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World Journal of Gastroenterology 2008年第14期14卷 2235-2240页

作者： Yun-Chun Li Tian-Zhi Tan jian-Guo zheng Chun zhang Department of Nuclear Medicine West China Hospital Sichuan University 37 Guoxue Alley Chengdu 610041 Sichuan Province China

AIM:To explore and compare the radiochemical behavior and biological property of anti-sense oligonuc-leotide (ASON) labeled with technetium-99m using N-hydroxysuccinimidyl S-acetylmercaptoacetyltriglycl ine (NHS-MAG3) and hydrazinonictinamide derivative (HYNIC). METHODS:After HYNIC and NHS-MAG3 were synthesized, ASON was labeled with technetium-99m using HYNIC and NHS-MAG3 as a bifunctional chelator. The in vivo and in vitro stability, binding rates of labeled compounds to serum albumen, biodistribution of 99mTc-MAG3-ASON and 99mTc-HYNIC-ASON in BALB/C mouse and its HT29 tumor cellular uptake were compared. RESULTS:The labeling efficiency and stability of 99mTc-MAG3-ASON were significantly higher than those of 99mTc-HYNIC-ASON (P = 0.02, and P = 0.03, respectively). 99mTc-MAG3-ASON had a significantly lower rate of binding to serum albumen than 99mTc-HYNIC-ASON (P 0.05) and significantly higher in lung and kidney (P < 0.05). The HT29 tumor cellular uptake rate of 99mTc-MAG3-ASON was significantly higher than that of 99mTc-HYNIC-ASON (P < 0.05). CONCLUSION:99mTc-MAG3-ASON shows superior radiochemical behaviors and biological properties than 99mTc-HYNIC-ASON. 99mTc-MAG3-ASON is a potential radiopharmaceutical agent for in vivo application.

关键词： Anti-sense oligonucleotide Radiolabeling Technetium-99m N-hydroxysuccinimidyl S-acetylmercapt oacetyltriglycline Hydrazinonictionamide derivative

Impact of admission creatinine level on clinical outcomes of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention with drug-eluting stent implantation

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Chinese Medical Journal 2008年第23期121卷 2379-2383页

作者： zhang Qi zhang Rui-yan SHEN Jie zhang jian-sheng HU jian YANG zheng-kun zhang Xian zheng Ai-fang SHEN Wei-feng Department of Cardiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Background Prognosis of patients with acute ST-elevation myocardial infarction （STEMI） and renal dysfunction （RD） who received primary percutaneous coronary intervention （PCI） has not been fully investigated in the drug-eluting stent （DES） era. This study aimed to evaluate the impact of admission serum creatinine level on short-term outcomes in patients with acute STEMI undergoing DES-based primary PCI. Methods Primary PCI with DES implantation was attempted in 619 consecutive STEMI patients within 12 hours of symptom onset. Among them, 86 patients had a serum creatinine level ≥115 μmol/L on admission （RD group）, and the remaining 533 patients had normal renal function （non-RD group）. The primary endpoint was 30-day major adverse cardiac events （MACE, including death, non-fatal reinfarction, and target vessel revascularization）, and the secondary endpoint was subacute stent thrombosis. Results Patients in the RD group were older than those in the non-RD group. There are more female patients in the RD group and they had a history of hypertension, myocardial infarction and revascularization. The occurrence rates of Killip class ≥2 （29.1% vs 18.6%, P=0.02） and multi-vessel （62.8% vs 44.5%, P=0.001） and triple vessel disease （32.6% vs 18.2%, P=0.002）, in-hospital mortality （9.3% vs 3.8%, P=0.03）, and MACE rate during hospitalization （17.4% vs 7.7%, P=-0.006） were higher in the RD group than those in the non-RD group. At a 30-day clinical follow-up, the MACE-free survival rate was significantly reduced in the RD group （76.7% vs 89.9%, P=-0.0003）. Angiographic stent thrombosis occurred in 3 （3.5%） and 7 （1.3%） of patients in the RD group and non-RD group, respectively （P=0.15）. Multivariate analysis revealed that the serum creatinine level 〉115 μmol/L on admission was an independent predictor for MACE rate at a 30-day follow-up （Hazard ratio （HR） 3.31,95% CI 1.19-9.18, P 〈0.001）. Conclusion Despite similar prevalence of stent thrombosis at a 30-day clinical follow-u

关键词： acute myocardial infarction percutaneous coronary intervention drug-eluting stent renal dysfunction prognosis

Chinese expert consensus on organ protection of transplantation(2022 edition)

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 516-526页

作者： jian-Hui Li Xiao Xu Yan-Feng Wang Hai-Yang Xie Jing-Yu Chen Nian-Guo Dong Mitesh Badiwala Li-Ming Xin Roberto Vanin Pinto Ribeiro Hao Yin Hao zhang jian-zheng zhang Feng Huo Jia-Yin Yang Hong-Ji Yang Hui Pan Shao-Guang Li Yin-Biao Qiao Jia Luo Hao-Yu Li Jun-Jun Jia Hao Yu Han Liang Si-Jia Yang Hao Wang Zhong-Yang Liu Li-Cheng zhang Xiao-Yi Hu Hao Wu Yi-Qing Hu Pei-Fu Tang Qi-Fa Ye Shu-Sen zheng Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310000China Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationWuhan 430062China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Wuxi Lung Transplantation Center Wuxi People’s Hospital Affiliated with Nanjing Medical UniversityWuxi 214023China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Peter Munk Cardiac Centre Toronto General Hospital-University Health NetworkTorontoCanada School of Computer Engineering and Science Shanghai UniversityShanghai 200444China Organ Transplant Center Shanghai Changzheng HospitalShanghai 200003China Department of Orthopedics Chinese PLA General HospitalBeijing 100039China National Clinical Research Center for Orthopedics Sports Medicine&RehabilitationBeijing 100039China Department of Surgery General Hospital of Guangzhou Military Command of PLAGuangzhou 510040China Department of Liver Surgery Liver Transplantation CenterWest China Hospital of Sichuan UniversityChengdu 610041China Organ Transplantation Center Sichuan Provincial People’s Hospital and School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Lung Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Introduction Organ transplantation increases survival and improves qual-ity of life to many patients with end-stage organ ***-gan shortage is a worldwide problem that restricts organ trans-plantation[1].Organ procurement and preservation as well as ischemia-reperfusion injury(IRI)after transplantation are the im-portant factors affecting prognosis of *** the de-velopment of organ transplantation technology in the 20th cen-tury,organ protection technology has been a most promising con-cept in this *** preservation solutions such as the Collins solution,University of Wisconsin(UW)solution,and histidine-tryptophan-ketoglutarate(HTK)solution were developed sequen-tially[2],which developed rapidly in static cold storage(SCS)*** remains the standard preservation technique for organ transplantation[2].

关键词： organ preservation transplantation

Telomerase activity in gastric cancer and its clinical implications

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World Journal of Gastroenterology 1999年第4期5卷 44-47页

作者： ZHAN Wen Hua, MA Jin Ping, PENG Jun Sheng, GAO Jing Song, CAI Shi Rong, WANG jian Ping, zheng zhang Qing and WANG Lei

AIM To study the telomerase expression in gastric carcinoma and its clinical implications. METHODS Telomerase activity was examined in gastric cancer and corresponding normal tissues using a modified TRAP (telomeric repeat amplification protocol) assay (TRAP eze) in tissue samples from 94 gastric carcinomas and 58 normal tissues, 12 gastric adenomas and 9 gastric ulcer lesions. RESULTS Telomerase activity was present in 81 of the 94 (86 2%) gastric cancer tissues, whereas no telomerase activity was detected in any normal tissues. The incidence of telomerase activity in gastric cancer tissues was unrelated to the tumor diameter, histological grade, tumor invasion in depth, lymph node metastasis and TNM stage. CONCLUSION Telomerase plays an important role in carcinogenesis and progression of gastric cancer, and it is suggested to be a useful tumor marker.

关键词： stomach neoplasms telomerase tumor markers

哑铃型钢管混凝土拱肋极限承载力的线弹性分析方法

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交通运输工程学报 2017年第3期17卷 25-35页

作者：杨绿峰解威威郑健张伟广西大学防灾减灾与工程安全广西重点实验室广西南宁530004 广西大学工程防灾与结构安全教育部重点实验室广西南宁530004

为了提高哑铃型钢管混凝土拱肋极限承载力的计算效率,提出了极限承载力分析的高效自适应弹性模量缩减法;根据连续条件和截面塑性承载性能,建立了钢管混凝土哑铃型构件压弯承载力相关方程,通过回归分析得到了相应的齐次广义屈服函数;采... 详细信息

为了提高哑铃型钢管混凝土拱肋极限承载力的计算效率,提出了极限承载力分析的高效自适应弹性模量缩减法;根据连续条件和截面塑性承载性能,建立了钢管混凝土哑铃型构件压弯承载力相关方程,通过回归分析得到了相应的齐次广义屈服函数;采用单一组合材料梁单元建立了拱肋的线弹性有限元迭代模型,通过自适应缩减高承载单元弹性模量模拟结构在加载过程中的刚度损伤,确定拱肋的极限承载力,并与模型试验、非线性有限元法和等效梁柱法计算结果进行了对比。计算结果表明:建立的齐次广义屈服函数计算结果稳定、可靠,克服了传统广义屈服函数计算结果受荷载初始值影响的缺陷;采用自适应弹性模量缩减法只需较少的离散单元数与迭代步数即可获得稳定的极限承载力,且与模型试验结果误差小于3%,计算耗时小于16s,相对非线性有限元法具有良好的计算精度和效率;哑铃形截面拱肋相比圆形截面拱肋具有更好的承载性能,矢跨比、含钢率和荷载作用方式是影响钢管混凝土拱肋极限承载力的重要因素;随着矢跨比增大,极限承载力增速减缓;随着含钢率增大,极限承载力几乎呈线性增长;随着集中力与均布力比值增大,其对极限承载力的影响逐渐减弱;轴力与弯矩是拱肋的主要内力,随着矢跨比增大,弯矩对极限承载力的影响更加显著。

关键词：桥梁工程极限承载力弹性模量缩减法钢管混凝土哑铃型拱肋广义屈服函数

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居住区共享泊位资源优化配置模型及算法

交通运输系统工程与信息 2017年第2期17卷 160-167页

作者：姚恩建张正超张嘉霖薛飞罗烨堃北京交通大学交通运输学院北京100044

对于缓解城市停车难问题,基于泊位共享的理念充分挖掘现有私人或者专用停车位资源以供社会车辆停放的方法成为一种新的思路.由于共享车位可利用的停车时段通常具有严格的时间窗约束和片段化特征,导致共享车位资源在实际运营中难以得到... 详细信息

对于缓解城市停车难问题,基于泊位共享的理念充分挖掘现有私人或者专用停车位资源以供社会车辆停放的方法成为一种新的思路.由于共享车位可利用的停车时段通常具有严格的时间窗约束和片段化特征,导致共享车位资源在实际运营中难以得到高效利用.本文旨在通过设计优化配置算法,以提高共享泊位利用率为目标,将居住区泊位拥有者愿意出租的停车时段与停车需求进行匹配,从而实现共享车位的高效利用.首先,基于具有颜色约束的加权顶点着色问题,建立共享车位资源优化配置模型;其次,针对以上NP-C问题,分析蚁群算法的路径选择及信息素更新策略并设计求解算法;最后,根据居住区泊位空闲特性设计仿真实验,并与"先到先服务"的停车位资源配置方法对比,结果显示,本文提出的优化方法可以将泊位利用时长提高11.82%.

关键词：城市交通停车位资源优化利用停车泊位共享图着色蚁群算法

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高炉与KR双流程联动优化脱硫

钢铁 2017年第2期52卷 5-9页

作者：王振阳张建良刘征建张贺顺安钢程铮明北京科技大学冶金与生态工程学院北京100083 首钢京唐钢铁集团有限公司炼铁作业部河北唐山063200

基于首钢京唐高炉工序与KR工序脱硫条件,对双流程的脱硫特点及经济性分别进行分析,发现焦炭为高炉硫负荷的主要来源。降低焦比或减少高硫炼焦煤的配比,是降低高炉硫负荷的有效措施,当铁水中w(S)由0.01%升高至0.05%时,高炉工序吨铁脱硫... 详细信息

基于首钢京唐高炉工序与KR工序脱硫条件,对双流程的脱硫特点及经济性分别进行分析,发现焦炭为高炉硫负荷的主要来源。降低焦比或减少高硫炼焦煤的配比,是降低高炉硫负荷的有效措施,当铁水中w(S)由0.01%升高至0.05%时,高炉工序吨铁脱硫成本迅速下降,而当铁水中w(S)由0.06%变化至0.10%时,吨铁脱硫成本下降趋势变缓;KR脱硫吨铁成本随铁水中w(S)增加而逐渐升高。硫负荷为4 kg时,双流程综合脱硫成本最低时的铁水中w(S)_(min)为0.067%,且w(S)_(min)随硫负荷的增加而升高。当考虑炼焦配煤的采购成本时,由于硫质量分数高的炼焦配合煤采购成本较低,当采用高硫煤炼焦时,炼焦配煤带来的成本降低,不仅可以抵消由于双流程脱硫任务量增加而带来的成本增加,还可以使综合脱硫成本降低。

关键词：高炉 KR流程联动脱硫

球面收敛二元矢量喷管气动及红外特性研究:模拟高空状态

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航空动力学报 2017年第2期32卷 390-397页

作者：征建生张靖周单勇季靖远南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室南京210016 先进航空发动机协同创新中心北京100191

针对高空状态下球面收敛二元矢量喷管排气系统,通过数值模拟研究了喷管俯仰偏转角对排气系统气动和红外辐射特性的影响,并与地面状态进行了对比分析.在该研究参数范围内,研究结果表明:在俯仰偏转角为20°范围内,俯仰偏转对排气系统推力... 详细信息

针对高空状态下球面收敛二元矢量喷管排气系统,通过数值模拟研究了喷管俯仰偏转角对排气系统气动和红外辐射特性的影响,并与地面状态进行了对比分析.在该研究参数范围内,研究结果表明:在俯仰偏转角为20°范围内,俯仰偏转对排气系统推力系数和总压恢复系数的影响微弱,气动推力矢量角与俯仰偏转角几乎相等,高空状态下,喷管的推力系数和总压恢复系数下降0.5%与1.1%;热喷流峰值红外辐射强度仅为地面状态的12%~24%,排气系统的总体红外辐射强度峰值与地面状态下的比值峰值在0.35~0.45之间;随着下俯仰偏转角的增加,排气系统红外辐射峰值呈现下降的趋势.

关键词：高空状态球面收敛二元矢量喷管俯仰偏转气动特性红外辐射特性

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan zhang Xiaomin Cheng Qinghua Guan Jing Dong Bixian Chen Lujie Jia Jing zhang Yongzheng zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

CSDE~2 WFQ:An Energy Efficient Scheduler for wireless terminal

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CSDE~2 WFQ:An Energy Efficient Scheduler for wireless termin...