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Numerical simulation of plasma response to externally applied resonant magnetic perturbation on the J-TEXT tokamak

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Plasma Science and Technology 2018年第5期20卷 23-29页

作者： Bicheng li Zhonghe jianG jian LV Xiang li Bo RAO Yonghua DING State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People＇s Republic of China

Nonlinear magnetohydrodynamic（MHD） simulations of an equilibrium on the J-TEXT tokamak with applied resonant magnetic perturbations（RMPs） are performed with NIMROD（non-ideal MHD with rotation,open discussion）.Numerical simulation of plasma response to RMPs has been developed to investigate magnetic topology,plasma density and rotation *** results indicate that the pure applied RMPs can stimulate 2/1 mode as well as 3/1 mode by the toroidal mode coupling,and finally change density profile by particle *** the same time,plasma rotation plays an important role during the entire evolution process.

关键词： resonant magnetic perturbations tearing mode particle transport

Melatonin ameliorated okadaic-acid induced Alzheimer-like lesions

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Acta Pharmacologica Sinica 2004年第3期25卷 22-26页

作者： Yi-peng WANG,Xian-tao li,Shi-jie liU,xin-wen ZHOU,Xiao-chuan WANG,jian-zhi WANG2 TongjiMedical College,Huazhong University of Science and Technology,Wuhan 430030,China Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

AIM: To explore the protective effects of melatonin (Mel) on the abnormal phosphorylation of neuronal cytoskeletal proteins. METHODS: We generated a neuroblastoma (SH-SY5Y) cell system in which cytoskeletal proteins are abnormally phosphorylated resulting in microtubule disruption due to the marked inhibition of protein phosphatase activities by okadaic acid (OA). RESULTS: OA-induced declines in cell viability and mitochondrial metabolic activity were remarkably prevented by Mel. In addition, the hyperphosphorylation/accumulation of neurofilament- (NF-) H/M subunits and the disruption of microtubules, induced by OA, were significantly inhibited by Mel. CONCLUSION: Our results suggest multiple protective functions of Mel against a series of pathological lesions known to culminate in AD, including abnormal phosphorylation of cytoskeletal proteins, microtubule disassembly and mitochondrion-initiated cell toxicity.

关键词： Alzheimer disease protein phosphatase okadaic acid neurofilament proteins melatonin

A Clinical Observation of Functional Abdominal Pain Syndrome in Patients Treated by Traditional Chinese Spinal Orthopedic Manipulation

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Chinese Journal of Integrative Medicine 2018年第2期24卷 140-146页

作者： QU liu-xin xinG li-yang Wanda Norman CHEN Hong li Ming-ju GAO Song li Ping Department of Chinese Orthopedics and Traumatology Zhongda Hospital School of Medicine Southeast UniversityNanjing 210009 China Department of Acupuncture and Moxibustion Zhongda Hospital School of Medicine Southeast University Nanjing 210009 China Acupuncturist at Gateway Sports Medicine Portland OR 97216 USA Department of Gastroenterology Zhongda Hospital School of Medicine Southeast University Naniina 210009. China

Objective： To evaluate the clinical effect of traditional Chinese spinal orthopedic manipulation（TCSOM） in treating patients with functional abdominal pain syndrome（FAPS） in comparison with Pinaverium Bromide（Dicetel, PBD）, and to assess a possible cause for FAPS. Methods： Eighty patients with FAPS were randomly and equally assigned to the TCSOM group and PBD group according to the random number table. All patients in the TCSOM group were treated with a maximum of 5 times of spinal manipulations. Patients in the PBD group were instructed to take 50 mg 3 times a day, consistently for 2 weeks. The symptoms of pre-and post-treatment were assessed on a visual analog scale（VAS） pain score. A symptom improvement rating（SIR） was implemented to evaluate the effects of the treatments. Results： The symptoms of 27 cases of the TCSOM group were relieved soon after the first TCSOM treatment and 9 cases were significantly improved. The VAS pain scores in the TCSOM group were significantly lower than those in the PBD group after 2 weeks treatment. According to the SIR based on VAS, the TCSOM group included 30 cases with excellent results, 7 cases with good, and 3 cases with poor. Adverse events to the treatment were not reported. Based on VAS, the PBD group reported 8 cases with excellent results, 10 cases with good and 22 cases with poor. There was a significant difference between the two groups（P〈0.01）. Conclusions： The displacement of intervertebral discs and/or vertebra in the thoracic or lumbar region seems to be a contributing factor in the symptoms of FAPS. TCSOM is an effective treatment for FAPS.

关键词： functional abdominal pain syndrome spinal manipulation orthopedic Jiaji(EX-B2) Back-Shu acupoints visual analog scale

Towards a universal organogelator:A general mixing approach to fabricate various organic compounds into organogels

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Science China Chemistry 2011年第7期54卷 1051-1063页

作者： DUAN PengFei li YuanGang jianG jian WANG TianYu liU MingHua Beijing National Laboratory for Molecular Science CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China College of Chemistry and Chemical Engineering Xi'an University of Science and Technology Xi'an 710054 China

Low-molecular-weight organogels(LMOG) have been attracting a surge interest in fabricating soft *** the finding of the gelator molecules has been developed from serendipity to objective design,the achievement of the gelator molecules still needs good design and tedious organic *** this paper,we proposed a simple and general mixing approach to get the organogel for nearly all the organic compounds and even soluble nanoparticles without any *** have designed a universal gelator molecule,which forms organogels with more than 40 kinds of organic solvents from aploar to polar *** interestingly,when other organic compounds or even nanomaterials,which are soluble in certain organic solvents,are mixed with this gelator molecule,they can form organogels no matter whether the individual compounds could form organogel or *** method is applicable to nearly all kinds of soluble organic compounds and opens an efficient and universal way to fabricate gel materials.

关键词： organogel hybrid system supramolecular chemistry self-assembly soft matter

Structural evolution and electronic properties of phosphorus-doped hydrogenated amorphous silicon thin films deposited by PECVD

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Science China(Technological Sciences) 2013年第1期56卷 103-108页

作者： HE jian li Wei XU Rui QI KangCheng jianG YaDong School of Optoelectronic Information University of Electronic Science and Technology of China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China

The relationship between structure and electronic properties of phosphorus-doped hydrogenated amorphous silicon(a-Si:H) thin films was *** with different features were prepared by plasma enhanced chemical vapor deposition(PECVD) at various substrate *** spectroscopy and Fourier transform infrared(FTIR) spectroscopy were used to evaluate the structural evolution,meanwhile,electronic-spin resonance(ESR) and optical measurement were applied to explore the electronic properties of P-doped a-Si:H thin *** results revealed that the changes in materials structure affect directly the electronic properties and the doping efficiency of dopant.

关键词： a-Si:H PECVD Raman FTIR ESR

Petatrichol B: A Pentacyclic Triterpenoid with Unusual Skeleton from Petasites tricholobus

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Chinese Chemical Letters 2005年第10期16卷 1351-1353页

作者： Wei Dong XIE Ping lin li Zhong jian JIA College of Chemistry and Chemical Engineering National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000

A novel pentacyclic triterpenoid, petatrichol B, was isolated from the rhizome of Petasites tricholobus. Its structure was established by means of spectroscopic analysis （EIMS, HRSIMS, IR, 1D NMR and 2D NMR）.

关键词： Petasites tricholobus Compositae triterpenoid petatrichol B.

Simulation of the Interface between the Indian Summer Monsoon and the East Asian Summer Monsoon:Intercomparison between MPI-ESM and ECHAM5/MPI-OM

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Advances in Atmospheric Sciences 2016年第3期33卷 294-308页

作者： Yiran GUO Jie CAO Hui li jian WANG Yuchao DING Department of Atmospheric Sciences Yunnan UniversityKunming 650091 Yunnan Key Laboratory of International Rivers and Transboundary Eco-security Kunming 650091

The time-mean and interannual variability of the interface between the Indian summer monsoon and East Asian summer monsoon （IIE） was assessed using both Max-Planck-Institute Earth System Model （MPI-ESM） and ECHAM5/MPI-OM and by calculating diagnostics and skill metrics around the IIE area. Progress has been made in modeling these aspects by moving from ECHAM5/MPI-OM to MPI-ESM. MPI-ESM is more skillful than ECHAM5/MPI-OM in modeling the time-mean state and the extreme condition of the IIE. Though simulation of the interannual variability significantly deviates to some extent in both MPI-ESM and ECHAM5/MPI-OM, MPI-ESM-LR shows better skill in reflecting the relationship among sea surface temperature anomalies over the Pacific, circulation anomalies over East Asia, and liE variability. The temperature becomes warmer under the RCP2.6 and RCP8.5 scenarios in comparison with the historical experiments, but the position of the liE and the key physical process in relation to the IIE variability almost remains the same, suggesting that the Indian summer monsoon tends to change in phase with the East Asian summer monsoon under each RCP scenario. The relatively realistic description of the physical processes modulated by terrain in MPI-ESM may be one of the most important reasons why MPI-ESM performs better in simulating the liE.

关键词： Asian summer monsoon IIE MPI-ESM ECHAM5/MPI-OM intercomparison

The Reactivity of 2,4,6-Tirphenylpyridinium Ylids

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Chinese Chemical Letters 2003年第2期14卷 111-114页

作者： Shrong Shi liN jian Mei WANG Cheng Yong li Department of Chemistry Peking UniversityBeijing 100871

Triphenylpyridinium ylid 2, generated by the decarboxylation of betaine 1, were noted to react with acetyl chloride, chloroform or acetone to form addition-elimination product and proton extraction - carbanion addition products, respectively. The reaction with chloroform was determined as pseudo first order from kinetic experiments. The values of kobsd and t1/2 for decarboxylation at 20, 40 and 50C were calculated to be 4.6 x 10-4, 8.8 x 10-3, 2.8 x 10-2 min-1 and 1.5 x 103, 78, 24 minutes, respectively.

关键词： Pyridinium ylid pyridinium betaine 4-H pyridine kinetic experiment.

Interleukin-17 and acute coronary syndrom

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 664-669页

作者： Sheng-an SU Hong MA li SHEN Meixiang XIANG jian-an WANG Cardiovascular Key Lab of Zhejiang Province Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University

Inflammation plays an important role in atherosclerosis, which is also crucial for acute coronary syndrome (ACS). Recent studies have revealed that interleukin (IL)-17, which was regarded as a pro-inflammatory cytokine, has a dual function in the progress of ACS. In this review, we sum up both experimental and clinical studies on the relevance of IL-17 to atherosclerosis and its complications, and summarize the research progress on the effect of IL-17 on the atherosclerotic plaque stability and ACS onset. Although the studies are controversial and the mechanism remains unclear we highlight the knowledge of the role of IL-17 in ACS and elucidate its potential mechanism.

关键词：心脏疾病临床冠状动脉调查结果