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Three-dimensional cell-based strategies for liver regeneration

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BIOCELL 2024年第7期48卷 1023-1036页

作者： DAN guo XI XIA jian YANG Liver Transplant Center Transplant CenterWest China HospitalSichuan UniversityChengdu610041China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu610212China

Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern *** recent years,the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical *** review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver ***,we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver ***,we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical *** collective insights presented herein highlight the signiﬁcance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.

关键词： Three-Dimensional Liver regeneration Organoids Stem cells Cell therapy

Novel process for facile preparation of mesoporous silica-based materials with controllable pore structure from coal fly ash Author links open overlay panel

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Particuology 2024年第8期91卷 128-137页

作者： jian-ming gao Zhen Li Shujia Ma Yuanyuan Zhang Fangqin Cheng Institute of Resources and Environment Engineering State Environmental Protection Key Laboratory of Efficient Utilization Technology of Coal Waste ResourcesShanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related WastesShanxi UniversityTaiyuan 030006China

Extraction of silica from fly ash to produce mesoporous silica materials is one of the most important utilization *** silica could not be synthesized on a large-scale by conventional sol-gel *** this paper,facile preparation of mesoporous silica with controllable pore structure from fly ash by the template-free process via two steps of mineral phase transformation and selective acid etching was *** influence of crystalline structure and acid etching degree on structure of as-synthesized mesoporous silica materials was revealed,as well as mechanism of crystalline structure transformation and pore structure *** results show that mullite and quartz could be transformed into acid-soluble kaliophilite when fly ash reacted with K_(2)CO_(3)at temperature of 800-1100℃.The hexagonal kaliophilite would be transformed into orthorhombic KAlSiO_(4)-O1 phase when the temperature is controlled at 1100℃.Mesoporous silica with specific surface area of 475.93 m^(2)/g and 642.57 m^(2)/g could be synthesized from activated fly ash with kaliophilite and KAlSiO_(4)-O1 phase crystalline *** controlling the degree of acid etching,mesoporous silica materials with different pore structures can be *** paper provides a cost-effective and large-scale process for the preparation of mesoporous silica materials with controllable pore structure from solid waste fly ash.

关键词： Fly ash Mesoporous silica Crystal transformation Acid etching Controllable pore structure

Lipid metabolism-related long noncoding RNAs:A potential prognostic biomarker for hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第33期30卷 3799-3802页

作者： Rui-Nan Zhang jian-gao Fan Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

The incidence rates of hepatocellular carcinoma(HCC)have increased in recent *** advancements in therapy and early diagnosis improving shortterm prognosis,long-term outcomes remain *** noncoding RNAs(lncRNAs)and lipid metabolism play crucial roles in the development and progression of *** lipid synthesis promotes HCC progression,and lncRNAs can reprogram the expression of lipogenic ***,lipid metabolism-related(LMR)-lncRNAs regulate lipid anabolism,accelerating the onset and progression of *** suggests that LMR-lncRNAs could serve as novel prognostic biomarkers and therapeutic targets.

关键词： Long noncoding RNAs Lipid metabolism Hepatocellular carcinoma Prognosis Biomarker

Improving mathematical model of burden distribution and correcting chute angle to cope with fluctuation of stock line

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Journal of Iron and Steel Research International 2024年第2期31卷 342-356页

作者： jian-sheng Chen Wen-guo Liu Hao guo Wang Ding Qing-guo Xue Jing-song Wang Hai-bin Zuo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China MCC Capital Engineering&Research Incorporation Limited Beijing100176China Hunan Valin Xiangtan Iron and Steel Co. Ltd.Xiangtan411101HunanChina

Accurate evaluations of the burden distribution are of critical importance to stabilize the operation of blast *** mathematical model and discrete element method(DEM)are two attractive methods for predicting burden *** on DEM,the initial velocities of the pellet,sinter,and coke were calculated,and the velocity attenuations of the above three particles between the burden and the chute were *** initial velocity and velocity attenuation were applied to a mathematical model for improving the ***,based on the improved model,a scheme for rectifying the chute angles was proposed to address the fluctuation of the stock line and maintain a stable burden *** validity of the scheme was confirmed via a stable burden distribution under different stock *** mathematical model has been successfully applied to evaluate the online burden distribution and cope with the fluctuation of the stock line.

关键词： Burden distribution Mathematical model Discrete element method Velocity attenuation Stock line fluctuation

Overvoltage Calculation Method for Sending System Under DC Fault Disturbance Considering the Influence of Renewable Energy

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 1865-1875页

作者： Haoyue Gong jianbo guo Qiang guo jian Zhang Qinyong Zhou Libo Zhang China Electric Power Research Institute Beijing 100192China

Bipolar blocking and commutation failure in the renewable energy transmission system through ultra-high voltage direct current will produce significant temporary *** paper analyzes the physical process of sending end grid overvoltage caused by two types of DC faults and establishes a DC overvoltage model considering renewable energy *** to characteristics of the sending end grid,the influence of the system equivalent impedance,the proportion of renewable energy output,the active and reactive power coefficients of the renewable energy sources during the low voltage ride through process on the overvoltage is analyzed respectively,and the relationship between the proportion of renewable energy output and the short-circuit ratio under the overvoltage constraint is *** validity and practicality of the model and analysis method proposed in this paper are verified by combining the typical transmission system at the sending end of the actual power grid and regional power grid systems.

关键词： Bipolar blocking commutation failure low voltage ride through renewable energy temporary overvoltage

Ultralow-phase-noise and broadband frequency-hopping coupled optoelectronic oscillator under quiet point operation

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Photonics Research 2024年第8期12卷 1785-1793页

作者： HUI LIU MINGYANG guo TIAN ZHANG jian DAI KUN XU State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Advancements in microwave photonics have yielded novel approaches for generating high-purity microwave *** these,optoelectronic oscillators(OEOs)and coupled optoelectronic oscillators(COEOs)have demonstrated the capability to generate frequency-independent microwaves with exceptionally low phase ***,the tunability of the oscillators is rather limited due to the necessity for narrowband electronic bandpass filters,presenting challenges in achieving both wide and rapid tuning ***,we present a COEO featuring ultralow phase noise,flexible tuning capability,and high *** is achieved through a quiet point(QP)-operated harmonic mode-locked fiber laser,which effectively mitigates optical amplifier noise and supermode competition,thus significantly diminishing the necessity for ultra-narrow electronic *** to the liberated tuning ability,we present an oscillator that can be tuned from 2 GHz to 18 GHz,with phase noise as low as-140 d Bc/Hz at 10 k Hz under the QP *** then illustrate the practical application of the proposed oscillator in generating frequency-hopping signals with consistent spurious modes less than-85 d Bc,absolute phase noise below-135 d Bc/Hz at 10 k Hz,hopping resolution of 1.25 MHz,and fractional frequency stability below 6.1×10^(-12)at 1 s averaging time when locked to a *** presented COEO structure emerges as a compelling solution for agile and low-noise microwave sources in advanced wireless communication and radar systems.

关键词： optoelectronic tuning amplifier

Pt single atoms coupled with Ru nanoclusters enable robust hydrogen oxidation for high-performance anion exchange membrane fuel cells

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Nano Research 2024年第7期17卷 6147-6156页

作者： jianmei Wang Bingxing Zhang Xiaozhong Zheng Xuerui Liu Wei guo Zhouxin Luo Yongfeng Liu Mingxia gao jian Chen Zhongbin Zhuang Hongge Pan Wenping Sun School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Lab of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Institute of Science and Technology for New Energy Xi’an Technological UniversityXi’an 710021China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou 310027China

The sluggish reaction kinetics of alkaline hydrogen oxidation reaction(HOR)is one of the key challenges for anion exchange membrane fuel cells(AEMFCs).To achieve robust alkaline HOR with minimized cost,we developed a single atom-cluster multiscale structure with isolated Pt single atoms anchored on Ru nanoclusters supported on nitrogen-doped carbon nanosheets(Pt1-Ru/NC).The well-defined structure not only provides multiple sites with varied affinity with the intermediates but also enables simultaneous modulation of different sites via interfacial *** addition to weakening Ru–H bond strength,the isolated Pt sites are heavily involved in hydrogen adsorption and synergistically accelerate the Volmer step with the help of Ru ***,this catalyst configuration inhibits the excessive occupancy of oxygen-containing species on Ru sites and facilitates the HOR at elevated *** Pt1-Ru/NC catalyst exhibits superior alkaline HOR performance with extremely high activity and excellent *** AEMFC with a 0.1 mg·cmPGM^(−2)loading of Pt1-Ru/NC anode catalyst achieves a peak powder density of 1172 mW·cm^(−2),which is 2.17 and 1.55 times higher than that of Pt/C and PtRu/C,*** work provides a new catalyst concept to address the sluggish kinetics of electrocatalytic reactions containing multiple intermediates and elemental steps.

关键词： nanoclusters multiscale structure hydrogen oxidation reaction electrocatalysis anion exchange membrane fuel cells

Inverse reliability analysis and design for tunnel face stability considering soil spatial variability

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1552-1564页

作者： Zheming Zhang jian Ji Xiangfeng guo Siang Huat Goh Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China Department of Civil and Environmental Engineering National University of SingaporeSingapore

The traditional deterministic analysis for tunnel face stability neglects the uncertainties of geotechnical parameters,while the simplified reliability analysis which models the potential uncertainties by means of random variables usually fails to account for soil spatial *** overcome these limitations,this study proposes an efficient framework for conducting reliability analysis and reliability-based design(RBD)of tunnel face stability in spatially variable soil *** three-dimensional(3D)rotational failure mechanism of the tunnel face is extended to account for the soil spatial variability,and a probabilistic framework is established by coupling the extended mechanism with the improved Hasofer-Lind-Rackwits-Fiessler recursive algorithm(iHLRF)as well as its inverse analysis *** proposed framework allows for rapid and precise reliability analysis and RBD of tunnel face *** demonstrate the feasibility and efficacy of the proposed framework,an illustrative case of tunnelling in frictional soils is presented,where the soil's cohesion and friction angle are modelled as two anisotropic cross-correlated lognormal random *** results show that the proposed method can accurately estimate the failure probability(or reliability index)regarding the tunnel face stability and can efficiently determine the required supporting pressure for a target reliability index with soil spatial variability being taken into ***,this study reveals the impact of various factors on the support pressure,including coefficient of variation,cross-correlation between cohesion and friction angle,as well as autocorrelation distance of spatially variable soil *** results also demonstrate the feasibility of using the forward and/or inverse first-order reliability method(FORM)in high-dimensional stochastic *** is hoped that this study may provide a practical and reliable framework for determining the stability of tunnels in complex

关键词： Limit analysis Tunnel face stability Spatial variability HLRF algorithm Inverse reliability method

Ramsey Numbers of Trees Versus Multiple Copies of Books

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 600-612页

作者： Xiao-bing guo Si-nan HU Yue-jian PENG School of Mathematical Sciences Luoyang Normal UniversityLuoyang 471934China School of Mathematics Hunan UniversityChangsha 410082China

Given two graphs G and H,the Ramsey number R(G,H) is the minimum integer N such that any two-coloring of the edges of K_(N) in red or blue yields a red G or a blue *** v(G) be the number of vertices of G and χ(G) be the chromatic number of *** s(G) denote the chromatic surplus of G,the number of vertices in a minimum color class among all proper χ(G)-colorings of *** showed that R(G,H)≥(v(G)-1)(χ(H)-1)+s(H) if G is connected and v(G)≥s(H).A connected graph G is H-good if R(G,H)=(v(G)-1)(χ(H)-1)+s(H).Let tH denote the disjoint union of t copies of graph H,and let G∨H denote the join of G and *** a complete graph on n vertices by K_(n),and a tree on n vertices by T_(n).Denote a book with n pages by B_(n),i.e.,the join K_(2) ∨■.Erd?s,Faudree,Rousseau and Schelp proved that T_(n) is B_(m)-good if n≥*** this paper,we obtain the exact Ramsey number of T_(n) versus 2B_(2).Our result implies that T_(n) is 2B_(2)-good if n≥5.

关键词： ramsey number ramsey goodness tree book