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Construct a 3D microsphere of HMX/B/Al/PTFE to obtain the high energy and combustion reactivity

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Defence Technology（防务技术） 2024年第2期32卷 45-54页

作者： jian Wang Jie Chen Yaofeng Mao Yongjun Deng Wei Cao Fude nie Jun Wang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621999PR China Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province Mianyang 621010PR China

Metal(aluminum and boron)based energetic materials have been wildly applied in various fields including aerospace,explosives and micro-devices due to their high energy ***,the low combustion efficiency and reactivity of metal fuels,especially boron(B),severely limit their practical ***,multi-component 3D microspheres of HMX/B/Al/PTFE(HBA)have been designed and successfully prepared by emulsion and solvent evaporation method to achieve superior energy and combustion *** reactivity and energy output of HBA are systematically measured by ignitionburning test,constant-volume explosion vessel system and bomb *** to the increased interfacial contact and reaction area,HBA shows higher flame propagation rate,faster pressurization rate and larger combustion heat of 29.95 cm/s,1077 kPa/s,and 6164.43 J/g,which is 1.5 times,3.5 times,and 1.03 times of the physical mixed counterpart(HBA-P).Meanwhile,HBA also shows enhanced energy output and reactivity than 3D microspheres of HMX/B/PTFE(HB)resulting from the high reactivity of *** reaction mechanism of 3D microspheres is comprehensively investigated through combustion emission spectral and thermal analysis(TG-DSC-MS).The superior reactivity and energy of HBA originate from the surface etching of fluorine to the inert shell(Al_(2)O_(3) and B_(2)O_(3))and the initiation effect of Al to *** work offers a promising approach to design and prepare high-performance energetic materials for the practical applications.

关键词： HMX/B/Al/PTFE 3D microspheres Surface etching Reaction mechanism

Tumor recurrence and survival prognosis in patients with advanced gastric cancer after radical resection with radiotherapy and chemotherapy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1660-1669页

作者： Shuang-Fa nie Chen-Yang Wang Lei Li Cheng Yang Zi-Ming Zhu jian-Dong Fei Department of General Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 75000Hebei ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China

BACKGROUND Advanced gastric cancer is a common malignancy that is often diagnosed at an advanced stage and is still at risk of recurrence after radical surgical ***,as one of the important treatment methods for gastric cancer,is of great significance for improving the survival rate of ***,the tumor recurrence and survival prognosis of gastric cancer patients after radio-therapy and chemotherapy are still *** To analyze the tumor recurrence after radical radiotherapy and chemotherapy for advanced gastric cancer and provide more in-depth guidance for *** A retrospective analysis was performed on 171 patients with gastric cancer who received postoperative adjuvant radiotherapy and chemotherapy in our hospital from 2021 to *** Kaplan-Meier method was used to calculate the recurrence rate and survival rate;the log-rank method was used to analyze the single-factor prognosis;and the Cox model was used to analyze the prognosis associated with multiple *** The median follow-up time of the whole group was 63 months,and the follow-up rate was 93.6%.Stage II and III patients accounted for 31.0%and 66.7%,*** incidences of Grade 3 and above acute gastrointestinal reactions and hematological adverse reactions were 8.8%and 9.9%,respectively.A total of 166 patients completed the entire chemoradiotherapy regimen,during which no adverse reaction-related deaths *** terms of the recurrence pattern,17 patients had local recurrence,29 patients had distant metastasis,and 12 patients had peritoneal implantation *** 1-year,3-year,and 5-year overall survival(OS)rates were 83.7%,66.3%,and 60.0%,*** 1-year,3-year,and 5-year disease-free survival rates were 75.5%,62.7%,and 56.5%,*** analysis revealed that T stage,peripheral nerve invasion,and the lymph node metastasis rate(LNR)were independent prognostic factors for *** Postoperative intensi

关键词： Tumor recurrence Survival prognosis Advanced gastric cancer Radical resection Retrospective study

Groundwater recharge via precipitation in the Badain Jaran Desert,China

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Journal of Groundwater Science and Engineering 2024年第1期12卷 109-118页

作者： Zhe Wang Li-juan Wang jian-mei Shen Zhen-long nie Le Cao Ling-qun Meng Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technology Innovation Center for Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China

Precipitation infiltration serves as a significant source of groundwater in the Badain Jaran *** investigate variations in precipitation infiltration within the desert,this study collected data on moisture content and temperature from the vadose zone through in-situ field *** these data,a numerical model is employed to explore the mechanism of groundwater recharge via *** results are as follows:(1)Moisture content and temperature in the shallow vadose zone exhibit significant seasonal variations,with moisture content diminishing with increasing depth;(2)Groundwater recharge via precipitation infiltration initially increases and then decreases with groundwater level depth(GWD).Peak groundwater recharge via precipitation occurs at a GWD of 0.75 m,decreasing to merely 0.012 cm at GWDs exceeding 2 m;(3)Groundwater is no longer susceptible to phreatic water evaporation when the GWD reaches approximately 3.7 ***,GWD plays a crucial role in governing groundwater recharge via precipitation in the Badain Jaran Desert.

关键词： Badain Jaran Desert Vadose zone Groundwater recharge In situ monitoring Numerical simulation

Endovascular embolization for upper gastrointestinal bleeding due to portal hypertension caused by a superior mesenteric arteriovenous fistula

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Portal Hypertension & Cirrhosis 2024年第1期3卷 39-42页

作者： Yu He Hong nie jian Shen Shuai Zhang Binyan Zhong Xiaoli Zhu Department of Interventional Radiology Shanghai Sixth People's HospitalShanghaiChina Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina

To the Editor,Upper gastrointestinal bleeding(UGIB)caused by portal hypertension is not uncommon in clinical practice,but UGIB caused by superior mesenteric arteriovenous fistula(SMAVF)is extremely *** primary etiologies of SMAVF are associated with traumatic or iatrogenic injury,and congenital lesions.1,2 Although many patients remain asymptomatic after unrecognized injury to the superior mesenteric artery(SMA)for many years,most previous studies reported delayed presentation of persistent epigastric pain,vomiting and nausea,ascites,mesenteric ischemia,or *** incidence of SMAVF is 0.09%,with a mortality rate of 39%–77%.3 Thus,prompt diagnosis and treatment are very important to prevent morbidity and mortality.

关键词： mortality bleeding hypertension

Effectiveness and safety of Jiawei Xiaoyao pill(加味逍遥丸)in the treatment of premenstrual syndrome(liver depression,spleen deficiency,and blood-heat syndrome):a multi-center,randomized,placebo-controlled trial

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Journal of Traditional Chinese Medicine 2024年第2期44卷 373-380页

作者： LI Xiyu YANG Yanhong SUN jian nie Quanfang LIU Lifen LI Guifen YU Junping ZHANG Zhuangjin XU Yi ZOU Ting SHI Yun Department of Gynecology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Gynecology Luoyang 1st Hospital of TCMLuoyang 471099China Department of Gynecology Zaozhuang Hospital of TCMZaozhuang 277099China Department of Gynecology and Obstetrics Loudi Central HospitalLoudi 417099China Department of Gynecology and Obstetrics Yiyang 1st Hospital of TCMYiyang 413002China Department of Gynecology Harrison International Peace HospitalHengshui 053000China Department of Gynecology and Obstetrics Shanxi Fenyang HospitalFenyang 032299China Department of Gynecology and Obstetrics Hengyang Chinese Medicine HospitalHengyang 421001China Scientific Research Institute of Beijing Tongrentang Technology Development Co. Ltd.Beijing 100061China Female Reproductive and Health Medicine Research Committee of Chinese Traditional Medicine Association Beijing 100061China

OBJECTIVE:To investigate the effectiveness and safety of Jiawei Xiaoyao pill(加味逍遥丸,JXP)in the treatment of symptoms associated with premenstrual syndrome(PMS).METHODS:A total of 144 regularly menstruating women with PMS were recruited at 8 sites in China from August 2017 to December 2018,and randomized to receive either a JXP or a matching placebo(12 g/d,6 g twice a day)for 3 menstrual *** primary indicator was the reduced Daily Record of Severity of Problems(DRSP)scores in the luteal phase after 3 months of *** safety outcomes included clinical adverse events(AEs),adverse reactions(ARs),changes in vital signs,and laboratory ***:JXP surpassed the placebo in reducing DRSP scores(psychological/somatic dysfunction)in the luteal phase over 3 menstrual cycles of treatment(PFAS=0.002,PPPS=0.001).Additionally,there were no significant differences in the incidence of AEs,severe AEs,withdrawal due to AEs and ARs between the two groups(all P>0.05),and no clinically significant adverse medical events related to the test drug ***:JXP was superior to the placebo in relieving the symptoms associated with PMS,which signified that JXP may be effective,safe,and welltolerated as an alternative therapy.

关键词： premenstrual syndrome randomized controlled trial double-blind method Jiawei Xiaoyao pill

Insight-HXMT on-orbit thermal control status and thermal deformation impact analysis

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Radiation Detection Technology and Methods 2023年第3期7卷 337-349页

作者： Ai-Mei Zhang Yi-Fan Zhang Jin-Yuan Liao Yu-Peng Xu Yu-Sa Wang Wen-Bo Luo Yu-Peng Zhou Zhi-ying Qian Xiao-Bo Li Fang-Jun Lu Shuang-Nan Zhang Li-Ming Song Cong-Zhan Liu Fan Zhang jian-yin nie Juan Wang Sheng Yang Tong Zhang Xiao-Jing Liu Rui-Jie Wang Xu-Fang Li Yi-Fei Zhang Zheng-Wei Li Xue-Feng Lu He Xu Di Wu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Beijing Institute of Spacecraft System Engineering CASTBeijing 100094China

Purpose The Hard X-ray Modulation Telescope is China’s first X-ray astronomy satellite launched on June 15,2017,dubbed *** and passive thermal control measures are employed to keep devices at suitable *** this paper,we analyzed the on-orbit thermal monitoring data of the first 5 years and investigated the effect of thermal deformation on the point spread function(PSF)of the *** We examined the data of the on-orbit temperatures measured using 157 thermistors placed on the collimators,detectors and their support structures and compared the results with the thermal control *** thermal deformation was evaluated by the relative orientation of the two star sensors installed on the main support *** effect was estimated with evolution of the PSF obtained with calibration scanning observations of the Crab *** The on-orbit temperatures met the thermal control requirements thus far,and the effect of thermal deformation on the PSF was negligible after the on-orbit pointing calibration.

关键词： X-ray Insight-HXMT Thermal control Temperature Star sensor data Pointing PSF

Role of hsa_circ_0007482 in pterygium development: insights into proliferation, apoptosis, and clinical correlations

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1387-1395页

作者： Li-Yun Zhang Xin Liu Shuo Zheng Wen-Qun Xi Xue-Ping Wu Dan-Yao nie Hui-Ling Hu jian-Tao Wang Xin-Hua Liu Jing Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518000Guangdong ProvinceChina

AIM:To investigate the impact of hsa_circ_0007482 on the proliferation and apoptosis of human pterygium fibroblasts(HPFs)and its correlation with the severity grades of ***:Pterygium and normal conjunctival tissues were collected from the superior area of the same patient’s eye(n=33).The correlation between pterygium severity and hsa_circ_0007482 expression using quantitative reversetranscription polymerase chain reaction(RT-qPCR)were *** distinct siRNA sequences targeting hsa_circ_0007482,along with a negative control sequence,were transfected into *** proliferation was assessed using the cell counting *** levels of Ki67,proliferating cell nuclear antigen(PCNA),Cyclin D1,Bax,B-cell lymphoma-2(Bcl-2),and Caspase-3 were measured via *** staining was employed to detect Ki67 and vimentin *** was evaluated using flow ***:Hsa_circ_0007482 expression was significantly higher in pterygium tissues compared to normal conjunctival tissues(P<0.001).Positive correlations were observed between hsa_circ_0007482 expression and pterygium severity,thickness,and vascular *** of hsa_circ_0007482 inhibited cell proliferation,reducing the mRNA expression of Ki67,PCNA,and Cyclin D1 in ***_circ_0007482 knockdown induced apoptosis,increasing mRNA expression levels of Bax and Caspase-3,while decreasing Bcl-2 expression in ***,hsa_circ_0007482 knockdown attenuated vimentin expression in ***:The downregulation of hsa_circ_0007482 effectively hampers cell proliferation and triggers apoptosis in *** are discernible positive correlations detected between the expression of hsa_circ_0007482 and the severity of pterygium.

关键词： hsa_circ_0007482 circular RNA pterygium cell proliferation apoptosis

Conversion therapy of a giant hepatocellular carcinoma with portal vein thrombus and inferior vena cava thrombus:A case report and review of literature

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World Journal of Clinical Cases 2024年第16期12卷 2847-2855页

作者： Wen-Jie Song jian Xu Ye nie Wei-Min Li jian-Ping Li Li Yang Meng-Qi Wei Kai-Shan Tao Department of Hepatobiliary Surgery Xijing HospitalAir Force Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Radiotherapy The First Affiliated Hospital of the Fourth Military Medical UniversityXi'an 710032Shaanxi ProvinceChina State Key Laboratory of Cancer Biology Department of PathologyXijing Hospital and School of Basic MedicineXijing HospitalAir Force Medical UniversityXi'an 710000Shaanxi ProvinceChina Department of Radiology Xijing HospitalAir Force Medical UniversityXi'an 710032Shaanxi ProvinceChina

BACKGROUND The prognosis of hepatocellular carcinoma(HCC)combined with portal and hepatic vein cancerous thrombosis is poor,for unresectable patients the combination of targeted therapy and immune therapy was the first-line recommended treatment for advanced HCC,with a median survival time of only about 2.7-6 *** this case report,we present the case of a patient with portal and hepatic vein cancerous thrombosis who achieved pathologic complete response after conversion *** SUMMARY In our center,a patient with giant HCC combined with portal vein tumor thrombus and hepatic vein tumor thrombus was treated with transcatheter arterial chemoembolization(TACE),radiotherapy,targeted therapy and immunotherapy,and was continuously given icaritin soft capsules for oral *** 7 months of conversion therapy,the patient's tumor shrank and the tumor thrombus subsided *** pathology of surgical resection was in complete remission,and there was no progression in the postoperative follow-up for 7 months,which provided a basis for the future strategy of combined conversion *** In this case,atezolizumab,bevacizumab,icaritin soft capsules combined with radiotherapy and TACE had a good *** patients with hepatocellular carcinoma combined with hepatic vein/inferior vena cava tumor thrombus,adopting a high-intensity,multimodal proactive strategy under the guidance of multidisciplinary team(MDT)is an important attempt to break through the current treatment dilemma.

关键词： Hepatocellular carcinoma Icaritin Conversion Downstaging Portal vein thrombus Case report

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村域社会资本与农村老人的社区治理参与

北京社会科学 2024年第3期 101-113页

作者：聂建亮陈博晗西北大学公共管理学院西北大学民政部政策理论研究基地

基于对全国11个省份1137位农村老人的问卷调查,从村域社会网络、村域信任和村域规范3个维度考察了村域社会资本对农村老人社区治理参与的影响。结果表明,村域社会网络、村域信任和村域规范均显著正向影响农村老人的社区治理参与,且这一... 详细信息

基于对全国11个省份1137位农村老人的问卷调查,从村域社会网络、村域信任和村域规范3个维度考察了村域社会资本对农村老人社区治理参与的影响。结果表明,村域社会网络、村域信任和村域规范均显著正向影响农村老人的社区治理参与,且这一结果具有稳健性。村域社会网络、村域信任和村域规范对农村老人社区治理参与的影响存在着性别、年龄和政治身份的群体差异,特别是村域社会资本的各个维度仅显著影响了非党员群体的社区治理参与,而对党员群体的影响不显著。研究进一步发现,村域社会资本主要通过公平感提升和支持获得状况改善影响农村老人的社区治理参与。要发挥村域社会资本的作用,须打造社区参与平台及空间,为积累村域社会资本提供土壤;还须通过培育参与意识和公共精神,促进村域社会资本的积累,延续村域社会资本的生命力。

关键词：村域社会资本农村老人社区治理参与基层治理乡村振兴