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Pseudo-random sequence generator based on the generalized Henon map

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The Journal of China Universities of Posts and Telecommunications 2008年第3期15卷 64-68页

作者： ZHENG Fan TIAN Xiao-jian SONG Jing-yi li Xue-yan College of Electronic Science and Engineering Jilin University Changchun 130012 China

By analysis and comparison of several chaotic systems that are applied to generate pseudo-random sequence, the generalized Henon map is proposed as a pseudo-random sequence generator. A new algorithm is created to solve the problem of non-uniform distribution of the sequence generated by the generalized Henon map. First, move the decimal point of elements in the sequence to the fight; then, cut off the integer; and finally, quantify it into a binary sequence. Statistical test, security analysis, and the application of image encryption have strongly supported the good random statistical characteristics, high linear complexity, large key space, and great sensitivity of the binary sequence.

关键词： pseudo-random sequence chaos the generalized Henon map

GdCl₃ abates hepatic ischemia-reperfusion injury by inhibiting apoptosis in rats

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Hepatobiliary & Pancreatic Diseases International 2009年第5期8卷 518-523页

作者： jian-yi li Xi Gu Wen-Hai Zhang Shi Jia Yong Zhou Department of General Surgery Shengjing Hospital China Medical University Shenyang 110004 China.

BACKGROUND:Gadolinium chloride(GdCl3)is a specific inhibitor of Kupffer cells(KCs),which are important promoters of various liver *** is therefore of interest to explore the role of KCs in liver ischemia-reperfusion injury and their relations with apoptosis caused by ischemia-reperfusion injury. METHODS:One hundred male Wistar rats(190-210 g, 6-7 weeks old)were divided into two groups at random, GdCl3 group and control *** were collected at 0.5,1,6,12,and 24 hours from each group after *** alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were measured by an automatic biochemical ***-αin serum was measured by enzyme-linked immunosorbent assay(EliSA). Malondialdehyde(MDA)in the liver mitochondria was measured by a colorimetric *** changes in the liver and immunohistochemical staining for caspase-3 were observed under an optical *** ratio of apoptotic cells was measured by TdT-mediated dUTP nick-end labeling(TUNEL),and ultrastructural features of apoptosis were observed with a transmission electron microscope(TEM). RESULTS:The levels of ALT in the GdCl3 group were lower than those in the control group after reperfusion for 0.5, 1,6 and 12 hours(P<0.05);and the levels of AST in the GdCl3 group were lower than those in the control group after reperfusion for 6 and 12 hours(P<0.05).The levels of TNF-αin the GdCl 3 group were lower than those in the control group after reperfusion for each time(P<0.05). The concentrations of MDA after reperfusion in the GdCl3 group were lower than those in the control group after reperfusion for 6,12 and 24 hours(P<0.05).After reperfusion for 0.5,1,6 and 12 hours,the integral optical density(IOD)of caspase-3-positive cells was lower in theGdCl3 group than in the control group(P<0.05).After reperfusion for 1,6,and 12 hours,the IOD of cells stained by TUNEL in the GdCl3 group was lower than that in the control group(P<0.05). CONCLUSIONS:GdCl3

关键词： gadolinium chloride Kupffer cell ischemia-reperfusion injury caspase-3 apoptosis

The role of radical prostatectomy and definitive external beam radiotherapy in combined treatment for high-risk prostate cancer:a systematic review and meta-analysis

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Asian Journal of Andrology 2020年第4期22卷 383-389页

作者： Xu Cheng Zhi-Hui Wang Mou Peng Zhi-Chao Huang Lu yi yi-jian li Lei yi Wen-Zhi Luo Jia-Wen Chen yin-Huai Wang Department of Urology The Second Xiangya Hospital of Central South UniversityChangsha 410011China T.H.Chan School of Public Health Harvard UniversityBostonMA 02115USA

The first-line treatment options for high-risk prostate cancer(PCa)are definitive external beam radiotherapy(EBRT)with or without androgen deprivation therapy(ADT)and radical prostatectomy(RP)with or without adjuvant ***,few randomized trials have compared the survival outcomes of these two *** systematically evaluate the survival outcomes of high-risk PCa patients treated with EBRT-or RP-based therapy,a comprehensive and up-to-date meta-analysis was performed.A systematic online search was conducted for randomized or observational studies that investigated biochemical relapse-free survival(bRFS),cancer-specific survival(CSS),and/or overall survival(OS),in relation to the use of RP or EBRT in patients with high-risk *** summary hazard ratios(HRs)were estimated under the random effects *** identified heterogeneity between studies using Q tests and measured it using I2 *** evaluated publication bias using funnel plots and Egger's regression asymmetry *** studies(including one randomized controlled trial[RCT])of low risk of bias were selected and up to 9504 patients were *** comparing EBRT-based treatment with RP-based treatment,the pooled HRs for bRFS,CSS,and OS were 0.40(95%confidence interval[CI]:0.24–0.67),1.36(95%CI:0.94–1.97),and 1.39(95%CI:1.18–1.62),*** OS for RP-based treatment and better bRFS for EBRT-based treatment have been identified,and there was no significant difference in CSS between the two ***-based treatment is recommended for high-risk PCa patients who value long-term survival,and EBRT-based treatment might be a promising alternative for elderly patients.

关键词： high risk prostatectomy prostatic neoplasms radiotherapy survival

Comparative analysis of different feeder layers with 3T3 fibroblasts for culturing rabbits limbal stem cells

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1021-1027页

作者： Hui-Xian Wang Xiao-Wei Gao Bing Ren Yan Cai Wen-Jing li Yu-li Yang yi-jian li Medical College of Shihezi University Ophthalmic Center No.474 Hospital of Chinese PLA Southwest Hospital Third Military Medical University

AIM： To explore the possibility of human umbilical cord mesenchymal stem cells（h UCMSCs）, human umbilical vein endothelial cells（h UVECs）, human dental pulp stem cells（h DPSCs） and human periodontal ligament stem cells（h PDLSCs） serving as feeder cells in co-culture systems for the cultivation of limbal stem ***： Different feeder layers were cultured in Dulbecco＇s modified Eagle＇s medium（DMEM）/F12 and were treated with mitomycin C. Rabbits limbal stem cells（LSCs） were co-cultured on h UCMSCs, h UVECs, h DPSCs, h PDLSCs and NIH-3T3, and then comparative analysis were made between each group to see their respective colony-forming efficiency（CFE） assay and immunofluorescence（IPO13,CK3/12）.RESULTS： The efficiency of the four type cells in supporting the LSCs morphology and its cellular differentiation was similar to that of NIH-3T3 fibroblasts as demonstrated by the immunostaining properties analysis, with each group exhibiting a similar strong expression pattern of IPO13, but lacking CK3 and CK12 expression in terms of immunostaining. But h UCMSCs, h DPSCs and h PDLSCs feeder layers were superior in promoting colony formation potential of cells when compared to h UVECs and feedercell-free ***： hUCMSCs, hDPSCs and hPDLSCs can be a suitable alternative to conventional mouse NIH-3T3 feeder cells, so that risk of zoonotic infection can be diminished.

关键词： limbal stem cells feeder layers umbilical cord mesenchymal stem cells umbilical vein endothelial cells dental pulp stem cells periodontal ligament stem cells

Biosafety of a 3D-printed intraocular lens made of a poly (acrylamide-co-sodium acrylate) hydrogel in vitro and in vivo

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1521-1530页

作者： Jia-Wen li yi-jian li Xi-Su Hu Yu Gong Ben-Bin Xu Hai-Wei Xu Zheng-Qin yin Southwest Hospital/Southwest Eye Hospital Third Military Medical University(Army Medical University)Chongqing 400038China Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Chongqing 400038China Smart Materials and Surfaces Lab Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle upon Tyne NE18STUK

AIM:To assess the biosafety of a poly(acrylamide-cosodium acrylate)hydrogel(PAH)as a 3D-printed intraocular lens(IOL)***:The biosafety of PAH was first evaluated in vitro using human lens epithelial cells(LECs)and the ARPE19 cell line,and a cell counting kit-8(CCK-8)assay was performed to investigate alterations in cell proliferation.A thin film of PAH and a conventional IOL were intraocularly implanted into the eyes of New Zealand white rabbits respectively,and a sham surgery served as control *** anterior segment photographs,intraocular pressure(IOP),blood parameters and electroretinograms(ERG)were *** cytokines in the aqueous humor,such as TNFαand IL-8,were examined by *** apoptosis of the retina was investigated by TUNEL assay,and macro PAHge activation was detected by ***:PAH did not slow cell proliferation when cocultured with human LECs or ARPE19 *** implantation of a thin film of a 3 D-printed IOL composed of PAH did not affect the IOP,blood parameters,ERG or optical structure in any of the three experimental groups(n=3 for each).Both TNFαand IL-8 in the aqueous humor of PAH group were transiently elevated 1 wk post-operation and recovered to normal levels at 1 and 3 mo ***1+macroPAHges in the anterior chamber angle in PAH group were increased markedly compared to those of the control group;however,there was no significant difference compared to those in the IOL ***:PAH is a safe material for 3D printing of personal IOLs that hold great potential for future clinical applications.

关键词： cataract biosafety lens epithelial cells ARPE19 cells intraocular lens 3D printing poly hydrogel rabbit

基于应变片法的低温条件下热膨胀特征参数的测量方法与装置（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第5期15卷 323-330页

作者： Ke TANG Long SHA yi-jian li Tao JIN Shu-juan liU Institute of Refrigeration and Cryogenics Zhejiang University

研究目的:为了满足低温系统的材料选择和结构设计对于材料热膨胀特征参数的需求,研发低温条件下精确、快速、方便操作、低成本的热膨胀特征参数测量方法和系统装置。创新要点:完成了卡玛合金箔应变片在77–293 K低温温区敏感系数的修正... 详细信息

研究目的:为了满足低温系统的材料选择和结构设计对于材料热膨胀特征参数的需求,研发低温条件下精确、快速、方便操作、低成本的热膨胀特征参数测量方法和系统装置。创新要点:完成了卡玛合金箔应变片在77–293 K低温温区敏感系数的修正,保证了基于应变片技术的低温条件材料热膨胀特征参数测量的精度;所研制装置合理的热设计和等速率式温度控制模式使得材料热膨胀特征参数在77–293 K温区的测量可在14小时内快速完成。研究方法:针对77–293 K温区,基于应变片测量方法,研制了采用比例-积分-微分(PID)温控系统的固体材料热膨胀特征参数测量装置(见图2和3)。通过将304不锈钢的测量数据与美国国家标准与技术研究院(NIST)公布数据进行比较,完成了卡玛合金箔应变片在77–293 K低温温区的敏感系数修正(见图7和8)。采用修正后的敏感系数进行无氧铜线性收缩率测量,并与NIST公布数据比较(见图9和表2),验证了该装置在77–293 K低温温区的测量精度。重要结论:获得了77–293 K低温温区卡玛合金箔应变片敏感系数的修正结果;基于修正敏感系数的应变片法测量装置,采用0.3 K/min的等速率式温度控制模式,可实现77–293 K低温温区固体材料热膨胀特征参数的精确、快速测量。

关键词：热膨胀线性收缩率应变片低温

Melatonin protects liver from intestine ischemia reperfusion injury in rats

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World Journal of Gastroenterology 2008年第48期14卷 7392-7396页

作者： jian-yi li Hong-Zhuan yin Xi Gu Yong Zhou Wen-Hai Zhang yi-Min Qin The Fifth Department of General Surgery Shengjing Affiliated Hospital of China Medical University Shenyang 110004 Liaoning Province China The Second Department of General Surgery Shengjing Affiliated Hospital of China Medical University Shenyang 110004 Liaoning Province China The Sixth Department of General Surgery Shengjing Affiliated Hospital of China Medical University Shenyang 110004 Liaoning Province China Department of General Surgery The First People's Hospital of Shenyang Shenyang 110004 Liaoning Province China

AIM: To investigate the protective effect of melatonin on liver after intestinal ischemia-reperfusion injury in rats. METHODS: One hundred and fifty male Wistar rats, weighing 190-210 g, aged 7 wk, were randomly divided into melatonin exposure group, alcohol solvent control group and normal saline control group. Rats in the melatonin exposure group received intraperitoneal (IP) melatonin (20 mg/kg) 30 min before intestinal ischemia-reperfusion (IR), rats in the alcohol solvent control group received the same concentration and volume of alcohol, and rats in the normal saline control group received the same volume of normal saline. Serum samples were collected from each group 0.5, 1, 6, 12, and 24 h after intestinal IR. Levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured with an auto-biochemical analyzer. Serum TNF-α was tested by enzyme-linked immunosorbent assay (EliSA). Malondialdehyde (MDA) in liver was detected by colorimetric assay. Pathological changes in liver and immunohistochemical straining of ICAM-1 were observed under an optical microscope. RESULTS: The levels of ALT measured at various time points after intestinal IR in the melatonin exposure group were significantly lower than those in the other two control groups (P liver after intestinal IR injury, thus improving the liver function.

关键词： Melatonin Intestinal ischemia-reperfusion injury liver TNF-α

Melatonin abates liver ischemia/reperfusion injury by improving the balance between nitric oxide and endothelin

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 574-579页

作者： Wen-Hai Zhang, jian-yi li and Yong Zhou Department of 5th General Surgery, Second Affiliated Hospital , China Medical University, Shenyang 110004, China Department of 5th General Surgery Second Affiliated Hospital (Shengjing Hospital) China Medical University Shenyang 110004 China. surgeonzwh@***

BACKGROUND: Melatonin exerts complex physiological and pharmacological effects on multiple systems and organs. We hypothesized that melatonin might abate ischemia/ reperfusion (I/R) injury in the liver by inhibiting excessive oxidative stress and keeping nitric oxide (NO) from being scavenged by free radicals. The aim of the present study was to investigate whether melatonin protects the liver from I/R injury and, if so, by what underlying mechanism. METHODS: Under anesthesia, Wistar rats were intraperi- toneally injected with 20 mg/kg melatonin (dissolved in physiological saline containing 4% ethanol, Mel group), 4% alcohol (Alc group), or physiological saline (NS group). The artery, portal vein and bile duct of the left lobe of the liver were clamped for 60 minutes and then released. At different time points after I/R, the rats were sacrificed and blood samples were collected to measure the levels of serum alanine aminotransferase (ALT), lactic dehydrogenase (LDH), and NO. Hepatic tissue samples were collected for measuring endothelin expression by immunohistochemical staining and for routine morphological and histological examination. RESULTS: The levels of both ALT and LDH in the Mel group were significantly reduced for up to 24 hours after I/R compared with the Alc and NS groups (Plin-positive cells were significantly fewer in the Mel group than in the Alc and NS groups at 6 hours after I/R (Plity and decreased endothelin expre

关键词： melatonin liver ischemia/reperfusion nitric oxide endothelin

Long-term outcomes of drug-eluting versus bare-metal stent implantation in patients with chronic total coronary artery occlusions

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Chinese Medical Journal 2009年第6期122卷 643-647页

作者： HAN Ya-ling ZHANG jian li yi WANG Shou-li JING Quan-min yi Xian-hua MA ying-yan LUAN Bo WANG Geng WANG Bin Department of Cardiology Shenyang Northern Hospital Shenyang Liaoning 110016 China

Background There are limited data on the efficacy of drug-eluting stents （DES） for treatment of chronic total occlusions （CTO）. The aim of the study was to evaluate the long-term clinical outcomes of DES implantation for CTO compared with bare-metal stent （BMS） implantation.Methods Between June 1995 and December 2006, a total of 1184 patients with successful recanalization of at least one de novo CTO lesion were consecutively registered, including 660 （55.7%） who underwent DES and 524 （44.3%） who underwent BMS implantation. All patients were followed up for up to 5 years for occurrence of major adverse cardiac events （MACE）. Long-term survival rates were estimated with the Kaplan-Meier method.Results Baseline clinical and angiographic characteristics were comparable between the two groups except that patients in the DES group received longer dual antiplatelet therapy （（7.4±2.5） months vs （1.7±0.8） months, P 〈0.001）. Average follow-up periods were （4.7±0.89） and （3.2±1.3） years for the BMS and DES groups, respectively. There was no significant difference in 5-year survival rates between the two groups （90.3% for DES group vs 89.6% for BMS group, Log-rank P=0.38）, but the 5-year target vessel revascularization （TVR）-free survival rate in the DES group was significantly higher than that in the BMS group （81.6% vs 73.5%, Log-rank P 〈0.001）. The cumulative MACE-free survival in the DES group was also significantly higher than that in the BMS group （80.6% vs 71.5%, Log-rank P〈0.001）. The rates of readmission caused by cardiovascular disease （27.0% vs 37.8%, P 〈0.001） and the need for bypass surgery were significantly lower in the DES group （1.5% vs 3.4%, P 〈0.05）. By multivariable analysis, DES implantation could significantly lower the long-term MACE risk of PCI for CTO patients （HR： 0.492; 95% Cl 0.396-0.656, P 〈0.001）. Left ventricular ejection fraction 〈50% and elderly （〉65 years） were identified as independent predictors of long-term MACE during follow-up.Concl

关键词： chronic disease coronary artery disease percutaneous transluminal coronary angioplasty drug eluting stent