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GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

World Journal of Stem Cells 2024年第5期16卷 538-550页

作者： Yang-Zhou jiang Lan-Yue Hu mao-shan Chen Xiao-Jie Wang Cheng-Ning Tan Pei-Pei Xue Teng Yu Xiao-Yan He Li-Xin Xiang Yan-Ni Xiao Xiao-Liang Li Qian Ran Zhong-Jun Li Li Chen Laboratory of Radiation Biology Department of Blood TransfusionLaboratory Medicine CenterThe Second Affiliated HospitalThird Military Medical UniversityChongqing 400037China Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center Ministry of Education of the People’s Republic of ChinaChongqing 400037China

BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ***,the positive regulators of ANKRD26 are still *** To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 *** Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family *** to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activi

关键词： Ankyrin repeat domain containing 26 GATA binding protein 2 Thrombocytopenia 2 Transcriptional regulation Myeloid-derived cell lines

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Slaughter Performance, Muscle Quality and Nutritional Composition of Duoluo Goats in Sichuan Province

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Agricultural Biotechnology 2024年第2期13卷 12-16页

作者： Mingliang ZHOU shan WU Qian PANG Basangzhuoma Minghua CHEN Hualong FU Jinbin mao Pinggui YANG Sichuan Academy of Grassland Sciences Chengdu 611731China Animal Husbandry Station of Ganzi Tibetan Autonomous Prefecture Kangding 626000China

[Objectives] This study was conducted to understand the biological characteristics of Duoluo goats. [Methods] With male and female Duoluo goats as the research object, related performance indexes were determined and analyzed after slaughter. [Results] The weights of one-year-old male and female Duoluo goats before slaughter were (25.68±2.37) and (24.51±1.97) kg, respectively;the dressing percentages were (43.55±3.24) % and (43.84±3.42) %, respectively;and the net meat percentages were (33.02±2.32) % and (34.19±2.46) %, respectively. (2) The cooked meat rates of male and female Duoluo goats were (65.49±1.42) % and (65.36±1.55) %, respectively;the shearing force was (5.48±1.24) and (5.65±1.02) N, respectively;and the loin-eye muscle areas were (8.95±1.72) and (8.82±1.15) cm 2, respectively. (3) The protein contents of male and female Duoluo goats were (20.07±0.42) and (19.47±1.22) g/100 g, respectively;and the fat contents were (1.30±0.80) % and (2.92±0.55) %, respectively;and the cholesterol contents were (71.76±11.47) and (74.83±2.68) mg/100 g, respectively;(4) The Ca contents of male and female Duoluo goats were (69.53±10.89) and (63.00±4.56) mg/kg, respectively;the Fe contents were (16.73±1.83) and (14.77±0.58) mg/kg, respectively;and the Zn contents were (38.47±3.68) and (31.83±2.22) mg/kg, respectively. (5) In the muscles of male and female Duoluo goats, the contents of essential amino acids were (7.44±0.24) and (7.26±0.41) g/100 g , respectively;the contents of non-essential amino acids were (11.81±0.33) and (11.42±0.67) g/100 g, respectively;and the contents of flavor amino acids were (8.79±0.27) and (8.42±0.57) g/100 g, respectively. [Conclusions] This study lays a foundation for the excavation and utilization of the resource, Duoluo goats.

关键词： Duoluo goat Slaughter Muscle quality Amino acid

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Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng Si-Jing Wang Lin Guo Pan-Pan Ma Xiao-Long Ye Ming-Lin Pan Bo Hang jian-Hua mao Antoine M Snijders Yi-Bing Lu Da-Fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

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A pilot study of precision treatment for patients with lung cancer pain by Longteng Tongluo recipe(龙藤通络方) using serum genomics

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1006-1016页

作者： WU Ruixin FANG Qingliang GUAN Sisi WEI Xianglong shan Mengjun mao Zhujun GONG Yabin XU Ling ZHOU Di DONG Changsheng Preclinical Department Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese Medicine School of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Department of Oncology Longhua HospitalShanghai University of Traditional Chinese Medicine Department of Oncology the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine Department of Oncology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine Cancer Institute of Traditional Chinese Medicine/Department of Oncology Longhua HospitalShanghai University of Traditional Chinese Medicine

OBJECTIVE: To investigate the efficacy of Longteng Tongluo recipe(龙藤通络方, LTTL) combined with threestep analgesia for the treatment of lung cancer pain, and the changes in serum miRNA expressions before-and after treatment with LTTL and its correlation with lung cancer pain. The possible mechanism underlying LTTL effects on the treatment of lung cancer pain was conducted. METHODS: The pilot study was conducted at the oncology ward of the Yueyang Hospital and the Longhua Hospital between March 2018 and October 2019. A prospective, single-blind, placebo controlled, randomized clinical trial of LTTL or placebo combined with three-step analgesia treatments were administered to 24 cancer pain patients diagnosed with lung cancer. Analgesic efficacy was investigated as the primary outcome. Equivalent morphine consumption and numerical rating scale(NRS) scores were used as the secondary outcome. In the present study, we utilized deep sequencing techniques to compare the differential miRNA expressions in serum samples obtained from two groups: the lung cancer pain treatment group(LTTL + three-step analgesia) and the control group(placebo + three-step analgesia). Next, we employed the target prediction database to investigate the target genes for differential miRNA expressions and Gene Ontology(GO) analysis along with Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis to examine the roles and the major biochemical and signaling pathways related to the differentially expressed target genes, respectively. RESULTS: LTTL treatment significantly reduces the NRS score(P = 0.021) as compared to those before treatment, along with significant reductions in the total morphine equivalent consumption(P = 0.007) and the average daily equivalent morphine consumption(P = 0.003) as opposed to the control group. The expressions of 31 miRNAs differed considerably between the two groups of patients( ≥ 2 times up-modulated or down-regulated between these groups, P < 0.05).

关键词： Longteng Tongluo recipe MicroRNA-chip Supporting information high-throughput nucleotide sequencing lung neoplasms neoplasm metastasis pain

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共同富裕视角下民族地区新型区域文化产业合作研究

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贵州民族研究 2024年第2期45卷 131-137页

作者：宋姗姗柳建文山东师范大学音乐学院山东济南250014 南开大学周恩来政府管理学院天津300350

民族地区是我国的特色文化资源富集区,文化产业则是民族地区实现共同富裕的内源式发展资源,亦是民族地区实现共同富裕的比较优势产业,更是民族地区实现共同富裕的文化变迁基础。从现状看,民族地区区域文化资源缺乏统筹整合,跨区域文化... 详细信息

民族地区是我国的特色文化资源富集区,文化产业则是民族地区实现共同富裕的内源式发展资源,亦是民族地区实现共同富裕的比较优势产业,更是民族地区实现共同富裕的文化变迁基础。从现状看,民族地区区域文化资源缺乏统筹整合,跨区域文化产业协同发展不足,文化产业外向型发展能力弱,文化产业在带动民族地区共同富裕中的优势未能充分发挥出来。基于此,民族地区应以新型区域合作推进民族地区文化产业发展,强化区域内部的资源整合与区域文化圈建设,推动跨区域文化产业合作,积极开展国际次区域文化产业合作,同时加强新型区域文化产业合作的配套制度建设和政策供给。

关键词：共同富裕民族地区文化产业新型区域合作

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Recent progress and strategies of cathodes toward polysulfides shuttle restriction for lithium-sulfur batteries

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Rare Metals 2024年第9期43卷 4132-4161页

作者： Xing-You Rao Shuang-Fei Xiang jian Zhou Zhen Zhang Xiang-Yu Xu Yuan-Yuan Xu Xin-Chi Zhou Zheng-Dao Pan Su-Chong Tan Shi-Xing Dong Zhou-Lu Wang Yu-Tong Wu Yun-Lei Zhou Xiang Liu Yi Zhang shan jiang School of Energy Sciences and Engineering Nanjing Tech UniversityNanjing 211816China School of Materials Science and Engineering and Institute of Smart Fiber Materials Zhejiang Sci-Tech UniversityHangzhou 310018China jiangSu Sailboat Petrochemical Co. LtdLianyungang 222000China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200China

Lithium-sulfur batteries(LSBs)have already developed into one of the most promising new-generation high-energy density electrochemical energy storage systems with outstanding features including high-energy density,low cost,and environmental ***,the development and commercialization path of LSBs still presents significant limitations and challenges,particularly the notorious shuttle effect triggered by soluble longchain lithium polysulfides(LiPSs),which inevitably leads to low utilization of cathode active sulfur and high battery capacity degradation,short cycle life,*** research efforts have been conducted to develop various sulfur host materials capable of effectively restricting the shuttle *** review firstly introduces the fundamental electrochemical aspects of LSBs,followed by a comprehensive analysis of the mechanism underlying the shuttle effect in Li–S batteries and its profound influence on various battery components as well as the overall battery ***,recent advances and strategies are systematically reviewed,including physical confinement,chemisorption,and catalytic conversion of sulfur hosts for restricting LiPSs shuttle *** interplay mechanisms of sulfur hosts and LiPSs are discussed in detail and the structural advantages of different host materials are ***,key insights for the rational design of advanced host materials for LSBs are provided,and the upcoming challenges and the prospects for sulfur host materials in lithium-sulfur batteries are also explored.

关键词： Lithium-sulfur batteries Polysulfides Shuttle effect Host

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Conversion therapy of a giant hepatocellular carcinoma with portal vein thrombus and inferior vena cava thrombus:A case report and review of literature

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World Journal of Clinical Cases 2024年第16期12卷 2847-2855页

作者： Wen-Jie Song jian Xu Ye Nie Wei-Min Li jian-Ping Li Li Yang Meng-Qi Wei Kai-shan Tao Department of Hepatobiliary Surgery Xijing HospitalAir Force Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Radiotherapy The First Affiliated Hospital of the Fourth Military Medical UniversityXi'an 710032Shaanxi ProvinceChina State Key Laboratory of Cancer Biology Department of PathologyXijing Hospital and School of Basic MedicineXijing HospitalAir Force Medical UniversityXi'an 710000Shaanxi ProvinceChina Department of Radiology Xijing HospitalAir Force Medical UniversityXi'an 710032Shaanxi ProvinceChina

BACKGROUND The prognosis of hepatocellular carcinoma(HCC)combined with portal and hepatic vein cancerous thrombosis is poor,for unresectable patients the combination of targeted therapy and immune therapy was the first-line recommended treatment for advanced HCC,with a median survival time of only about 2.7-6 *** this case report,we present the case of a patient with portal and hepatic vein cancerous thrombosis who achieved pathologic complete response after conversion *** SUMMARY In our center,a patient with giant HCC combined with portal vein tumor thrombus and hepatic vein tumor thrombus was treated with transcatheter arterial chemoembolization(TACE),radiotherapy,targeted therapy and immunotherapy,and was continuously given icaritin soft capsules for oral *** 7 months of conversion therapy,the patient's tumor shrank and the tumor thrombus subsided *** pathology of surgical resection was in complete remission,and there was no progression in the postoperative follow-up for 7 months,which provided a basis for the future strategy of combined conversion *** In this case,atezolizumab,bevacizumab,icaritin soft capsules combined with radiotherapy and TACE had a good *** patients with hepatocellular carcinoma combined with hepatic vein/inferior vena cava tumor thrombus,adopting a high-intensity,multimodal proactive strategy under the guidance of multidisciplinary team(MDT)is an important attempt to break through the current treatment dilemma.

关键词： Hepatocellular carcinoma Icaritin Conversion Downstaging Portal vein thrombus Case report

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钙钛矿太阳能电池材料缺陷对器件性能与稳定性的影响

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物理学报 2024年第6期73卷 16-33页

作者：王静高姗段香梅尹万健宁波大学物理科学与技术学院宁波315211 苏州大学能源学院能源与材料创新研究院苏州215006

基于钙钛矿太阳能电池材料独特的光电特性,特别是光电转换效率在初期短时间内的快速提升,使其成为当前光伏领域中最富吸引力的光吸收材料之一.然而,近年来转换效率的增长步入缓慢阶段,同时材料的长期稳定性也成为商业化应用的关键挑战,... 详细信息

基于钙钛矿太阳能电池材料独特的光电特性,特别是光电转换效率在初期短时间内的快速提升,使其成为当前光伏领域中最富吸引力的光吸收材料之一.然而,近年来转换效率的增长步入缓慢阶段,同时材料的长期稳定性也成为商业化应用的关键挑战,这些问题背后的物理机制与材料缺陷密切相关.为进一步提高电池效率和结构稳定性,必须深刻理解和精准地掌握这些缺陷的特性.本文全面回顾了钙钛矿材料中各类缺陷对光伏性能和稳定性的影响,包括传统刚性模型缺陷、非常规性缺陷、复合型缺陷、离子迁移和缺陷对载流子寿命的影响,论述了缺陷与材料结构稳定性之间的紧密关联性,并对未来关于缺陷的研究方向进行了展望.

关键词：钙钛矿太阳能电池缺陷非辐射复合稳定性

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数字教材赋能知识教学变革的逻辑与路径

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课程．教材．教法 2024年第4期44卷 35-41页

作者：单新涛王鉴玉溪师范学院教师教育学院玉溪653100 杭州师范大学未来教育研究院杭州311121 浙江省新型智库中国教育现代化研究院

知识教学是教学活动的根基。数字时代的知识变革赋予知识教学新的特征,主要表现为:教学内容的关联性、整合性和开放性不断增强,教学方式的多样化和具身性得以彰显,教学反馈的个性化和过程性更加突出。这些特征有助于化解当下知识教学存... 详细信息

知识教学是教学活动的根基。数字时代的知识变革赋予知识教学新的特征,主要表现为:教学内容的关联性、整合性和开放性不断增强,教学方式的多样化和具身性得以彰显,教学反馈的个性化和过程性更加突出。这些特征有助于化解当下知识教学存在的割裂化、离身化和低效化问题。教材是驱动教学变革的重要力量,数字教材通过重组课程教学内容、引导教学方式变革和优化教学评价而赋能知识教学,最终促进学生发展及其素养提升。把握数字教材赋能知识教学变革的实现路径,应树立与数字时代相适应的教学观念,形成与数字教材性能相匹配的教学方式,慎思数字教材赋能教学变革的限度和尺度。

关键词：数字教材知识教学教学变革

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Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing

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Virologica Sinica 2024年第1期39卷 134-143页

作者： Changcheng Wu Ruhan A Sheng Ye Fei Ye Weibang Huo Roujian Lu Yue Tang jianwei Yang Xuehong Meng Yun Tang Shuang Chen Li Zhao Baoying Huang Zhongxian Zhang Yuda Chen Dongfang Li Wenling Wang Ke-jia shan jian Lu Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing100052China Chongqing Municipal Key Laboratory for High Pathogenic Microbes Chongqing Center for Disease Control and PreventionChongqing400042China MGI BGI-ShenzhenShenzhen518083China Thermo Fisher Scientific Beijing100013China School of Public Health Baotou Medical CollegeBaotou014030China BGI PathoGenesis Pharmaceutical Technology Shenzhen518000China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing100871China College of Life Sciences University of Chinese Academy of SciencesBeijing100049China

The monkeypox virus(MPXV)has triggered a current outbreak *** sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and *** is a significant challenge but necessary to optimize the strategy and application of rapid full-length genome identification and to track variations of MPXV in clinical specimens with low viral loads,as it is one of the DNA viruses with the largest genome and the most AT-biased,and has a significant number of tandem *** we evaluated the performance of metagenomic and amplicon sequencing techniques,and three sequencing platforms in MPXV genome sequencing based on multiple clinical specimens of five mpox cases in Chinese *** rapidly identified the full-length genome of MPXV with the assembly of accurate tandem repeats in multiple clinical *** sequencing enables cost-effective and rapid sequencing of clinical specimens to obtain high-quality MPXV ***-generation sequencing facilitates the assembly of the terminal tandem repeat regions in the monkeypox virus genome and corrects a common misassembly in published ***,several intra-host single nucleotide variations were identified in the first imported mpox *** study offers an evaluation of various strategies aimed at identifying the complete genome of MPXV in clinical *** findings of this study will significantly enhance the surveillance of MPXV.

关键词： Monkeypox virus(MPXV) Metagenomic Next generation sequencing Amplicon Third-generation sequencing

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