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Cellular & Molecular Immunology 2012年第5期9卷 410-416页

作者： jian-Ping Ma Hou-Jun Xia Gao-Hong Zhang jian-bao han Li-Guo Zhang Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingChina Graduate University of the Chinese Academy of Sciences BeijingChina CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijingChina

It is currently widely accepted that immune activation in HIV-infected individuals leads to a severe loss of CD4＋ T cells and the progression to AIDS. However, the underlying mechanism of this immune activation remains unclear. Experimental data suggest that the activation of plasmacytoid dendritic cells （pDCs） by plasma viremia may play a critical role in HIV-induced immune activation. In this study, we found that the level of immune activation was higher in the late phase of SIVmac239 infection compared with chronic infection, which suggests that immune activation might be related to disease progression in SIVmac239-infected non-human primate models. Our work also showed that chloroquine could effectively inhibit the activation of pDCs in vitro and in vivo. However, chloroquine treatment of SIVmac239-infected macaques had no significant influence on the Cellular composition of peripheral blood in these animals.

关键词： Chinese rhesus macaque chloroquine immune activation pDC SIV

Tissue distribution of SARS-CoV-2 in non-human primates after combined intratracheal and intranasal inoculation

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Science China(Life Sciences) 2021年第10期64卷 1792-1794页

作者： Tian-Zhang Song jian-bao han Xiang Yang Ming-Hua Li Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming National High-level Biosafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academic of SciencesKunming 650107China

Dear Editor,As of 5 July,2020,approximately 20,162,000 confirmed cases of coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),have been reported globally,including an estimated 740,000 *** the clinical manifestations of COVID-19 are heterogeneous,viral infection and pathological changes in the respiratory system,especially the lungs,still represent common characteristics of *** nose,served as the entrance to the respiratory system,seems to produce absent or minimal symptoms of nasal congestion or rhinorrhea during SRAS-CoV-2 infection,while other viral rhinitis(i.e.,adenovirus,rhinovirus,influenza virus,etc.)are characterized by typical nasal symptoms,including nasal congestion,rhinorrhea,and *** studies suggest that,despite a lack of other nasal symptoms,anosmia is an important sign of early-stage COVID-19(Lechien et al.,2020).

关键词： nasal respiratory acute

Permanent lining castable with low bulk density and thermal conductivity:bauxite castable for tundish obtained by adding pearlescent sand

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Journal of Iron and Steel Research International 2024年第3期31卷 634-646页

作者： Yi Wang jian Yang bao Wang Hai-jun Zhang Juan han Pei-yan Pei Wen-long Lv jian-an Zhou The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Wuhan Research Institute of Metallurgical Construction MCCWuhan 430081HubeiChina

The low thermal conductivity and light mass of castables for tundish permanent linings are crucial for minimizing the heat loss of molten *** consideration of the low bulk density and thermal conductivity of pearlescent sand,the thermal insulation performance of castables was attempted to be improved by adding pearlescent *** sand was modified to prevent the strength of its porous structure from *** modification mechanism of pearlescent sand and the effect of pearlescent sand on the performance of bauxite castables were *** results suggested that the addition of the modified pearlescent sand significantly raised the apparent porosity and decreased the bulk density of bauxite *** 1000℃,the bulk density of more than 60%of the modified pearlescent sand-bauxite castable was only 2.03 g/cm^(3).The mechanical properties and thermal shock resistance of the modified pearlescent sand-bauxite castable were inferior to those of conventional bauxite castable but were adequate to meet the use conditions of casta-bles for tundish permanent *** high temperatures of 200-800℃,the thermal conductivity of more than 60%of the modified pearlescent sand-bauxite castable was smaller than that of conventional bauxite *** addition of the modified pearlescent sand can greatly reduce the thermal conductivity and bulk density of bauxite castable.

关键词： Pearlescent sand-Hydrophobic modification Bauxite castable Thermal insulation performance Mechanical property

Emerging SARS-CoV-2 B.1.621/Mu variant is prominently resistant to inactivated vaccine-elicited antibodies

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Zoological Research 2021年第6期42卷 789-791页

作者： Xiaochun Xie jian-bao han Guanqin Ma Xiao-Li Feng Xiaohong Li Qing-Cui Zou Zhong-Hua Deng jianxiong Zeng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China Kunming National High-level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

Although it first appeared almost two years ago,the COVID-19 pandemic continues to have an impact on a global scale,in part due to newly emerging SARS-CoV-2 variants such as Delta and *** B.1.621 variant,first identified in Colombia in January 2021,was classified as a variant of interest(VOI)and designated as Mu by the World Health Organization(WHO)in August ***,its infectivity and resistance to neutralizing antibodies remain largely ***,in comparison to Delta,the Mu variant showed an unexpectedly enhanced immune resistance to inactivated vaccine-elicited ***,Mu demonstrated less infectivity than Delta,implying a biological trade-off between viral transmission and immune *** study strongly calls for urgent evaluation of the protective efficacy of current COVID-19 vaccines against the Mu *** of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)are of concern regarding control of the global COVID-19 pandemic(Wang et al.,2021).The SARS-CoV-2 B.1.621 variant was first identified in Colombia in January *** its epidemiological prevalence,the WHO defined B.1.621(named Mu)as a VOI on 30 August *** of September 2021,the WHO has classified four variants of concern(VOC),i.e.,Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2),and two VOI,i.e.,Lambda(C.37)and Mu(B.1.621)(Supplementary Figure S1A).

关键词： Figure protective continue

Hybrid tri-memristor hyperchaotic map and application in Wasserstein Generative Adversarial Nets

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Science China(Technological Sciences) 2024年第6期67卷 1855-1865页

作者： GU Yang bao han YU XiHong HUA ZhongYun bao BoCheng XU Quan School of Microelectronics and Control Engineering Changzhou UniversityChangzhou213159China School of Computer Science and Technology Harbin Institute of TechnologyShenzhen518055China

Inspired by basic circuit connection methods,memristors can also be utilized in the construction of complex discrete chaotic *** investigate the dynamical effects of hybrid memristors,we propose two hybrid tri-memristor hyperchaotic(HTMH)mapping structures based on the hybrid parallel/cascade and cascade/parallel operations,*** the HTMH mapping structure with hybrid parallel/cascade operation as an example,this map possesses a spatial invariant set whose stability is closely related to the initial states of the *** distributions and bifurcation behaviours dependent on the control parameters are explored with numerical ***,the memristor initial offset-boosting mechanism is theoretically demonstrated,and memristor initial offset-boosting behaviours are numerically *** results clarify that the HTMH map can exhibit hyperchaotic behaviours and extreme multistability with homogeneous coexisting infinite *** addition,an FPGA hardware platform is fabricated to implement the HTMH map and generate pseudorandom numbers(PRNs)with high ***,the generated PRNs can be applied in Wasserstein generative adversarial nets(WGANs)to enhance training stability and generation capability.

关键词： memristor hybrid tri-memristor map spatial invariant set hyperchaos extreme multistability generative adversarial nets

Temperature-controlled DCP Fluorescent Probe Based on Hydrogel-immobilized Quantum Dots Composite

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 931-936页

作者：童伊琳杨坤 han Xuecai YU Kan bao Jiaqi Faculty Information Science and Technology Wenhua CollegeWuhan 430074China State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430074China Yangtze Optical Fibre and Cable Joint Stock Limited Company Wuhan 430074China

A composite was created by incorporating the quantum dot-enhanced SiO_(2)nanoparticles within this *** on this composite,a temperature-controlled fluorescent probe for DCP was developed.A meticulous examination of this probe revealed its attributes and factors affecting its *** using temperature modulation,the probe was adept at detecting DCP concentrations ranging between 1.0×10^(-6)and 9.0×10^(-6)mol/*** a probe offers remarkable selectivity,repeatability,and robust stability,so that the detection of DCP can be carried out at different temperatures,and a fast,reliable,sensitive and low-cost intelligent detection method is realized.

关键词： temperature-controlled fluorescent probe hydrogel-immobilized quantum dots composite DCP

BIM-based framework of automatic tunnel segment assembly and deviation control

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Underground Space 2024年第3期16卷 59-78页

作者： jian Gong Tengfei bao Zheng Zhu Hong Yu Yangtao Li The National Key Laboratory of Water Disaster Prevention Hohai UniversityNanjing 210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China College of Hydraulic and Environmental Engineering China Three Gorges UniversityYichang 443002China Zhejiang Design Institute of Water Conservancy and Hydro-Electric Power Hangzhou 310002China

The design of universal segments and deviation control of segment assembly are essential for robust and low-risk tunnel construction.A building information modeling(BIM)-based framework was proposed for parametric modeling,automatic assembly,and deviation control of universal ***,segment models of different levels of detail(LoDs)were built based on BIM visual programming language(VPL)for different project life ***,the geometric constraints,requirements,and procedures for parametric segment assembly were distilled to develop a program that combines a novel typesetting algorithm with a 3D path replanning *** is implemented by introducing a point indication matrix,characterizing segments by sides,and manipulating geometries in a ***,3D path replanning,with non-uniform rational B-splines(NURBS)and arcs as basic shapes,was used to resolve unacceptable deviation situations after ***,the proposed framework was validated on a water diversion line and was found to be more effective and accurate than the previous method.

关键词： Parametric generative design BIM Deviation control Typesetting 3D path replanning

Product quality prediction based on RBF optimized by firefly algorithm

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Journal of Systems Engineering and Electronics 2024年第1期35卷 105-117页

作者： han Huihui WANG jian CHEN Sen YAN Manting College of Electronics and Information Engineering Tongji UniversityShanghai 201804China

With the development of information technology,a large number of product quality data in the entire manufacturing process is accumulated,but it is not explored and used *** traditional product quality prediction models have many disadvantages,such as high complexity and low *** overcome the above problems,we propose an optimized data equalization method to pre-process dataset and design a simple but effective product quality prediction model:radial basis function model optimized by the firefly algorithm with Levy flight mechanism(RBFFALM).First,the new data equalization method is introduced to pre-process the dataset,which reduces the dimension of the data,removes redundant features,and improves the data *** the RBFFALFM is used to predict product *** expe riments conducted on real-world product quality datasets validate that the new model RBFFALFM combining with the new data pre-processing method outperforms other previous me thods on predicting product quality.

关键词： product quality prediction data pre-processing radial basis function swarm intelligence optimization algorithm

Prediction of lime utilization ratio of dephosphorization in BOF steelmaking based on online sequential extreme learning machine with forgetting mechanism

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 508-517页

作者： Runhao Zhang jian Yang han Sun Wenkui Yang State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

The machine learning models of multiple linear regression(MLR),support vector regression(SVR),and extreme learning ma-chine(ELM)and the proposed ELM models of online sequential ELM(OS-ELM)and OS-ELM with forgetting mechanism(FOS-ELM)are applied in the prediction of the lime utilization ratio of dephosphorization in the basic oxygen furnace steelmaking *** ELM model exhibites the best performance compared with the models of MLR and ***-ELM and FOS-ELM are applied for sequential learning and model *** optimal number of samples in validity term of the FOS-ELM model is determined to be 1500,with the smallest population mean absolute relative error(MARE)value of 0.058226 for the *** variable importance analysis reveals lime weight,initial P content,and hot metal weight as the most important variables for the lime utilization *** lime utilization ratio increases with the decrease in lime weight and the increases in the initial P content and hot metal weight.A prediction system based on FOS-ELM is applied in actual industrial production for one *** hit ratios of the predicted lime utilization ratio in the error ranges of±1%,±3%,and±5%are 61.16%,90.63%,and 94.11%,*** coefficient of determination,MARE,and root mean square error are 0.8670,0.06823,and 1.4265,*** system exhibits desirable performance for applications in actual industrial pro-duction.

关键词： basic oxygen furnace steelmaking machine learning lime utilization ratio dephosphorization online sequential extreme learning machine forgetting mechanism

Effect of Mo and cold forging deformation on strength and ductility of cobalt-based alloy L605

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Journal of Iron and Steel Research International 2024年第7期31卷 1811-1823页

作者： Zhong-lin Wang Zhi-hua Gong Quan Li han-sheng bao School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014017Inner MongoliaChina Institute of Special Steels Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

Mo element was added to cobalt-based alloy L605,and cold forging deformation was *** effects of the addition and cold forging deformation on the microstructure and mechanical properties of the alloy were studied by thermodynamic calculation,electron backscatter diffraction,transmission electron microscopy,and X-ray *** stacking fault energy(SFE)of the alloy decreased after the addition,and the formation of stacking faults and intersections were promoted to improve the strength and *** tensile strength of the alloy with Mo increased from 1190 to 1702 MPa after 24%cold deformation,producing significant work *** strengthening mechanism is strain-induced martensitic transformation(SIMT)and deformation *** alloy,combined with Mo and after 24%deformation,had both high strength and ductility in comparison with the original cobalt-based alloy *** is attributed to the lower SFE which caused the increase in stacking fault *** the tensile process,theε-hcp phase was easily generated at the stacking fault to reduce the stress concentration and increase the *** SIMT by adjusting the density of stacking faults can improve the mechanical properties of cobalt-based ***ε-hcp phase,the interaction between deformation twins and dislocations,and the interaction between e-hcp phases during cold forging deformation caused local stress concentration,lowering ductility and toughness.

关键词： Cobalt-based alloy-Stacking fault energy Strain-induced martensitic transformation Deformation twin Cold forging deformation