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Effect of a systemic intervention combined with a psychological intervention in stroke patients with oropharyngeal dysfunction

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World Journal of Psychiatry 2024年第6期14卷 904-912页

作者： Jie Song jian-dong wang Di Chen Jing Chen Jin-Feng Huang Mao Fang Second Ward Department of NeurologyThe Second Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161006Heilongjiang ProvinceChina Third Ward Department of NeurologyThe Second Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161006Heilongjiang ProvinceChina

BACKGROUND Stroke frequently results in oropharyngeal dysfunction(OD),leading to difficulties in swallowing and eating,as well as triggering negative emotions,malnutrition,and aspiration pneumonia,which can be detrimental to ***,routine nursing interventions often fail to address these issues *** and psychological interventions can improve dysphagia symptoms,relieve negative emotions,and improve quality of ***,there are few clinical reports of systemic interventions combined with psychological interventions for stroke patients with *** To explore the effects of combining systemic and psychological interventions in stroke patients with *** This retrospective study included 90 stroke patients with OD,admitted to the Second Affiliated Hospital of Qiqihar Medical College(January 2022–December 2023),who were divided into two groups:regular and *** function grading(using a water swallow test),swallowing function[using the standardized swallowing assessment(SSA)],negative emotions[using the selfrating anxiety scale(SAS)and self-rating depression scale(SDS)],and quality of life(SWAL-QOL)were compared between groups before and after the intervention;aspiration pneumonia incidence was *** Post-intervention,the coalition group had a greater number of patients with grade 1 swallowing function compared to the regular group,while the number of patients with grade 5 swallowing function was lower than that in the regular group(P<0.05).Post-intervention,the SSA,SAS,and SDS scores of both groups decreased,with a more significant decrease observed in the coalition group(P<0.05).Additionally,the total SWAL-QOL score in both groups increased,with a more significant increase observed in the coalition group(P<0.05).During the intervention period,the total incidence of aspiration and aspiration pneumonia in the coalition group was lower than that in the control group(4.44%vs 20.00%;P<0.05).CONCLUSION Systemic int

关键词： Stroke Oropharyngeal dysfunction Systemic interventions Psychological intervention Curative effect Negative emotion

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A FEM-DFN model for the interaction and propagation of multi-cluster fractures during variable fluid-viscosity injection in layered shale oil reservoir

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Petroleum Science 2022年第6期19卷 2796-2809页

作者： Chu-Hao Huang Hai-Yan Zhu jian-dong wang jian Han Guang-Qing Zhou Xuan-He Tang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanPR China Petroleum Engineering Technology Research Institute Shengli Oilfield CompanySINIOPECDongying257000ShandongPR China Chongqing Gas Field Southwest Oil and Gas Field CompanyPetro ChinaChongqing400021PR China

To investigate the height growth of multi-cluster fractures during variable fluid-viscosity fracturing in a layered shale oil reservoir,a two-dimensional finite element method(FEM)-discrete fracture network(DFN)model coupled with flow,stress and damage is proposed.A traction-separation law is used to describe the mixed-mode response of the damaged adhesive fractures,and the cubic law is used to describe the fluid flow within the *** rock deformation is controlled by the in-situ stress,fracture cohesion and fluid pressure on the hydraulic fracture *** coupled finite element equations are solved by the explicit time difference *** effects of the fracturing treatment parameters including fluid viscosity,pumping rate and cluster spacing on the geometries of multifractures are *** results show that variable fluid-viscosity injection can improve the complexity of the fracture network and height of the main fractures *** pumping rate of15 m^(3)/min,variable fluid-viscosity of 3-9-21-36-45 mPa s with a cluster spacing of 7.5 m is the ideal treatment *** field application shows that the peak daily production of the application well with the optimized injection procedu re of variable fluid-viscosity fracturing is 171 tons(about 2.85 times that of the adjacent well),which is the highest daily production record of a single shale oil well in China,marking a strategic breakthrough of commercial shale oil production in the Jiyang Depression,Shengli *** variable fluid-viscosity fracturing technique is proved to be very effective for improving shale oil production.

关键词： Shale oil reservoir FEM-DFN model Fracture propagation Variable fluid-viscosity injection Bedding planes

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Cementitious property of NaAlO2-activated Ge slag as cement supplement

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International Journal of Minerals,Metallurgy and Materials 2019年第12期26卷 1594-1603页

作者： Hua-zhe Jiao Shu-fei wang Ai-xiang Wu Hui-ming Shen jian-dong wang International Joint Research Laboratory of Henan Province for Underground Space Development and Disaster Prevention Henan Polytechnic UniversityJiaozuo 454000China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

Germanium(Ge),a waste residue leaching from zinc(Zn)smelting process,has potential cementitious properties and could be recycled as a cement supplement activated by chemical *** this work,a test was conducted to determine the hydration properties of Ge slag-cement-based composites with Ge slag(GS)/ordinary Portland cement(PC)contents of 0wt%,5wt%,10wt%,15wt%,20wt%,and 25wt% and water-to-binder ratio(w/b)of *** activators Ca(OH)2,AlCl3,NaAlO2,and Na2CO3 were mixed under 1wt%,2wt%,3wt%,and 4wt% dosages of GS *** composition and microstructure of the hydration products were investigated by the combined approaches of X-ray diffraction(XRD),thermogravimetry-differential scanning calorimetry(TG-DSC),scanning electron microscopy(SEM),and energy-dispersive X-ray spectroscopy(EDS).First,the GS cementitious property is attributed to the high content of CaSO4·***,the activators affected the acceleration performance in the following order:NaAlO2,Na2CO3,AlCl3,and Ca(OH)*** importantly,the 28-day unconfined compressive strength(UCS)is 45.34 MPa at the optimum formula of 0.6wt% NaAlO2,15wt% GS,and 85wt% PC,which is 9.16% higher than the ***,NaAlO2 is beneficial for the ettringite(AFt)generation,resulting in the C-S-H structure ***,the Zn^2+ residue inhibited the AFt formation,representing an important challenge to the strength growth with curing ***,the GS could be recycled as a supplement to the cement under the activator NaAlO2.

关键词： Ge slag from zinc process recycling activator cement supplements strength

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Helicobacter pylori and 17β-estradiol induce human intrahepatic biliary epithelial cell abnormal proliferation and oxidative DNA damage

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 519-527页

作者： Fei Ma Yong Yang jian-dong wang Zhi-Wei Quan Di Zhou Department of Oncology Xinhua Hospital Shanghai Jiaotong University School of Medicine Department of General Surgery Shanghai Jiaotong University School of Medicine

BACKGROUND: Biliary cancers are more common in females, and previous studies have suggested that Helicobacter pylori (H. pylori) exists in the biliary system. However, the effects of H. pylori infection and estrogen on the biological behaviors of human biliary epithelium mucosa remain unknown. The present study aimed to clarify their effects on the proliferation, apoptosis, migration and oxidative DNA damage of a human intrahepatic biliary epithelial cell (HIBEC) line in vitro. METHODS: HIBECs were co -cultured with 17 beta-estradiol (at 10(-9) mol/L, 10(-7) mol/L, and 10(-5) mol/L) and H. pylori (at MOI=0.5:1, 1:1, and 2:1) and continuously passaged until the 15th generation (approximately 45 days). Then, the following assays were performed. HIBEC proliferation was measured using the CCK-8 assay, plate clone-formation assay and by determining Ki-67 expression with immunocytochemistry; cell apoptosis and migration were investigated using Annexin-V/PI and transwell assays, respectively; and reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) production were detected by flow cytometry and immunofluorescence staining combined with confocal laser scanning microscopy, respectively. The results were the basis for evaluating the level of oxidative stress and the related DNA damage in HIBECs. RESULTS: HIBECs maintained a normal morphology and vitality when treated with 17 beta-estradiol (at 10(-9) mol/L) and H. pylori (at MOI=0.5:1 and 1:1). 17 beta-estradiol at 10(-7) mol/L and 10(-5) mol/L and H. pylori at MOI=2:1, by contrast, caused cell death. Compared with controls, HIBECs treated with 17 beta-estradiol (10(-9) mol/L) and H. pylori (MOI=1:1) had a higher up-regulation of proliferation, Ki-67 expression, clone formation, migration activity and the expression of ROS and 8-OHdG and exhibited a down-regulation of apoptosis. The above effects were further increased when 17 beta-estradiol and H. pylori were combined (P<0.05). CONCLUSIONS: H. pylori and 17

关键词： H. pylori 17 beta-estradiol binary tract proliferation

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Impact of climate change on wheat yield and quality in the Yellow River Basin under RCP8.5 during 2020–2050

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Advances in Climate Change Research 2022年第3期13卷 397-407页

作者： Xiao-Xu LONG Hui JU jian-dong wang Shi-Hong GONG Guang-Yong LI Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agriculture SciencesBeijing 100081China College of Water Resources&Civil Engineering China Agricultural UniversityBeijing 100083China Department of Irrigation and Drainage China Institute of Water Resources and Hydropower ResearchBeijing 100048China

Studying the impact of future climate change on the yield and quality of wheat in the Yellow River Basin(YRB)is both essential for rationalizing the utilization of climate resources and ensuring national food *** this study,we employed corrected refined meteorological grid data(30 km×30 km)generated by the Climate-Weather Research and Forecasting model under RCP8.5,coupled with the DSSAT-CERES-Wheat model to predict the impact of climate change on wheat phenology,yield,and grain nitrogen content(GNC)in the YRB from 2020 to *** to the type of wheat variety and planting management in the YRB,we designed five wheat ecological regions(I-V).The results show that from 2020 to 2050,the agro-meteorological resource,involving temperature,solar radiation,and precipitation,would have an overall increasing trend during the wheat growth seasons in the *** growth period of wheat was generally shortened by approximately 8 d,including 6 d less from sowing to anthesis,and 2 d less from anthesis to *** general,the predicted wheat yield showed a decreasing trend in the YRB,with an average reduction of 0.19%over the period from 2020 to 2050 compared with the baseline period from 1975 to 2005,and the spatial variation in wheat yield change was considerably *** the future,the Qing‒Zang Spring Wheat region(V)in the western part of the YRB would be the only region with a yield increase of 35.4%,whereas the Northern Spring Wheat region(I)in the northern part of the YRB would be the region exhibiting the greatest decrease of 9.9%.Moreover,compared with the baseline,the GNC would increase by an average of 2.3%in the YRB,with a significant increase in the southern and central parts during *** GNC increase in the Huang‒Huai Winter Wheat region(III)was the highest with a 12.5%increment,but the Qing‒Zang Spring Wheat region(V)is the only region where GNC would decline,with an average decrease of 18.9%.This study implies that wheat yield and GNC have a

关键词： Yellow river basin Climate change Wheat Yield Grain nitrogen content

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A Review on Particle Reinforced Mg Matrix Composites Fabricated by Powder Metallurgy

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 391-400页

作者： Zhiyuan Liu Li Jin jian Zeng Fulin wang Fenghua wang Shuai dong Jie dong National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

This paper provides a comprehensive review of research progress in particle-reinforced Mg matrix composites prepared via powder *** article discusses different strategies,such as micro-sized,nano-sized particles,and multi-particle hybridization,which has been employed to enhance the performance of the *** addition,a range of preparation techniques that optimize the dispersion of the reinforcing particles are *** paper also highlights how the different configurations between the reinforcements and matrix alloy impact the composites’***,the article outlines the prospects of particles reinforced Mg matrix composites fabricated via powder metallurgy and recommends modification methods that could be explored to further develop these materials for various applications.

关键词： Magnesium matrix composites Reinforcing particle Powder metallurgy Mechanical properties Configuration

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Establishment of a diagnostic model of coronary heart disease in elderly patients with diabetes mellitus based on machine learning algorithms

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Journal of Geriatric Cardiology 2022年第6期19卷 445-455页

作者： Hu XU Wen-Zhe CAO Yong-Yi BAI Jing dong He-Bin CHE Po BAI jian-dong wang Feng CAO Li FAN Chinese PLA Medical School Chinese PLA General HospitalBeijingChina Department of Cardiology the Second Medical CenterNational Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijingChina Department of General Surgery the First Medical CenterChinese PLA General HospitalBeijingChina Institute of Geriatrics the Second Medical CenterChinese PLA General HospitalBeijingChina Medical Big Data Research Center&National Engineering Laboratory for Medical Big Data Application Technology Chinese PLA General HospitalBeijingChina Department of Respiratory Diseases Chinese PLA Rocket Force Characteristic Medical CenterBeijingChina

OBJECTIVE To establish a prediction model of coronary heart disease(CHD)in elderly patients with diabetes mellitus(DM)based on machine learning(ML)*** Based on the Medical Big Data Research Centre of Chinese PLA General Hospital in Beijing,China,we identified a cohort of elderly inpatients(≥60 years),including 10,533 patients with DM complicated with CHD and 12,634 patients with DM without CHD,from January 2008 to December *** collected demographic characteristics and clinical *** selecting the important features,we established five ML models,including extreme gradient boosting(XGBoost),random forest(RF),decision tree(DT),adaptive boosting(Adaboost)and logistic regression(LR).We compared the receiver operating characteristic curves,area under the curve(AUC)and other relevant parameters of different models and determined the optimal classification *** model was then applied to 7447 elderly patients with DM admitted from January 2018 to December 2019 to further validate the performance of the *** Fifteen features were selected and included in the ML *** classification precision in the test set of the XGBoost,RF,DT,Adaboost and LR models was 0.778,0.789,0.753,0.750 and 0.689,respectively;and the AUCs of the subjects were 0.851,0.845,0.823,0.833 and 0.731,*** the XGBoost model with optimal performance to a newly recruited dataset for validation,the diagnostic sensitivity,specificity,precision,and AUC were 0.792,0.808,0.748 and 0.880,*** The XGBoost model established in the present study had certain predictive value for elderly patients with DM complicated with CHD.

关键词： patients admitted coronary

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Individualized nomogram improves diagnostic accuracy of stage Ⅰ-Ⅱ gallbladder cancer in chronic cholecystitis patients with gallbladder wall thickening

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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 180-188页

作者： Di Zhou jian-dong wang Yong Yang Wen-Long Yu Yong-Jie Zhang Zhi-Wei Quan Department of General Surgery Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092 China Department of Biliary Tract Surgery Ⅱ Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

BACKGROUND： Early diagnosis of gallbladder cancer（GBC） can remarkably improve the prognosis of patients. This study aimed to develop a nomogram for individualized diagnosis of stage Ⅰ-Ⅱ GBC in chronic cholecystitis patients with gallbladder wall ***： The nomogram was developed using logistic regression analyses based on a retrospective cohort consisting of 89 consecutive patients with stage Ⅰ-Ⅱ GBC and 1240 patients with gallbladder wall thickening treated at one biliary surgery center in Shanghai between January 2009 and December 2011. The accuracy of the nomogram was validated by discrimination, calibration and a prospective cohort treated at another center between January 2012 and December 2014（n=928）.RESULTS： Factors included in the nomogram were advanced age, hazardous alcohol consumption, long-standing diagnosed gallstones, atrophic gallbladder, gallbladder wall calcification, intraluminal polypoid lesion, higher wall thickness ratio and mucosal line disruption. The nomogram had concordance indices of 0.889 and 0.856 for the two cohorts, respectively. Internal and external calibration curves fitted well. The area under the receiver-operating characteristic curves of the nomogram was higher than that of multidetector row computed tomography in diagnosis of stage Ⅰ-Ⅱ GBC（P〈0.001）.CONCLUSION： The proposed nomogram improves individualized diagnosis of stage Ⅰ-Ⅱ GBC in chronic cholecystitis patients with gallbladder wall thickening, especially for those the imaging features alone do not allow to confirm the diagnosis.

关键词： chronic cholecystitis gallbladder wall thickening gallbladder cancer individualized diagnosis nomogram

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LISR28 Is Involved in Pollen Germination by Affecting Filamentous Actin Dynamics

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Molecular Plant 2013年第4期6卷 1163-1175页

作者： Li-Juan Cao Meng-Meng Zhao Chang Liu Huai-jian dong wang-Cheng Li Hai-Yun Ren Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education College of Life Science Beijing Normal University Beijing 100875China

Alternative splicing plays important roles in gene regulation and contributes to protein complexity. Previous studies suggest that alternative splicing exists in members of the villin/gelsolin/fragmin superfamily. In this study, a ser- ine/argine-rich （SR） protein cDNA with 28kDa protein （LISR28） was isolated from a lily （Lilium Iongiflorum） expression library. Protein domain analysis showed that LISR28 had similar structures to Arabidopsis SR45 （AtSR45）, and LISR28 could complement the phenotype of loss of AtSR45 function. Therefore, overexpression of LISR28 and AtSR45 mutant （atsr45-1） were used in the following experiments. Overexpression of LISR28 in Arabidopsis completely inhibited pollen germina- tion. In contrast, the pollen germination of atsr45-1 was earlier than that of wild-type. In addition, pollen of atsr45-1 contained less F-actin at the corresponding hydration stage during pollen germination compared to that of wild-type. Alternative splicing analysis showed that Arabidopsis villinl （AtVLN1） transcript encoding the full-length protein was increased, and that encoding the truncated protein was decreased in atst45-1. Moreover, the mRNA expression level of other actin-binding proteins （ABPs） abundant in Arabidopsis pollen was also changed in atsr45-1. In conclusion, we hypothesize that LISR28 alters F-actin dynamics probably through its alternative splicing activities to affect directly or indirectly the alternative splicing of AtVLN1 and the expression of different ABPs, which then affects the pollen germination.

关键词： SR protein alternative splicing F-actin.

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Focal intrahepatic strictures:A proposal classification based on diagnosis-treatment experience and systemic review

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World Journal of Clinical Cases 2020年第23期8卷 5902-5917页

作者： Di Zhou Bo Zhang Xiao-Yu Zhang Wen-Bin Guan jian-dong wang Fei Ma Department of General Surgery Xinhua Hospital Affiliated with Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200092China Department of General Surgery Xinhua Hospital Affiliated with Shanghai Jiao Tong UniversitySchool of MedicineChongming BranchShanghai 202150China Department of Pathology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200092China Shanghai Institute for Pediatric Research Shanghai 200092China

BACKGROUND Focal intrahepatic strictures(FIHS)refer to local strictures of the small and medium intrahepatic bile *** are easily misdiagnosed due to their rare incidence,and few studies have focused on the diagnosis and treatment *** To propose a new classification for FIHS in order to guide its diagnosis and *** The symptoms,biochemistry results,imaging results,endoscopic examination results and initial and final diagnoses of 6 patients with FIHS admitted between January 2010 and December 2019 were retrospectively *** The 6 patients were diagnosed with intratubular growth-type intrahepatic cholangiocarcinoma(IG-ICC),recurrent multiple hepatocellular carcinoma(rmHCC)with bile duct tumor thrombus(BDTT),adenosquamous carcinoma(ASC),hepatolithiasis,small duct primary sclerosing cholangitis(SD-PSC)and autoimmune hepatitis(AIH).The initial and final diagnoses were not consistent in 4 *** was performed in patients with IG-ICC,ASC and hepatolithiasis according to the locations of their *** with rmHCC with BDTT received lenvatinib/sintilimab,while patients with SD-PSC and AIH received *** proposed the following classification system for FIHS:type I:FIHS located within one segment of the liver;type II:FIHS located at the confluence of the bile ducts of one segment or two adjacent segments;type III:FIHS connected to the left or right hepatic duct;and type IV:Multiple FIHS located in both lobes of the *** Our proposed classification system might help to guide the diagnosis and treatment of *** should be performed not only for malignant FIHS but also for benign strictures with severe secondary damage that cannot be improved by nonsurgical methods.

关键词： Focal intrahepatic strictures Pathology Classification Endoscopy Hepatectomy Treatment

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