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TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2020年第25期26卷 3586-3602页

作者： jian-Feng gu Wei Fu Hai-Xin Qian Wen-Xiu gu Yang Zong Qian Chen Long Lu Department of General Surgery Changshu No.1 People’s Hospital Affiliated to Soochow UniversityChangshu 215500Jiangsu ProvinceChina Department of Oncology Changshu No.1 People’s Hospital Affiliated to Soochow UniversityChangshu 215500Jiangsu ProvinceChina Department of General Surgery the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC) is one of the deadliest solid tumors. Identification of diagnostic and therapeutic biomarkers for PDAC is urgently needed. Transducin(β)-like 1 X-linked receptor 1(TBL1 XR1) has been linked to the progression of various human cancers. Nevertheless, the function and role of TBL1 XR1 in pancreatic cancers are *** To elucidate the function and potential mechanism of TBL1 XR1 in the development of *** Ninety patients with histologically-confirmed PDAC were included in this study. PDAC tumor samples and cell lines were used to determine the expression of TBL1 XR1. CCK-8 assays and colony formation assays were carried out to assess PDAC cell viability. Flow cytometry was performed to measure the changes in the cell cycle and cell apoptosis. Changes in related protein expression were measured by western blot analysis. Animal analysis was conducted to confirm the impact of TBL1 XR1 in *** Patients with TBL1 XR1-positive tumors had worse overall survival than those with TBL1 XR1-negative tumors. Moreover, we found that TBL1 XR1 strongly promoted PDAC cell proliferation and inhibited PDAC cell apoptosis. Moreover, knockdown of TBL1 XR1 induced G0/G1 phase arrest. In vivo animal studies confirmed that TBL1 XR1 accelerated tumor cell growth. The results of western blot analysis showed that TBL1 XR1 might play a key role in regulating PDAC cell proliferation and apoptosis via the PI3 K/AKT *** TBL1 XR1 promoted PDAC cell progression and might be an effective diagnostic and therapeutic marker for pancreatic cancer.

关键词： Pancreatic ductal adenocarcinoma TBL1XR1 Proliferation PI3K/AKT pathway

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Three-dimensional crosslinked nanoarchitectonics of CoP@NC anchored on Ti_(3)C_(2)T_(x) with high ionic diffusion and enhanced sodium storage performance

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Journal of Materiomics 2023年第6期9卷 1185-1195页

作者： Zhihao gu Jiabao Li Penghao Song Yu Wang jian Yang Tianyi Wang Chengyin Wang School of Chemistry and Chemical Engineering Yangzhou University180 Si-Wang-Ting RoadYangzhou225002JiangsuChina

Transition metal phosphides(CoP,etc.),featuring rich natural abundance and remarkable theoretical capacity,suffer from extremely poor rate capability and severe energy decay for sodium storage due to their huge volume change and low electronic ***,an elaborate hierarchical superstructure,nitrogen-doped carbon wrapped CoP in-situ anchored on Ti_(3)C_(2)Tx MXene(CoP@NC/Ti_(3)C_(2)Tx),was fabricated by crosslinking ZIF-67 on Ti_(3)C_(2)Tx flakes followed by successive carbonization and *** principle,the dual modification for CoP nanoparticles through NC coating and Ti_(3)C_(2)T_(x) support can dramatically accelerate the ionic/electronic transportation and alleviate the structure change upon repeated sodiation/desodiation,thus leading to superior electrode integrity,modified ohmic polarization,and excellent electrochemical ***,the elaborated hierarchical superstructure delivers impressive sodium storage performances with large capacity(396.06 mA·h/g at 0.1 A/g up to 100 cycles),robust rate performance(237.8 mA·h/g at 2.0 A/g),and satisfied cyclability(capacity retention of 81.3%at 1.0 A/g after 1,200 cycles).In principle,systematic electrochemical and characterizations measurements manifest that the high pseudocapacitive effect to charge storage,enhanced ionic diffusion kinetics,and remarkable electrochemical reversibility contribute to the impressive sodium storage performance of target CoP@NC/Ti_(3)C_(2)T_(x).Importantly,the unique modification strategy reported in this study paves a way to fabricate high-performance electrode for SIBs.

关键词： CoP ZIF-67 Ti_(3)C_(2)T_(x) High-performance Sodium-ion battery

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Synthesis of MnZn Ferrite Nanoscale Particles by Hydrothermal Method

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Journal of Central South University 2000年第1期12卷 37-39页

作者： gu Ying-ying SANG Shang-bin HUANG Ke-long LIU jian-shen College of Chemistry and Chemical Engineering Central South University of TechnologyChangsha 410083China

Hydrothermal method was used to synthesize nanoscale particles of MnZn ferrites. The crystallites were characterized by XRD, TEM and SEM. The effects of the reaction time, temperature and additives on the product were investigated. Crystallization process would be carried out above 160 ℃ for 5 h or more, higher temperature can reduce the reaction time. Additives were used to remove impurities such as Fe 2O 3, ZnMnO 3.10～15 nm pure slightly agglomerated MnZn ferrite crystallites with a narrow grain size distribution were obtained.

关键词： hydrothermal method MnZn ferrite nanoscale particles additives

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Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity

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World Journal of Gastroenterology 2020年第26期26卷 3750-3766页

作者： jian-guo Gao Mo-Sang Yu Meng-Meng Zhang Xue-Wei gu Yue Ren Xin-Xin Zhou Dong Chen Tian-Lian Yan you-Ming Li Xi Jin Department of Gastroenterology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Colorectal Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Conventional Crohn’s disease(CD)treatments are supportive rather than curative and have serious side ***-derived mesenchymal stem cells(ADSCs)have been gradually applied to treat various *** therapeutic effect and underlying mechanism of ADSCs on CD are still not *** To investigate the effect of ADSC administration on CD and explore the potential *** Wistar rats were administered with 2,4,6-trinitrobenzene sulfonic acid(TNBS)to establish a rat model of CD,followed by tail injections of green fluorescent protein(GFP)-modified *** cytometry,qRT-PCR,and Western blot were used to detect changes in the Wnt signaling pathway,T cell subtypes,and their related *** The isolated cells showed the characteristics of ADSCs,including spindle-shaped morphology,high expression of CD29,CD44,and CD90,low expression of CD34 and CD45,and osteogenic/adipogenic *** therapy markedly reduced disease activity index and ameliorated colitis severity in the TNBS-induced rat model of ***,serum anti-sacchromyces cerevisiae antibody and panti-neutrophil cytoplasmic antibody levels were significantly reduced in ADSCtreated ***,the GFP-ADSCs were colocalized with intestinal epithelial cells(IECs)in the CD rat ***-ADSC delivery significantly antagonized TNBS-induced increased canonical Wnt pathway expression,decreased noncanonical Wnt signaling pathway expression,and increased apoptosis rates and protein level of cleaved caspase-3 in *** addition,ADSCs attenuated TNBS-induced abnormal inflammatory cytokine production,disturbed T cell subtypes,and their related markers in *** Successfully isolated ADSCs show therapeutic effects in CD by regulating IEC proliferation,the Wnt signaling pathway,and T cell immunity.

关键词： Crohn’s disease Adipose-derived mesenchymal stem cell Intestinal epithelial cell Wnt pathway T cell Inflammation

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Trace heavy metals and harmful elements in roots and rhizomes of herbs:Screening level analysis and health risk assessment

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Chinese Herbal Medicines 2022年第4期14卷 622-629页

作者： Xiaoli Wu Peiling Wu Mengying gu jian Xue Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Objective:Heavy metal and harmful element contamination are frequently reported in Chinese herbal medicines(CHMs),and roots and rhizomes parts showed a higher content than other *** investigate the residue level and assess the potential human health risk of heavy metals and harmful elements in roots and rhizomes,720 batches of the sample representing 20 species of herbs from different sources were ***:The content of Pb,Cd,As,Hg,and Cu in the digests was determined using *** chronic hazard index estimate based on non-cancer hazard quotient(HQ)was applied for potential health risk assessment of Pb,Cd,As,Hg,and Cu via consumption of ***:Compared with the Chinese limit standard(Chinese Pharmacopoeia Commission,2020 edition)of Pb,Cd,As,Hg,and Cu in Ginseng Radix et Rhizoma,the exceedance percentage of Pb in total samples was 14.1%,which were generally far higher than Cd,As,Hg,and *** risk assessment results based on hazard quotient calculating showed that total HQ of Cu,Pb,As,Cd,and Hg in Pulsatillae Radix and Clematidis Radix et Rhizoma exceeded 1,with the value of 1.543 and ***,Arsenic had the highest HQ value(0.957)in Pulsatillae ***:Consuming raw materials of Pulsatillae Radix and Clematidis Radix et Rhizoma may pose a potential risk and Arsenic residues in Pulsatillae Radix deserved special attention.

关键词： contamination level harmful element heavy metal potential risk assessment roots and rhizomes of herbs

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On the relationship between tropical cyclone size and environmental helicity in the South China Sea

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Atmospheric and Oceanic Science Letters 2022年第4期15卷 32-37页

作者： Min Li Kekuan Chu jian-Feng gu Zhe-Min Tan School of Atmospheric Sciences Nanjing UniversityNanjingChina Key Laboratory of Mesoscale Severe Weather/Ministry of Education Nanjing UniversityNanjingChina Department of Meteorology University of ReadingLondonUK

In this study,the impact of environmental factors on tropical cyclone(TC)outer-core size was investigated for both migrating and local TCs in the South China Sea during the period 2001–*** all the thermodynamic and dynamic factors,the low-level environmental helicity showed the strongest positive correlation with TC outer-core *** helicity favors the development and organization of convection in TCs,and the corresponding strong inflow and large angular momentum fluxes into the system is beneficial for the maintenance and enlargement of TC outer-core ***,the asymmetric distribution of helicity may account for the asymmetry of TC outer-core ***,the environmental helicity,as an integrated dynamic factor,can provide an alternative view on TC outer-core size.

关键词： Tropical cyclone Outer-core size Helicity Angular momentum

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Pairing Effects on Bubble Nuclei

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Chinese Physics Letters 2019年第3期36卷 24-27页

作者： Yan-Zhao Wang Yang Li Chong Qi jian-Zhong gu Department of Mathematics and Physics Shijiazhuang Tiedao University Institute of Applied Physics Shijiazhuang Tiedao University Department of Physics Royal Institute of Technology (KTH) China Institute of Atomic Energy

In the framework of the Skyrme–Hartree–Fock–Bogoliubov approach with the Sk T interaction, the pairing effects on the proton bubble structures of ^(46)Ar and ^(206)Hg are discussed. In calculations, three kinds of pairing forces (volume, surface and mixed pairing interactions) are used. For ^(46)Ar, it is shown that the bubble structure with the volume pairing is almost the same as that with the mixed pairing. The bubble with the surface pairing is less pronounced than those with the volume and mixed pairings. Analyzing the density distributions and occupation probabilities of the proton s states and the quasi-degeneracy between the proton 2s_(1/2) and 1d_(3/2) orbitals, we explain the difference between the bubble structure with the surface pairing and those with the volume and mixed pairings. For ^(206)Hg, it is seen that the proton density distribution with the surface pairing is different from those with the volume and mixed pairings in the whole region of the radial distance. In addition, it is found that the bubbles with the three pairing forces are different from each other and the least pronounced bubble is obtained with the surface pairing. Thus the selection of the pairing force is important for the study of the nuclear bubble structure.

关键词： Pairing Effects Bubble Nuclei Hg

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Breeding against mycorrhizal symbiosis:Modern cotton (Gossypium hirsutum L.) varieties perform more poorly than older varieties except at very high phosphorus supply levels

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Journal of Integrative Agriculture 2023年第3期22卷 701-715页

作者： WANG Xin-xin ZHANG Min SHENG jian-dong FENG gu Thomas W.KUYPER College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193P.R.China State Key Laboratory of North China Crop Improvement and Regulation/Mountain Area Research Institute Hebei Agricultural UniversityBaoding 071001P.R.China College of Resource and Environmental Sciences Xinjiang Agricultural UniversityUrumqi 830052P.R.China Soil Biology Group Wageningen University&ResearchWageningen 6700AAThe Netherlands

Cotton (Gossypium hirsutum L.) is an importantfiber cash crop,but its root traits related to phosphorus (P) acquisition,including mycorrhizal root traits,are poorly *** cotton varieties bred in northwestern China that were released between 1950 and 2013 were grown in pots with or without one arbuscular mycorrhizal fungal (AMF) species(Funneliformis mosseae) at three P supply levels (0,50 and 300 mg P as KH_(2)PO_(4)kg^(-1)).Eleven root traits were measured and calculated after 7 wk of *** more recent accessions had smaller root diameters,acquired less P and produced less biomass,indicating an (inadvertent) varietal selection for thinner roots that provided less cortical space for AMF,which then increased the need for a high P fertilizer *** the two lower P levels,the mycorrhizal plants acquired more P and produced more biomass than non-mycorrhizal plants (3.2 vs.0.9 mg P per plant;1.8 vs.0.9 g biomass per plant at P_(0);14.5 vs.1.7 mg P per plant;and 4.7 vs.1.6 g biomass per plant at P_(50)).At the highest P level,the mycorrhizal plants acquired more P than non-mycorrhizal plants (18.8 vs.13.4 mg per P plant),but there was no difference in biomass (6.2 vs.6.3 g per plant).At the intermediate P level,root diameter was significantly positively correlated with shoot biomass,P concentration and the P content of mycorrhizal *** results of our study support the importance of the outsourcing model of P acquisition in the root economics space *** varietal selection in the last decades,resulting in thinner roots and a lower benefit from AMF,has led to a lower productivity of cotton varieties at moderate P supply (i.e.,when mycorrhizal,the average biomass of older varieties 5.0 g per plant *** of newer varieties 4.4 g per plant),indicating the need to rethink cotton breeding efforts in order to achieve high yields without very high P *** feasible way to solve the problem of inadvertent varietal selection for cotto

关键词： cotton varieties plant breeding arbuscular mycorrhizal fungi root economics space outsourcing phosphorus acquisition

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A Series of Lanthanide-organic Frameworks Constructed by Ln_4(OH)_4 Clusters and Mixed Ligands

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Chinese Journal of Structural Chemistry 2019年第1期38卷 103-108,4页

作者： gu Xiang-Yu JIN Cong-Cong CHENG jian-Wen Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Institute of Physical Chemistry Zhejiang Normal University

Three new lanthanide-organic compounds, namely, [Ln_2(OH)_2(oba)(2-pc)_2]n(Ln =Er(1), Ho(2), and Dy(3))(oba = 4,4?-oxybis(benzoate), 2-pc = 2-pyrazinecarboxylic acid) have been obtained under hydrothermal conditions. These compounds are isostructural and exhibit 2 D layered structures by incorporating [Ln_4(μ_3-OH)_4]^(8+) clusters and the mixed linkers of oba and 2-pc. It is interesting that decarboxylation occurred in the ortho position and 2,3-pyrazinedicarboxylic acid was partially transformed into 2-pc under hydrothermal conditions. Compound 3 emits a typical Dy^(3+) emission spectrum. Furthermore, the PXRD, TGA and IR spectra were also studied.

关键词： lanthanide cluster mixed ligands luminescence

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Kinetics and leaching behaviors of aluminum from pharmaceutical blisters in sodium hydroxide solution

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Journal of Central South University 2015年第12期22卷 4545-4550页

作者：王重庆王晖顾帼华符剑刚刘又年 School of Chemistry and Chemical Engineering Central South University School of Minerals Processing and Bioengineering Central South University

A hydrometallurgical process was developed for recycling pharmaceutical *** aluminum from pharmaceutical blisters using sodium hydroxide(NaOH) solutions was investigated with respect to leaching behaviors and ***9(34) orthogonal design of experiments suggests that the most significant factor is NaOH concentration followed by temperature and leaching *** experiments demonstrate that the leaching rate of aluminum increases with increasing of the *** optimum conditions are temperature of 70 °C,leaching time of 20 min,NaOH concentration of 1.25 mol/L,liquid-to-solid mass ratio of 15:1 and agitation speed of 400 r/*** optimum conditions,the leaching rate is up to 100%,implying that aluminum and polyvinyl chloride(PVC) plastic in pharmaceutical blisters are separated *** of leaching aluminum is best described by the product layer diffusion control model,and the activation energy is calculated to be 19.26 kJ/mol.

关键词： aluminum kinetics leaching behavior pharmaceutical blisters sodium hydroxide

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