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Chinese Chemical Letters 2019年第12期30卷 2051-2052页

作者： fu-jian Xu Key Lab of Biomedical Materials of Natural Macromolecules Beijing University of Chemical Technology Ministry of Education.State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing Laboratory of Biomedical Materials Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology

It is highly desired to have bioactive surfaces for biomaterials and controllable interactions with *** functions were widely achieved by attaching functional peptides to the surface of *** is well known that an antifouling layer can help reducing the nonspecific cell ***,it is unclear how an antifouling PEG layer affects the function of peptides attached on material surface in controlling cell *** highlight introduced the recent JACS paper from *** and coworkers in addressing this question thoroughly.

关键词： Antifouling PEG Biomaterials Surface modification Cell behaviors

Flow field simulation of double layer atomizer

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Transactions of Nonferrous Metals Society of China 2009年第S2期19卷 485-489页

作者： ZHAO Wen-jun CAO fu-yang ning Zhi-liang SUN jian-fei School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

The influences of parameters,such as delivery tube structure,gas pressure and the distance between the primary atomizer and the secondary atomizer,on gas flow field were investigated by *** effects of primary pressure on gas velocity at the centerline were *** atomizing experiment was carried out to validate gas scatter *** results show that the structure of primary atomizer plays an important role in the flow field near the exit of delivery *** protector with conical surface at the body extends certain length into the gas flow field to generate greater negative pressure near the tip of delivery tube. The application of primary gas can suppress the circulation generated by only using the secondary atomizer.

关键词： atomization gas flow field simulation

Ultrathin poly(cyclocarbonate-ether)-based composite electrolyte reinforced with high-strength functional skeleton

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Journal of Energy Chemistry 2023年第6期81卷 603-612,I0013页

作者： Xiaojiao Zheng Da Xu ning fu Zhenglong Yang Shanghai Key Laboratory of D&A for Metal-functional Materials School of Materials Science and EngineeringTongji UniversityShanghai 200092China School of Chemical and Environmental Engineering Anyang Institute of TechnologyAnyang 455000HenanChina

Composite polymer electrolytes(CPEs)are considered to be the most promising to break through the performance and safety limitations of traditional lithium-ion batteries because of their excellent electrochemical and mechanical *** at the performance limitations of the most common polyether matrix such as poly(ethylene oxide)(PEO),a novel poly(cyclocarbonate-ether)polymer matrix was prepared by in-situ thermal curing,the weaker interaction between its C=O bond and Li^(+)can promote the rapid transport of Li^(+).Adding ionic liquid and active filler LLZTO to the matrix can synergistically reduce the crystallinity of matrix and promote the dissociation of lithium *** addition,a 3D functional skeleton made of polyacrylonitrile(PAN)and lithium fluoride(LiF)can greatly improve the mechanical strength of polymer matrix after cold pressing,and Li F is also conducive to interface *** thickness of the optimal sample(VP6L/CPL)was only 25μm,and its ionic conductivity,lithium ion transference number,and electrochemical stability window were as high as 7.17×10^(-4)S cm^(-1)(25℃),0.54 and 5.4 V,respectively,while the mechanical strength reaches 6.1 MPa,which can fully inhibit the growth of lithium *** excellent electrochemical performance and mechanical strength enable the assembled Li|VP6L/CPL|Li battery to be continuously charged for over 200 h and cycled stably for more than 2300 h,and Li|VP6L/CPL|LFP battery can be stably cycled for more than 400 and 550 cycles at 1 C(40℃)and 0.5 C(25℃),respectively.

关键词： Composite polymer electrolytes Polymer matrix 3D functional skeleton Plasticization Synergistic effect

Inhibitive Determination of Heavy Metal Ions by Conductometric Nitrate Reductase Biosensor

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Chemical Research in Chinese Universities 2009年第4期25卷 443-445页

作者： WANG Xue-jiang XIA Si-qing ZHAO jian-fu ZHAO Hong-ning RENAULT Nicole Jaffrezic State Key Laboratory of Pollution Control and Resources Reuse Tongji University Shanghai 200092 P R. China Laboratoire de Sciences Analytiques（UMR CNRS 5180） Universite Claude Bernard Lyon 1 Universite ＇de Lyon Villeurbanne Cedex 69622 France

A conductometric nitrate biosensor based on methyl viologen/Nafion/nitrate reductase（NR） interdigitated electrode for heavy metal determination was *** activity of NR（EC 1.***.6.2） from Asper gillusniger（***） was assayed as a function of metal concentration in the presence of Cu^2＋,Zn^2＋,Cd^2＋ and Pb^2＋.Parameters influencing the performance of the biosensor were optimized for the application of it in the inhibition determination of heavy metal *** limits for Cu^2＋,Zn^2＋,Cd^2＋ and Pb^2＋ were about 0.05,0.5,0.1 and 1.0 μmol/L,*** results show that NR activity could not be regained after exposure to Cu^2＋,but could be partially recovered after exposure to Zn^2＋,Pb^2＋ and Cd^2＋.

关键词： Conductometric biosensor Heavy metal Nitrate reductase

Cause analysis and solutions of water blocking damage in cracked/non-cracked tight sandstone gas reservoirs

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Petroleum Science 2021年第1期18卷 219-233页

作者： Jie Wang fu-jian Zhou Unconventional Natural Gas Institute China University of Petroleum(Beijing)Bejjing 102249China State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum(Beijing)Beijing 102249China

After hydraulic fracturing treatment,a reduction in permeability caused by the invasion of fracturing fluids is an inevitable problem,which is called water blocking ***,it is important to mitigate and eliminate water blocking damage to improve the flow capacities of formation fluids and flowback rates of the fracturing ***,the steady-state core flow method cannot quickly and accurately evaluate the effects of chemical agents in enhancing the fluid flow capacities in tight *** paper introduces a time-saving and accurate method,pressure transmission test(PTT),which can quickly and quantitatively evaluate the liquid flow capacities and gas-drive flowback rates of a new ***,scanning electron microscopy(SEM)was used to analyze the damage mechanism of different fluids and the adsorption of chemical agents on the rock *** core flow experiments were used to evaluate the effects of the nanoemulsion on enhancing flowback rates in heterogeneous tight *** results show that the water blocking damage mechanisms differ in matrices and *** main channels for gas channeling are fractures in cracked cores and pores in non-cracked *** cores suffer less damage from water blocking than non-cracked cores,but have a lower potential to reduce water *** PTT and SEM results show that the permeability reduction in tight sandstones caused by invasion of external fluids can be list as guar gum fracturing fluid>slickwater>*** core flow experiments show that for low-permeability heterogenous s andstone reservoirs with a certain permeability ratio,the nanoemulsion can not only reduce reverse gas channeling degree,but also increase the flowback rate of the fracturing *** nanoemulsion system provides a new solution to mitigate and eliminate water blocking damage caused by fracturing fluids in tight sandstone gas reservoirs.

关键词： Hydraulic fracturing Water blocking damage Nanoemulsion Pressure transmission test Liquid flow capacity Flowback rate

Preservation of left colic artery in laparoscopic colorectal operation: The benefit challenge

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 825-833页

作者： fu-Cheng Liu jian-ning Song Ying-Chi Yang Zhong-Tao Zhang General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China General Surgery Beijing Fengtai HospitalBeijing 100071China

BACKGROUND During laparoscopic resection for colorectal cancer,there is controversy regarding whether the left colic artery(LCA)should be preserved at its *** To investigate the prognostic significance of preservation of the LCA in colorectal cancer *** Patients were divided into two *** high ligation(H-L)technique(refers to ligation performed 1 cm from the beginning of the inferior mesenteric artery)group consisted of 46 patients,and the low ligation(L-L)technique(refers to ligation performed below the initiation of the LCA)group consisted of 148 *** time,blood loss,lymph nodes with tumor invasion,postoperative complications and recovery time,recurrence rate,and 5-year survival rate were compared between the two *** The average number of lymph nodes detected in postoperative pathological specimens was 17.4/person in the H-L group and 15.9/person in the L-L *** were 20 patients(43%)with positive lymph nodes(lymph node metastasis)in the H-L group and 60 patients(41%)in the L-L *** statistical differences were found between the *** occurred in 12 cases(26%)in the H-L group and in 26 cases(18%)in the L-L *** incidences of postoperative anastomotic complications and functional urinary complications were significantly lower in the L-L *** 5-year survival rates in H-L and L-L groups were 81.7%and 81.6%,respectively,and relapse-free survival rates were 74.3%and 77.1%,*** two groups were similar *** Complete mesenteric resection combined with lymph node dissection around the inferior mesenteric artery root while preserving the LCA is a beneficial surgical approach during laparoscopic resection for colorectal cancer.

关键词： Cancer Complete mesenteric resection Inferior mesenteric artery Urinary complications Lymph

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

Cytokines that target immune killer cells against tumors

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Cellular & Molecular Immunology 2020年第7期17卷 722-727页

作者： jian Qiao Yang-Xin fu The Department of Pathology University of Texas Southwestern Medical CenterDallasTX 75235USA

T-cell-stimulating cytokines have shown promise as monotherapies or in combination with other therapeutic modalities for immunotherapy of ***,their efficacy is limited due to their short half-life,pleiotropic roles,and induction of severe toxicity even at therapeutic *** overcome these major therapeutic barriers,cytokine-based products are being further developed to improve their therapeutic *** approaches include manipulating their activity to preferentially bind to effector immune cells rather than immune-suppressive cells,prolonging their half-life in vivo and modifying them to target *** review focuses on IL-2,IL-15,and IL-10,which have potent effects on immune cells that mediate effective antitumor *** will summarize the recent progress of these cytokines in both preclinical studies and selective clinical applications and will discuss our perspectives on the development of new strategies to potentiate cytokine-based immunotherapy.

关键词： IL-2 IL-15 IL-10 cytokine therapy cancer

Multi-level virtual prototyping of electromechanical actuation system for more electric aircraft

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Chinese Journal of Aeronautics 2018年第5期31卷 892-913页

作者： jian fu Jean-Charles MARE Liming YU Yongling fu School of Mechanical Engineering and Automation Beihang University Institut Clement Ader (CNRS UMR 5312) INSA-Toulouse Flying College Beihang University

Electromechanical actuators（EMAs） are becoming increasingly attractive in the field of more electric aircraft because of their outstanding benefits, which include reduced fuel burn and maintenance cost, enhanced system flexibility, and improved management of fault detection and isolation. However, electromechanical actuation raises specific issues when being used for safetycritical aerospace applications like flight controls： huge reflected inertia to load, jamming-type failure, and increase of backlash with service due to wear and local dissipation of heat losses for thermal balance. This study proposes an incremental approach for virtual prototyping of EMAs. It is driven by a model-based system engineering process in order to enable simulation-aided *** practices supported by Bond graph formalism are suggested to develop a model＇s structure efficiently and to make the model ready for use（or extension） by addressing the above mentioned issues. Physical effects are progressively introduced, and the realism of lumped-parameter models is increased step-by-step. In particular, multi-level component models are architected to ensure continuity between engineering activities. The models are implemented in the AMESim simulation environment, and simulation responses are given to illustrate how they can be used for preliminary sizing, control design, thermal balance verification, and faults to failure analysis. The proposed best practices intend to provide engineers with fast, reusable, and efficient means to assess performance virtually and enhance maturity, performance, and robustness.

关键词： Bond graph Electromechanical actuator Flight control Model-based system engi-neering More electric aircraft Power-by-wire

The Material Behavior and Fracture Mechanism of a Frangible Bullet Composite

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Chinese Physics Letters 2013年第7期30卷 143-147页

作者： LI jian RONG Ji-Li ZHANG Yu-ning XU Tian-fu LI Bin Guangxi Key Laboratory of Automobile Components and Vehicle Technology Guangxi University of Science and TechnologyLiuzhou 545006 School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081

The quasi-static and dynamic compressive mechanical properties of a bullet composite are investigated using the scattered spot technique,an electronic universal testing machine,and a Split–Hopkinson pressure *** stress-strain curves under static and dynamic loading are also obtained,and the strain rate effect is *** rupture structure is observed under a scanning electron microscope,and the microscopic damage mechanism of the bullet composite is *** show that the composite is sensitive to the strain rate,such that the compressive strength of the composite increases with increased strain *** relationship of the compressive strength and elastic modulus with the logarithmic strain rate is nonlinear.

关键词： composite strain dynamic