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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He jian-ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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阿莫西林-克拉维酸钾与阿莫西林的不良反应对比分析

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临床医学研究与实践 2017年第22期2卷 77-78页

作者：白建平撒照华王招娣闫小玉陕西省宝鸡市陇县人民医院药剂科陕西宝鸡721200

目的对阿莫西林-克拉维酸钾与阿莫西林的不良反应进行比较。方法回顾性分析我院应用阿莫西林-克拉维酸钾与阿莫西林治疗的15 628例患者的临床资料,依据患者应用药物的不同分为阿莫西林组7 814例及阿莫西林-克拉维酸钾组7814例,比较应用... 详细信息

目的对阿莫西林-克拉维酸钾与阿莫西林的不良反应进行比较。方法回顾性分析我院应用阿莫西林-克拉维酸钾与阿莫西林治疗的15 628例患者的临床资料,依据患者应用药物的不同分为阿莫西林组7 814例及阿莫西林-克拉维酸钾组7814例,比较应用两种药物的不良反应发生情况。结果阿莫西林组不良反应发生率(2.07%)高于阿莫西林-克拉维酸钾组(0.72%),不良反应持续时间长于阿莫西林-克拉维酸钾组,不良反应治疗后对原疾病的影响(14.20%)高于阿莫西林-克拉维酸钾组(3.57%),差异有统计学意义(P<0.05)。结论与阿莫西林相比,阿莫西林-克拉维酸钾在临床应用中,不良反应较少,且症状持续时间短,对原疾病治疗的影响少,较为安全。

关键词：阿莫西林阿莫西林-克拉维酸钾不良反应

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面向工程素养培育的毕业设计模式改革

电气电子教学学报 2017年第2期39卷 127-130页

作者：成建平赵海涛程崇虎沈建华南京邮电大学通信与信息工程学院江苏南京210003 南京邮电大学信息与通信工程国家级实验教学示范中心江苏南京210003

毕业设计是学生工程素养培育的重要环节,而在传统毕业设计模式中难以得到有效的锻炼和培养。本文以工程素养的内涵分析为切入点,结合我校电子信息类专业毕业设计环节中强化学生工程素养培育的改革实践,从管理体制机制、支撑保障条件、... 详细信息

毕业设计是学生工程素养培育的重要环节,而在传统毕业设计模式中难以得到有效的锻炼和培养。本文以工程素养的内涵分析为切入点,结合我校电子信息类专业毕业设计环节中强化学生工程素养培育的改革实践,从管理体制机制、支撑保障条件、考核和评价体系等角度进行了探索与实施,经教学实践取得了满意的结果。

关键词：工程素养毕业设计教学模式改革

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响应面法优化亚麻籽氢氰酸提取条件

食品工业科技 2016年第21期37卷 201-204页

作者：寇向龙徐美蓉张建平赵宾宾韩舜愈甘肃农业大学食品科学与工程学院甘肃兰州730070 甘肃省农业科学院甘肃兰州730070

为了提高亚麻籽中的氢氰酸含量检测的效率,同时确保其准确性,用响应面法对异烟酸-巴比妥酸比色法前处理中的提取方法进行了优化。运用Design Expert 7.0数据分析软件在单因素实验的基础上采用3因素3水平的响应面分析法,建立了氢氰酸提... 详细信息

为了提高亚麻籽中的氢氰酸含量检测的效率,同时确保其准确性,用响应面法对异烟酸-巴比妥酸比色法前处理中的提取方法进行了优化。运用Design Expert 7.0数据分析软件在单因素实验的基础上采用3因素3水平的响应面分析法,建立了氢氰酸提取率与各影响因子的回归方程。结果表明:氢氰酸的最佳提取条件为液固比50∶1(m L/g)、提取时间45 min、氢氧化钠吸收液浓度10 g/L,氢氰酸实际提取率可达96.12%。结论:此方法真实可靠,可用于大批量检测亚麻籽中的氢氰酸含量。

关键词：亚麻籽氢氰酸生氰糖苷异烟酸-巴比妥酸比色法响应面法

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“补钙”粉煤灰混凝土可泵性的材料措施研究

河西学院学报 2017年第5期33卷 26-29页

作者：梁谦程建萍李星赵海龙河西学院土木工程学院河西走廊水资源保护利用研究所甘肃张掖734000 甘肃省临洮县水务局甘肃定西730500

文章概述了泵送混凝土的发展趋势及前景,论述了在混凝土拌合物中,加大粉煤灰取代水泥用量并采取"补钙"措施的粉煤灰水化机理.结合工程实际中出现的混凝土可泵性问题,从材料方面论述了材料选用对泵送"补钙"粉煤灰混凝土可泵性的影响.文... 详细信息

文章概述了泵送混凝土的发展趋势及前景,论述了在混凝土拌合物中,加大粉煤灰取代水泥用量并采取"补钙"措施的粉煤灰水化机理.结合工程实际中出现的混凝土可泵性问题,从材料方面论述了材料选用对泵送"补钙"粉煤灰混凝土可泵性的影响.文章针对不同情况,提出相应的材料措施,以提高"补钙"粉煤灰混凝土的可泵性.

关键词：粉煤灰混凝土泵送混凝土可泵性,流动性

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改变水分子簇的结构及诱发的生物效应研究

天津理工学院学报 2003年第4期19卷 8-12页

作者：张建平赵林谭欣天津大学化工学院天津300072

概述了水分子簇理论研究的基本状况,以及改变水分子团簇结构的4种方法,包括外加磁场、外加电场、激光辐射以及直接加热法;最后简要介绍了改变水分子团簇结构所诱发的生物效应.

关键词：水分子簇生物效应结构改变分子结构氢键团簇结构

Bearing capacity analysis using the method of characteristics

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Acta Mechanica Sinica 2013年第2期29卷 179-188页

作者： jian-ping Sun Zhi-Ye zhao Yi-Pik Cheng School of Civil and Environmental Engineering Nanyang Technological University Department of Civil Environmental and Geomatic EngineeringUniversity College London

Using the method of characteristics,the bearing capacity for a strip footing is *** method of characteristics leads to an exact true limit load when the calculations of the three terms in the bearing capacity formula are consistent with one collapse mechanism and the soil satisfies the associated flow *** the same time,the method of characteristics avoids the assumption of arbitrary slip surfaces,and produces zones within which equilibrium and plastic yield are simultaneously satisfied for given boundary *** exact solution without superposition approximation can still be expressed by Terzaghi＇s equation of bearing capacity,in which the bearing capacity factor N γλ is dependent on the dimensionless parameter λ and the friction angle φ.The influence of groundwater on the bearing capacity of the shallow strip footing is considered,which indicates that when the groundwater effect is taken into account,the error induced by the superposition approximation can be reduced as compared with dry soil *** results are presented in the form of charts which give the modified value（Nwγλc /Nγλc） of bearing capacity ***,an approximated analytical expression,which provides results in close agreement with those obtained by numerical analysis in this paper,has been suggested for practical application purposes.

关键词： Bearing capacity·The method of characteristics·Groundwater·Strip footing

A new Planetary Boundary Layer model and its application to heavy rain modeling

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Chinese Science Bulletin 2005年第16期50卷 1756-1766页

作者： SUN jian ZHOU Xiuji zhao ping Chinese Academy of Meteorological Sciences Beijing 100081 China

A new Planetary Boundary Layer (PBL) model (namely MY-4 in this paper) was developed with reference to Mellor-Yamada’s Level 4 turbulent closure concept. Having been coupled with a meso-scale model MM5, MY-4 was util-ized to simulate a heavy-rain process, which took place over South China during June 8-9, 1998. Its model outputs indi-cated that the rainfall process was well captured in terms of its intensity and geographical distribution. More importantly, in comparison with MM5’s original boundary layer models, MY-4 made the following improvements: (1) MY-4 not only simulated the major weather systems like low vortexes and low-level jets more accurately, thus improving the general weather pattern of the rainfall process, but it was also capa-ble of restraining the occurrence of false rainfall centers with maximum precipitation amounts exceeding 160 mm. (2) Having been compared with the wind profile observed at Hong Kong, it revealed that MY-4 could reproduce the wind speed fluctuations in a short time scale reasonably well, which was not yet achieved in the original PBL models in MM5. Furthermore, a more detailed comparative study was made on the results simulated by MY-4 and a PBL model (which is based on Mellor-Yamada’s Level 2.5 concept) re-spectively. It showed that the contributions of turbulences generated by the two categories of PBL models to the wind fields at a lower atmosphere were increasingly different even in the first 1-2 hours of integrations. As the analysis dem-onstrated, under the nonlinear interactions within the meso-scale MM5 model, it was the turbulences in the boundary layer that had the most important impacts on the final model outputs and MY-4 seemed to better reflect this turbulent process, hence leading to the aforementioned im-provements.

关键词：行星边界层模型重雨模型天文学

Mechanism of formation of low level jets in the South China Sea during spring and summer of 1998

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Chinese Science Bulletin 2003年第2期48卷 1265-1270页

作者： ping zhao jian Sun Xiuji Zhou Chinese Acad Meteorol Sci Beijing 100081 Peoples R China

The mechanism responsible for the formation of the low-level jet (LLJ) over the South China Sea during spring and summer of 1998 was analyzed through using the assimilated grid data provided by the South China Sea mon-soon experiment (SCSMEX). More analyses were empha-sized on a heavy rainfall process in the Zhujiang Delta area between 8th and 10th June 1998 in which a LLJ played a key role. Furthermore, the MM5 meso-scale model was utilized in studying the effects of the weather systems on the LLJ. The results showed that the kinetic energy associated with the LLJ transferred upward when the LLJ formed, which results in the fact that the big velocity of the LLJ expanded upward to higher level. Simulation verifies that a synop-tic-scale low pressure in the low troposphere of the west of South China moved toward the east, with a low-troposphere synoptic-scale high pressure in the western Pacific moving toward the west. In this process, the approach of both sys-tems leads to the reinforcement of pressure gradient force between them, making the kinetic energy needed by the for-mation of the LLJ increase. Through this process the LLJ formed and developed over the South China Sea between the low and high pressures. Because the formation of the LLJ indicates the enhancement of summer monsoon in the South China Sea, the mechanism responsible for formation of the LLJ could be used in explaining an enhancement of summer monsoon in the South China Sea.

关键词： low level jet numerical simulation monsoon over the South China sea

心肌肌钙蛋白I与急性心肌梗死患者近期预后的关系

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心脑血管病防治 2004年第2期4卷 15-17页

作者：胡剑平汪兆骏黄山市人民医院安徽黄山245000

目的　探讨急性心肌梗死 (AMI)患者血清心肌肌钙蛋白I(cTnI)水平与近期预后的关系。方法　测定 5 1例AMI患者的血清cTnI,根据cTnI水平分为二组 ,观察住院期间心力衰竭、缺血性胸痛、心脏性死亡的发生率 ,测定左心室射血分数 (LVEF) ,分... 详细信息

目的　探讨急性心肌梗死 (AMI)患者血清心肌肌钙蛋白I(cTnI)水平与近期预后的关系。方法　测定 5 1例AMI患者的血清cTnI,根据cTnI水平分为二组 ,观察住院期间心力衰竭、缺血性胸痛、心脏性死亡的发生率 ,测定左心室射血分数 (LVEF) ,分析cTnI水平与它们的关系。结果　在 5 1例AMI患者中 ,cTnI较高组 2 9例 ,较低组 2 2例 ,住院期间发生心力衰竭为 4 1 38%相对于 9 0 9% ,(P <0 0 1) ,缺血性胸痛为 4 4 83%相对于 18 18% ,(P <0 0 5 ) ,心脏性死亡为 3例相对于 0例 ,LVEF为 4 8%± 12 %相对于 5 8%± 12 % ,(P <0 0 5 ) ,存在显著差异。结论　血清cTnI是AMI患者住院期间预后的独立预测因子。

关键词：心肌肌钙蛋白Ⅰ 急性心肌梗死预后