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Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis

Genes & Diseases 2024年第5期11卷 442-455页

作者： jianxiong Xu Jinxuan wang Hongping Zhang Yidan Chen Xiaojuan Zhang Ying Zhang Ming Xie Jun Xiao Juhui Qiu Guixue wang Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering Modern Life Science Experiment Teaching Center of Bioengineering CollegeChongqing UniversityChongqing 400030China Jinfeng Laboratory Chongqing 401329China School of Basic Medical Sciences Chengdu Medical CollegeChengduSichuan 610500China Chongqing Emergency Medical Center(Chongqing University Central Hospital) Chongqing 400014China

The clearance of apoptotic cell debris,containing professional phagocytosis and non-professional phagocytosis,is essential for maintaining the homeostasis of healthy ***,we discovered that endothelial cells could engulf apoptotic cell debris in atherosclerotic ***-cell RNA sequencing(RNA-seq)has revealed a unique endothelial cell subpopulation in atherosclerosis,which was strongly associated with vascular injury-related ***,integrated analysis of three vascular injury-related RNA-seq datasets showed that the expression of scavenger receptor class B type 1(SR-B1)was up-regulated and specifically enriched in the phagocytosis pathway under vascular injury ***-cell RNA-seq and bulk RNA-seq indicate that SR-B1 was highly expressed in a unique endothelial cell subpopulation of mouse aorta and strongly associated with the reorganization of cellular adherent junctions and cytoskeleton which were necessary for ***,SR-B1 was strongly required for endothelial cells to engulf apoptotic cell debris in atherosclerotic plaque of both mouse and human ***,this study demonstrated that apoptotic cell debris could be engulfed by endothelial cells through SR-B1 and associated with the reorganization of cellular adherent junctions and cytoskeleton.

关键词： Apoptotic cell debris Atherosclerosis Endothelial engulfment Single-cell RNA sequencing Scavenger receptor class B type 1

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590份燕麦种质资源营养器官表型性状遗传多样性分析

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草地学报 2024年第1期32卷 158-167页

作者：王凤宇梁国玲刘文辉青海省青藏高原优良牧草种质资源利用重点实验室青海大学(青海省)畜牧兽医科学院青海西宁 810016

为明确燕麦(Avena sativa)种质资源营养器官表型性状的遗传多样性和各性状之间的相关关系,进而为燕麦育种和种质资源创新利用提供理论依据,本研究以国内外收集的590份燕麦种质资源为研究对象,在青海省西宁市湟中区对其从地上器官质量性... 详细信息

为明确燕麦(Avena sativa)种质资源营养器官表型性状的遗传多样性和各性状之间的相关关系,进而为燕麦育种和种质资源创新利用提供理论依据,本研究以国内外收集的590份燕麦种质资源为研究对象,在青海省西宁市湟中区对其从地上器官质量性状、茎部性状、叶部性状和分蘖性状的遗传多样性进行评价分析,并利用相关性分析和聚类分析方法,评价其营养器官表型性状的遗传变异水平.结果表明:590份燕麦种质资源质量性状遗传多样性指数以茎节绒毛最高(1.026),苗期株型最低(0.162);数量性状的遗传多样性指数以第三茎节茎粗最高(2.09),旗叶叶面积最低(1.87);变异系数以无效分蘖数(54.92％)最大,茎节数最小(12.20％);茎部性状和倒二叶长、倒二叶叶面积是影响燕麦种子和饲草产量的重要因子.590份燕麦资源可分为4大类群,其中类群Ⅲ可作为饲草型育种目标的亲本材料,类群Ⅳ可作为抗倒伏育种材料.

关键词：皮燕麦茎部性状叶部性状表型性状遗传多样性

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Recent advances in core-shell organic framework-based photocatalysts for energy conversion and environmental remediation

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Journal of Energy Chemistry 2024年第8期95卷 168-199,I0004页

作者： Qibing Dong Ximing Li Yanyan Duan Qingyun Tian Xinxin Liang Yiyin Zhu Lin Tian Junjun wang Atif Sial Yongqian Cui Ke Zhao Chuanyi wang School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021ShaanxiChina Guangdong Engineering Technology Research Center for Environmental Purification and Functional Materials Guangzhou Institute of Industrial IntelligenceGuangzhou 511400GuangdongChina jiangxi Key Lab of Flexible Electronics Flexible Electronics Innovation InstituteJiangxi Science and Technology Normal UniversityNanchang 330013JiangxiChina Helmholtz-Zentrum Berlin für Materialien und Energie Kekuléstraße 512489 BerlinGermany

Direct conversion of solar energy into chemical energy in an environmentally friendly manner is one of the most promising strategies to deal with the environmental pollution and energy *** a variety of materials developed as photocatalysts,the core-shell metal/covalent-organic framework(MOF or COF)photocatalysts have garnered significant attention due to their highly porous structure and the adjustability in both structure and *** existing reviews on core-shell organic framework photocatalytic materials have mainly focused on core-shell MOF ***,there is still a lack of indepth reviews specifically addressing the photocatalytic performance of core-shell COFs and MOFs@***,there is an urgent need for a comprehensive review encompassing these three types of core-shell *** on this,this review aims to provide a comprehensive understanding and useful guidelines for the exploration of suitable core-shell organic framework photocatalysts towards appropriate photocatalytic energy conversion and environmental ***,the classification,synthesis,formation mechanisms,and reasonable regulation of core-shell organic framework were ***,the photocatalytic applications of these three kinds of core-shell structures in different areas,such as H_(2)evolution,CO_(2)reduction,and pollutants degradation are ***,the main challenges and development prospects of core-shell organic framework photocatalysts were *** review aims to provide insights into the development of a novel generation of efficient and stable core-shell organic framework materials for energy conversion and environmental remediation.

关键词： Organic framework Core-shell structure Photocatalysis Energy conversion Environmental remediation

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面向民用飞机需求验证的自动化测试技术研究

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图学学报 2024年第2期45卷 308-316页

作者：汪澔武仲芝唐剑中国商用飞机有限责任公司北京民用飞机技术研究中心北京102211

在商用飞机全生命周期的研制过程中,需求与概念论证环节作为商用飞机研制的早期环节,将极大地影响整个商用飞机的全生命周期成本。其中功能定义作为需求与概念论证阶段的核心产物之一,以一种统一化、标准化的描述了目标产品一系列的预... 详细信息

在商用飞机全生命周期的研制过程中,需求与概念论证环节作为商用飞机研制的早期环节,将极大地影响整个商用飞机的全生命周期成本。其中功能定义作为需求与概念论证阶段的核心产物之一,以一种统一化、标准化的描述了目标产品一系列的预期行为表达。功能性需求作为功能定义的重点输出产物,决定了商用飞机的核心产品竞争力。基于功能仿真的需求验证作为一种常用的需求质量评价手段,通过建立飞机的测试模型,仿真模拟特定场景下飞机的运行行为,以结果为评判依据确认早期方案设计是否满足需求。然而,在实际面向需求的仿真测试过程中,碍于场景外部环境的多变性,往往会出现“组合爆炸式”的测试用例,极大地增加了测试的规模和成本。为解决上述问题,提出基于模型的测试(MBT)方法,通过基于系统建模语言(SysML)模型自动化生成测试用例,缩短验证过程的周期并保证需求验证的可追溯性。

关键词：需求验证测试用例基于模型的测试 SysML

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Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2826-2841页

作者： Gang wang Tao Liu Wen-Ting He School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor Prevention and Treatment and Translational Medicine Engineering Innovation Center of Lanzhou University Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Digestive System Tumor Translational Medicine Engineering Research Center of Gansu Province Lanzhou UniversityLanzhou 730000Gansu ProvinceChina The Second Hospital&Clinical Medical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical *** over a decade of development and increasing research achievements in this field,a systematic and comprehensive analysis of the research hotspots and future trends is *** To address this problem by employing bibliometric tools to explore the publication years,countries/regions,institutions,journals,authors,keywords,and references in this *** The literature was collected from Web of Science ***-6.2R4,a widely used bibliometric analysis software package,was used for institutional analysis and reference burst *** 1.6.19 was used for journal cocitation analysis,author co-authorship and co-citation ***‘online platform for bibliometric analysis(https://***/app)’was used to assess the total number of publications and the cooperation relationships between ***,we employed the bibliometric R software package(version R.4.3.1)in R-studio,for a comprehensive scientific analysis of the *** Our analysis included a total of 1466 publications,revealing a significant yearly increase in articles on the study of gastrointestinal tumor *** United States(n=393)and Helmholtz Association(n=93)have emerged as the leading countries and institutions,respectively,in this field,with Hans Clevers and Toshiro Sato being the most contributing *** most influential journal in this field is *** most impactful reference is"Long term expansion of epithelial organs from human colon,adenoma,adenocarcinoma,and Barrett's epithelium".Keywords analysis and citation burst analysis indicate that precision medicine,disease modeling,drug development and screening,and regenerative medicine are the most cutting-edge *** focal points were further detailed based on the *** This bibl

关键词： Gastrointestinal tumor organoids Bibliometric analysis Drug development and screening Model CiteSpace

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结合生态网络解析白洋淀浮游生物生态位和种间联结性特征

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环境科学 2024年第9期45卷 5298-5307页

作者：霍笑康王永刚周灵同王书航姜霞陈珂王鹏飞中国环境科学研究院湖泊水污染治理与生态修复技术国家工程实验室国家环境保护湖泊污染控制重点实验室北京100012 兰州理工大学生命科学与工程学院兰州730050 青海省生态环境监测中心西宁810002

为了解白洋淀浮游生物群落结构及其优势种的生态位特征,于2022年春季(3月)、夏季(7月)和秋季(9月)对白洋淀浮游生物进行采样调查.通过构建生态网络图并结合非度量多维尺度分析(NMDS)解析3个季节浮游生物群落结构变化特征,并运用改进的Le... 详细信息

为了解白洋淀浮游生物群落结构及其优势种的生态位特征,于2022年春季(3月)、夏季(7月)和秋季(9月)对白洋淀浮游生物进行采样调查.通过构建生态网络图并结合非度量多维尺度分析(NMDS)解析3个季节浮游生物群落结构变化特征,并运用改进的Levins公式和Petraitis指数评估了浮游生物优势种的生态位宽度和生态位重叠度,通过卡方检验和种间联结性系数判断总体和优势种种间联结度.结果表明,浮游生物在整个淀区的生态位宽度较窄.浮游动物以轮虫为主,浮游植物主要是硅藻门、蓝藻门和绿藻门.浮游生物的群落变化具有明显的季节性特征.与夏秋季相比,春季浮游生物种类较少,种间联通度较低.夏季浮游动物优势种重叠度高,种间竞争加剧,而浮游植物的种间重叠在3个季节均处于较低水平.夏秋季节浮游植物各优势种种间的联结性均呈显著正联结关系(W>χ20.05),群落结构稳定.浮游动物和浮游植物的跨域生态网络在秋季表现出较高的负相关性比例,尤其在浮游动物的桡足类和枝角类与浮游植物的绿藻门和蓝藻门之间.白洋淀浮游生物的物种丰富,季节性差异明显,优势种以窄生态位为主,浮游生物群落总体处于较稳定的状态,桡足类和枝角类与绿藻和蓝藻之间存在较强的捕食关系.

关键词：白洋淀浮游生物生态网络生态位种间联结

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全膝关节置换中的缺血再灌注损伤

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中国组织工程研究 2024年第6期28卷 955-960页

作者：杨毅峰黄健叶楠王琳内蒙古医科大学第二附属医院内蒙古自治区呼和浩特市010000

背景:以往针对缺血再灌注损伤的相关机制、表现、防治已有报道。但对全膝关节置换引起的下肢骨骼肌缺血再灌注损伤研究较少,此文重点对全膝关节置换引起下肢缺血再灌注损伤的发病机制、临床影响及防治方法进行综述。目的:通过对全膝关... 详细信息

背景:以往针对缺血再灌注损伤的相关机制、表现、防治已有报道。但对全膝关节置换引起的下肢骨骼肌缺血再灌注损伤研究较少,此文重点对全膝关节置换引起下肢缺血再灌注损伤的发病机制、临床影响及防治方法进行综述。目的:通过对全膝关节置换引起下肢缺血再灌注损伤的相关文献进行归纳总结,分析其机制、意义,为进一步研究骨骼肌缺血再灌注损伤给出提示。方法:应用计算机检索PubMed数据库、CNKI、万方数据库及维普数据库2000-01-01/2022-04-30发表的相关文章,英文检索词为“ischemia-reperfusion injury,total knee arthroplasty,tourniquet,mechanism,pathophysiology,skeletal muscle,treatment”;中文检索词为“缺血再灌注损伤,全膝人工关节置换术,止血带,机制,病理生理,骨骼肌,治疗”。排除重复性研究及部分相关性较低的基础类文章。最终纳入68篇文献进行综述。结果与结论:(1)缺血再灌注损伤的发病机制与氧自由基、细胞内钙超载、中性粒细胞活化相关,还和高浓度一氧化氮、无复流现象以及细胞凋亡等机制相关,更详尽的机制研究能为将来的防治提供依据;(2)下肢缺血再灌注损伤会造成局部骨骼肌损伤,这可能由手术本身的创伤引起,也可能是缺血再灌注损伤的作用,还需要更有针对性的研究区别二者关系;(3)下肢缺血再灌注损伤甚至会影响远端器官,造成肾脏、肺脏损伤,还会影响局部及全身循环;(4)明确缺血再灌注损伤的影响能为将来的防治指明方向,目前的防治措施主要包括缺血预处理,麻醉药物、抗氧化剂等药物预防;(5)针对全膝关节置换手术引起的下肢骨骼肌缺血再灌注损伤的详细综述,能为将来的诊疗决策提供依据。

关键词：缺血再灌注损伤全膝关节置换止血带机制病理生理骨骼肌治疗

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Green development and economic resilience:Evidence from Chinese resource-based cities

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Frontiers of Engineering Management 2024年第2期11卷 194-206页

作者： Zongrun wang Xuxin CAO Xiaohang REN School of Business Central South UniversityChangsha 410083China

Resource-based cities are currently facing challenges due to ecological pollution and an unbalanced industrial structure,which hinders sustainable economic *** focus on green development as a strategy for economic growth and environmental protection is becoming increasingly *** study employs a spatial econometric model to explore the effect of green development on economic resilience in Chinese resource-based cities from 2011 to 2019,revealing a positive correlation between green development and economic *** each 1 unit increase in green development,economic resilience increases by an average of 0.512 ***,the analysis of heterogeneity reveals differences in the factors influencing various resource-based *** addition,provincial green policies bolster economic resilience by encouraging green *** research aids in comprehending the balance between the economy and the environment.

关键词： economic resilience green development spatial econometric models resource-based cities

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Atomistic origin of high grain boundary resistance in solid electrolyte lanthanum lithium titanate

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Journal of Materiomics 2024年第6期10卷 1214-1221页

作者： Shang Peng Yongjin Chen Xuefeng Zhou Mingxue Tang jianbo wang Hua wang Lin Guo Lujun Huang Wenge Yang Xiang Gao Center for High Pressure Science and Technology Advanced Research(HPSTAR) Beijing100094China School of Physics and Technology Center for Electron MicroscopyMOE Key Laboratory of Artificial Micro-and Nano-structuresand Institute for Advanced StudiesWuhan UniversityWuhan430072China School of Chemistry Beijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing100191China School of Materials Science and Engineering Harbin Institute of TechnologyP.O.Box 433Harbin150001China

Lanthanum lithium titanate is one of the promising electrolytes for solid-state lithium-ion batteries due to its high bulk ionic conductivity up to∼10^(−3) S/***,the practical application of this material has been bottlenecked by high grain boundary(GB)resistance,while the underlying mechanism is still under *** we report a comprehensive study with direct evidence to reveal the origin of high GB resistance in La_(2/3)–xLi_(3x)TiO_(3)(LLTO).Atomic-scale observations via advanced scanning transmission electron microscopy show that the GBs are uniformly subject to subsurface segregation of La atoms to compensate for the excess surface *** La segregation leads to an abrupt decrease of charge carrier concentration neighboring GBs and hence is supposed to have deleterious effect on GB *** findings suggest a novel mechanism of space-charge-induced cation segregation,which shed lights on the intrinsic origin of low GB ionic conductivity in LLTO.

关键词： Space-charge layer Cation segregation Intergranullar glassy film Solid-state electrolyte Ionic conductivity

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Sr(Cr_(0.2)Mn_(0.2)Fe_(0.2)C_(0.2)Ni_(0.2))O_(3):A novel high-entropy perovskite oxide with enhanced electromagnetic wave absorption properties

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Journal of Materiomics 2024年第6期10卷 1176-1185页

作者： Mengru Li Qing Zhi Jinlu Li Chengwen Wu Xuewen jiang Zhiyu Min Rui Zhang Hailong wang Haibin wang Bingbing Fan School of Materials Science and Engineering Zhengzhou University Zhengzhou450001China School of Material Science and Engineering Luoyang Instiute pf Science and TechnologyLuoyang471023HenanChina Institute of Advanced Ceramics Henan Acaderry of SciencesZhengzhou450046China

Perovskite materials(ABO_(3))possess a wealth of elements selectable and exhibit a diverse range of octahedral *** emergence of high-entropy perovskite ceramics provides a fresh perspective for advancing the field of wave-absorbing *** this study,we concentrate on the wet chemical synthesis of a high-entropy perovskite oxide,Sr(Cr_(0.2)Mn_(0.2)Fe_(0.2)C_(0.2)Ni_(0.2))O_(3),and investigate its crystal structure,microstructure,chemical composition,magnetic properties,and microwave absorbing *** results indicate that when sintered at a temperature of 1,350℃,the sample achieves a minimum reflection loss of-54.0 dB at a frequency of 9.68 GHz,accompanied by a maximum effective absorption bandwidth(EAB)of 7.44 GHz at the thickness of 1.8 *** high-entropy design of the B-site induces distortions of oxygen vacancy and octahedral structure of the perovskite *** leads to the fine tuning of its dielectric and magnetic properties,thereby endowing perovskite with excellent electromagnetic wave absorption ***,perovskite emerges as a promising new electromagnetic wave absorption material with significant potential.

关键词： High-entropy ceramics Perovskite Microwave absorption Magnetism

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