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Normality and Quasinormality of Zero-free Meromorphic Functions

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Acta Mathematica Sinica,English Series 2012年第4期28卷 707-716页

作者： jian ming chang changshu Institute of Technology Department of Mathematics

Let k, K ∈1N and F be a family of zero-free meromorphic functions in a domain D such that for each f ∈ F, f（k） - 1 has at most K zeros, ignoring multiplicity. Then F is quasinormal of order at most v=k/k＋1,where v is equal to the largest integer not exceeding k/k＋*** particular, if K = k, then F is normal. The results are sharp.

关键词： Meromorphic functions normal family

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钢铁件渗碳层深度的电磁无损检测

热加工工艺 2004年第3期33卷 45-46页

作者： JIA jian-ming (chang-zhou College of Information Technology,changzhou 213015,China) 健明常州信息职业技术学院江苏常州213015

通过分析磁矫顽力与渗碳层深度之间的关系,应用所试制的电磁无损检测仪(DWY-1)测量渗碳层深度。实践证明,该仪器完全能满足生产实际对渗碳层深度的测量要求。

关键词：无损检测电磁检测渗碳

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正规定则与重值

数学学报（中文版） 2011年第2期54卷 265-270页

作者：徐焱常建明南京师范大学数学科学学院南京210046 常熟理工学院数学系常熟215500

设■为区域D内的一亚纯函数族,ψ(≠0)为D内的全纯函数,k为正整数.如果对每个f∈■,有f(z)≠0,f^((k))(z)≠0及f^((k))(z)-ψ(z)的零点重级至少为(k+2)/k。

关键词：亚纯函数正规族例外函数重数

低氧对人骨髓间充质干细胞向神经细胞分化的影响

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广东医学 2017年第20期38卷 3065-3069页

作者：刘礼金施剑明殷嫦嫦景德镇市第一人民医院骨二科江西景德镇333000 九江学院转化医学重点实验室江西九江332000

目的探讨低氧对人骨髓间充质干细胞(hB MSCs)向神经细胞分化的影响。方法将第2代hB M-SCs进行传代、纯化,取第4代hB MSCs进行流式细胞仪检测鉴定;以含1%FBS的α-MEM为基础诱导培养基,根据处理条件不同分为4组:常氧对照组、低氧对照组(3... 详细信息

目的探讨低氧对人骨髓间充质干细胞(hB MSCs)向神经细胞分化的影响。方法将第2代hB M-SCs进行传代、纯化,取第4代hB MSCs进行流式细胞仪检测鉴定;以含1%FBS的α-MEM为基础诱导培养基,根据处理条件不同分为4组:常氧对照组、低氧对照组(3%氧浓度)、常氧诱导组[添加20 ng/mL表皮生长因子(EGF)及20 ng/mL碱性成纤维细胞生长因子(bF GF)]、低氧诱导组(3%氧浓度下添加20 ng/mL EGF及20 ng/mL bF GF)。连续诱导3 d后,采用RT-PCR及Western blot技术检测神经元特异性烯醇化酶(NSE)、微管相关蛋白2(MAP-2)及胶质纤维酸性蛋白(GFAP)在基因及蛋白水平表达变化。结果第4代hB MSCs流式鉴定结果示:骨髓基质标志CD105、CD90、CD29表达分别为95.8%、98.2%、95.1%,而造血细胞标志CD19表达为0.2%;与常氧对照组比较,低氧对照组NSE、MAP-2、GFAP在基因及蛋白水平表达均无明显改变(P>0.05),而常氧诱导组及低氧诱导组相应表达均升高(P<0.05),且低氧诱导组表达高于常氧诱导组(P<0.05)。结论低氧促进EGF联合bF GF对hB MSCs向神经元细胞及神经胶质细胞分化的诱导作用。

关键词：低氧人骨髓间充质干细胞神经细胞分化

The high levels of DLC-1 contribute to the carcinogenesis in human gliomas

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The high levels of DLC-1 contribute to the carcinogenesis in...

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yong-jian LU,ming-chang LI,Zhong-Min YUAN~* Institute of Neuroscience and the Second Affiliated Hospital,Guangzhou Medical College,Guangzhou,510260,China

＜正＞The decrease of DLC-1（deleted in liver cancer -1） expression led to an aberrant increase in the GTPase activity of Rho factors which contributes to the *** evidences suggested that DLC-1 acted as a tumor suppressor in a number of common human cancers,including HCC,breast,colon,ovarian,uterine,gastric,lung,pancreatic, prostate,renal and nasopharyngeal ***,the role of DLC-1 in human gliomas remained *** the study, we found that human glioma tissues presented high levels of DLC-1 compared with the control tissues by real-time PCR（P ＜0.001）.Western blot and Immunohistochemistry confirmed the results ***,the DLC-1 mRNA levels in WHO grade I gliomas were considerably higher than that in gradeⅡ-Ⅳgliomas（P＜0.001）.By the utility of the glioma cell lines U25 IMG and U87MG,we determined that the mRNA levels of DLC-1 did not change in the condition of 5-aza-2’- deoxycytidine（5’-AZA） alone or the combination of 5’-AZA and trichostatin A（TSA）.Overexpression of wild type DLC- 1 significantly promoted the proliferation of the glioma cells,while DLC- 1/K714E,a dominant negative mutant without GAP enzyme activity,inhibited the ***,our data defined a specific role for DLC-1 that in human gliomas the high levels of DLC-1 may contribute to the carcinogenesis.

关键词： DLC-1 glioma GAP

来源： cnki会议评论

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-jian Tang Yuan-ming Pan Wei Li Rui-Qiong Ma jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu jian Zhang Ya Gao Shuyue Li Cui chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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热轧不锈钢复合板力学性能及工艺优化

中国冶金 2018年第7期28卷 24-27,36页

作者：王小勇张海刘建明马长文首钢集团有限公司技术研究院宽厚板研究所

研究了热轧不锈钢复合板的力学性能及工艺优化。借助显微组织观察技术及热模拟技术对复合板复层塑性恶化的原因及不锈钢再结晶行为进行了研究,并结合研究结果,通过再热处理进行了工艺优化。结果表明,低温终轧使得复层产生明显的加工硬... 详细信息

研究了热轧不锈钢复合板的力学性能及工艺优化。借助显微组织观察技术及热模拟技术对复合板复层塑性恶化的原因及不锈钢再结晶行为进行了研究,并结合研究结果,通过再热处理进行了工艺优化。结果表明,低温终轧使得复层产生明显的加工硬化是导致不锈钢复层塑性恶化的主要原因,通过适当温度的再热处理可以明显改善复层的塑性,获得理想的强塑性匹配。

关键词：不锈钢复合板塑性加工硬化再结晶

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柔性石墨接地体在山区杆塔接地网中的应用

科学技术与工程 2017年第10期17卷 198-201页

作者：甘艳邹建明张昌黄道春金颀华中电网有限公司武汉430000 武汉大学电气工程学院武汉430072

为解决山区杆塔设计存在地形复杂、土壤电阻率高等问题,提出了一种石墨膨润土和柔性石墨接地体在山区杆塔建设中配合使用的方法;并用数值仿真软件CDEGS对典型山区地形接地电阻仿真计算,针对不同地形地貌并结合柔性石墨接地体的优势提出... 详细信息

为解决山区杆塔设计存在地形复杂、土壤电阻率高等问题,提出了一种石墨膨润土和柔性石墨接地体在山区杆塔建设中配合使用的方法;并用数值仿真软件CDEGS对典型山区地形接地电阻仿真计算,针对不同地形地貌并结合柔性石墨接地体的优势提出一套优化设计和改造方案。工程实际应用表明,在山区特殊地形采用独特的杆塔接地网型式;并用石墨膨润土改善接地体周围土壤环境,能有效控制杆塔接地电阻在规程要求内,具有较高的应用价值和推广价值。

关键词：石墨接地体山区杆塔接地石墨膨润土