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PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression

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Cancer Communications 2022年第8期42卷 750-767页

作者： Hong-Yong Cui Wei Wei Mei-Rui Qian Ruo-Fei Tian Xin Fu Hong-Wei Li Gang Nan Ting Yang Peng Lin Xi Chen Yu-Meng ZhuBin Wang Xiu-Xuan Sun jian-hua dou jian-Li jiang Ling Li Shi-Jie Wang Zhi-Nan Chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi’anShaanxi 710032P.R.China State Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxi 710032P.R.China Department of Clinical Medicine Medical College of Yan’an UniversityYan’anShaanxi 716000P.R.China Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’anShaanxi 710127P.R.China

Background:The mechanism underlying colorectal cancer(CRC)initiation and progression remains elusive,and overall survival is far from *** studies have shown that PDGFA-associated protein 1(PDAP1)is upregulated in several cancers including ***,we aimed to identify the cause and consequence of PDAP1 dysregulation in CRC and evaluate its role as a potential therapeutic ***:Multi-omics data analysis was performed to identify potential key players in CRC initiation and ***(IHC)staining was applied to determine the expression pattern of PDAP1 in CRC ***1 conditional knockout mice were used to establish colitis and CRC mouse *** sequencing,a phosphoprotein antibody array,western blotting,histological analysis,5-bromo-2′-deoxyuridine(BrdU)incorporation assay,and interactome analysis were applied to identify the underlying mechanisms of PDAP1.A human patient-derived xenograft(PDX)model was used to assess the potential of PDAP1 as a therapeutic ***:PDAP1 was identified as a potential key player in CRC development using multi-omics data ***1 was overexpressed in CRC cells and correlated with reduced overall *** investigation showed that PDAP1 was critical for the regulation of cell proliferation,migration,invasion,and ***,depletion of Pdap1in intestinal epithelial cells impaired mucosal restitution in dextran sulfate sodium salt-induced colitis and inhibited tumor initiation and growth in colitis-associated *** studies showed that c-Myc directly transactivated PDAP1,which contributed to the high PDAP1 expression in CRC ***1 interacted with the juxtamembrane domain of epidermal growth factor receptor(EGFR)and facilitated EGFRmitogen-activated protein kinase(MAPK)signaling activation,which resulted in FOS-related antigen 1(FRA-1)expression,thereby facilitating CRC progres***,silencing of PDAP1 could hinder the

关键词： carcinogenesis colorectal cancer FRA-1 PDAP1 c-Myc

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Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du Hao You Junfeng huang Mudong Tu hua Li Yong Peng Wei dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-jian Wang Xiu-Liang Xu jiang-hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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Encapsulation of bimetallic phosphides into graphitized carbon for pH-universal hydrogen evolution reaction

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Journal of Energy Chemistry 2021年第12期30卷 253-261,I0005页

作者： jian Zhou Yibo dou Tao He Xiang-Jing Kong Lin-hua Xie jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation Faculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

Exploring nonprecious electrocatalysts for water splitting with high efficiency and durability is critically ***,bimetallic phosphides are encapsulated into graphitized carbon to construct a C@NiCoP composite nanoarray using bimetallic metal-organic framework(MOF) as a self-sacrificial *** resulting C@NiCoP exhibits superior performance for pH-universal electrocatalytic hydrogen evolution reaction(HER),particularly representing a low overpotential of 46.3 mV at 10 mA cm^(-2) and Tafel slope of 44.1 mV dec^(-1) in alkaline *** structural characterizations combined with theoretical calculation demonstrate that tailored electronic structure from bimetal atoms and the synergistic effect with graphitized carbon layer could jointly optimize the adsorption ability of hydrogen on active sites in HER process,and enhance the electrical conductivity as *** addition,the carbon layer served as a protecting shell also prevents highly dispersed NiCoP components from agglomeration and/or loss in harsh media,finally improving the *** work thus provides a new insight into optimizing activity and stability of pH-universal electrocatalysts by the nanostructural design and electronic structure modulation.

关键词： Bimetallic phosphides Graphitized carbon Hydrogen evolution reaction MOF template Electronic structure

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胆必清颗粒剂抗炎作用实验研究

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天津医科大学学报 2001年第3期7卷 303-304,313页

作者：刘印忠高建华窦淑兰天津医科大学药理教研室 300070

目的 :观察胆必清颗粒剂对实验性小白鼠和大白鼠炎症的影响。方法 :用二甲苯致炎法、角叉菜胶致炎法、皮下植入棉球诱导肉芽组织增生法 ,分别引起小白鼠耳廓的炎症、大白鼠足爪炎症和皮下肉芽组织增生 ,研究胆必清颗粒剂的抗炎症作用。... 详细信息

目的 :观察胆必清颗粒剂对实验性小白鼠和大白鼠炎症的影响。方法 :用二甲苯致炎法、角叉菜胶致炎法、皮下植入棉球诱导肉芽组织增生法 ,分别引起小白鼠耳廓的炎症、大白鼠足爪炎症和皮下肉芽组织增生 ,研究胆必清颗粒剂的抗炎症作用。结果 :胆必清颗粒剂组与空白组比较 ,胆必清颗粒剂可使小白鼠耳廓的肿胀度明显减轻 (P<0.01),大剂量组优于小剂量组 (P<0.05) ,其余各剂量组均无明显差异 ;胆必清颗粒剂可使大白鼠足爪肿胀度明显减轻 (P<0.01或P<0.05) ,大剂量组优于中剂量组 (P<0.01)和小剂量组 ,中剂量组优于小剂量组 ,有剂量依赖性 ;大剂量、中剂量组肉芽组织增生明显受到抑制(P<0.01)。结论

关键词：胆必清颗粒剂炎症大白鼠小白鼠药理实验

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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分子印迹膜-固相萃取-高效液相色谱法同时检测橙子中噻苯隆和氯吡脲

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食品科学 2025年第1期46卷 176-183页

作者：石雨王建豆瑞祁迎春董晓牛志睿任景俞黄华赵怡雪延安大学石油工程与环境工程学院延安市环境检测与修复重点实验室陕西延安716000 北京理工大学化学与化工学院北京100081

以聚多巴胺(polydopamine,PDA)修饰的聚偏氟乙烯(polyvinylidene fluoride,PVDF)膜为基膜,噻苯隆(thidiazuron,TDZ)为模板,甲基丙烯酸(methacrylic acid,MAA)为功能单体,乙二醇二甲基丙烯酸酯(ethylene glycol dimethacrylate,EGDMA)为交联剂,合成TDZ分子印迹膜(molecularly imprinted membrane,MIM),并将其应用于橙子中TDZ及其结构类似物氯吡脲(forchlorfenuron,CPPU)的高选择性同时提取。扫描电子显微镜表征结果表明,致密分子印迹聚合物通过PDA涂层固定在PDA@PVDF膜的三维网络结构表面;性能测试结果表明,MIM对TDZ和CPPU的吸附容量分别是相应非印迹膜的1.80、1.89倍,分别在20、30 min达到吸附平衡;MIM对干扰物质香豆素和3-叔丁基苯酚的特异性因子分别达到23.2和19.3。以MIM为固相萃取膜片,成功从橙子样品中高选择性同时提取TDZ和CPPU,在加标浓度为2.0、3.0、5.0μmol/L时,高效液相色谱法检测的加标回收率分别为90.3%~99.4%和88.2%~98.1%,相对标准偏差分别为0.9%~2.5%和1.2%~3.0%(n=3)。该方法能同时快速检测TDZ和CPPU,操作简单,具有较好的灵敏度、精密度及回收率,检测成本低,适用于果蔬中TDZ和CPPU残留的检测。

关键词：分子印迹膜固相萃取高效液相色谱法特异性识别噻苯隆氯吡脲

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Simulation and Instability Investigation of the Flow around a Cylinder between Two Parallel Walls

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Journal of Thermal Science 2015年第2期24卷 140-148页

作者： dou hua-Shu BEN An-Qing Faculty of Mechanical Engineering and Automation Zhejiang Sci-Tech University

The two-dimensional flows around a cylinder between two parallel walls at Re=40 and Re=100 are simulated with computational fluid dynamics(CFD). The governing equations are Navier-Stokes equations. They are discretized with finite volume method(FVM) and the solution is iterated with PISO Algorithm. Then, the calculating results are compared with the numerical results in literature, and good agreements are obtained. After that, the mechanism of the formation of Karman vortex street is investigated and the instability of the entire flow field is analyzed with the energy gradient theory. It is found that the two eddies attached at the rear of the cylinder have no effect on the flow instability for steady flow, i.e., they don't contribute to the formation of Karman vortex street. The formation of Karman vortex street originates from the combinations of the interaction of two shear layers at two lateral sides of the cylinder and the absolute instability in the cylinder wake. For the flow with Karman vortex street, the initial instability occurs at the region in a vortex downstream of the wake and the center of a vortex firstly loses its stability in a vortex. For pressure driven flow, it is confirmed that the inflection point on the time-averaged velocity profile leads to the instability. It is concluded that the energy gradient theory is potentially applicable to study the flow stability and to reveal the mechanism of turbulent transition.

关键词： numerical simulation cylinder energy gradient theory stability inflection point

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Electrochemical preparation of the Fe-Ni36 Invar alloy from a mixed oxides precursor in molten carbonates

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International Journal of Minerals,Metallurgy and Materials 2020年第12期27卷 1695-1702页

作者： Yan-peng dou Di-yong Tang hua-yi Yin Di-hua Wang School of Resource and Environmental Sciences Wuhan UniversityWuhan 430072China

The Fe-Ni36 alloy was prepared via the one-step electrolysis of a mixed oxides precursor in a molten Na2CO3-K2CO3 eutectic melt at 750℃,where porous Fe_(2)O_(3)-NiO pellets served as the cathode and the Ni10 Cu11 Fe alloy was an inert *** the electrolysis,Ni O was preferentially electro-reduced to Ni,then Fe_(2)O_(3)was reduced and simultaneously alloyed with nickel to form the Fe-Ni36 *** cell voltages were applied to optimize the electrolytic conditions,and a relatively low energy consumption of 2.48 k W·h·kg^(-1) for production of Fe Ni36 alloy was achieved under 1.9 V with a high current efficiency of 94.6%.The particle size of the alloy was found to be much smaller than that of the individual *** process provides a low-carbon technology for preparing the Fe-Ni36 alloy via molten carbonates electrolysis.

关键词： molten carbonates cyclic voltammetry electro-reduction inert anode Invar36 alloy

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