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Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction:An exploratory proposal based on basic and clinical data

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World Journal of Gastroenterology 2024年第1期30卷 34-49页

作者： Yu-Wei Zhou Yue Ren Miao-Miao Lu Ling-Ling Xu Wei-Xin Cheng Meng-Meng Zhang Lin-Ping Ding Dong Chen jian-guo gao Juan Du Ci-Liang Jin Chun-Xiao Chen Yun-Fei Li Tao Cheng Peng-Lei jiang Yi-Da Yang Peng-Xu Qian Peng-Fei Xu Xi Jin Department of Gastroenterology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Endoscopy Center Children’s Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second People’s Hospital of Yuhang DistrictHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Hangzhou Shangcheng District People’s HospitalHangzhou 310003Zhejiang ProvinceChina Department of Colorectal Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Women’s Hospital and Institute of Genetics Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Center of Stem Cell and Regenerative Medicine and Bone Marrow Transplantation CenterThe First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

Crohn’s disease(CD)is caused by immune,environmental,and genetic *** can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains *** biological and small-molecule drugs have advanced the treatment of CD;however,a considerable proportion of patients are non-responsive to all known *** achieve a breakthrough in this field,innovations that could guide the further development of effective therapies are of utmost *** this review,we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases,and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary *** supporting evidence is fully summarized,including the existence of lymphatic system dysfunction,recognition of the inside-out model,disorders of immune cells,changes in cell plasticity,partial overlap of the underlying mechanisms,and common gut-derived fatty and bile acid *** benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases,especially CD,as this model is good at presenting and mimicking lymphatic *** importantly,the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD.

关键词： Inflammatory bowel disease Crohn’s disease Lymphatic system Inside-out model Immune cells Zebrafish

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Fluorite REE characteristics of the Diyanqinamu Mo deposit,Inner Mongolia, China

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Chinese Journal Of Geochemistry 2015年第4期34卷 610-619页

作者： Long jian Hairui Sun jian'guo gao Faculty of Land Resource Engineering Kunming University of Science and Technology Development and Research Center of China Geological Survey National Exploration and Development Planning Technical Guidance Center in Ministry of Land and Resorces China University of Geosciences State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences

The Diyanqinamu Mo deposit, a newly discovered porphyry deposit in the northern-central part of the Great Xing'an Range, Inner Mongolia, China, is characterized by widely distributed fluorite. It is important to note that almost all the fluorite that is paragenetic with molybdenite is purple. The Tb/Ca–Tb/La ratios of these purple fluorite samples show that they have a hydrothermal *** unidirectional solidification texture at the apex of the aplitic granite and the low F contents in the andesite suggest that most of F in fluorite was derived from granitic melts. These observations suggest that the fluorite was related to the magmatic-hydrothermal fluids. All the fluorite separates have consistent total REE contents with LREE-depleted, HREE-enriched, negative Eu anomaly,unapparent Ce anomaly and positive Y anomaly. These characteristics are significantly different than those of country granite, andesite and tuff whole-rock. The positive Y anomaly of the fluorite separates implies that the hydrothermal fluids migrated a long distance, as suggested by the fact that the fluorite-molybdenite veins were mostly hosted in andesite and tuff, far from the Mo ore-forming granites. The features of LREE-depleted and HREE-enriched fluorite are due to the REE-complex in the F-enriched fluids during migration. The stronger negative Eu anomaly of fluorite than those of country rocks suggests that the Eu anomaly of the original hydrothermal fluid was enhanced by the high temperature(generally above 200 or250 °C). The widespread magnetite in the studied deposit indicates that the magmatic-hydrothermal fluid was oxidized at early stage. On the other hand, the pyrite was also paragenetic, with the molybdenite and unapparent Ce anomaly implying that the hydrothermal fluid probably experienced oxygen fugacity decreasing during migration,which is important for Mo mineralization.

关键词：钼矿床稀土元素特征内蒙古萤石中国热液成因岩浆热液迁移过程

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Applying Humboldt’s holistic perspective in China’s sustainability

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Geography and Sustainability 2021年第2期2卷 123-126页

作者： jian-guo gao Department of Ecology Peking UniversityBeijingChina

Alexander von Humboldt,was a great German geobotanist,educator and naturalist who greatly influenced sci-ence and humanities for more than two hundred *** addition to scientific contributions(such as the un-derstanding of vegetation distribution,the concepts of isotherm and pressure contours,and the initial concept of continental drift theory),he firmly believed in the concept of the interconnection of everything and the method-ological approach of a holistic perspective to development,which has significance in achieving the UN Sustainable Development Goals,because they include both synergy and trade-offs among these *** has undergone tremendous changes since its reform and opening up in 1978 and now faces severe challenges in sustainable *** scientific methods applied by Chinese scientists in sustainability fulfil the Humboldtian holistic perspective of *** I provide four successful cases and their significant implications for addressing the increasingly severe water shortage,biological conservation,and conflicts between human well-being and *** four examples discussed in this article are enlightened to establish a strong,just,and influential government and require empirical research to implement sustainable development plans.I believe that it’s vital to encourage and supervise public participation for a successful program;for example,the participants should not be restricted to project executors,i.e.,farmers or workers,but also students and *** poverty must be priori-tized,and well-being is the ultimate goal for sustainable *** review article provides an extremely valuable reference for other developing or even developed countries to address sustainability challenges.

关键词： Biological conservation Climate change Energy Food security Holistic perspective Water resource Sustainable development goals

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Investigation on the flow control of micro-vanes on a supersonic spinning projectile

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Defence Technology（防务技术） 2016年第3期12卷 227-233页

作者： Jie MA Zhi-hua CHEN Zhen-gui HUANG jian-guo gao Qiang ZHAO Key Laboratory of Transient Physics Nanjing University of Science and Technology

Studies have shown that micro-wedge vortex generators(MVG)can effectively control the flow separation of supersonic boundary *** order to improve the flight stability of spinning projectile,the original standard 155 mm projectile was taken as an example,and the micro-vanes were mounted at the projectile shoulder to investigate the separation control on the aerodynamic characteristics of *** simulations were performed with the use of DES method for the flow fields of projectiles with and without micro-vanes,and the characteristics of the boundary layer structures and aerodynamic data were compared and *** results show that the micro-vanes can be used to inhibit separation of fluid on projectile surface,and improve the flight stability and firing dispersion of projectile.

关键词： Spinning projectile Micro-vane Stability Aerodynamic characteristics Fluid control

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ABSORPTION SPECTRA OF 4f ELECTRON TRANSITIONS OF NEODYMIUM COMPLEX WITH 8-HYDROXYQUINOLINE AND OCTYLPHENOL POLY(ETHYLENEGLYCOL)ETHER

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Chinese Chemical Letters 1992年第10期3卷 855-856页

作者： Nai Xing WANG jian guo gao Department of Chemistry Shandong UniversityJinan250100 Research Institute of Qilupetro-Chemical Co Zibo255434

In this paper the absorption spectra of 4f electron transitions of the neodymlum complex with 8-hydroxyquinoline and octylphenol poly(ethyleneglycol)ether have been studied. The marked intensification of the band at low octylphenol poly(ethyleneglycol)ether concentration is found normally at 575 nm, and its resolution into three sharp bands centering at 572, 580 and 584 nm. The absorbances of the absorption maxima are 3.5 (at 572 nm), 7.2 (at 580 nm) and 10.2 (at 584 nm) times greater than that of the chloride.

关键词： ABSORPTION SPECTRA OF 4f ELECTRON TRANSITIONS OF NEODYMIUM COMPLEX WITH 8-HYDROXYQUINOLINE AND OCTYLPHENOL POLY ETHYLENEGLYCOL)ETHER

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Neg-Entropy Mechanism as a Target for Natural Medicines

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Engineering 2024年第7期38卷 11-12页

作者： Tian-Le gao Hui-Hui guo jian-Dong jiang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Current strategies for drug discovery research mainly focus on molecular targets,in which structure biology plays a central role,such as the detailed mechanism of a drug-target *** principle of this approach is the presumed molecular mechanism or genetic background of the disease being *** this approach has brought progress in understanding the mode of action for some drugs,most prevalent illnesses-especially chronic diseases-are multifactorial and present with a group of symptoms,as is often the case in cardiovascular diseases,metabolic disorders,cancers,and so *** newly emerging term“multi-morbidity”(i.e.,multiple co-occurring diseases)describes a grand challenge for this strategy,and successful drug intervention for multimorbidity should be multifaceted[1].So,our research team has shifted its attention to a new direction that views the disease as a whole instead of a single-molecule abnormality,and focusing on drugs with multiple targets.

关键词： drugs diseases cardiovascular

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Current status of Helicobacter pylori eradication and risk factors for eradication failure

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World Journal of Gastroenterology 2020年第32期26卷 4846-4856页

作者： Tian-Lian Yan jian-guo gao Jing-Hua Wang Dan Chen Chao Lu Cheng-Fu Xu Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND The Helicobacter pylori(***)eradication rate is decreasing in the general population of *** To evaluate the *** eradication status in real-world clinical practice and to explore factors related to eradication *** Patients with *** infection who were treated with standard 14-d quadruple therapy and received a test of cure at a provincial medical institution between June 2018 and May 2019 were *** and clinical data were *** rates were calculated and compared between regimens and *** analysis was performed to identify predictors of eradication *** Of 2610 patients enrolled,eradication was successful in 1999(76.6%)***-containing quadruple regimens showed a higher eradication rate than other quadruple therapy regimens(83.0%vs 69.0%,P<0.001).The quadruple therapy containing amoxicillin plus clarithromycin achieved the highest eradication rate(83.5%).Primary therapy had a higher eradication rate than rescue therapy(78.3%vs 66.5%,P<0.001).In rescue therapy,the amoxicillinand furazolidone-containing regimens achieved the highest eradication rate(80.8%).Esomeprazole-containing regimens showed a higher eradication rate than those containing other proton pump inhibitors(81.8%vs 74.9%,P=0.001).Multivariate regression analysis found that older age,prior therapy,and use of omeprazole or pantoprazole were associated with an increased risk of eradication CONCLUSION The total eradication rate is 76.6%.Amoxicillin-containing regimens are superior to other ***,prior therapy,and use of omeprazole or pantoprazole are independent risk factors for eradication failure.

关键词： Helicobacter pylori Eradication Quadruple therapy Proton pump inhibitor Retrospective study

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Highly crystallization-induced emissive luminophores with mechanoluminescent features for two-photon harvesting fluorescence imaging and latent fingerprint identification

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Nano Research 2024年第7期17卷 6475-6482页

作者： jian Lu Juan gao Rui-Xuan Qian Shuai-Hua Wang Fa-Kun Zheng guo-Cong guo Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Fluorescence imaging can be employed in fields of medical treatment,astronomical exploration,and national defense *** fluorescence imaging often takes the single-photon techniques,which is vulnerable to background interference and ***,two-photon fluorescence imaging can achieve much higher-resolution fluorescence imaging for reducing scattering and deeper ***,by assembling the tetraphenylethylene backbones with nontoxic and non-noble K^(+)ions,compound 1([(Hdma)K(H_(2)ettc)]_(n),H_(4)ettc=4',4''',4''''',4'''''''-(ethene-1,1,2,2-tetrayl)tetrakis(([1,1'-biphenyl]-4-carboxylic acid)))with the crystallization-induced emissions exhibited charming fluorescence imaging under two-photon excitation microscopy(TPEM).Besides,luminescent powders based on compound 1 can achieve high-resolution fingerprint recognition,providing secure access control and identification for a novel authentication *** with the commercial fluorescent dyes coumarin-6,the as-synthesized compound 1 showed great solvent stability,indicating its durability against harsh ***,compound 1 shows mechanoluminescent properties for the perturbation of weak supramolecular interactions within ordered arrangements of the H_(2)ettc^(2−)*** novel compound has provided an important insight to the development of twophoton fluorescence imaging and advanced external-stimuli responsive materials.

关键词： crystallization-induced emission fluorescence imaging two-photon absorption fingerprint recognition mechanoluminescence

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Transurethral seminal vesiculoscopy in the diagnosis and treatment of persistent or recurrent hemospermia： a single- institution experience

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Asian Journal of Andrology 2009年第5期11卷 566-570,I0002页

作者： Zhi-Yong Liu Ying-Hao Sun Chuan-Liang Xu jian-guo Hou Xu gao Xin Lu Hua-Mao Ye Lin-Hui Wang Xiao-Feng gao Shanghai Changhai Hospital the Second Military Medical University Shanghai 200433 China

The diagnosis and treatment of hemospermia presents significant difficulty, especially if it persists or recurs. In this retrospective study, we assessed whether transurethral seminal vesiculoscopy is feasible and effective in the diagnosis and treatment of hemospermia. To address this complex condition, we report our experience in a population of patients treated with transurethral seminal vesiculoscopy. From February 2006 to July 2008, 72 hemospermic patients underwent transurethral seminal vesiculoscopy examination and treatment at our urology center. Transurethral seminal vesiculoscopy was performed by a 7-F or 8-F rigid ureteroscope. The endoscopic procedure was conducted through the normal anatomic route of the seminal tracts. In this series, the mean follow-up period was 21.7 months. Definite diagnosis was made for 93.1% patients, and 94.4% patients were cured or showed a decrease in their symptoms. Postoperative complications were not observed in the study. Our study proves that transurethral seminal vesiculoscopy is effective in the diagnosis and treatment of hemospermia with minimal complication.

关键词： diagnosis hemospermia transurethral seminal vesiculoscopy treatment

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Amorphous high-entropy phosphoxides for efficient overall alkaline water/seawater splitting

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Journal of Materials Science & Technology 2024年第6期173卷 1-10页

作者： Han-Ming Zhang Lihao Zuo Yuhang gao Junxia guo Caizhen Zhu jian Xu Jinfeng Sun School of Materials Science and Engineering Hebei University of Science and TechnologyShijiazhuangHebei 050018China Hebei Key Laboratory of Flexible Functional Materials ShijiazhuangHebei 0500180China Institute of Low-dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhenGuangdong 518060China

Designing and synthesizing cost-effective bifunctional catalysts for overall alkaline water/seawater splitting is still a huge challenge for hydrogen ***,Co/Ni/Fe/Mn based-amorphous high-entropy phosphoxide self-standing electrode(CNFMPO)is synthesized by the facile and fast electrodeposition *** exhibits excellent bifunctional electrocatalytic performances on alkaline water/seawater *** hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)overpotentials of CNFMPO in alkaline water/seawater are as low as 43/73 and 252/282 mV to reach a current density of 10 mA cm^(-2),***,two-electrode electrolyzers with CNFMPO||CNFMPO successfully achieve the current density of 10 mA cm^(-2) at low voltages of 1.54 and 1.56 V for overall alkaline water/seawater splitting,*** exhibits satisfactory long-term stability on overall alkaline water/seawater splitting for the surface reconstruction into active metal hydroxide/(oxy)hydroxide,phosphite,and ***,no hypochlorite is detected during seawater electrolysis for the beneficial chlorite oxidation inhibition of the reconstructed phosphite and *** excellent catalytic performances of CNFMPO are due to the unique amorphous structure,multi-component synergistic effect,beneficial electronic structure modulation,and surface reconstruction during the catalytic reaction ***,CNFMPO has shown potential promotion to the development of the water/seawater splitting industry as a promising substituent for noble-metal *** work provides new insights into the design of efficient bifunctional catalysts for overall water/seawater splitting.

关键词： Amorphous high-entropy phosphoxides Water/seawater splitting Synergistic effect Surface reconstruction Electronic structure modulation Inhibition of chloride oxidation reaction

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