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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang jian wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

基于机器学习筛选猪活体肌内脂肪含量间接选育和构建预测模型的关键性状

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南京农业大学学报 2025年第1期48卷 161-170页

作者：吴建杨文孟孜查成万吴望军南京农业大学动物科技学院江苏南京210095

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测... 详细信息

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测定初生重、断奶重、屠宰前活体重和IMF含量等14个性状,然后通过相关性分析从14个性状中初步筛选出影响IMF含量的性状因素,再通过随机森林模型评估各性状因素对IMF含量影响的重要性,进一步通过LASSO回归和逐步回归筛选出影响IMF含量的关键性状因素;在此基础上,利用广义线性模型(generalized linear model,GLM)分析关键性状因素不同水平对IMF含量的影响。[结果]相关性分析结果显示,猪IMF含量与断奶重(r=0.13, P0.05)。胸腰椎结合处背膘厚大于26 mm组的平均IMF含量(2.73%)显著高于其他背膘厚组(P0.05)。[结论]本研究通过机器学习确定了性别、断奶重、屠宰前活体重和胸腰椎结合处背膘厚4个与IMF含量显著相关的活体可测定性状,并发现平均IMF含量随着屠宰前活体重和胸腰椎结合处背膘厚的增加呈明显的上升趋势。

关键词：猪肌内脂肪间接选择模型构建机器学习活体可测定性状

Comparisons of urban-related warming in Beijing using different methods to calculate the daily mean temperature

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Science China Earth Sciences 2019年第4期62卷 693-702页

作者： Deming ZHAO jian wu CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of Sciences Department of Atmospheric Science Yunnan University

To evaluate the contribution of urban surface expansion to regional warming using different methods to calculate the daily mean surface air temperature(SAT), satellite-based images displaying urban surface expansion over the past 37 years(1980–2016) across China were collected for use in nested numerical experiments using the weather research and forecasting(WRF) regional climate model. The contribution of urban surface expansion to urban-related warming was determined using the daily mean SAT averages based on four time records each day(00, 06, 12, and 18 h UTC, T_4) and averages of the SAT maximum(Tmax) and minimum(Tmin)(Txn). The contribution of urban surface expansion to urban-related warming(relative value) in Beijing was 0.110°C per decade(22.8% of total warming) for T_4 and 0.094°C per decade(20.2%) for Txn. The values obtained when using T_4 were larger than those obtained when using Txn. Differences in the urban-related warming calculated using T_4 and Txncould be attributed to the smaller changing trends in Txnin the urban-surface expansion experiment, which resulted from a large changing trend in Tminand a much smaller changing trend in Tmax. The changes in the diurnal cycle of the energy budget due to urban surface expansion induced changes in the diurnal cycle of SAT, as evidenced by the four time records each day, as well as Tmaxand Tmin. This was especially true for periods of intense urban surface expansion, although the annual mean SAT calculated using Txnwas larger than that calculated using T_4. The increase in impervious area(walls, streets, etc.) due to urban surface expansion, as well as the widespread use of building materials with a large heat capacity resulted in a marked increase in ground heat flux in the daytime. This restricted the increase in SAT in the daytime, but promoted it at night. The increases in SAT due to urban surface expansion were not symmetrical, being smaller in the daytime and larger at night.

关键词： Urban surface expansion Surface air temperature Daily mean temperature Changing trend Urban-related warming

Numerical Investigation of Inlet Distortion on an Axial Flow Compressor Rotor with Circumferential Groove Casing Treatment

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Chinese Journal of Aeronautics 2008年第6期21卷 496-505页

作者： Huang jian wu Hu School of Power and Energy Northwestern Polytechnieal University Xi' an 710072 China

On the base of an assumed steady inlet circumferential total pressure distortion, three-dimensional time-dependent numerical simulations are conducted on an axial flow subsonic compressor rotor. The performances and flow fields of a compressor rotor, either casing treated or untreated, are investigated in detail either with or without inlet pressure distortion. Results show that the circumferential groove casing treatment can expand the operating range of the compressor rotor either with or without inlet pressure distortion at the expense of a drop in peak isentropic efficiency. The casing treatment is capable of weakening or even removing the tip leakage vortex effectively either with or without inlet distortion. In clean inlet circumstances, the enhancement and forward movement of tip leakage vortex cause the untreated compressor rotor to stall. By contrast, with circumferential groove casing, the serious flow separation on the suction surface leads to aerodynamic stalling eventually. In the presence of inlet pressure distortion, the blade loading changes from passage to passage as the distorted inflow sector is traversed. Similar to the clean inlet circumstances, with a smooth wall casing, the enhancement and forward movement of tip leakage vortex are still the main factors which lead to the compressor rotor stalling eventually. When the rotor works trader near stall conditions, the blockage resulting from the tip leakage vortex in all the passages is very serious. Especially in several passages, flow-spillage is observed. Compared to the clean inlet circumstances, circumferential groove casing treatment can also eliminate the low energy zone in the outer end wall region effectively.

关键词： axial flow compressor inlet distortion casing treatment aerodynamic stability numerical simulation

Lump and interaction solutions to the (3+1)-dimensional Burgers equation

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Chinese Physics B 2020年第3期29卷 50-54页

作者： jian Liu jian-Wen wu Department of Mathematics and Physics Quzhou UniversityQuzhou 324000China Department of Physics Zhejiang Normal UniversityJinhua 321004China

The(3+1)-dimensional Burgers equation, which describes nonlinear waves in turbulence and the interface dynamics,is considered. Two types of semi-rational solutions, namely, the lump–kink solution and the lump–two kinks solution, are constructed from the quadratic function ansatz. Some interesting features of interactions between lumps and other solitons are revealed analytically and shown graphically, such as fusion and fission processes.

关键词： (3+1)-dimensional Burgers equation lump solution interaction wave solution bilinear form

Results of Ionospheric Heating Experiments Involving an Enhancement in Electron Density in the High Latitude Ionosphere

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Plasma Science and Technology 2016年第9期18卷 890-896页

作者： wu Jun wu jian Zhengwen Key Lab for Electromagnetic Environment Beijing 102206China China Research Institute of Radio Wave Propagation Beijing 102206China

Observations are presented of the phenomenon of the enhancement in electron density and temperature that is caused by a powerful pump wave at a frequency near the fifth gyrofrequency. The observations show that the apparent enhancement in electron density extending over a wide altitude range and the enhancement in electron temperature around the reflection altitude occur as a function of pump frequency. Additionally, the plasma line spectra show unusual behavior as a function of pump frequency. In conclusion, the upper hybrid wave resonance excited by the pump wave plays a dominating role and leads to the enhancement in electron temperature at the upper hybrid altitude. The phenomenon of apparent enhancement in electron density does not correspond to the true enhancement in electron density, this may be due to some mechanism that preferentially involves the plasma transport process and leads to the strong backscatter of radar wave along the magnetic line, which remains to be determined.

关键词： ionospheric heating electron density enhancement electron temperatureenhancement

Local scour by multiple slit-type energy dissipaters

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Journal of Hydrodynamics 2020年第6期32卷 1221-1224页

作者： Li Yao jian-hua wu College of Water Conservancy and Ecological Engineering Nanchang Institute of TechnologyNanchang330099China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China

Energy dissipation and scour control are all the key issues for the design of hydraulic *** the basis of the high energy dissipation for the multiple slit-type energy dissipaters(M-STED)developed by the authors,in this work,the characteristics of the scour hole for the M-STED were experimentally investigated through three sets of those physical models with five cases and a scour hole form index was *** results show that,the M-STED results in not only the high energy dissipation but also the mild upstream slope of the scour hole thanks to the scour hole form index of larger than 0.5,which is in favor of the safety of the release works.

关键词： Energy dissipation scour scour hole form index multiple slit-type energy dissipater

Unified Model for Generation Complex Networks with Utility Preferential Attachment

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Communications in Theoretical Physics 2006年第1X期46卷 183-186页

作者： wu jian-Jun State Key Loboratory of Rail Traffic Control and Safety Beijing Jiaotong University Beijing 100044 China School of Traffic and Transportation Beijing Jiaotong University Beijing 100044 China

In this paper, based on the utility preferential attachment, we propose a new unified model to generate different network topologies such as scale-free, small-world and random networks. Moreover, a new network structure named super scale network is found, which has monopoly characteristic in our simulation experiments. Finally, the characteristics of this new network are given.

关键词： generation complex networks utility preferential attachment

Bilinear Bäcklund Transformation for a Variable-Coefficient Kadomtsev–Petviashvili Equation

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Chinese Physics Letters 2011年第6期28卷 24-27页

作者： wu jian-Ping Institute of Electronic Technology Information Engineering UniversityZhengzhou 450004

Resorting to the Hirota bilinear form,a bilinear Bäcklund transformation(BT)is obtained for a variable-coefficient Kadomtsev–Petviashvili *** applications,based on the resulting bilinear BT,single-soliton solutions and two-soliton solutions together with their soliton characteristics are presented for the ***,starting from the bilinear BT,a Lax pair and a new variable-coefficient(2+1)-dimensional nonlinear evolution equation is derived.

关键词： equation bilinear soliton