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DUSP2 deletion with CRISPR/Cas9 promotes Mauthner cell axonal regeneration at the early stage of zebrafish

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Neural Regeneration Research 2023年第3期18卷 577-581页

作者： guo-jian shao Xin-Liang Wang Mei-Li Wei Da-Long Ren Bing Hu School of Life Sciences Division of Biomedical SciencesUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Local Livestock and Poultry Genetic Resource Conservation and Bio-Breeding College of Animal Science and TechnologyAnhui Agricultural UniversityHefeiAnhui ProvinceChina

Axon regeneration of central neurons is a complex process that is tightly regulated by multiple extrinsic and intrinsic *** expression levels of distinct genes are changed after central neural system(CNS)injury and affect axon regeneration.A previous study identified dusp2 as an upregulated gene in zebrafish with spinal cord ***,we found that dual specificity phosphatase 2(DUSP2)is a negative regulator of axon regeneration of the Mauthner cell(M-cell).DUSP2 is a phosphatase that mediates the dephosphorylation of *** this study,we knocked out dusp2 by CRISPR/Cas9 and found that M-cell axons of dusp2(-/-)zebrafish had a better regeneration at the early stage after birth(within 8 days after birth),while those of dusp2^(+/-)zebrafish did *** of DUSP2 in Tg(Tol 056)zebrafish by single-cell electroporation retarded the regeneration of M-cell *** blotting results showed that DUSP2 knockout slightly increased the levels of phosphorylated *** findings suggest that knocking out DUSP2 promoted the regeneration of zebrafish M-cell axons,possibly through enhancing JNK phosphorylation.

关键词： axon regeneration central nervous system CRISPR/Cas9 DUSP2 JNK Mauthner cell single-cell electroporation spinal cord injury two-photon axotomy zebrafish

Effect of NDC80 in human hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第20期23卷 3675-3683页

作者： Lin-Ling Ju Lin Chen Jun-Hong Li Yi-Fan Wang Ru-jian Lu Zhao-Lian Bian jian-guo shao Nantong Institute of Liver Diseases Nantong Third People's HospitalNantong University Hematology Laboratory Affiliated Hospital of Nantong University

AIM To investigate the role of nuclear division cycle(NDC)80in human hepatocellular *** NDC80 gene expression was analyzed by real-time reverse transcription polymerase chain reaction in 47paired hepatocellular carcinoma(HCC)and adjacent *** HCC cell line SMMC-7721 was transfected with lentivirus to silence endogenous NDC80 gene expression,which was confirmed by real-time polymerase chain reaction and western *** effects of NDC80silencing on SMMC-7721 cell proliferation were evaluated by Cellomics Array Scan VTI *** cycle analysis and apoptosis were detected with flow *** formation was assessed by fluorescence *** NDC80 expression levels in HCC tissues were significantly higher than those in the adjacent *** studies demonstrated that NDC80 silencing significantly reduced SMMC-7721 cell proliferation and colony *** of NDC80 resulted in increased apoptosis and cell cycle arrest at ***80 contributed to HCC progression by reducing apoptosis and overcoming cell cycle arrest. CONCLUSION Elevated expression of NDC80 may play a role in promoting the development of HCC.

关键词： NDC80 Cell proliferation Apoptosis Cell cycle Hepatocellular carcinoma

Understanding the Thermal Impedance of Silicone Rubber/Hexagonal Boron Nitride Composites as Thermal Interface Materials

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Chinese Journal of Polymer Science 2024年第3期42卷 352-363,I0008页

作者： Yuan Ji Shi-Da Han Hong Wu shao-Yun guo Feng-Shun Zhang jian-Hui Qiu The State Key Laboratory of Polymer Materials Engineering Sichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyPolymer Research InstituteSichuan UniversityChengdu 610065China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Department of Mechanical Engineering Faculty of Systems Science and TechnologyAkita Prefectural UniversityAkita 015-0055Japan

Silicone rubber(SR) composites are most widely used as thermal interface materials(TIMs) for electronics heat dissipation. Thermal impedance as the main bottleneck limiting the performance of TIMs is usually neglected. Herein, the thermal impedance of SR composites loaded with different levels of hexagonal boron nitride(h-BN) as TIMs was elaborated for the first time by the ASTM D 5470 standard test and finite element analysis. It was found that elastic modulus and surface roughness of SR composites increased with the increase of h-BN content, indicating that the conformity was reduced. When the assembly pressure was 0.69 MPa, there existed an optimal h-BN content at which the contact resistance was minimum(0.39 K·cm^(2)·W^(-1)). Although the decreased bond line thickness(BLT) by increasing the assembly pressure was beneficial to reduce the thermal impedance, the proper assembly pressure should be selected to prevent the warpage of the contact surfaces and the increase in contact resistance, according to the compression properties of the SR composites. This study provides valuable insights into fabrication of high-performance TIMs for modern electronic device applications.

关键词： Thermal interface materials Hexagonal boron nitride Thermal impedance Surfaces

STUDIES ON THE REACTION OF ORGANOTELLURONIUM SALTS

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Chinese Chemical Letters 1991年第1期2卷 51-54页

作者： Qi ZHONG Yu Long CHEHG jian guo shao Chang Qing LIU Chemistry Department Yangzhou Teachers CollegeYangzhou225002

The structural studies of the telluronium saltrformation between dibutyl telluride and secondary (?)-bromo compounds and the use of the obtai- ned salts for the olefination of carbonyl compounds were reported.

关键词： CHC CN OH CIC STUDIES ON THE REACTION OF ORGANOTELLURONIUM SALTS OCH

A New Reagent for the Reduction of Aromatic Nitro Compounds

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Chinese Chemical Letters 1997年第8期8卷 683-684页

作者： jian guo shao Long Cheng WANG Ming ZHENG Qi ZHONG(Medical and Pharmaceutical Research Centre, Chemistry Department of Teachers College, Yangzhou University, Yangzhou, 225002) Med. and Pharmaceutical Res. Centre Chem. Department of Teachers College Yangzhou University Yangzhou 225002 China

Aromatic nitro compounds were reduced to the corresponding anilines by refluxing with potassium selenated borohydride (KBH2Se3) prepared from potassium borohydride and selenium in refluxed formamide.

关键词： A New Reagent for the Reduction of Aromatic Nitro Compounds

Multicolored Bipartite Ramsey Numbers of Large Cycles

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 347-357页

作者： shao-qiang LIU Yue-jian PENG College of Mathematics and Statistics Hanshan Normal UniversityChaozhou 521041China School of Mathematics Hunan UniversityChangsha 410082China

For an integer r≥2 and bipartite graphs Hi,where 1≤i≤r,the bipartite Ramsey number br(H1,H2,…,Hr)is the minimum integer N such that any r-edge coloring of the complete bipartite graph KN;N contains a monochromatic subgraph isomorphic to Hi in color i for some 1≤i≤*** show that if r≥3;α1,α2>0,αj+2≥[(j+2)!-1]Σi=1^(j+1)α1 for j=1,2…r-2,then br(C2[α1n],C2[α2n],…,C2[αrn]=(Σ=j=1^(r)a j+o(1))n.

关键词： ramsey number bipartite ramsey number regularity lemma

Cyr61 Alleviates Cholangitis by Inhibiting Cytotoxic Effects of CD8^(+) T Cells on Biliary Epithelial Cells

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Current Medical Science 2021年第6期41卷 1205-1213页

作者： Tiao-chun CHENG Han LI Xi LUO Lin-ling JU Lin CHEN jian-guo shao Yong-jun SHE Min LI Zhao-lian BIAN Medical School of Nantong University Nantong 226006China Nantong Institute of Liver Disease Nantong Third People’s Hospital Nantong UniversityNantong 226006China Department of Gastroenterology and Hepatology Nantong Third People’s HospitalNantong UniversityNantong 226006China Department of Anesthesiology Nantong Third People’s HospitalNantong UniversityNantong 226006China

Objective:Primary biliary cholangitis(PBC)is a chronic progressive cholestatic liver *** recent years,researchers have found that cysteine-rich angiogenic inducer 61(Cyr61,also known as CCN1)has a potential role in reducing portal inflammation in patients with *** study aimed to explore the relationship between Cyr61 and PBC to provide new ideas and an experimental basis for the clinical treatment of ***:After induction of the overexpression of Cyr61 in a mouse model of PBC using recombinant adenovirus,hematoxylin and eosin staining and pathological scores were used to indicate intrahepatic inflammation and bile duct ***-time PCR was used to detect changes in inflammation-related cytokines in the *** further study the mechanism,we assessed whether Cyr61 protects bile duct epithelial cells from cytotoxic ***:Serum and hepatic Cyr61 levels were increased in the murine model of *** of Cyr61 alleviated hepatic inflammation and bile duct injury in ***61 inhibited the cytotoxic effects of CD8^(+)T cells by acting on biliary epithelial cells(BECs)in ***:Our results provide novel insight into the pathogenesis of PBC and suggest that Cyr61 plays a dominant role in the cytotoxic effects on BECs in ***,therapeutic strategies targeting Cyr61 could be a potent therapy for PBC.

关键词： cysteine-rich angiogenic inducer 61 primary biliary cholangitis inflammation bile duct damage cytotoxicity

Automated federated learning‐based adversarial attack and defence in industrial control systems

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IET Cyber-Systems and Robotics 2024年第2期6卷 109-127页

作者： guo-Qiang Zeng Jun-Min shao Kang-Di Lu Guang-Gang Geng jian Weng College of Cyber Security Jinan UniversityGuangzhouChina National Joint Engineering Research Center of Network Security Detection and Protection Technology Jinan UniversityGuangzhouChina College of Information Science and Technology Donghua UniversityShanghaiChina

With the development of deep learning and federated learning(FL),federated intrusion detection systems(IDSs)based on deep learning have played a significant role in securing industrial control systems(ICSs).However,adversarial attacks on ICSs may compromise the ability of deep learning-based IDSs to accurately detect cyberattacks,leading to serious ***,in the process of generating adversarial samples,the selection of replacement models lacks an effective method,which may not fully expose the vulnerabilities of the *** authors first propose an automated FL-based method to generate adversarial samples in ICSs,called AFL-GAS,which uses the prin-ciple of transfer attack and fully considers the importance of replacement models during the process of adversarial sample *** the proposed AFL-GAS method,a lightweight neural architecture search method is developed to find the optimised replacement model composed of a combination of four lightweight basic ***,to enhance the adversarial robustness,the authors propose a multi-objective neural archi-tecture search-based IDS method against adversarial attacks in ICSs,called MoNAS-IDSAA,by considering both classification performance on regular samples and adver-sarial robustness *** experimental results on three widely used intrusion detection datasets in ICSs,such as secure water treatment(SWaT),Water Distribution,and Power System Attack,demonstrate that the proposed AFL-GAS method has obvious advantages in evasion rate and lightweight compared with other four ***,the proposed MoNAS-IDSAA method not only has a better classification performance,but also has obvious advantages in model adversarial robustness compared with one manually designed federated adversarial learning-based IDS method.

关键词： adversarial attacks adversarial robustness automated federated learning Industrial control system intrusion

Harnessing data using symbolic regression methods for discovering novel paradigms in physics

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 1-11页

作者： jianyang guo Wan-jian Yin College of Energy Soochow Institute for Energy and Materials Innovations(SIEMIS)Jiangsu Provincial Key Laboratory for Advanced Carbon Materials and Wearable Energy TechnologiesSoochow UniversitySuzhou 215006China Shanghai Qi Zhi Institute Shanghai 200232China Light Industry Institute of Electrochemical Power Sources Soochow UniversitySuzhou 215006China

In recent years,machine-learning methods have profoundly impacted research in the interdisciplinary fields of ***,most machine-learning models lack interpretability,and physicists doubt the credibility of their conclusions because they cannot be combined with prior physical ***,this review focuses on symbolic regression,which is an interpretable machine-learning ***,the relevant concepts of machine learning are introduced in conjunction with ***,we provide an overview of symbolic regression ***,the recent directions for the application of symbolic regression methods in different subfields of physics are outlined,and an overview of the ways in which the applications of symbolic regression have evolved in the realm of physics is *** major aim of this review is to introduce the basic principles of symbolic regression and explain its applications in the field of physics.

关键词： machine learning genetic programming symbolic regression