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Synergistic and feedback signaling mechanisms in the regulation of inflammation in respiratory infections

Cellular & Molecular Immunology 2012年第2期9卷 131-135页

作者： Wenzhuo Y Wang Jae Hyang lim jian-dong li Center for Inflammation Immunity and Infection and Department of Biology Georgia State University Atlanta GA USA Department of Microbiology and Immunology University of Rochester Medical Center Rochester NY USA

Pneumonia, the most typical and frequent lower respiratory tract infection （LRTI）, is a leading cause of health problems in the United States. Bacteria represent the most prevailing cause of pneumonia in both children and adults. Although pneumonia with a single bacterial infection is common, a significant portion of patients with pneumonia is polymicrobial. This infection is often complexed with other physiological factors such as cytokines and growth factors. Nontypeable Haemophilus influenzae （NTHi） is the most frequently recovered Gram-negative bacterial pathogen in the respiratory system and induces strong inflammatory responses. NTHi also synergizes with other respiratory pathogens, such as Streptococcus pneumoniae and respiratory viruses and pro-inflammatory cytokines, such as tumor necrosis factor-alpha （TNF-α）. It is noteworthy that NTHi not only synergizes with growth factors such as transforming growth factor-beta （TGF-β）, but also utilizes growth factor receptors such as TGF-β receptor and epidermal growth factor receptor （EGFR）, to enhance inflammatory responses. Although appropriate inflammation is a protective response against invading pathogens, an uncontrolled inflammatory response is often detrimental to the host. Thus, inflammation must be tightly regulated. The human immune system has evolved strategies for controlling overactive inflammatory response. One such important mechanism is via regulation of negative feedback regulators for inflammation. CYLD, a multifunctional deubiquitinase, was originally reported as a tumor suppressor, but was recently identified as a negative regulator for nuclear factor-kappa B （NF-κB） signaling. It is induced by NTHi and TNF-α via a NF-κB-dependent mechanism, thereby serving as an inducible negative feedback regulator for tightly controlling inflammation in NTHi infection.

关键词： CYLD negative regulation NF-κB nontypeable Haemophilus influenzae synergistic regulation

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liSR28 Is Involved in Pollen Germination by Affecting Filamentous Actin Dynamics

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Molecular Plant 2013年第4期6卷 1163-1175页

作者： li-Juan Cao Meng-Meng Zhao Chang liu Huai-jian dong Wang-Cheng li Hai-Yun Ren Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education College of Life Science Beijing Normal University Beijing 100875China

Alternative splicing plays important roles in gene regulation and contributes to protein complexity. Previous studies suggest that alternative splicing exists in members of the villin/gelsolin/fragmin superfamily. In this study, a ser- ine/argine-rich （SR） protein cDNA with 28kDa protein （liSR28） was isolated from a lily （lilium Iongiflorum） expression library. Protein domain analysis showed that liSR28 had similar structures to Arabidopsis SR45 （AtSR45）, and liSR28 could complement the phenotype of loss of AtSR45 function. Therefore, overexpression of liSR28 and AtSR45 mutant （atsr45-1） were used in the following experiments. Overexpression of liSR28 in Arabidopsis completely inhibited pollen germina- tion. In contrast, the pollen germination of atsr45-1 was earlier than that of wild-type. In addition, pollen of atsr45-1 contained less F-actin at the corresponding hydration stage during pollen germination compared to that of wild-type. Alternative splicing analysis showed that Arabidopsis villinl （AtVLN1） transcript encoding the full-length protein was increased, and that encoding the truncated protein was decreased in atst45-1. Moreover, the mRNA expression level of other actin-binding proteins （ABPs） abundant in Arabidopsis pollen was also changed in atsr45-1. In conclusion, we hypothesize that liSR28 alters F-actin dynamics probably through its alternative splicing activities to affect directly or indirectly the alternative splicing of AtVLN1 and the expression of different ABPs, which then affects the pollen germination.

关键词： SR protein alternative splicing F-actin.

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Investigation of lacrimal sac space-occupying lesions using color doppler ultrasound, computed tomography, and computed tomography dacryocystography

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1224-1230页

作者： Zhen-Bin Qian Bo Yu Ye Yang Wei Fang jian-li dong li-Qing Wei National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Sijiqing Street Community Health Service Center Hangzhou 310000Zhejiang ProvinceChina

AIM:To observe the imaging features of color Doppler ultrasound(CDU)and computed tomography(CT)or computed tomography dacryocystography(CT-DCG)in different types of lacrimal sac space-occupying lesions(SOLs).METHODS:This retrospective case series study included 21 patients with lacrimal sac SOLs who underwent lacrimal sac surgery between January 2018 and March *** imaging features of CDU and CT or CT-DCG in these patients were extracted from the examination cloud *** images were observed and ***:The detection rate of lacrimal SOLs between CDU(21/21,100%)and CT or CT-DCG(20/21,95.2%)had no statistically significant difference(P=1.0).CDU could detect the blood flow signals in all SOLs except mucocele and mucopeptide *** them,polyps had characteristic imaging changes on CDU and *** mucoceles and mucopeptide concretions had characteristic imaging changes on CDU,which could provide more information for differential ***:The morphology and internal blood flow signals of lacrimal sac SOLs can be observed using *** or CT-DCG has advantages in observing structural damage around the lacrimal sac ***,CDU may be used as a routine examination to exclude lacrimal sac SOLs before dacryocystorhinostomy in the absence of preoperative CT or CT-DCG.

关键词： lacrimal sac computed tomography computed tomography dacryocystography color Doppler ultrasound space-occupying lesions

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Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease

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World Journal of Gastroenterology 2014年第4期20卷 1079-1087页

作者： Chao Wang Juan Han liang Xiao Chang-E Jin dong-jian li Zhen Yang Department of General Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Biliary and Pancreatic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Surgery and Biological Therapy Shenzhen Second People’s Hospital the First Affiliated Hospital of Shenzhen University Department of Respiratory Medicine Shenzhen People’s Hospital

AIM: To investigate the association between endogenous hydrogen sulfide (H2S) and portal hypertension as well as its effect on vascular smooth muscle cells.

关键词： Portal hypertension, Apoptosis, B-cell lymphoma-2, B-cell lymphoma-XL, Cystathionine γ -lyase, pERK 1/2, Hydrogen sulfide

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Double balloon enteroscopy in the old: Experience from China

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World Journal of Gastroenterology 2012年第22期18卷 2859-2866页

作者： Qiong He Qiang Zhang jian-dong li Ya-dong Wang Tian-Mo Wan Zhen-Yu Chen De-Shou Pan jian-Qun Cai Si-De liu Bing Xiao Ya-li Zhang Bo jiang Yang Bai Fa-Chao Zhi Guangdong Provincial Key Labora-tory of Gastroenterology Nanfang Hospital Southern MedicalUniversity Guangzhou 510515 Guangdong Province China Department of Epidemiology School of Public Health and Tropical Medicine Southern Medical University Guangzhou 510515 Guangdong Province China Department of Gastroenterology Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong Province China

AIM: To evaluate the safety, efficacy and management of double balloon enteroscopy (DBE) carried out in those aged individuals with suspicious small intestine diseases. METHODS: DBE is a wonderful invention of the past decade and is widely used as an examination tool for the gastrointestinal tract. From January 2003 to July 2011, data from patients who were ≥ 65 years old and underwent DBE examination in the Nanfang Hospital were included in a retrospective ***: Fifty-nine individuals were found and subsequently analyzed. The mean age was 69.63 ± 3.89 years (range 65-84), 34 were males. Indications for DBE were melena/hematochezia (36 cases), abdominal pain (15 cases), diarrhea (3 cases), stool change (1 case), weight loss (1 case), vomiting (2 cases), and debilitation (1 case). The average duration of symptoms was 33.34 ± 64.24 mo. Twenty-seven patients suffered from age-related diseases. Severe complications were not found during and after DBE. Comparison between systolic and diastolic blood pressure before and after DBE was statistically significant (mean ± SD, P < 0.01, P < 0.05, respectively). Small bowel pathologies were found by DBE in 35 patients, definite diagnoses were made in 31 cases, and detection rate and diagnostic yield for DBE were 68.6% and 60.8%, respectively. CONCLUSION: DBE is a safe and effective method for gastrointestinal examination in the aged population. Aging alone is not a risk factor for elderly patients with suspicious gastrointestinal diseases and thorough preparation prior to the DBE procedure should be made for individuals with multiple diseases especially cardiopulmonary disorders.

关键词： Double balloon enteroscopy Capsule endos-copy Small bowel diseases Multiple systematic diseases

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Inhibitory effects of prostaglandin E₁ on activation of hepatic stellate cells in rabbits with schistosomiasis

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Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 176-181页

作者： Wei-Long Zou Zhen Yang Yun-Jin Zang dong-jian li Zhi-Peng liang Zhong-Yang Shen Institute of Transplantation General Hospital of the Chinese People's Armed Police Forces Beijing China. wlzouah@***

BACKGROUND: liver fibrosis is the result of an imbalance between synthesis and degradation of extracellular matrix proteins of the liver. At the cellular and molecular levels, this progressive process is mainly characterized by activation of hepatic stellate cells (HSCs). Schistosoma japonica is one of the most prevalent causes of liver fibrosis in China. It is characterized by hepatocyte damage, inflammation, and chronic parasite egg-induced granuloma formation leading to fibrosis. This study aimed to investigate the inhibitory effects of prostaglandin E1 (PGE1) on activation of HSCs and the alteration of type Ⅰ and Ⅲ collagen in rabbits with schistosomiasis. The study may promote the clinical application of praziquantel and PGE1 as a combined therapy to reverse hepatic fibrosis caused by schistosomiasis. METHODS: Rabbits were percutaneously infected with cercaria of S. japonicum. Seven rabbits were subjected to intravenous injections of PGE1 (2.5 μg/kg daily) from days 60 to 120 after infection. The ultrastructural changes in activated HSCs were observed under transmission electron microscopy. The expression of α-smooth muscle actin (α-SMA) was detected by immunohistochemistry. Fibril-forming collagens were detected by picrosirius staining. RESULTS: Activation of HSCs was a characteristic alteration in schistosome-induced hepatic fibrosis. The expression of contraction-related α-SMA and thecontent of collagens were increased. Exogenous PGE1 markedly inhibited the activation of HSCs and reduced the expression of α-SMA around the hepatic sinusoids (Plight microscope in the untreated and treated groups was 37.25±9.71 vs. 13.38±4.24 (P<0.01) and 9.66±3.52 vs. 6.23±1.81 (P<0.05), respectively. CONCLUSIONS: Activation of HSCs may play a key role in the progress of schistosome-induced hepatic fibrosis. PGE1 effect

关键词： hepatic fibrosis schistosome hepatic stellate cells prostaglandin E1 fibril-forming collagen

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液控止回蝶阀消除水锤效果的计算机仿真及试验研究

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水利水电技术 2009年第1期40卷 94-96,101页

作者：董健莉水利部山西水利水电勘测设计研究院山西太原030024

基于特征线法理论,利用数值求解方法,结合实际,进行了禹门口提水工程泵站液控止回蝶阀消除水锤的计算机仿真和现场测试研究,取得了二者相互吻合的结果,得出了液控止回蝶阀消除水锤效果良好、可满足该供水工程安全运行的结论。

关键词：缓闭式蝶阀水锤计算机仿真禹门口提水工程泵站

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五管瓶初论

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东南文化 2009年第3期 93-98页

作者：董健丽故宫博物院北京100009

五管瓶为古人沟通天地的媒介,发源于东汉,经历代发展至宋到达鼎盛,其作用也由随葬的明器发展为具有象征意义的陈设用器。其象征意义与阴阳五行等中国传统文化思想相关,蕴涵吉祥之意。

关键词：五管瓶发展阴阳五行

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Nasal cytology with emphasis on mast cells can improve the diagnosis and treatment of chronic rhinosinusitis

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Chinese Medical Journal 2019年第18期132卷 2237-2241页

作者： Hua-li Ren jian-dong li Feng-Shu Yue Jin-Lu Sun Elie E.Rebeiz Theoharis C.Theoharides Department of Allergy Beijing Electric Power Hospital Beijing 100073 China Department of Otolaryngology Beijing Electric Power Hospital Beijing 100073 China Department of Allergy Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Otolaryngology Tufts Medical Center Boston MA 02111 USA Molecular Immunopharmacology and Drug Discovery Laboratory Department of Integrative Physiology and Pathobiology Tufts University School of Medicine Boston MA 02111 USA Sackler School of Graduate Biomedical Sciences Program in Pharmacology and Experimental Therapeutics Tufts University Boston MA 02153 USA Department of Internal Medicine Tufts University School of Medicine and Tufts Medical Center Boston MA 02111 USA

Objective:Chronic rhinosinusitis (CRS) involves inflammation of the nasal and para-nasal *** to its heterogeneous nature,unknown pathogenesis,and high recurrence rate,effective treatment is *** cytology is presently not a part of the routine diagnosis or treatment decision for *** sources:A literature search was performed for published papers in English between January 1990 and June 2019 using *** sdection:Terms used were chronic rhinosinusids,eosinophils,etiology,immunopathology,inflammation,mast cells,nasal cytology,polyps,and *** reviews and original articles were collected and ***:There is no standard nasal fluid,mucus sampling,or staining techniques for identifying inflammatory cell *** were divergent from different ***,the main focus of these papers on the cells in nasal washings was eosinophils,with infrequent mentioning of other cell types that may imply different etiology and *** heterogeneous cell profile of CRS and the role of mast cells have been unappreciated due to the lack of specific immunohistochemical technique or study of its unique ***:Nasal cytology could help distinguish the type and the activation state of inflammatory *** it can help in providing a clearer picture of CRS pathogenesis,identifying different patient groups,and developing effective treatments.

关键词： Rhinitis Sinusitis Nasal polyps Nasal mucosa Cytology Inflammation Eosinophils Mast cells

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硫酸盐三价铬镀铬工艺的应用及维护

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电镀与涂饰 2011年第9期30卷 24-26页

作者：董建利杭州顿力实业有限公司浙江杭州311107

简要概括了三价铬电镀在我国的发展情况,论述了三价铬电镀工艺的优缺点,介绍了硫酸盐体系三价铬电镀工艺在实际生产中的应用,重点阐述了镀液组成的维护,工艺条件的控制,以及杂质的影响与处理。

关键词：三价铬装饰性电镀硫酸盐工艺维护

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