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Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2685-2697页

作者： Fangyan Gao Yueyao Wu Runtian Wang Yuhui Yao Yiqiu Liu Lingling Fan Jingtong Xu jian Zhang xin Han Xiaoxiang Guan Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization School of Medicine&Holistic Integrative MedicineNanjing University of Chinese MedicineNanjing 210023China Department of Oncology the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210023China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing 211166China

Targeting androgen receptor(AR)has shown great therapeutic potential in triple-negative breast cancer(TNBC),yet its efficacy remains ***,we aimed to identify promising targeted agents that synergize with enzalutamide,a second-generation AR inhibitor,in *** using a strategy for screening drug combinations based on the Sensitivity Index(SI),we found that MK-8776,a selective checkpoint kinase1(CHK1)inhibitor,showed favorable synergism with enzalutamide in AR-positive *** combination of enzalutamide and MK-8776 was found to exert more significant anti-tumor effects in TNBC than the single application of enzalutamide or MK-8776,***,a nanoparticle-based on hyaluronic acid(HA)-modified hollow-manganese dioxide(HMnO_(2)),named HMnE&M@H,was established to encapsulate and deliver enzalutamide and *** HA-modified nanosystem managed targeted activation via pH/glutathione ***&M@H repressed tumor growth more obviously than the simple addition of enzalutamide and MK-8776 without a ***,our study elucidated the synergy of enzalutamide and MK-8776 in TNBC and developed a novel tumor-targeted nano drug delivery system HMnE&M@H,providing a potential therapeutic approach for the treatment of TNBC.

关键词： Triple-negative breast cancer Androgen receptor Checkpoint kinase 1 Enzalutamide MK-8776 Synergy HMnO_(2) Nanodrug delivery system

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Effect of heat treatment on microstructural evolution,mechanical properties and tribological properties of H13 steel prepared using selective laser melting

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Journal of Iron and Steel Research International 2024年第5期31卷 1246-1259页

作者： Li-xiong Han Yan Wang Shi-feng Liu Zhao-hui Zhang Wei Liu xin Yang Dang-shen Ma jian Zhou Ying-kang Wei College of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina Zhejiang University City College Hangzhou310015ZhejiangChina China Iron and Steel Research Institute Group Co. Ltd.Beijing100081China

H13 tool steel was successfully prepared by selective laser melting(SLM)*** effects of heat treatment on the microstructure,mechanical properties,and tribological properties of SLMed H13 steel were *** heat treatment process involved a solution treatment and a double aging treatment of the deposited H13 tool steel prepared by *** aim is to optimize the microstructure and mechanical properties of SLMed H13 *** to the rapid heating and cooling effects of SLM,carbide precipitation in the deposited H13 steel was not uniform and residual stresses were *** purpose of the solution treatment is to dissolve the solution at a high temperature to eliminate the residual stresses and defects introduced by the SLM-forming *** solution treatment and first aging treatment produced the precipitation of small carbides at the grain boundaries and inside the crystals,which increased the hardness of SLMed H13 *** hardness increased from 538±4.0 HV of the as-deposited sample to 548±5.8 HV of samples after the first aging ***,the ultimate tensile strength and the elongation at break decreased from 1882 MPa and 11.5%in the as-deposited sample to 1697 MPa and 7.9%in those after the first aging treatment,***,the friction coefficient and wear rate in the as-deposited sample decreased from 0.5160 and 2.36×10^(–6)mm^(−3)N^(−1)m^(−1)to 0.4244 and 1.04×10^(–6)mm^(−3)N^(−1)m^(−1),***,the distribution of carbides inside the crystals was not *** second aging treatment adjusted the morphology of carbide precipitation and made it more uniform,but the precipitation of carbides grew and settled at the bottom of the grain *** hardness decreased to 533±6.7 HV compared with that with the first aging treatment,but the ultimate tensile strength and plasticity reached a balance(1807 MPa,14.05%).Accordingly,the friction coefficient and wear rate also showed a stable and decreasin

关键词： Selective laser melting H13 steel Solution aging Double aging Friction and wear Retained austenite

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Reversible Mn^(2+)/Mn^(4+)double-electron redox in P3-type layer-structured sodium-ion cathode

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Journal of Energy Chemistry 2024年第2期89卷 79-88,I0004页

作者： Jie Zeng jian Bao Ya Zhang Xun-Lu Li cui Ma Rui-Jie Luo Chong-Yu Du Xuan Xu Zhe Mei Zhe Qian Yong-Ning Zhou Department of Materials Science Fudan UniversityShanghai 200433China Shanghai Xuanyi New Energy Development Co. LtdShanghai 201800China Global Institute of Future Technology Shanghai Jiao Tong UniversityShanghai 200240China

The balance between cationic redox and oxygen redox in layer-structured cathode materials is an important issue for sodium batteries to obtain high energy density and considerable cycle *** redox can contribute extra capacity to increase energy density,but results in lattice instability and capacity fading caused by lattice oxygen gliding and oxygen *** this work,reversible Mn^(2+)/Mn^(4+)redox is realized in a P3-Na_(0.65)Li_(0.2)Co_(0.05)Mn_(0.75)O_(2)cathode material with high specific capacity and structure stability via Co *** contribution of oxygen redox is suppressed significantly by reversible Mn^(2+)/Mn^(4+)redox without sacrificing capacity,thus reducing lattice oxygen release and improving the structure *** X-ray techniques reveal that P3 phase is well maintained in a wide voltage window of 1.5-4.5 V ***^(+)/Na even at 10 C and after long-term *** is disclosed that charge compensation from Co/Mn-ions contributes to the voltage region below 4.2 V and O-ions contribute to the whole voltage *** synergistic contributions of Mn^(2+)/Mn^(4+),Co^(2+)/Co^(3+),and O^(2-)/(O_n)^(2-)redox in P3-Na_(0.65)Li_(0.2)Co_(0.05)Mn_(0.75)O_(2)lead to a high reversible capacity of 215.0 m A h g^(-1)at 0.1 C with considerable cycle *** strategy opens up new opportunities for the design of high capacity cathode materials for rechargeable batteries.

关键词： Sodium batteries Cathode materials Layered structure Co substitution

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Fundamentals and application in phytoremediation of an efficient arsenate reducing bacterium Pseudomonas putida ARS1

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Journal of Environmental Sciences 2024年第3期137卷 237-244页

作者： Ze-Wen Wang Guang Yang jian Chen Yaoyu Zhou Avelino Nunez Delgado Hui-Ling cui Gui-Lan Duan Barry P.Rosen Yong-Guan Zhu Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450052China State Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Cellular Biology and Pharmacology Florida International UniversityHerbert Wertheim College of MedicineMiamiFL33199USA University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China College of Resources and Environment Hunan Agricultural UniversityChangsha 410128China Department of Soil Science and Agricultura Chemistry Engineering Polytechnic SchoolUniversity of Santiago de CompostelaCampus Univ.s/n27002LugoSpain

Arsenic is a ubiquitous environmental ***-mediated arsenic biotransformations significantly infuence arsenic mobility and *** transformations by soil and aquatic organisms have been well documented,while little is known regarding effects due to endophytic *** endophyte Pseudomonas putida ARS1 was isolated from rice grown in arsenic contaminated *** ARS1 shows high tolerance to arsenite(As(Ⅲ))and arsenate(As(V)),and exhibits efficient As(V)reduction and As(Ⅲ)effux *** exposed to 0.6 mg/L As(V),As(V)in the medium was completely converted to As(Ⅲ)by *** ARS1 within 4 *** sequencing showed that *** ARS1 has two chromosomal arsenic resistance gene clusters(arsRCBH)that contribute to efficient As(V)reduction and As(Ⅲ)effux,and result in high resistance to *** globosa is a strong arsenic accumulator with high potential for arsenic phytoremediation,which takes up As(Ⅲ)more efficiently than As(V).Co-culture of *** ARS1 and *** enhanced arsenic accumulation in *** by 69%,and resulted in 91%removal of arsenic(at initial concentration of 0.6 mg/L As(V))from water within 3 *** study provides a promising strategy for in situ arsenic phytoremediation through the cooperation of plant and endophytic bacterium.

关键词： Arsenic Pseudomonas putida Arsenate reduction Endophyte Wolffia globosa Phytoremediation

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Integrating machine learning and CALPHAD method for exploring low-modulus near-β-Ti alloys

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Rare Metals 2024年第1期43卷 309-323页

作者： Hao Zou Yue-Yan Tian Li-Gang Zhang Ren-Hao Xue Zi-Xuan Deng Ming-Ming Lu jian-xin Wang Li-Bin Liu School of Computer Science and Engineering Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Traditional theoretical and empirical calculation methods can guide the design of β-and metastable β-alloys for bio-titanium. However, it is still difficult to obtain novel near-β-Ti alloys with low modulus. This study developed a method that combines machine learning with calculation of phase diagrams(CALPHAD) to facilitate the design of near-β-Ti alloys. An elastic modulus database of Ti–Nb–Zr–Mo–Ta–Sn system was constructed first, and then three features(the electron to atom ratio, mean absolute deviation of atom mass, and mean electronegativity) were selected as the key factors of modulus by performing a three-step feature selection. With these features, a highly accurate model was built for predicting the modulus of near-β-Ti alloys. To further ensure the accuracy of modulus prediction, machine learning with the elastic constants calculated was leveraged by CALPHAD database. The root mean square error of the well-trained model can be as low as 6.75 GPa. Guided by the prediction of machine learning and CALPHAD, three novel near-β-Ti alloys with elastic modulus below 50 GPa were successfully designed in this study. The best candidate alloy(Ti–26Nb–4Zr–4Sn–1Mo–Ta) exhibits an ultra-low modulus(36.6 GPa) after cold rolling with a thickness reduction of 20%. Our method can greatly save time and resources in the development of novel Ti alloys, and experimental verifications have demonstrated the reliability of this method.

关键词： Near-β-Ti alloy Machine learning Calculation of phase diagram Low-modulus alloy Feature selection

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Correction to:Assembly-level analysis on temperature coefficient of reactivity in a graphite-moderated fuel salt reactor fueled with low-enriched uranium

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Nuclear Science and Techniques 2024年第2期35卷 234-235页

作者： Xiao-Xiao Li De-Yang cui Chun-Yan Zou jian-Hui Wu Xiang-Zhou Cai Jin-Gen Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academy in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

Following publication of the original article,the authors observed that both Fig.5 and Fig.4 depict the same *** 5 was inaccurately referenced and *** correct Fig.5 is copied below:The original article has been updated.

关键词： fuel enriched reactivity

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Metal-organic nanosheet assembly ions sieving membrane for precise lithium ion and anion/solvent separation toward robust lithium metal battery

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Science China Chemistry 2024年第10期67卷 3320-3327页

作者： jian-Qiang Shen Tian-Tian Zhao Ying-Li Song Lingjuan Zhang Ya-Nan Gao Xiao-Nan cui Peng Zhao Xian-Ming Zhang Key Laboratory of Magnetic Molecules & Magnetic Information Materials Ministry of EducationSchool of Chemistry & Material ScienceShanxi Normal University College of Chemistry and Chemical Engineering Taiyuan University of Technology

Metal-organic nanosheets（MONs） as a novel material with tunable pore structures and low mass transfer resistance,have emerged as molecular sieves for the separation of gases and *** theory,they can also serve as ion sieves for lithium metal batteries（LMBs）,realizing the high-energy and dendritic free ***,there are rarely relevant reports,because it is difficult to simultaneously balance efficient ion sieving ability,high ion passing rate and high electrochemical ***,we synthesized a stable ultrathin MON[Zn2（Bim）4]([Zn2（Bim）4]Nanosheet,HBim=benzimidazolate),which can achieve both efficient lithium ion sieving ability,high lithium ion passing rate and high electrochemical stability at the same *** separator assembled by this MON exhibits high Li+transfer number of 0.81 due to the accurate lithium ion and anion/solvent *** battery containing such separator shows high lithium ionic conductivity of 0.74 m S cm-1and low activation energy of 0.099 eV,which can be attributed to the nanometer level thickness and the ion sieving *** is more,we realized the application of MONs-based ion sieves in LMBs with intercalation cathodes for the first *** the LiFePO4|Li battery with as-assembled separator demonstrates improved Coulombic efficiency（>99%） and significantly extended cycling life（>1600 cycles） with 80% capacity retention.

关键词： lithium sieving membrane metal-organic nanosheets lithium metal battery lithium ion and anion separation lithium ion and solvent separation

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The opration therapeutics of the ossification of the yellow ligament with thoracic vertebra

The opration therapeutics of the ossification of the yellow ...

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第二届华东地区骨科学术大会暨山东省第九次骨科学术会议

作者： Zhang Zuo-lun Yuan Ze-nong Sun jian-min cui xin-gang Department Of Spine surgery ShanDong Provincial Hospital JiNan 250021

＜正＞Objective to study the diagnosis and opration therapeutics of the ossification of the yellow ligament with thoracic vertebra，to discuss the etiopathogenisis，patho，therapeutics effect and complication． Method to summarize and analyze through using retrospective study with 92 pafients of TOLF from 1989．3 to 2006．12．47 were men，45 were women，the mean age was 51．8 years（32-76）．The main clinical manifestation was that of 92patients were the decrease of the muscle force of low limb and ambulation unstesdiness．69 had the ache of waist and back．92 had the legs’acroanesthesia，33 had intermittent claudication．，and 13 had ladder *** the 84 patients showed off the lesion of upper motor neuron，and 8 had the lesion of lower motor neuron．2 had skeletal fluorosis，3 were *** the other 79 patients had no identify *** therapeutics method was excision decompression of canalis spinalis meta-jade，it is that using mini-drill through isolate-abrasive reduction-whole—decompression’S exposing mothed will decompress affect’S segment canalis spinalis meta-jade，and relief the compression of spinal and dural． Result of the 92 patients，there were 68 affected individuals in T9—12（74％）．and 9 was in T7-11，1 Was in T2-3，2 was in T2-6，2 was in T3-6．T he mean affected neural scute sections were 3．1（1-9）．10 showed off saltation．9 Was combined with cervico-brustwirbel intervertebral disk hernia．65 were visited followed more than 2．5 years after operation．34 was excellent，25 was better and 6 was *** affection feature which was observed in operation was that thickening and ossification with the yellow ligament，pykno—thickening with vertebral plate，hyperplasy and intro-gathering with articular process close，and some were combined with interspinal ligaments’ossification，canalis spinalis were stegnosis or slit—shaped，dura sac was *** its patho-display was thickening and ossification with the yellow ligament，the proliferation of fibroblast and cartila

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Analysis of Solutions of the Holling-Tanner Model

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Acta Mathematicae Applicatae Sinica 2024年

作者： Ying-chao HAO Kun-lun HUANG xin-tian JIA cui-Ping LI School of Mathematical Sciences Beihang University

In this paper we consider a kind of predator-prey model named Holling-Tanner model. Firstly, we prove all solutions of this model to be bounded from above. Secondly, we find a positive invariant set of the model, and prove the existence of stable limit cycle in this invariant set by Poincar′e-Bendixson theorem for the unstable equilibrium. Thirdly, we get the region of parameters in which the corresponding stable equilibrium are also globally asymptotically stable. Lastly, we give a bifurcation diagram and illustration with two limit cycles for special parameters through numerical simulation. By our knowledge, the invariant set constructed in this paper is better than that in the book written by Murray.

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Multipath Selection Algorithm Based on Dynamic Flow Prediction

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Journal of Computer and Communications 2024年第7期12卷 94-104页

作者： Jingwen Wang Guolong Yu xin cui School of Computer Science and Technology Shandong University of Technology Zibo China

Traditional traffic management techniques appear to be incompetent in complex data center networks, so proposes a load balancing strategy based on Long Short-Term Memory (LSTM) and quantum annealing by Software Defined Network (SDN) to dynamically predict the traffic and comprehensively consider the current and predicted load of the network in order to select the optimal forwarding path and balance the network load. Experiments have demonstrated that the algorithm achieves significant improvement in both system throughput and average packet loss rate for the purpose of improving network quality of service.

关键词： Data Center Network Software Defined Network Load Balance Long Short-Term Memory Quantum Annealing Algorithms

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