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A novel arterial pouch model of saccular aneurysm by concomitant elastase and collagenase digestion

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第10期8卷 697-703页

作者： YANG xin-jian, li li, WU Zhong-xue (Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China) Department of Interventional Neuroradiology Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China

Background: An ideal aneurysm model of cerebral aneurysm is of great importance for studying the pathogenesis of the lesion and testing new techniques for diagnosis and treatment. Several models have been created in rabbits and are now widely used in experimental studies; however, every model has certain intrinsic limitations. Here we report the development of a novel saccular aneurysm model in rabbits using an arterial pouch that is subject to in vitro pre-digestion with combined elastase and collagenase. Methods: A segment of right common carotid artery (CCA) was dissected out and treated with elastase (60 U/ml, 20 min) followed by type I collagenase (1 mg/ml, 15 min) in vitro. The graft was anastomosed to an arterial arch built with the left CCA and the remaining right CCA, while the other end of the graft was ligated. The dimension and tissue structure of the pouch were analysed immediately, 2 or 8 weeks after operation. Findings: Ten terminal aneurysms were produced. The gross mor-phology of the aneurysm resembles the human cerebral terminal aneurysms. We have observed the following pathological changes: (1) growth of the aneurysm (mean diameter increased from (2.0±0.1) to (3.2±0.3) mm at 2 weeks, P<0.001, n=7~10); (2) thinning of the aneurysmal wall (the mean wall thickness decreased to 44% at 2 weeks), which was accompanied by significant losses of elastic fibres, collagen and the cellular component; and (3) spontaneous rupture (3 out of 9, one aneurysm ruptured 24 h after operation with the other two at 2 and 4 weeks respectively). Conclusion: This rabbit arterial pouch model mimics human cerebral aneurysms in relation to morphology and histology. In particular, this model exhibited an increased tendency of spontaneous rupture.

关键词： Animal model Collagenase Elastase Intracranial aneurysm

Transesterified Chinese Spicehush (lindera communis) seed oil as a biodiesel fuel

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Forestry Studies in China 2007年第2期9卷 132-136页

作者： Wang Wei-gang Ma Lei jiang jian-xin jiang li Zhang Zhi-xiang College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

Studies were carried out on the transesterification of the Chinese Spicehush （lindera communis） seed （LCS） oil with methanol for the production of biodiesel. The methyl esters of LCS oil were compared with soybean esters to determine biodiesel fuel performance and properties. The fatty acids content in the seed kernel oil （LKO） and coat oil （LCO） were quantified by gas chromatography and mass spectrometry method （C-C-MS）. LKO contains 95.1% saturated acids （capric, lauric, myristic and palmitic） and 2.3% unsaturated acids （oleic）. LCO contains 24.6% saturated acids （palmitic and stearic） and 73.6% unsaturated acids （oleic, linoleic and palmitoleic）. The kinematic viscosity, cold filter plugging point, cloud point, flash point and cetane index were determined. The methyl esters of LKO had a higher kinematic viscosity and a lower cold filter plugging point value, so it has better performance in cold weather. The biodiesel of LCS oil has fuel properties within the limits prescribed by American （ASTM D 6751-02） standards, except for a slightly lower flash point of LKO biodiesel than that prescribed by these standards （130℃）. Thus, LKO and LCO biodiesel have great potential to be used on a large scale as fuel for diesel engines.

关键词： biodiesel lindera communis oil transesterification property

Structure, composition and enzymatic hydrolysis of steam-exploded lespedeza stalks

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Forestry Studies in China 2007年第2期9卷 137-141页

作者： Wang Kun Wang Fang jiang jian-xin Zhu li-wei Fan Hong-zhuai College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

Pretreatment of lespedeza stalks by steam explosion has been studied. The results indicate that steam-exploded pretreatment has strong effects on physical features, morphology, crystallinity, and composition of lespedeza stalks as shown by scanning electron microscopy （SEM）, infrared （IR）, and X-ray diffraction spectrometry methods. After steam explosion, the cellulose and lignin contents of lespedeza stalks varied only slightly, but the hemicellulose content had decreased from 29.34% to 7.48%. The cellulose obtained by steam-exploded pretreatment had a higher degree of crystallinity than that of the raw material. At the explosion condition of 2.25 MPa and 4 min, lignocellulose is easier to hydrolyze by enzyme than the original lignocellulose. The concentration of reduced sugar in the hydrolyzate liquid increased from 71.77 to 162.84 g·L^-1.

关键词： steam explosion lespedeza stalks structure composition enzymatic hydrolysis

Reaction mechanism of metal and pyrite under high-pressure and high-temperature conditions and improvement of the properties

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Chinese Physics B 2022年第6期31卷 607-614页

作者： Yao Wang Dan Xu Shan Gao Qi Chen Dayi Zhou xin Fan xin-jian li lijie Chang Yuewen Zhang Hongan Ma Xiao-Peng Jia State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China Key Laboratory of Material Physics of Ministry of Education School of Physics and MicroeletronicsZhengzhou UniversityZhengzhou 450052China

Pyrite tailings are the main cause of acid mine *** propose an idea to more effectively use pyrite,and it is modified by exploiting the reducibility of metal represented by Al under high-pressure and high-temperature(HPHT)*** increasing the Al addition,the conductivity of pyrite is effectively improved,which is nearly 734 times higher than that of unmodified pyrite at room ***-principles calculations are used to determine the influence of a high pressure on the pyrite *** high pressure increases the thermal stability of pyrite,reduces pyrite to highconductivity Fe7S8(pyrrhotite)by *** hardness and density tests the influence of Al addition on the hardness and toughness of samples is *** we discuss the possibility of using other metal-reducing agents to improve the properties of pyrite.

关键词： high-pressure and high-temperature(HPHT) pyrite thermoelectric properties waste recycling

Micro-structured lepidocrocite-type H_(1.07)Ti_(1.73)O_(4)as anode for lithium-ion batteries with an ultrahigh rate and long-term cycling performance

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Rare Metals 2021年第6期40卷 1391-1401页

作者： li-Juan Hou Rui-Chao liu Hui-Yu Yuan De-Zhi Kong Wei-Xia Shen Jin-Hao Zang Juan Guo Shu-Ge Dai Ming-Lang Wang Ting-Ting Xu xin-jian li Ye Wang Key Laboratory of Material Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Henan Province for High Temperature Functional Materials Zhengzhou 450000China Shandong Key Laboratory of Medical Physics and Image Processing&Shandong Provincial Engineering and Technical Center of light Manipulations School of Physics and ElectronicsShandong Normal UniversityJinan 250358China

The lepidocrocite-type H_(1.07)Ti_(1.73)O_(4) microsized structures with a tap density of 0.88 g·cm^(-3) were prepared through the ion exchange method with K_(0.8)li_(0.27)Ti_(1.73)O_(4) powder as the precursor,and they exhibited good rate performance and outstanding cycle stability as an anode material for lithium ion batteries(liB).The ion exchange method provides favorable conditions for H_(1.07)Ti_(1.73)O_(4) as an anode electrode material for liBs.X-ray photoelectron spectroscopy(XPS)result demonstrates the existence of defects in the nonstoichiometric H1.07Ti1.73O4,which have a beneficial effect on the liB *** electrochemical performance test proves that the half-cell with microsized H_(1.07)Ti_(1.73)O_(4)as the anode electrode can maintain a specific capacity of 129.5 mAh·g^(-1) after 1100 cycles and 101 mAh·g^(-1)after 3000 long cycles at high current densities of 2.0 and 5.0 A·g^(-1),*** addition,the small volume change rate of 3.6%in H_(1.07)Ti_(1.73)O_(4)during li ion insertion was confirmed by real-time in situ transmission electron microscopy(TEM).The liFePO_(4)||H_(1.07)Ti_(1.73)O_(4)full battery exhibits a longterm cycling stability with a specific capacity of73.8 mAh·g^(-1) at a current density of 500 mA·g^(-1) after 200 cycles.

关键词： Lepidocrocite-type H_(1.07)Ti_(1.73)O_(4) Anode material of lithium ion batteries Long cycle stability

Synthesis, Structure of Organophosphonyl Polyoxotungstates of Formula [C_6H_(11)P (O)]_2 X^(n+)W_(11)O^((8-n)-)_(39) (X^(n+)=P^(5+), Si^(4+), B^(3+), Ga^(3+))

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Chinese Chemical Letters 1999年第8期10卷 705-706页

作者： Zhen Gang SUN Jing Fu liU Xiao Hong WANG Shu Mei YUE jian xin li (Department of chemistry, Northeast Normal University, Changchun 130024) Department of Chemistry Northeast Normal University Changchun 130024 China

Cyclohexanephosphonyl heteropolyundecatungstates of formula [C6H11P(O)]2 Xn+ W11O398-n- (Xn+=P5+, Si4+, B3+, Ga3+ have been prepared. purified and characterized by elemental analysis .IR and 1H. 31P and 183W NMR.

关键词： Polyoxometalates organophosphorus,complex

BrΦnsted acid-promoted ‘on-water’ C(sp^3)-H functionalization fot the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction

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Chinese Chemical Letters 2020年第2期31卷 349-352页

作者： Shuo Yuan Sixi Wang Min Zhao Danqing Zhang Jinjie Chen jian-xin li Jingya Zhang Yihui Song Jinyi Wang Bin Yu Hongmin liu School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules,which have showed broad and interesting biological *** efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry *** this communication,we report an efficient BrΦnsted acid-promoted C(sp^3)-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine,2-formylbenzoic acid and various *** title compounds were generated in high to excellent yields(up to 96%)regardless of the electronic nature and steric effects of the *** this reaction,an isoindolinone scaffold,one C-C single bond,and two C-N bonds were formed simultaneously with high atom *** this work,we have envisioned that the methyl group linked to the electron-deficient Nheterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal ***,the title compounds have exhibited promising activity against the SKP2-CKS1 interaction.

关键词： Isoindolinone Triazolo[1,5-a]pyrimidine Biaryl scaffold C(sp^3)-H activation Molecular hybridization SKP2-CKS1 interaction

Ursolic acid based bone anabolic agents targeted to tryptophan hydroxylase 1（Tph-1）

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Ursolic acid based bone anabolic agents targeted to tryptoph...

The Improvement of Bulk-Heterojunction Order in Polymer Photovoltaic Device

中国化学会第十届全国天然有机化学学术会议

作者： jian-xin li State Key Lab of Analytical Chemistry for life Science School of Chemistry and Chemical Engineering Nanjing University

＜正＞Osteoporosis is a major public health problem worldwide,especially among the postmenopausal women due to a dramatic reduction of estrogen ***,the only clinically available anabolic agent for osteoporosis is parathyroid hormone（PTH）*** hydroxylase 1（Tph-1）is the principal enzyme in the biosynthesis of peripheral *** studies revealed

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来源： cnki会议评论

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光谱学与光谱分析 2011年第12期31卷 3175-3179页

作者： YUAN Dan CHEN Zhi-jian XIAO li-xin MU li-ping QU Bo GONG Qi-huang State Key Laboratory for Mesoscopic Physics and Department of Physics Peking UniversityBeijing 100871China

The blend morphology and vertical arrangement are critical to the performance of organic bulk-heterojunction photovoltaic *** the present paper,the authors proposed a new annealing method that controls the blend morphology and vertical arrangement of two materials by means of simultaneously applying external electrical field and violet irradiation on the active layer of poly(3-hexylthiophene) (P3HT) and -phenyl C61-butyric acid methyl ester(PCBM) during annealing *** using this annealing method,the power conversion efficiency increased by 36%,which was caused by vertical phased-separated blend of crystalline P3HT and PCBM and better charge extraction of electrodes.X-ray photoelectron spectroscopy(XPS) was measured to prove more fullerene derivatives at the organic/cathode interfaces by using this annealing *** X-ray diffraction(XRD) analysis and UV-Vis absorption spectrum analysis also revealed more ordered polymer crystallization.

关键词： Polymer photovoltaic device Bulk-heterojunction Annealing method