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Contralateral C7 transfer combined with acellular nerve allografts seeded with differentiated adipose stem cells for repairing upper brachial plexus injury in rats

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Neural Regeneration Research 2019年第11期14卷 1932-1940页

作者： jian-tao yang Jin-tao Fang Liang Li Gang Chen Ben-Gang Qin Li-Qiang Gu Department of Microsurgery & Orthopedic Trauma the First Affiliated Hospital of Sun Yat-sen University

Nerve grafting has always been necessary when the contralateral C7 nerve root is transferred to treat brachial plexus injury. Acellular nerve allograft is a promising alternative for the treatment of nerve defects, and results were improved by grafts laden with differentiated adipose stem cells. However, use of these tissue-engineered nerve grafts has not been reported for the treatment of brachial plexus injury. The aim of the present study was to evaluate the outcome of acellular nerve allografts seeded with differentiated adipose stem cells to improve nerve regeneration in a rat model in which the contralateral C7 nerve was transferred to repair an upper brachial plexus injury. Differentiated adipose stem cells were obtained from Sprague-Dawley rats and transdifferentiated into a Schwann cell-like phenotype. Acellular nerve allografts were prepared from 15-mm bilateral sections of rat sciatic nerves. Rats were randomly divided into three groups: acellular nerve allograft, acellular nerve allograft + differentiated adipose stem cells, and autograft. The upper brachial plexus injury model was established by traction applied away from the intervertebral foramen with micro-hemostat forceps. Acellular nerve allografts with or without seeded cells were used to bridge the gap between the contralateral C7 nerve root and C5–6 nerve. Histological staining, electrophysiology, and neurological function tests were used to evaluate the effect of nerve repair 16 weeks after surgery. Results showed that the onset of discernible functional recovery occurred earlier in the autograft group first, followed by the acellular nerve allograft + differentiated adipose stem cells group, and then the acellular nerve allograft group;moreover, there was a significant difference between autograft and acellular nerve allograft groups. Compared with the acellular nerve allograft group, compound muscle action potential, motor conduction velocity, positivity for neurofilament and S100, diameter o

关键词： nerve regeneration peripheral nerve injury brachial plexus injury contralateral C7 nerve root acellular nerve adipose stem cells Schwann cells tissue engineering nerve nerve grafting nerve defect neural regeneration

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Decomposition of dimethyl sulfide in a wire-cylinder pulse corona reactor

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第1期10卷 127-132页

作者： jian-tao yang Yao SHI Jie CHEN Qing-fa SU Da-hui WANG Jing CAO Department of Environmental Science Zhejiang University Hangzhou 310028 China

Decomposition of dimethyl sulfide (DMS) in air was investigated experimentally by using a wire-cylinder dielectric barrier discharge (DBD) reactor at room temperature and atmospheric pressure.A new type of high pulse voltage source with a thyratron switch and a Blumlein pulse-forming network (BPFN) was adopted in our *** maximum power output of the pulse voltage source and the maximum peak voltage were 1kW and 100kV,*** important parameters affecting odor decomposition,including peak voltage,pulse frequency,gas flow rate,initial concentration,and humidity,which influenced the removal efficiency,were *** results showed that DMS could be treated effectively and almost a 100% removal efficiency was achieved at the conditions with an initial concentration of 832mg/m3 and a gas flow rate of 1000ml/*** boosts the removal efficiency and improves the energy yield (EY) *** EY of 832mg/m3 DMS was 2.87mg/kJ when the relative humidity was above 30%.In the case of DMS removal,the ozone and nitrogen oxides were observed in the exhaust *** carbon and sulfur elements of DMS were mainly converted to carbon dioxide,carbon monoxide and sulfur ***,sulfur was discovered in the *** to the results,the optimization design for the reactor and the matching of high pulse voltage source can be reckoned.

关键词： Pulse corona discharge Blumlein pulse-forming network (BPFN) Decomposition Dimenthyl sulfide (DMS) Specific energy density Energy yield (EY)

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Comparison between direct repair and humana cellular nerve allografting during contralateral C7 transfer to the upper trunk for restoration of shoulder abduction and elbow flexion

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Neural Regeneration Research 2019年第12期14卷 2132-2140页

作者： Liang Li Wen-Ting He Ben-Gang Qin Xiao-Lin Liu jian-tao yang Li-Qiang Gu Department of Orthopedic Trauma and Microsurgery the First Affiliated Hospital of Sun Yat-sen University

Direct coaptation of contralateral C7 to the upper trunk could avoid the interposition of nerve grafts. We have successfully shortened the gap and graft lengths, and even achieved direct coaptation. However, direct repair can only be performed in some selected cases, and partial procedures still require autografts, which are the gold standard for repairing neurologic defects. As symptoms often occur after autografting, human acellular nerve allografts have been used to avoid concomitant symptoms. This study investigated the quality of shoulder abduction and elbow flexion following direct repair and acellular allografting to evaluate issues requiring attention for brachial plexus injury repair. Fifty-one brachial plexus injury patients in the surgical database were eligible for this retrospective study. Patients were divided into two groups according to different surgical methods. Direct repair was performed in 27 patients, while acellular nerve allografts were used to bridge the gap between the contralateral C7 nerve root and upper trunk in 24 patients. The length of the harvested contralateral C7 nerve root was measured intraoperatively. Deltoid and biceps muscle strength, and degrees of shoulder abduction and elbow flexion were examined according to the British Medical Research Council scoring system;meaningful recovery was defined as M3–M5. Lengths of anterior and posterior divisions of the contralateral C7 in the direct repair group were 7.64 ± 0.69 mm and 7.55 ± 0.69 mm, respectively, and in the acellular nerve allografts group were 6.46 ± 0.58 mm and 6.43 ± 0.59 mm, respectively. After a minimum of 4-year follow-up, meaningful recoveries of deltoid and biceps muscles in the direct repair group were 88.89% and 85.19%, respectively, while they were 70.83% and 66.67% in the acellular nerve allografts group. Time to C5/C6 reinnervation was shorter in the direct repair group compared with the acellular nerve allografts group. Direct repair facilitated the restorati

关键词： nerve regeneration contralateral C7 nerve root transfer nerve graft brachial plexus avulsion injury direct repair human acellular nerve allograft shoulder function elbow function nerve transfer phrenic nerve accessary nerve neural regeneration

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Clinical significance of expression of proliferating cell nuclear antigen and E-cadherin in gastric carcinoma

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World Journal of Gastroenterology 2017年第20期23卷 3721-3729页

作者： lin Hu Hong-lang li Wei-feng li Jun-min Chen jian-tao yang Jun-Jing Gu lin Xin Department of Gastrointestinal Surgery The Second Affiliated Hospital of Nanchang University

AIM to investigate the expression of proliferating cell nuclear antigen(p CNA)and E-cadherin in gastric carcinoma and to analyze their clinical *** A total of 146 patients were selected for this study,including 38 patients with intestinal metaplasia,42with dysplasia,and 66 with primary gastric *** addition,40 patients with normal gastric tissues were selected as *** expression of p CNA and E-cadherin was detected by *** in p CNA and the E-cadherin labeling indexes among normal gastric mucosa,intestinal metaplasia,dysplasia,and gastric carcinoma were *** with normal gastric tissues were assigned to a normal group,while gastric cancer patients were assigned to a gastric cancer *** difference in p CNA and E-cadherin expression between these two groups was *** relationship between expression of p CNA and E-cadherin and clinicopathological features was also explored in gastric cancer ***,prognosis-related factors,as well as the expression of p CNA and E-cadherin,were analyzed in patients with gastric cancer to determine the 3-year survival of these *** the difference in p CNA and the E-cadherin labeling indexes among normal gastric mucosa,intestinal metaplasia,dysplasia,and gastric carcinoma was statistically significant(p<0.05).During the transition of normal gastric mucosa to gastric cancer,the p CNA labeling index gradually increased,while the E-cadherin labeling index gradually decreased(p<0.05).the p CNA labeling index was significantly higher and the E-cadherin labeling index was significantly lower in gastric cancer than in dysplasia(p<0.05).the expression of p CNA was significantly higher in the gastric cancer group than in the normal group,but E-cadherin was weaker(p<0.05).there was a negative correlation between the expression of p CNA and E-cadherin in gastric carcinoma(r=-0.741,p=0.000).p CNA expression differed significantly between gastric

关键词： proliferating cell nuclear antigen E-cadherin Gastric cancer Gastric mucosa

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适用于子空间信号失配的参数可调多通道自适应检测器

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电子与信息学报 2016年第12期38卷 3011-3017页

作者：刘维建简涛杨海峰李胜喜王欢王永良空军预警学院武汉430019

针对存在信号失配时的子空间信号检测问题,该文提出一种具有恒虚警特性的参数可调检测器。根据系统设计需要,通过调节参数,参数可调检测器可实现对失配信号的灵活检测。与现有检测器相比,当不存在信号失配时,提出的可调检测器能提供更... 详细信息

针对存在信号失配时的子空间信号检测问题,该文提出一种具有恒虚警特性的参数可调检测器。根据系统设计需要,通过调节参数,参数可调检测器可实现对失配信号的灵活检测。与现有检测器相比,当不存在信号失配时,提出的可调检测器能提供更高的检测概率。该文推导了可调检测器解析的检测概率和虚警概率,并通过蒙特卡洛仿真进行了验证。

关键词：目标检测多通道信号检测子空间信号失配自适应信号检测

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城市交通可持续发展策略的思考

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现代城市研究 2004年第9期19卷 70-72页

作者：陈建凯杨涛广东省深圳市规划设计研究江苏南京市交通规划研究所

城市交通发展策略具有长期性和稳定性,对引导交通系统的健康发展具有重要的指导意义。结合国内外的先进经验、交通发展趋势等阐述了我国建立可持续城市交通系统过程中应予以坚持的若干重要策略,如土地利用与城市交通的协调、适当控制机... 详细信息

城市交通发展策略具有长期性和稳定性,对引导交通系统的健康发展具有重要的指导意义。结合国内外的先进经验、交通发展趋势等阐述了我国建立可持续城市交通系统过程中应予以坚持的若干重要策略,如土地利用与城市交通的协调、适当控制机动车拥有和使用以及加强交通需求管理等。

关键词：可持续发展策略可持续城市城市交通发展交通系统交通发展土地利用先进经验引导中国过程

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葶苈大枣泻肺汤加味治疗支气管哮喘46例

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上海中医药杂志 2001年第10期35卷 17-18页

作者：朱建秀顾涛杨永华上海第二医科大学附属瑞金医院中医科上海200025

葶苈大枣泻肺汤加味 ,治疗 46例支气管哮喘。结果 :临床治愈 6例 ,显效 2 1例 ,有效 11例 ,总有效率91 3%。

关键词：哮喘葶苈大枣泻肺汤疗效

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无磁仿真转台用凸轮转子马达叶片干扰力矩

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上海交通大学学报 2010年第12期44卷 1773-1777页

作者：刘鹏王旭永陶建峰扬飞鸿李付军上海交通大学机械与动力工程学院上海200240

介绍了一种新型的无磁仿真转台用凸轮转子连续回转电液伺服马达的工作原理及特点.通过对其叶片的系统受力分析,得出马达波动力矩产生的机理.利用Matlab软件对马达低速运行时,叶片产生的干扰力矩进行了仿真,并对不同减压阀出口油压及不... 详细信息

介绍了一种新型的无磁仿真转台用凸轮转子连续回转电液伺服马达的工作原理及特点.通过对其叶片的系统受力分析,得出马达波动力矩产生的机理.利用Matlab软件对马达低速运行时,叶片产生的干扰力矩进行了仿真,并对不同减压阀出口油压及不同叶片厚度下的干扰力矩进行对比,得出相关参数对该类型马达力矩波动产生的影响.为解决该类液压马达存在的低速速率波动现象提供了一定的理论依据.

关键词：凸轮转子干扰力矩力矩波动

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基于消费者介入理论的在线购买行为影响要素及预测研究

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管理工程学报 2025年第2期39卷 144-161页

作者：陶婉琼王子卓王健浙江工商大学统计数据工程技术与应用协同创新中心浙江大学管理学院浙江吉利控股集团有限公司浙江工商大学管理工程与电子商务学院浙江工商大学现代商贸研究中心

本文主要研究消费者在线购买行为的影响。本文首先从参与强度、消费者类型、购物流程类型和广告点击次数四个维度定义了表征消费者在线购买决策心理特征的消费者介入水平,然后基于消费者介入理论分别从群体水平和个体水平的视角分析消... 详细信息

本文主要研究消费者在线购买行为的影响。本文首先从参与强度、消费者类型、购物流程类型和广告点击次数四个维度定义了表征消费者在线购买决策心理特征的消费者介入水平,然后基于消费者介入理论分别从群体水平和个体水平的视角分析消费者介入水平维度对其购物数量和购物时间间隔等行为的影响。以此为基础,本文采用多种机器学习方法构建了消费者在线购买行为预测模型。通过对不同预测模型的比较发现,神经网络回归模型对购物数量预测的误差性最小和拟合度最高,而梯度提升回归模型对购物时间间隔预测的性能最好。同时,通过特征变量的重组设置对比实验,本文验证了在购买行为预测模型中引入介入水平维度的有效性和合理性。研究结果揭示了消费者介入水平对在线购买行为的影响规律,不仅丰富了相关理论,而且对网购平台和商家精确预测消费者购买行为、优化服务策略等方面具有重要的指导意义。

关键词：决策科学电子商务消费者介入在线购买行为预测模型

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Meige综合征的治疗进展

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中医眼耳鼻喉杂志 2015年第4期5卷 218-221页

作者：赵亚飞宋剑涛杨薇中国中医科学院眼科医院研究生中西医结合专业中国北京100040

Meige综合征又称“特发性眼睑综合征-口下颌肌张力异常综合征”，常发于中老年，以40～70岁居多，常见于女性，但报道男女比例不一。主要表现为双眼睑痉挛、口下颌肌张力障碍、面部肌张力失调样不自主运动。其病因和发病机制尚不清楚，... 详细信息

Meige综合征又称“特发性眼睑综合征-口下颌肌张力异常综合征”，常发于中老年，以40～70岁居多，常见于女性，但报道男女比例不一。主要表现为双眼睑痉挛、口下颌肌张力障碍、面部肌张力失调样不自主运动。其病因和发病机制尚不清楚，中医学对meige综合征的认识日渐深入，通过中药和针灸，并结合西医治疗，取得了明显的效果，现将近几年的治疗进展作一综述。

关键词： meige综合征肉毒杆菌菌素A 中医治疗心理干预

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