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Strategic insights into the cultivation of pancreatic cancer organoids from endoscopic ultrasonography-guided biopsy tissue

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World Journal of Gastroenterology 2024年第42期30卷 4532-4543页

作者： Jia-Li Yang Jun-Feng Zhang jian-you gu Mei Gao Ming-you Zheng Shi-Xiang guo Tao Zhang Institute of Hepatopancreatobiliary Surgery Chongqing General HospitalChongqing UniversityChongqing 401147China

BACKGROUND The frequent suboptimal efficacy of endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)to culture pancreatic cancer(PC)organoids(PCOs)poses a major challenge in the advancement of personalized medicine for advanced *** To explore how to obtain appropriate puncture tissues from EUS-FNB and optimize the strategy for efficiently constructing PCOs,providing an efficient tool for the advancement of personalized *** Patients who underwent EUS-FNB for the diagnosis of PC tissue were prospectively *** refined the endoscopic biopsy procedures and organoid cultivation *** tissue specimens verified by on-site pathological assessment were cultured in a semi-suspended medium in a microfluidic *** assessed differences in PCOs cultured beyond and below five generations examining patient demographics,specimen and organoid attributes,and the sensitivity of organoids to a panel of clinical drugs through cell viability *** In this study,16 patients with PC were recruited,one sample was excluded because onsite cytopathology showed no tumor *** organoid generation occurred in 93.3%(14 of 15)of the EUS-FNB specimens,with 60%(9 of 15)sustaining over five *** these patients,those with a history of diabetes,familial cancer,or larger tumors exhibited enhanced PCO *** key factors influencing longterm PCOs expansion included initial needle sample quality(P=0.005),rapid initiation of organoid culture postisolation(P≤0.001),and high organoid activity(P=0.031).Drug sensitivity analysis revealed a partial response in two patients following therapeutic intervention and surgery and stable disease in four patients,indicating a moderate correlation between organoid response and clinical *** Optimal initial needle sampling,rapid and precise biopsy sample processing,process isolated samples as soon as possible,and sufficient cellular material are crucial for successful cultiv

关键词： Endoscopic ultrasound-guided fine-needle biopsy Pancreatic cancer organoid Puncture technique Cultivation optimization strategy Drug screening

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重新理解马克思的“跨越论”思想

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四川大学学报（哲学社会科学版） 2001年第3期 12-18页

作者：汤剑波刘友古复旦大学哲学系硕士研究生上海200433

俄国民粹派曾首次提出“跨越论”问题。恩格斯基本上认为“跨越”是行不通的 ,而马克思则认为在特定条件下“跨越论”可以成立 ,这也涉及马克思晚年对唯物史观的一些重要阐述。在今天 ,马克思“跨越论”思想仍然有着强大的现实意义和生... 详细信息

俄国民粹派曾首次提出“跨越论”问题。恩格斯基本上认为“跨越”是行不通的 ,而马克思则认为在特定条件下“跨越论”可以成立 ,这也涉及马克思晚年对唯物史观的一些重要阐述。在今天 ,马克思“跨越论”思想仍然有着强大的现实意义和生命力。

关键词：资本主义社会主义 "卡夫丁峡谷" 马克思跨越论民粹派历史唯物主义俄国农村公社

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Anisotropic characteristics of granular materials under simple shear

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Journal of Central South University 2013年第8期20卷 2275-2284页

作者： QIAN jian-gu you Zi-pei HUANG Mao-song Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education (Tongji University) Shanghai 200092 China Department of Geotechnical Engineering Tongji University Shanghai 200092 China

The discrete element method was used to investigate the microscopic characteristics of granular materials under simple shear loading conditions. A series of simple tests on photo-elastic materials were used as a benchmark. With respect to the original experimental observations, average micro-variables such as the shear stress, shear strain and the volumetric dilatancy were extracted to illustrate the performance of the DEM simulation. The change of anisotropic density distributions of contact normals and contact forces was demonstrated during the course of simple shear. On the basis of microscopic characteristics, an analytical approach was further used to explore the macroscopic behaviors involving anisotropic shear strength and anisotropic stress-dilatancy. This results show that under simple shear loading, anisotropic shear strength arises primarily due to the difference between principal directions of the stress and the fabric. In addition, non-coaxiality, referring to the difference between principal directions of the strain rate and the stress, generates less stress-dilatancy. In particular, the anisotropic hardening and anisotropic stress-dilatancy will reduce to the isotropic hardening and the classical Taylor’s stress-dilatancy under proportional loading.

关键词： simple shear discrete element method anisotropy non-coaxiality

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NONLINEAR DYNAMICS RESPONSE OF CASING PIPE UNDER COMBINED WAVE-CURRENT

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Applied Mathematics and Mechanics(English Edition) 2005年第8期26卷 1040-1046页

作者： TANG you-gang（唐友刚） gu Jia-yang（谷家扬） ZUO jian-li（左建立） MIN jian-qin（闵建琴） Department of Naval Architecture and Ocean Engineering School of Civil Engineering Tianjin University Tianiin 300072. P. R. China

The vortex-induced nonlinear vibration of casing pipes in the deep water was studied considering the loads of current and combined wave-current. The vortex-induced vibration equation of a casing pipe was set up considering the beam mode and Morison＇s nonlinear fluid loads as well as the vortex-excited loads. The approach of calculating vortex-excited nonlinear vibration by Galerkin＇s method was proposed. The natural vibration frequencies and modes were obtained, and the response including primary resonance induced by current and the composite resonance under combined wave-current for the 170 m long casing pipe in the 160 m depth of water were investigated. The results show that the dynamics response of casing pipe obviously increases, and the complicated response behaviors of casing pipe are described under combined wavecurrent.

关键词： casing pipes in the deep water fluid dynamics combined wave-current vortex-excited vibration composite resonance

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Preparation of manganese sulfate from low-grade manganese carbonate ores by sulfuric acid leaching

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International Journal of Minerals,Metallurgy and Materials 2016年第5期23卷 491-500页

作者： Qing-quan Lin guo-hua gu Hui Wang Ren-feng Zhu you-cai Liu jian-gang Fu School of Minerals Processing and Bioengineering Central South University School of Chemistry and Chemical Engineering Central South University

In this study, a method for preparing pure manganese sulfate from low-grade ores with a granule mean size of 0.47 mm by direct acid leaching was developed. The effects of the types of leaching agents, sulfitric acid concentration, reaction temperature, and agitation rate on the leaching efficiency of manganese were investigated. We observed that sulfuric acid used as a leaching agent provides a similar leach- ing efficiency of manganese and superior selectivity against calcium compared to hydrochloric acid. The optimal leaching conditions in sul- furic acid media were determined; under the optimal conditions, the leaching efficiencies of Mn and Ca were 92.42% and 9.61%, respec- tively. Moreover, the kinetics of manganese leaching indicated that the leaching follows the diffusion-controlled model with an apparent ac- tivation energy of 12.28 kJ·mol-l. The purification conditions of the leaching solution were also discussed. The results show that manganese dioxide is a suitable oxidant of ferrous ions and sodium dimethyldithiocarbamate is an effective precipitant of heavy metals. Finally, through chemical analysis and X-ray diffraction analysis, the obtained product was determined to contain 98% of MnSOa4·H20.

关键词： manganese ore treamaent manganese carbonate leaching leaching kinetics manganese sulfate

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Flotation mechanisms of molybdenite fines by neutral oils

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International Journal of Minerals,Metallurgy and Materials 2018年第1期25卷 1-10页

作者： Qing-quan Lin guo-hua gu Hui Wang you-cai Liu jian-gang Fu Chong-qing Wang jiangxi Copper Technology Research Institute Co.Ltd. Jiangxi Copper Corporation School of Chemistry and Chemical Engineering Central South University School of Minerals Processing and Bioengineering Central South University

The flotation mechanisms of molybdenite fines by neutral oils were investigated through microflotation test, turbidity measure- ments, infrared spectroscopy, and interracial interaction calculations. The results of the flotation test show that at pH 2-11, the floatability of molybdenite fines in the presence of transformer oil is markedly better than that in the presence of kerosene and diesel oil. The addition of transformer oil, which enhances the floatability of molybdenite fines, promotes the aggregation of molybdenite particles. Fourier transform infrared measurements illustrate that physical interaction dominates the adsorption mechanism of neutral oil on molybdenite. Interracial inte- raction calculations indicate that hydrophobic attraction is the crucial force that acts among the oil collector, water, and molybdenite. Strong hydrophobic attraction between the oily collector and water provides the strong dispersion capability of the collector in water. Furthermore, the dispersion capability of the collector, not the interaction strength role in the flotation system of molybdenite fines. Our findings provide between the oily collectors and molybdenite, has a highly significant insights into the mechanism ofmolybdenite flotation.

关键词： molybdenite fines flotation mechanisms neutral oils interfacial interaction hydrophobic attraction

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Discrete numerical modeling of granular materials considering crushability

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Journal of Mountain Science 2017年第4期14卷 758-770页

作者： QIAN jian-gu gu jian-bo gu Xiao-qiang HUANG Mao-song Key Laboratory of Geotechnieal and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China Department of Geotechnical Engineering Tongji UniversityShanghai 200092China

The aim of this study is to numerically investigate the influence of particle breakage on the mechanical behavior of granular materials using a discrete element method(DEM). To enable particle crushing, non-crushable elementary particles are boned together to represents the granular aggregates which can be crushed when the external force exceeds its strength. The flaw of the aggregate was also modeled by randomly distributed void. Single particle crushing tests were carried out to determine the distribution of particle strength. The results of single particle crushing tests illustrate that the simulated single particle fracture strength and pattern agree well with the Weibull's distribution *** oedometer tests, drained monotonic and cyclic triaxial tests were also carried out to investigate the crushing of the aggregates and the associated mechanical behaviors. The effect of confining pressure on the crushing of aggregates and the mechanical behavior was also analyzed. It was found that the peak stress and dilation decrease significantly when particle crushing was *** deformation behavior of the specimen is essentially controlled by two factors: particle rearrangement-induced dilation and particle crushing-induced contraction. The increase of permanent strain and the reduction of dilation were observed during cyclic loading and they tend to reach a stable state after a certain number of cycles. The crushing of aggregate is most significant in the first two cycles. The results also indicated that for the same axial strain the volumetric strain and the bound breakage in the cyclic loading tests are significantly larger than that in the monotonic loading tests,especially at high cyclic stress ratio.

关键词： DEM simulation Granular materials Crushing Monotonic and Cyclic triaxial test

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Entropy majorization, thermal adiabatic theorem, and quantum phase transitions

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Frontiers of physics 2012年第2期7卷 244-251页

作者： Shi-jian gu (1) 1. Department of Physics and Institute of Theoretical Physics The Chinese University of Hong Kong Hong Kong China

Let a general quantum many-body system at a low temperature adiabatically cross through the vicinity of the system＇s quantum critical point. We show that the system＇s temperature is signif- icantly suppressed due to both the entropy majorization theorem in quantum information science and the entropy conservation law in reversible adiabatic processes. We take the one-dimensional transverse-field Ising model and the spinless fermion system as concrete examples to show that the inverse temperature might become divergent around the systems＇ critical points. Since the temper- ature is a measurable quantity in experiments, it can be used, via reversible adiabatic processes at low temperatures, to detect quantum phase transitions in the perspectives of quantum information science and quantum statistical mechanics.

关键词： quantum phase transition entropy majorization

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A Framework of Convergence Analysis of Mini-batch Stochastic Projected Gradient Methods

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Journal of the Operations Research Society of China 2023年第2期11卷 347-369页

作者： jian gu Xian-Tao Xiao School of Sciences Dalian Ocean UniversityDalian 116023China School of Mathematical Sciences Dalian University of TechnologyDalian 116023China

In this paper,we establish a unified framework to study the almost sure global convergence and the expected convergencerates of a class ofmini-batch stochastic(projected)gradient(SG)methods,including two popular types of SG:stepsize diminished SG and batch size increased *** also show that the standard variance uniformly bounded assumption,which is frequently used in the literature to investigate the convergence of SG,is actually not required when the gradient of the objective function is Lipschitz ***,we show that our framework can also be used for analyzing the convergence of a mini-batch stochastic extragradient method for stochastic variational inequality.

关键词： Stochastic projected gradient method Variance uniformly bounded Convergence analysis

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Fidelity spectrum:A tool to probe the property of a quantum phase

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Chinese Physics B 2016年第3期25卷 84-90页

作者： Wing Chi Yu Shi-jian gu Department of Physics and ITR The Chinese University of Hong KongHong KongChina

Fidelity measures the similarity between two states and is widely adapted by the condensed matter community as a probe of quantum phase transitions in many-body systems. Despite its success in witnessing quantum critical points, information about the fine structure of a quantum phase one can get from this approach is still limited. Here, we proposed a scheme called fidelity spectrum, By studying the fidelity spectrum, one can obtain information about the characteristics of a phase. In particular, we investigated the spectra in the one-dimensional transverse-field Ising model and the two- dimensional Kitaev model on a honeycomb lattice. It was found that the sPectra have qualitative differences in the critical and non-critical regions of the two models. From the distributions of them, the dominating k modes in a particular phase could also be captured.

关键词： quantum phase.transitions quantum information quanfized spin models

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