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中华麻醉学杂志 2010年第B2期30卷 15-18页

作者： CHI Xin-jin LI Shang-rong CHENG Nan HEI Zi-qing LUO Gang-jian GUAN jian-qiang zhang Rui zhang Qi Department of Anesthesiology Third Affiliated Hospital SUN Yat-Sen University Guangzhou 510630 China

Experimental investigation of nitrogen flow boiling heat transfer in a single mini-channel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2020年第2期21卷 147-166页

作者： Bei-chen zhang Qing-lian LI Yuan WANG jian-qiang zhang Jie SONG Feng-chen ZHUANG Science and Technology on Scramjet Laboratory National University of Defense TechnologyChangsha 410073China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China Space Engineering University Beijing 101416China

Flow boiling heat transfer of nitrogen at high subcritical pressure conditions in a single vertical mini-channel with the diameter of 2.0 mm was experimentally *** tested mass flux varied from 530 to 830 kg/(m^2·s),the inlet pressure ranged from 630 to 1080 kPa,and the heat flux ranged from 0 to 223.2 kW/m^*** of the mass flux and the inlet pressure on the nitrogen boiling curve were *** showed that within the limited test conditions,the merging of three boiling curves indicates the dominance of nucleate boiling and the inlet pressure has a positive enhancement on heat transfer *** heat transfer trends were identified with increasing heat *** low heat fluxes,the heat transfer coefficient increases first and then decreases with vapour *** intermediate heat fluxes,the heat transfer coefficient versus the vapour quality presents an inverted"U"*** high heat fluxes,a double valley shape was observed and the partial dry-out in intermittent flow and annular flow helps to interpret the *** increasing inlet pressure increases the heat transfer coefficient over a wide range of vapour quality until the partial dry-out *** lower surface tension and lower latent heat of evaporation enhance the nucleate boiling for higher inlet pressure.A modified experimental correlation(mean absolute error(MAE)=19.3%)was proposed on the basis of the Tran correlation considering both the nucleate boiling and the partial dry-out heat transfer mechanism.

关键词： Mini-channel Nitrogen Flow boiling Heat transfer Regenerative cooling

Investigations on the Chemiluminescence Reaction Between Luminol and Reductant

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Chemical Research in Chinese Universities 1992年第4期8卷 360-364页

作者： LU Jiu-ru, zhang Xin-rong, FENG Man-lian, zhang jian-qiang, zhang Zhu-jun (Department of Chemistry, Shanxi Normal University, Xian, 710062)

The chemiluminescence reaction between luminol and reductant was investigated by a flow-injection system. The results show that this reaction can be used for the determination of the reductant which is active to chemiluminescence in alkaline lumminol, and of the substance which can, in appropriate manner, be converted into the active reductant. The mechanism of the chemiluminescence reaction may be that the reductant reduces dissolved oxygen to O2 , then O2 reacts with alkaline luminol to generate chemiluminescence.

关键词： Reductant Luminol Chemiluminescence

The only purple-flower species in Actaea *** pollinated by a hornet

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Journal of Plant Ecology 2024年第4期17卷 181-196页

作者： Lin-Feng Qiu Jiu-Dong zhang Ying Li Xiao-Ying Liu Dan-Qing zhang Long Huang Ya-Peng Yang Shi-Yu Wang Yue-Yi Li Zi-Wei Ma Jie Sui Lin Wang Xiao-Fen Che Xian-Hua Tian Yi Ren jian-qiang zhang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China College of Life SciencesShaanxi Normal UniversityXi’an 710119China Key Laboratory of Medicinal Plant Resource and Natural Pharmaceutical Chemistry of Ministry of Education Shaanxi Normal UniversityXi’an 710119China College of Biological and Environmental Engineering Xi’an UniversityXi’an 710065China

Examining the pollination biology of plant species is not only crucial for enhancing our understanding of their reproductive biology,but also essential for elucidating their adaptation and evolutionary ***,we investigated the breeding system and pollination biology of two closely related species in *** flower of *** is unique in the genus with purple and chartaceous(paper-like)sepals,fewer stamens with yellow anthers and purple *** three seasons of field observation and exclusion experiments,we determined that *** was primarily pollinated by a hornet species,Vespa bicolor,which also served as the most efficient *** contrast,*** was primarily pollinated by large *** purpurea exhibited a significantly higher cumulative nectar volume than ***,which could be a crucial factor in attracting ***.A control experiment further demonstrated that removing the nectar leaf(petal)significantly decreased the visiting frequency of *** system studies revealed that both species were self-compatible,yet they primarily underwent outcrossing in natural *** study presents a compelling case of possible pollinator shift in *** accompanied by morphological divergence.A more in-depth investigation of this system would offer crucial insights into the extent to which pollinators are involved in the plant speciation process and whether they contribute to reproductive isolation between closely related species.

关键词： Actaea purpurea Actaea japonica breeding system pollinator shift speciation Vespa bicolor

Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo

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Acta Pharmacologica Sinica 2005年第11期26卷 1402-1408页

作者： Yu-jie zhang~(1,2), Chang-hua MA,Wan-liang LU, Xuan zhang, Xiao-liang WANG, jian-ning SUN, qiang zhang~(1.3) ~1 School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China,~2 Department of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China School of Pharmaceutical Sciences Peking University Health Science Center Beijing China Department of Chinese Pharmacy Beijing University of Traditional Chinese Medicine Beijing China

Aim: To investigate the enhancing effects of chitosan with or without enhancers on nasal recombinant hirudin-2 (rHV2) delivery in vitro and in vivo, and to evaluate the ciliotoxicity of these formulations. Methods: The permeation-enhancing effect of various chitosan formulations was estimated by using the permeation coefficient of fluorescein isothiocyanate recombinant hirudin-2 (FITC-rHV2) across the excited rabbit nasal epithelium in vitro. The effect was further evaluated by measuring the blood concentration level after nasal absorption of FITC-rHV2 in rats. The mucosal ciliotoxicity of different formulations was evaluated with an in situ toad palate model. Results: Chitosan at a concentration of 0.5% with or without various enhancers significantly increased the permeability coefficient (P) and relative bioavailability (Fr) of FITC-rHV2 compared with the blank control. The addition of 1 % sodium dodecylsulfate, 5% Brij35,5% Tween 80,1.5% menthol, 1% glycyrrhizic acid monoammonium salt (GAM) or 4% Azone into the 0.5% chitosan solution resulted in a further increase in absorption (P<0.05) compared with 0.5% chitosan alone. But co-administration of chitosan with 5% hydroxyl-propyl-beta-cyclodextrin (HP-β-CD), 5% lecithin or 0.1 % ethylenediamine tetraacetic acid (EDTA) was not more effective than using the 0.5% chitosan solution alone. Chitosan alone and with 5% HP-β-CD, 0.1 % EDTA, 1 % GAM or 5%Tween80 was relatively less ciliotoxic. Conclusion: Chitosan with or without some enhancers was able to effectively promote the nasal absorption of recombinant hirudin, while not resulting in severe mucosal ciliotoxicity. A chitosan formulation system would be a useful approach for the nasal delivery of recombinant hirudin.

关键词： nasal absorption hirudin chitosan formulation permeability bioavailability enhancer: ciliotoxicity

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高阻尼橡胶支座剪切性能压力相关性试验研究

铁道工程学报 2017年第1期34卷 47-51,117页

作者：王建强张振洋李政郑州大学郑州450001 河南省建筑设计研究院有限公司郑州450014 河南应用技术职业学院郑州450042

研究目的:在实际地震中由于水平倾覆力矩和竖向地震作用的影响,基础隔震结构中橡胶支座承受的竖向压力将会产生较大变化,而橡胶支座竖向压力的变化将会对支座的剪切性能产生一定影响,因而有必要对支座剪切性能的压力相关性进行研究。本... 详细信息

研究目的:在实际地震中由于水平倾覆力矩和竖向地震作用的影响,基础隔震结构中橡胶支座承受的竖向压力将会产生较大变化,而橡胶支座竖向压力的变化将会对支座的剪切性能产生一定影响,因而有必要对支座剪切性能的压力相关性进行研究。本文采用低周反复循环加载试验方法对高阻尼橡胶支座进行压剪试验,研究压应力和剪应变对支座剪切性能的影响,从而建立高阻尼橡胶支座剪切性能的压力相关性经验公式。研究结论:(1)随着压应力和剪应变的增大,支座的滞回曲线越来越饱满,支座的耗能能力增大,并出现了明显的刚度硬化现象;(2)支座的屈服力和等效阻尼比随着压应力的增大而增大,随着剪应变的增大,压应力对屈服力的影响逐渐增大,压应力对等效阻尼比的影响有所减小;(3)支座的屈服后刚度随着压应力的增大而减小,随着剪应变的增大,压应力对屈服后刚度的影响逐渐减小;(4)当剪应变较大时,水平等效刚度随着压应力的增大而增大;(5)根据试验结果给出了支座剪切性能的压力相关性经验公式,可供高阻尼橡胶支座基础隔震结构设计人员参考和使用。

关键词：高阻尼橡胶支座压剪试验剪切性能压力相关性

纳米碳材料在可穿戴柔性导电材料中的应用研究进展

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物理化学学报 2016年第10期32卷 2427-2446页

作者：夏凯伦蹇木强张莹莹清华大学化学系清华大学微纳米力学中心北京100084

可穿戴设备的兴起使得对柔性器件的需求日益提高,柔性导电材料作为可穿戴器件的重要组成部分而成为研究的热点。传统的电极材料主要是金属,因金属材料本身不具有柔性,一般通过降低金属层厚度以及设计波纹结构等策略实现其在柔性器件中... 详细信息

可穿戴设备的兴起使得对柔性器件的需求日益提高,柔性导电材料作为可穿戴器件的重要组成部分而成为研究的热点。传统的电极材料主要是金属,因金属材料本身不具有柔性,一般通过降低金属层厚度以及设计波纹结构等策略实现其在柔性器件中的应用,其加工程序复杂,成本较高。以碳纳米管和石墨烯为代表的纳米碳材料兼具良好的柔性和优异的导电性,且具有化学稳定、热稳定、光学透明性等优点,在柔性导电材料领域展现了极大的应用潜力。本文简要综述了近年来纳米碳材料在柔性导电材料领域的研究进展,首先介绍了碳纳米管基柔性导电材料,分别包括基于碳纳米管水平阵列、碳纳米管垂直阵列、碳纳米管薄膜、碳纳米管纤维的柔性导电材料;继而介绍了石墨烯基柔性导电材料,包括基于剥离法制备的石墨烯和化学气相沉积法制备的石墨烯以及石墨烯纤维基柔性导电材料;并简述了碳纳米管/石墨烯复合柔性导电材料;最后论述了纳米碳材料基柔性导电材料所面临的挑战并展望了其未来发展方向。

关键词：碳纳米管石墨烯纳米碳材料柔性导电材料可穿戴器件

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

东亚夏季风边缘摆动区陆面能量时空分布规律及其与气候环境的关系

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气象学报 2016年第6期74卷 876-888页

作者：曾剑张强王春玲中国气象局兰州干旱气象研究所、甘肃省干旱气候变化与减灾重点实验室、中国气象局干旱气候变化与减灾重点开放实验室兰州730020 北京市气象台北京100089 甘肃省气象局兰州730020 北京市气象服务中心北京100089

东亚夏季风边缘摆动区既是气候敏感区,也是生态脆弱区和农牧交错带,其特殊陆面能量空间分布格局和演变特征对理解该区域天气和气候变化有重要意义。然而受限于陆面观测资料缺乏,对这部分陆面特征的认识仍非常有限。通过对34a陆面模拟集... 详细信息

东亚夏季风边缘摆动区既是气候敏感区,也是生态脆弱区和农牧交错带,其特殊陆面能量空间分布格局和演变特征对理解该区域天气和气候变化有重要意义。然而受限于陆面观测资料缺乏,对这部分陆面特征的认识仍非常有限。通过对34a陆面模拟集成产品的分析,发现夏季风边缘摆动区内潜热和感热通量在空间上表现出明显的过渡特征,由摆动区外的相对均衡状态进入到摆动区内的"突变转换";陆面能量平衡具有明显的区域特征,能量平衡各分量在纬向和经向都表现出了"阶梯型"的变化。就演变而言,区域平均感热和潜热没有表现出规律性的递减或递增趋势,波动幅度在±20%以内,但在20世纪末存在一个较为明显的摆动相位转换:1997年之前夏季风边缘摆动区夏季风相对活跃,潜热通量总体高于其气候值而感热通量则低于其气候值,之后出现了相反的现象。此外,区内感热和潜热通量对气候环境干湿性质非常敏感,两者存在明显的线性关系。

关键词：东亚夏季风边缘摆动区陆面能量平衡空间分布气候特征

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芪附汤为主治疗病毒性心肌炎100例

上海中医药杂志 2001年第11期35卷 14-15页

作者：刘建荣张强湖南省郴州市中医院湖南郴州423000

用自拟芪附汤为主治疗病毒性心肌炎 (VMC) 10 0例 ,为治疗组 ,与对照组西药常规治疗的 5 0例作对照观察 ,疗程 4～ 6周。结果 :治疗组临床治愈率 5 1% ,总有效率 95 % ,对照组治愈率15 % ,总有效率 3 6% ,组间比较P <0 0 1。

关键词：病毒性心肌炎芪附汤西医治疗中医药治疗比较 VMC