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Papillary thyroid microcarcinoma with contralateral lymphatic skip metastasis and breast cancer: A case report

World Journal of Clinical Cases 2022年第11期10卷 3609-3614页

作者： Min Ding Ya-Hui Kong jian-hua gu Rong-Li Xie jian Fei Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Shanghai Changhang HospitalShanghai 200122China Department of General Surgery Shanghai Ruijin Rehabilitation HospitalShanghai 200023China Department of General Surgery Ruijin Hospital Luwan BranchShanghai Jiao Tong University School of MedicineShanghai 200020China

BACKGROUND The recognized pattern of cervical lymph node metastasis(CLNM)of papillary thyroid carcinoma involves a stepwise *** lymph node skip metastasis is very *** addition,the patient in our case report also suffered from a breast carcinoma accompanied by left supraclavicular lymphadenopathy,which made it difficult to distinguish the origin of the *** on this case,we recommended that more detailed physical and imaging examinations are needed for patients with uncommon cervical lymphatic metastasis of primary *** SUMMARY A 53-year-old women was admitted to the hospital for a neck mass in the left cervical region that had existed for 2 *** neck mass was suspected to be an enlarged lateral LN originating from papillary thyroid microcarcinoma of the contralateral thyroid lobe,according to ultrasound and ultrasound-guided fine needle aspiration *** patient underwent total thyroidectomy and radical cervical LN *** pathology confirmed the diagnosis of papillary thyroid microcarcinoma with contralateral lymphatic skip ***,a breast cancer was discovered 4 mo later,which was accompanied by ipsilateral supraclavicular LN *** accepted neoadjuvant chemotherapy and subsequent left modified radical mastectomy for *** patient is currently receiving postoperative radiotherapy,and no local recurrence was observed in the 6-mo follow-up after *** present a rare case of papillary thyroid microcarcinoma with contralateral lymphatic skipmetastasis and breast cancer with supraclavicular lymphatic metastasis.

关键词： Thyroid cancer Papillary Breast neoplasms Lymphatic metastasis Skip metastasis Contralateral metastasis Case report

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Fluorescence in situ hybridization-based confirmation of acute graftvs-host disease diagnosis following liver transplantation:A case report

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1102-1109页

作者： Jing-Jing Xiao Jin-Yu Ma Jun Liao Di Wu Chao Lv Hai-Yang Li Shi Zuo Hai-Tao Zhu hua-jian gu School of Clinical Medicine Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Hepatobiliary Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Pediatric Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

BACKGROUND Although acute graft-vs-host disease(aGvHD)is a rare complication of liver transplantation,it is poorly understood and has an extremely high mortality *** standardized diagnostic criteria or treatment regimens currently *** SUMMARY The present study investigated the etiology,diagnosis,and treatment of aGvHD following liver ***,diagnosis,disease course,histology,and treatment of an aGvHD case are reported,and associated literature is reviewed.A 64-year-old female required LTx due to primary biliary *** donor was a 12-year-old *** weeks following liver transplantation,the recipient developed pyrexia,diarrhea,rashes,and antibiotic-unresponsive *** symptoms together with laboratory investigations suggested a diagnosis of aGvHD,which was confirmed via peripheral blood fluorescent in situ *** XY chromosome fluorescent in situ hybridization indicating early chimerism achieved 93%sensitivity in the detection of *** immunosuppressants were discontinued,and high-dose intravenous methylprednisolone was initiated along with *** diarrhea resolved,the patient’s general condition continued to deteriorate until demise due to multi-system organ failure at 37 d post-liver *** case illustrates the life-threatening nature of *** Herein,we have summarized a post-LTx aGvHD case and reviewed associated literature in order to increase awareness and provide potentially risk-mitigating recommendations.

关键词： Liver transplantation Graft-vs-host disease Fluorescence in situ hybridization cytogenetics Chimerism Diagnosis Case report

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen gu hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Neural Respiratory Drive Measured Using Surface Electromyography of Diaphragm as a Physiological Biomarker to Predict Hospitalization of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients

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Chinese Medical Journal 2018年第23期131卷 2800-2807页

作者： Dan-Dan Zhang Gan Ln Xaan-Feng Zhu Ling-Ling Zhang Jia Gao Li-Cheng Shi jian-hua gu jian-Nan Liu Chronic Airway Disease Research Office Department of RespiratoryGeriatric Hospital of Nanjing Medical UniversityJiangsu Province Geriatric HospitalNanjingJiangsu 210024China

Background: Neural respiratory drive (NRD) using diaphragm electromyography through an invasive transesophageal multi?electrode catheter can be used as a feasible clinical physiological parameter in patients with chronic obstructive pulmonary disease (COPD) to provide useful information on the treatment response. However, it remains unknown whether the surface diaphragm electromyogram (EMGdi) could be used to identify the deterioration of clinical symptoms and to predict the necessity of hospitalization in acute exacerbation of COPD (AECOPD) patients. Methods: COPD patients visiting the outpatient department due to acute exacerbation were enrolled in this study. All patients who were subjected to EMGdi and classical parameters such as spirometry parameters, arterial blood gas analysis, COPD assessment test (CAT) score, and the modified early warning score (MEWS) in outpatient department, would be treated effectively in the outpatient or inpatient settings according to the Global Initiative for Chronic Obstructive Lung Disease guideline. When the acute exacerbation of the patients was managed, all the examination above would be repeated. Results: We compared the relationships of admission?to?discharge changes (Δ) in the normalized value of the EMGdi, including the change of the percentage of maximal EMGdi (ΔEMGdi%max) and the change of the ratio of minute ventilation to the percentage of maximal EMGdi (ΔVE/EMGdi%max) with the changes of classical parameters. There was a significant positive association between ΔEMGdi%max and ΔCAT,ΔPaCO2, and ΔpH. The change (Δ) of EMGdi%max was negatively correlated with ΔPaO2/FiO2 in the course of the treatment of AECOPD. Compared with the classical parameters including forced expiratory volume in 1 s, MEWS, PaO2/FiO2, the EMGdi%max (odds ratio 1.143, 95% confidence interval 1.004–1.300) has a higher sensitivity when detecting the early exacerbation and enables to predict the admission of hospital in the whole cohort. Conclusions: T

关键词： Acute Exacerbation of Chronic Obstructive Pulmonary Disease Neural Respiratory Drive Surface Diaphragm Electromyography

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Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第01期 337-349页

作者： Meiyun Xu Song gu Fulong Chen Zhe Zhao Peng Liu Daoben hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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新型组合式转子电机的分析计算与实验研究

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微电机 2006年第3期39卷 15-18,40页

作者：朱建华辜承林华中科技大学武汉430074

针对普通异步电机和开关磁阻电机的转子发热和转矩脉动等缺陷,提出高密度轴向叠片各向异性转子电机,并结合具体的电机参数,估算出组合式转子电机的气隙磁密和空载电动势,用实验加以验证。建立了电机的数学模型,分析了稳态性能,并通过各... 详细信息

针对普通异步电机和开关磁阻电机的转子发热和转矩脉动等缺陷,提出高密度轴向叠片各向异性转子电机,并结合具体的电机参数,估算出组合式转子电机的气隙磁密和空载电动势,用实验加以验证。建立了电机的数学模型,分析了稳态性能,并通过各种起动实验,证实了转子增加永磁体是解决ALA转子电机起动稳定性的一种有效手段。

关键词： ALA转子电机磁阻电动机组合式转子永磁同步电动机

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Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science China Chemistry 2025年

作者： Jing-Wen Xie Meng-Ting Wang Yan Jin Si Li jian-hua Qin Shuang-Quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian guo jian-Gang Shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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废轮胎流化床热解形变过程研究

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燃料化学学报 2001年第6期29卷 557-560页

作者：李鑫严建华池涌顾介元马增益岑可法能源清洁利用与环境工程教育部重点实验室

利用压汞仪和扫描电镜 (SEM)对废轮胎在鼓泡流化床热解反应器中热解的形变学进行了研究。结果表明 :4 0 0℃时热解半焦有局部的熔融现象 ;随温度的升高由于热解半焦的刚性变弱使孔总表面积和孔隙度降低 ;在不同温度下热解半焦的孔径分... 详细信息

利用压汞仪和扫描电镜 (SEM)对废轮胎在鼓泡流化床热解反应器中热解的形变学进行了研究。结果表明 :4 0 0℃时热解半焦有局部的熔融现象 ;随温度的升高由于热解半焦的刚性变弱使孔总表面积和孔隙度降低 ;在不同温度下热解半焦的孔径分布相似 ,主要集中在 2 0nm～ 2 0 0nm和 1μm～ 10 μm ,随热解温度的升高 2 0nm～ 2 0 0nm的中孔所占比例提高 ;热解温度的升高导致废轮胎热解半焦的弯曲度变大、孔结构变的更加复杂。

关键词：废轮胎流化床热解形变学废物处理

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行波型超声波电机驱动电路特性仿真与优化

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微电机 2002年第2期35卷 31-33页

作者：余建华辜承林华中科技大学湖北武汉430074

介绍了行波型超声波电机驱动电路的分析模型 ,叙述了仿真过程。

关键词：行波型超声波电机驱动电路特性仿真优化

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