang Wen-Hao Yuan jian-bo shao Guo-Qiang Cheng Ling-Kong Zeng Department of Neonatology Children’s Hospital of Fudan UniversityNational Children's Medical CenterShanghaiChina Key Laboratory of Neonatal Diseases of Ministry of Health ShanghaiChina Center for Molecular Medicine Children's Hospital of Fudan UniversityNational Children’s Medical CenterInstitutes of Biomedical SciencesFudan UniversityShanghai.China Institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghaiChina Department of Neonatology Chengdu Women's and Children’s Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduChina Department of Radiology Children’s Hospital of Fudan UniversityNational Children's Medical CenterShanghaiChina Department of Neonatology Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Radiology Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Background We collected neonatal neurological,clinical,and imaging data to study the neurological manifestations and imaging characteristics of neonates with coronavirus disease 2019(COVID-19).Methods This case-control study included newborns diagnosed with COVID-19 in Wuhan,China from January 2020 to July *** included newborns had complete neurological evaluations and head magnetic resonance *** normalized the extracted T2-weighted imaging data to a standard neonate template space,and segmented them into gray matter,white matter,and cerebrospinal *** comparison of gray matter volume was conducted between the two *** A total of five neonates with COVID-19 were included in this *** median reflex scores were 2 points lower in the infected group than in the control group(P=0.0094),and the median orientation and behavior scores were 2.5 points lower in the infected group than in the control group(P=0.0008).There were also significant differences between the two groups in the total scale score(P=0.0426).The caudate nucleus,parahippocampal gyrus,and thalamus had the strongest correlations with the Hammersmith neonatal neurologic examination(HNNE)score,and the absolute correlation coefficients between the gray matter volumes and each part of the HNNE score were all almost greater than *** We first compared the neurological performance of neonates with and without COVID-19 by quantitative neuroimaging and neurological examination *** the limited numbers of patients,more studies focusing on the structural or functional aspects of the virus in the central nervous system in different age groups will be carried out in the future.

关键词： Coronavirus disease 2019 Magnetic resonance imaging Neonates Quantitative neuroimaging Severe acute respiratory syndrome coronavirus 2

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Multicolored Bipartite Ramsey Numbers of Large Cycles

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 347-357页

作者： shao-qiang LIU Yue-jian PENG College of Mathematics and Statistics Hanshan Normal UniversityChaozhou 521041China School of Mathematics Hunan UniversityChangsha 410082China

For an integer r≥2 and bipartite graphs Hi,where 1≤i≤r,the bipartite Ramsey number br(H1,H2,…,Hr)is the minimum integer N such that any r-edge coloring of the complete bipartite graph KN;N contains a monochromatic subgraph isomorphic to Hi in color i for some 1≤i≤*** show that if r≥3;α1,α2>0,αj+2≥[(j+2)!-1]Σi=1^(j+1)α1 for j=1,2…r-2,then br(C2[α1n],C2[α2n],…,C2[αrn]=(Σ=j=1^(r)a j+o(1))n.

关键词： ramsey number bipartite ramsey number regularity lemma

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Signifying quantum uncertainty relations by optimal observable sets and the tightest uncertainty constants

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 43-50页

作者： Xiao-Bin Liang bo Li shao-Ming Fei School of Mathematics and Computer Science Shangrao Normal UniversityShangrao 334001China Quantum Information Research Center Shangrao Normal UniversityShangrao 334001China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China

Quantum uncertainty relations constrain the precision of measurements across multiple non-commuting quantum mechanical ***,we introduce the concept of optimal observable sets and define the tightest uncertainty constants to accurately describe these measurement *** any quantum state,we establish optimal sets of three observables for both product and summation forms of uncertainty relations,and analytically derive the corresponding tightest uncertainty *** demonstrate that the optimality of these sets remains consistent regardless of the uncertainty relation ***,the existence of the tightest constants excludes the validity of standard real quantum mechanics,underscoring the essential role of complex numbers in this ***,our findings resolve the conjecture posed in[***.118,180402(2017)],offering novel insights and potential applications in understanding preparation uncertainties.

关键词： uncertainty relation the tightest uncertainty constants optimal observable sets

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Synergistic silver-mediated and palladium-catalyzed nondirected olefination of aryl C–H bond: quick access to multi-substituted aryl olefins

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Science China Chemistry 2024年第3期67卷 882-889页

作者： jian Yao Lili shao Xiaohong Huo Xiaoming Wang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 20032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Transition metal-catalyzed olefination of aryl C-H bond is a powerful tool for the synthesis of alkenes. While the Pd-catalyzed oxidative C-H olefination of arenes, also known as Fujiwara-Moritani reaction, has been established as one of the most efficient methods, the substrates are largely limited to terminal olefins with electron-withdrawing group(s). Herein, we report a synergistic silver-mediated and palladium-catalyzed non-directed C-H olefination of arenes with vinyl(pseudo)halides, which offers a complementary strategy to the typical Fujiwara-Moritani reaction. The reactions proceeded well for a variety of halogenated arenes, heteroarenes, and olefin substrates, providing an efficient access to various multi-substituted aryl olefins, including trisubstituted/tetrasubstituted olefins and several complex olefins derived from medicines or natural products. Mechanistic studies indicated a bimetallic Pd/Ag cooperation is operative in the catalysis, i.e., the reaction is initiated by aryl C-H bond cleavage via ligation with phosphine/Ag species, followed by transferring of the aryl moiety to a vinyl palladium intermediate,which is in turn formed by oxidative addition of vinyl(pseudo)halide to a Pd complex. This method enables the synthesis of a wide range of challenging multi-substituted vinyl products from simple arenes(directing-group free) in a streamlined and controllable fashion.

关键词： direct C–H olefination multi-substituted aryl alkenes bimetallic Pd/Ag cooperation C–H functionalization

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The reaction mechanism and interfacial crystallization of Al nanoparticle-embedded Ni under shock loading

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Defence Technology（防务技术） 2024年第3期33卷 114-124页

作者： Yifan Xie jian-Li shao Rui Liu Pengwan Chen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Explosion Protection and Emergency Disposal Technology Engineering Research Center of the Ministry of Education Beijing100039China

The shock-induced reaction mechanism and characteristics of Ni/Al system,considering an Al nanoparticle-embedded Ni single crystal,are investigated through molecular dynamics *** the shock melting of Al nanoparticle,interfacial crystallization and dissolution are the main *** reaction degree of Al particle first increases linearly and then logarithmically with time driven by rapid mechanical mixing and following *** reaction rate increases with the decrease of particle diameter,however,the reaction is seriously hindered by interfacial crystallization when the diameter is lower than 9 nm in our ***,we found a negative exponential growth in the fraction of crystallized Al atoms,and the crystallinity of B2-NiAl(up to 20%)is positively correlated with the specific surface area of Al *** can be attributed to the formation mechanism of B2-NiAl by structural evolution of finite mixing layer near the collapsed *** shock melting of both Al particle and Ni matrix,the liquid-liquid phase inter-diffusion is the main reaction mechanism that can be enhanced by the formation of internal *** addition,the enhanced diffusion is manifested in the logarithmic growth law of mean square displacement,which results in an almost constant reaction rate similar to the mechanical mixing process.

关键词： Shock-induced reaction Molecular dynamics simulations Interfacial crystallization Reaction mechanism

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A Novel 3D Gait Model for Subject Identification Robust against Carrying and Dressing Variations

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Computers, Materials & Continua 2024年第7期80卷 235-261页

作者： jian Luo bo Xu Tardi Tjahjadi jian Yi College of Information Science and Engineering Hunan Normal UniversityChangsha410000China School of Engineering University of WarwickCoventryCV47ALUK

Subject identification via the subject’s gait is challenging due to variations in the subject’s carrying and dressing conditions in real-life *** paper proposes a novel targeted 3-dimensional(3D)gait model(3DGait)represented by a set of interpretable 3DGait descriptors based on a 3D parametric body *** 3DGait descriptors are utilised as invariant gait features in the 3DGait recognition method to address object carrying and *** 3DGait recognitionmethod involves 2-dimensional(2D)to 3DGaitdata learningbasedon3Dvirtual samples,a semantic gait parameter estimation Long Short Time Memory(LSTM)network(3D-SGPE-LSTM),a feature fusion deep model based on a multi-set canonical correlation analysis,and SoftMax recognition ***,a sensory experiment based on 3D body shape and pose deformation with 3D virtual dressing is used to fit 3DGait onto the given 2D gait images.3Dinterpretable semantic parameters control the 3D morphing and dressing *** degree measurement determines the semantic descriptors of 2D gait images of subjects with various shapes,poses and ***,using the 2D gait images as input and the subjects’corresponding 3D semantic descriptors as output,an end-to-end 3D-SGPE-LSTM is constructed and ***,body shape,pose and external gait factors(3D-eFactors)are estimated using the 3D-SGPE-LSTM model to create a set of interpretable gait descriptors to represent the 3DGait Model,i.e.,3D intrinsic semantic shape descriptor(3DShape);3D skeleton-based gait pose descriptor(3D-Pose)and 3D dressing with other ***,the 3D-Shape and 3D-Pose descriptors are coupled to a unified pattern space by learning prior knowledge from the *** research on CASIA B,CMU Mobo,TUM GAID and GPJATK databases shows that 3DGait is robust against object carrying and dressing variations,especially under multi-cross variations.

关键词： Gait recognition human identification three-dimensional gait canonical correlation analysis

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A Defense Planning Model for a Power System Against Coordinated Cyber-physical Attack

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Protection and Control of Modern Power Systems 2024年第5期9卷 84-95页

作者： Peiyun Li jian Fu Kaigui Xie bo Hu Yu Wang Changzheng shao Yue Sun Wei Huang State Key Laboratory of Power Transmission Equipment&System Secu-rity and New Technology Chongqing UniversityChongqing 400044China State Grid Chengdu Power Supply Com-pany State Grid Sichuan Electric Power Co.Ltd.Chengdu 610041China China Yangtze Power Co. LtdYichang 443002China

This paper proposes a tri-level defense planning model to defend a power system against a coor-dinated cyber-physical attack(CCPA).The defense plan considers not only the standalone physical attack or the cyber attack,but also coordinated *** defense strategy adopts coordinated generation and transmission expansion planning to defend against the *** the process of modeling,the upper-level plan represents the perspective of the planner,aiming to minimize the critical load shedding of the planning system after the *** load resources available to planners are extended to flex-ible loads and critical *** middle-level plan is from the viewpoint of the attacker,and aims at generating an optimal CCPA scheme in the light of the planning strategy determined by the upper-level plan to maximize the load shedding caused by the *** optimal operational behavior of the operator is described by the lower-level plan,which minimizes the load shedding by defending against the *** tri-level model is analyzed by the column and constraint generation algorithm,which de-composes the defense model into a master problem and *** studies on a modified IEEE RTS-79 system are performed to demonstrate the economic effi-ciency of the proposed *** Terms—Coordinated cyber-physical attack,flexible load,column-and-constraint generation,defense planning,robust optimization.

关键词： Coordinated cyber-physical attack flexible load column-and-constraint generation defense planning robust optimization.

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