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A new ginsengenin containing an oxacyclopentane-ring isolated from the acid hydrolysate of total ginsenosides

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Chinese Chemical Letters 2013年第6期24卷 524-526页

作者： Qing-Xiang Guan De-Ya Sun Ji-Hua Liu Wei Li Qin Meng Cong Geng jian-yuan yin School of Pharmacy Jilin University Beijing Laviana Pharmactech Co. Ltd.

Bioassay-guided fractionation of the acid hydrolysate of total ginsenosides of Panax ginseng *** （Araliaceae） led to the isolation of a novel ginsengenin（1）.The structure of 1 was determined as （20S,22S）-dammar-22,25-epoxy-3β,12β,20-triol by extensive spectroscopy and single-crystal X-ray diffraction *** cytotoxicity of 1 was further tested against SWl 116,HCTl 16,and A549 cells by the MTT method,with IC50 values in the range of 2.96-30.9μmol/L.

关键词： Ginsengenin Oxacyclopentane Cytotoxicity

Treatment of 78 Cases of Shoulder Periarthritis by Warming-needle Method

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Journal of Acupuncture and Tuina Science 2003年第5期1卷 47-48页

作者： LI jian-wu XIONG yuan-yin WU Xue-fei Acup-moxi Department of TCM Hospital of Wuhan City Hubei China 430014 Acup-moxi Department of TCM Hospital of Wuhan City Hubei China 430014

jiansanzhen, Tianzong (SI 11), Jugu (LI 16), jianzhen (SI 9), Binao (LI 14) and Quchi (LI 11) were given warming-needle moxibustion to treat shoulder periarthritis in 78 cases, and the result showed total effective rate was 97.4%. Key Words Warming-needle therapy - Shoulder joint - Inflammation Author: LI jian-wu (1955-), male, junior consultant doctorTranslator: WU Xue-fei

关键词： Warming-needle therapy Shoulder joint Inflammation

Multiple liver metastases of unknown origin:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 233-238页

作者： ying-Jin Wang Ze-Chuan Liu jian Wang yin-Mo Yang Department of Hepatobiliary Pancreatic Surgery Peking University First HospitalBeijing 100034China Department of Interventional and Vascular Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The liver is the most common site of digestive system tumor metastasis,but not all liver metastases can be traced back to the primary *** it is unusual,syphilis can impact the liver,manifesting as syphilitic hepatitis with inflammatory nodules,which might be misdiagnosed as *** SUMMARY This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three *** definitive diagnosis of a tumor had been made in the past decades,but signs of multiple liver metastases were recognized after a computed tomo-graphy scan without evidence of primary *** positive serological tests for syphilis and a biopsy of the liver nodules,a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis *** Clinicians must be aware of the possibility that syphilis can cause hepatic inflam-matory masses,especially when liver metastasis is suspected without evidence of primary lesions.A definitive diagnosis should be established in conjunction with a review of the patient’s medical history for accurate therapeutic intervention.

关键词： Syphilitic hepatitis Liver nodules Liver metastasis Treponema pallidum Case report

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan Yu Jing Wu Guang yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-jian Tang yuan-Ming Pan Wei Li Rui-Qiong Ma jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： yuan Zhao Yidan Zhang Xin Liu jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Mapping the landscape of gastric signet ring cell carcinoma:Overcoming hurdles and charting new paths for advancement

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World Journal of Clinical Oncology 2025年第2期16卷 94-109页

作者： Shu-yuan Wang Jing-Hang Wang Run-Kai Chen Zhen yuan Hao Cui Bo Wei jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medicine concepts progress,GSRCC,a distinct sub-type of GC,has drawn considerable attention from ***,there still persist some controversies regarding the associated research *** To summarize the current obstacles and potential future directions for research on *** To begin with,all literature related to GSRCC published from January 1,2004 to December 31,2023 was subjected to bibliometric analysis in this ***,this paper analyzed the research data using CiteSpace,GraphPad Prism v8.0.2,and VOSviewer,which was obtained from the Web of Science Core Collection *** analysis results were visually *** This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC,including cited references,authors,journals,countries,institutions,and *** popular keywords and clusters contain"prognosis","survival","expression","histology",and"chemotherapy".CONCLUSION The prognosis,precise definition and classification,as well as chemoresistance of GSRCC,continue to be crucial areas of ongoing research,whose directions are closely tied to advancements in molecular biology research on GSRCC.

关键词： Gastric cancer Signet ring cell carcinoma Bibliometric analysis CiteSpace VOSviewer

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抗生素AGPM生物合成途径的初步研究

微生物学通报 2003年第5期30卷 32-37页

作者：陈贵斌牛晋阳张建勇元英进胡宗定天津大学化工学院天津300072

采用前体添加实验法、静息细胞培养法以及酶抑制剂法对藤黄灰链霉菌中抗生素AG PM生物合成途径进行了初步探讨。研究表明能转化成聚酮合成所需活性前体的氨基酸如异亮氨酸、缬氨酸、蛋氨酸、谷氨酸等以及短链脂肪酸乙酸、丙酸、丁酸盐... 详细信息

采用前体添加实验法、静息细胞培养法以及酶抑制剂法对藤黄灰链霉菌中抗生素AG PM生物合成途径进行了初步探讨。研究表明能转化成聚酮合成所需活性前体的氨基酸如异亮氨酸、缬氨酸、蛋氨酸、谷氨酸等以及短链脂肪酸乙酸、丙酸、丁酸盐对抗生素AGPM合成均有明显促进作用 ;另外 ,在培养基中添加脂肪酸和聚酮生物合成途径的专一性抑制剂浅蓝菌素 (2 5μg mL)或脂肪酸合成抑制剂碘乙酰胺 (0 5mmol L)时 ,菌体生长不受影响 ,而抗生素AGPM合成受到强烈抑制 ,分别为对照的 35 3 %和 2 6 2 % ;当碘乙酰胺的浓度为 1mmol L时 ,抗生素AGPM合成几乎完全受到抑制。由此初步推断抗生素AGPM是由聚酮途径合成。

关键词：抗生素AGPM 生物合成途径聚酮途径藤黄灰链霉菌

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髋关节内骨软骨瘤一例报告

中国骨与关节杂志 2016年第12期5卷 946-948页

作者：张远鉴尹同珍张文路沧州中西医结合医院骨一科骨与软组织肿瘤科河北061000

骨软骨瘤是一种常见的原发性良性骨肿瘤,多见于儿童和青少年,常见累及的部位是股骨远端、桡骨近端、胫骨近端、腓骨近端、腓胫骨远端的干骺端,由于肌肉的牵拉,多背向关节生长,巨大骨软骨瘤非常少见,位于关节内的肿瘤更是罕见报道。临床... 详细信息

骨软骨瘤是一种常见的原发性良性骨肿瘤,多见于儿童和青少年,常见累及的部位是股骨远端、桡骨近端、胫骨近端、腓骨近端、腓胫骨远端的干骺端,由于肌肉的牵拉,多背向关节生长,巨大骨软骨瘤非常少见,位于关节内的肿瘤更是罕见报道。临床资料患者,女,48岁,左髋部疼痛、活动受限10年,

关键词：髋关节骨软骨瘤骨肿瘤